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Conserved domains on  [gi|595582277|ref|NP_001277686|]
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toll-like receptor 7 isoform a precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
484-786 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  484 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 563
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  564 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 643
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  644 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 723
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  724 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 786
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 174-786 2.64e-18

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  174 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 252
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  253 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 332
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  333 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 409
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  410 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 487
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  488 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 567
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  568 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 647
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  648 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 726
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  727 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 786
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.07e-15

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.07e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277    891 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582277    971 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
32-243 8.39e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   32 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 111
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  112 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 191
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 595582277  192 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 243
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 7.33e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   754 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 595582277   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
484-786 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  484 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 563
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  564 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 643
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  644 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 723
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  724 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 786
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 174-786 2.64e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  174 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 252
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  253 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 332
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  333 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 409
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  410 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 487
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  488 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 567
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  568 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 647
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  648 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 726
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  727 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 786
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-434 5.33e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 5.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  124 SGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVM 203
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  204 RNLKVLSLKDNNVTAVPTtlppNLLELYLYNNIIKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD 283
Cdd:COG4886    96 TNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------------------QLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  284 --NAFNSLTELKVLRLHSNSLQHVPPtWFKNMRNLQELDLSQNYLAreiEEAKFLHFLPNLVELDFSFNyELQvyhasiT 361
Cdd:COG4886   151 lpEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGN-QLT------D 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595582277  362 LPHSLSSLENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 434
Cdd:COG4886   220 LPEPLANLTNLETLDLSN-------NqlTDLPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.07e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.07e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277    891 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582277    971 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
656-788 1.66e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  656 LDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLLKHLEILDLSHNQLTKVPERLANcskSLTTLILKHNQ 735
Cdd:PRK15370  204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELPERLPS---ALQSLDLFHNK 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277  736 IRQLTKYFLEdalQLRYLDISSNKIQVIQK----------------TSFPENVLNNLEMLVLHHNRFLC 788
Cdd:PRK15370  274 ISCLPENLPE---ELRYLSVYDNSIRTLPAhlpsgithlnvqsnslTALPETLPPGLKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-350 2.12e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  198 DAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNC-------PRCYN---- 265
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRisvveglENLTNleel 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  266 -VPYPCTPCENnsPLQIHDNAFNSLTE-LKVLRLHSNSLQHVppTWFKNMRNLQELDLSQNYLaREIEEAK-FLHFLPNL 342
Cdd:cd21340    96 hIENQRLPPGE--KLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI-SDLEELLdLLSSWPSL 170


                  ....*...
gi 595582277  343 VELDFSFN 350
Cdd:cd21340   171 RELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
32-243 8.39e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   32 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 111
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  112 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 191
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 595582277  192 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 243
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 892-1018 9.46e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 9.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   892 YDAFIvyDTKNSAVTEWVLQELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAktESFKMA 971
Cdd:pfam01582    1 YDVFL--SFRGSDTREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYA--SSGWCL 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 595582277   972 FYLSH-QRLLDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCR----SSVLEWPA 1018
Cdd:pfam01582   74 DELVKiLECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
290-350 1.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.24e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595582277   290 TELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLaREIEEAKFLHfLPNLVELDFSFN 350
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
497-555 4.44e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.44e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277   497 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIgQTLNGSELWPLRELRYLDFSNNRL 555
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-784 2.47e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  640 DNR--YLDFFKNLFNLEVLDISRNSLNSLppEVFEGMPpNLKNLSLAKN------GLksffwdrlQLLKHLEILDLSHNQ 711
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKI--ENLENLV-NLKKLYLGGNrisvveGL--------ENLTNLEELHIENQR 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277  712 L------TKVPERLANCSKSLTTLILKHNQIRQLTkyFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHN 784
Cdd:cd21340   102 LppgeklTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
75-139 2.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.86e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595582277    75 NHIPSISPDSFRRLNHLEEIDLRCNCVPVllgskanvctkrlqIRPGSFSGLSDLKALYLDGNQL 139
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 7.33e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   754 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 595582277   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-259 3.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   75 NHIPSIsPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhlls 154
Cdd:COG4886   169 NQLTDL-PEELGNLTNLKELDLSNNQITDL---------------PEPLGNLTNLEELDLSGNQLTDLP----------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  155 leannifsitkENLTELVNIETLYLGQNcyyrnpcNVSysiEKDAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLY 233
Cdd:COG4886   222 -----------EPLANLTNLETLDLSNN-------QLT---DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLS 280

                         170       180
                  ....*....|....*....|....*.
gi 595582277  234 NNIIKKIQENDFNNLNELQVLDLSGN 259
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLL 306
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
484-786 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  484 SFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAF 563
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  564 EELQSLEVLDLSSNSHYFQAEGIThmlnftkklrlldKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWragdnry 643
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTNLE-------------SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  644 lDFFKNLFNLEVLDISRNSLNSLPPEvFEGMPpNLKNLSLAKNGLKSFFwDRLQLLKHLEILDLSHNQLTKVPERLANCs 723
Cdd:COG4886   153 -EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANL- 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  724 KSLTTLILKHNQIRQLTKyfLEDALQLRYLDISSNKIqviqkTSFPENV-LNNLEMLVLHHNRF 786
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 174-786 2.64e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  174 IETLYLGQNcyyrnpcNVSYSIEKDAFLVMRNLKVLSLKDNNVT-AVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQ 252
Cdd:PLN00113   95 IQTINLSNN-------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  253 VLDLSGNCpRCYNVPypctpcennsplqihdNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIee 332
Cdd:PLN00113  168 VLDLGGNV-LVGKIP----------------NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI-- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  333 AKFLHFLPNLVELDFSFNyelqvyHASITLPHSLSSLENLKilrvkgYVF---KELKNSSLSVLHKLPRLEVLDLGTNFI 409
Cdd:PLN00113  229 PYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNLQ------YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  410 --KIADLNIfkHFENLKLIDLSVNKISpseesrevGFCPNAQTSVDRHgpQVLEALhyfrydeyarSCRFKNKeppsfLP 487
Cdd:PLN00113  297 sgEIPELVI--QLQNLEILHLFSNNFT--------GKIPVALTSLPRL--QVLQLW----------SNKFSGE-----IP 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  488 LNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQ 567
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLP 428

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  568 SLEVLDLSSNShyfqaegithmlnftkklrlldklmmndndistsasrtmesdslrileFRGNHLDVLWragdnryldff 647
Cdd:PLN00113  429 LVYFLDISNNN------------------------------------------------LQGRINSRKW----------- 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  648 kNLFNLEVLDISRNSLNSLPPEVFEGmpPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCsKSL 726
Cdd:PLN00113  450 -DMPSLQMLSLARNKFFGGLPDSFGS--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC-KKL 525

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595582277  727 TTLILKHNQIR-QLTKYFLEDALqLRYLDISSNKIQviqkTSFPENvLNNLEMLV---LHHNRF 786
Cdd:PLN00113  526 VSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLS----GEIPKN-LGNVESLVqvnISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-434 5.33e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 5.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  124 SGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVM 203
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  204 RNLKVLSLKDNNVTAVPTtlppNLLELYLYNNIIKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD 283
Cdd:COG4886    96 TNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------------------QLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  284 --NAFNSLTELKVLRLHSNSLQHVPPtWFKNMRNLQELDLSQNYLAreiEEAKFLHFLPNLVELDFSFNyELQvyhasiT 361
Cdd:COG4886   151 lpEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGN-QLT------D 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595582277  362 LPHSLSSLENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 434
Cdd:COG4886   220 LPEPLANLTNLETLDLSN-------NqlTDLPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
497-842 2.93e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  497 QTLDLSRNNiffikpsDFQHLSFLKCLNLSGNTIGQTlnGSELWPLRELRYLDFSNNRLDLLySTAFEELQSLEVLDLSS 576
Cdd:COG4886    99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSN 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  577 NshyfqaeGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLwragdnryLDFFKNLFNLEVL 656
Cdd:COG4886   169 N-------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL--------PEPLANLTNLETL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  657 DISRNSLNSLPpeVFEGMPpNLKNLSLAKNGLKSFfwDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQI 736
Cdd:COG4886   234 DLSNNQLTDLP--ELGNLT-NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  737 RQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCV 816
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                         330       340
                  ....*....|....*....|....*.
gi 595582277  817 GPGAHKGQSVISLDLYTCELDLTNLI 842
Cdd:COG4886   389 LLLLLLTTTAGVLLLTLALLDAVNTE 414
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.07e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 75.05  E-value: 1.07e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277    891 CYDAFIVYdtknsAVTEWVLQELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKM 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582277    971 AFYLSHQRLLDEKVDVIILIFLE--KPLQKSKFLQLRKRLcRSSVLEWPANPQAHpyFWqclKNALTT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEviPSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FW---KKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-432 1.65e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   81 SPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhllsleanni 160
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL---------------PEELANLTNLKELDLSNNQLTDLP----------------- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  161 fsitkENLTELVNIETLYLGQNcyyrnpcnvsySIEK--DAFLVMRNLKVLSLKDNNVTAVPTTL--PPNLLELYLYNNI 236
Cdd:COG4886   153 -----EPLGNLTNLKSLDLSNN-----------QLTDlpEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQ 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  237 IKKIqENDFNNLNELQVLDLSGNcprcynvpypctpcennsplQIHD-NAFNSLTELKVLRLHSNSLQHVPPTwfKNMRN 315
Cdd:COG4886   217 LTDL-PEPLANLTNLETLDLSNN--------------------QLTDlPELGNLTNLEELDLSNNQLTDLPPL--ANLTN 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  316 LQELDLSQNYLAR-EIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLH 394
Cdd:COG4886   274 LKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 595582277  395 KLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNK 432
Cdd:COG4886   354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
570-786 3.02e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 3.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  570 EVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLD---- 645
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSllll 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  646 ---FFKNLFNLEVLDISRNS-LNSLPpevfegmppNLKNLSLAKNGLKSFFWDrLQLLKHLEILDLSHNQLTKVPERLAN 721
Cdd:COG4886    88 gltDLGDLTNLTELDLSGNEeLSNLT---------NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGN 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 595582277  722 CsKSLTTLILKHNQIRQLTKyFLEDALQLRYLDISSNKIqviqkTSFPENV--LNNLEMLVLHHNRF 786
Cdd:COG4886   158 L-TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI-----TDLPEPLgnLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-434 4.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 4.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  156 EANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNN 235
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  236 IIKKIQENDFNNLNELQVLDLSGNCPRcynvpypcTPCENNSPLQIHDN-------AFNSLTELKVLRLHSNSLQHVPPt 308
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNEEL--------SNLTNLESLDLSGNqltdlpeELANLTNLKELDLSNNQLTDLPE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  309 WFKNMRNLQELDLSQNYLaREIEEAkfLHFLPNLVELDFSFNyelqvyhaSIT-LPHSLSSLENLKILRVKGYVFKELKN 387
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQL-TDLPEE--LGNLTNLKELDLSNN--------QITdLPEPLGNLTNLEELDLSGNQLTDLPE 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 595582277  388 SslsvLHKLPRLEVLDLGTNfiKIADLNIFKHFENLKLIDLSVNKIS 434
Cdd:COG4886   223 P----LANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
656-788 1.66e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  656 LDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLLKHLEILDLSHNQLTKVPERLANcskSLTTLILKHNQ 735
Cdd:PRK15370  204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSI---PATLPDTIQEMELSINRITELPERLPS---ALQSLDLFHNK 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277  736 IRQLTKYFLEdalQLRYLDISSNKIQVIQK----------------TSFPENVLNNLEMLVLHHNRFLC 788
Cdd:PRK15370  274 ISCLPENLPE---ELRYLSVYDNSIRTLPAhlpsgithlnvqsnslTALPETLPPGLKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-350 2.12e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  198 DAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNC-------PRCYN---- 265
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRisvveglENLTNleel 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  266 -VPYPCTPCENnsPLQIHDNAFNSLTE-LKVLRLHSNSLQHVppTWFKNMRNLQELDLSQNYLaREIEEAK-FLHFLPNL 342
Cdd:cd21340    96 hIENQRLPPGE--KLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI-SDLEELLdLLSSWPSL 170


                  ....*...
gi 595582277  343 VELDFSFN 350
Cdd:cd21340   171 RELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
32-243 8.39e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   32 KTLPCEVKVNIPEAHVivdcTDKHLTEIPEGIPTNTTNLTLTINHIPSIsPDsfRRLNHLEEIDLRCNCVPVLlgskanv 111
Cdd:PRK15370  212 KSLPENLQGNIKTLYA----NSNQLTSIPATLPDTIQEMELSINRITEL-PE--RLPSALQSLDLFHNKISCL------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  112 ctkrlqirPGSFSglSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANnifSITKENLTELVNIETLYLGQNCYYRNPCNV 191
Cdd:PRK15370  278 --------PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPPGLKTLEAGENALTSLPASL 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 595582277  192 SYSiekdaflvmrnLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQEN 243
Cdd:PRK15370  345 PPE-----------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPEN 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
104-369 8.98e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.71  E-value: 8.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  104 LLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhllsleannifsitkENLTelVNIETLYLGQNC 183
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLP----------------------ENLQ--GNIKTLYANSNQ 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  184 YYRNPCNVSYSIEKDAFLVMR----------NLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQV 253
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRitelperlpsALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNV 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  254 LDLSGNCprcynvpYPCTPCENNSPLQIHDNAFNSL-----TELKVLRLHSNSL----QHVPPTwfknmrnLQELDLSQN 324
Cdd:PRK15370  312 QSNSLTA-------LPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQItvlpETLPPT-------ITTLDVSRN 377

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 595582277  325 YLAreieeakflhflpNLVE-LDFSFNYELQVYHASITLPHSLSSL 369
Cdd:PRK15370  378 ALT-------------NLPEnLPAALQIMQASRNNLVRLPESLPHF 410
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 892-1018 9.46e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 9.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   892 YDAFIvyDTKNSAVTEWVLQELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAktESFKMA 971
Cdd:pfam01582    1 YDVFL--SFRGSDTREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYA--SSGWCL 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 595582277   972 FYLSH-QRLLDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCR----SSVLEWPA 1018
Cdd:pfam01582   74 DELVKiLECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
290-350 1.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.24e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595582277   290 TELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLaREIEEAKFLHfLPNLVELDFSFN 350
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 203-434 1.89e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  203 MRNLKVLSLKDNNVTAVPT-TLPPNLLELYLYNNIIKKIQenDFNNLNELQVLDLSGNCprcynvpypCTPCENnsplqi 281
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQ---------IEKIEN------ 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  282 hdnaFNSLTELKVLRLHSNSLQHVppTWFKNMRNLQELDLS-QNylareieeakflhfLPNLVELDFSfnyelqvyhasi 360
Cdd:cd21340    64 ----LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR--------------LPPGEKLTFD------------ 111

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277  361 tlPHSLSSL-ENLKILRVKGyvfkelkN--SSLSVLHKLPRLEVLDLGTNFIK-IADL-NIFKHFENLKLIDLSVNKIS 434
Cdd:cd21340   112 --PRSLAALsNSLRVLNISG-------NniDSLEPLAPLRNLEQLDASNNQISdLEELlDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 495-787 2.17e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  495 YGQTLDLSRNNIFFIKPSD-FQHLSFLKCLNLSGNTI-GQTLNGS--------------------ELWPLRELRYLDFSN 552
Cdd:PLN00113   94 YIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFtGSIPRGSipnletldlsnnmlsgeipnDIGSFSSLKVLDLGG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  553 NRLDLLYSTAFEELQSLEVLDLSSNShyfQAEGITHMLNftkKLRLLDKLMMNDNDISTSASRTM-ESDSLrilefrgNH 631
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQ---LVGQIPRELG---QMKSLKWIYLGYNNLSGEIPYEIgGLTSL-------NH 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  632 LDVLWR------------AGDNRYLDFFKN------------LFNLEVLDISRNSLNSLPPEVFEGMPpNLKNLSLAKN- 686
Cdd:PLN00113  241 LDLVYNnltgpipsslgnLKNLQYLFLYQNklsgpippsifsLQKLISLDLSDNSLSGEIPELVIQLQ-NLEILHLFSNn 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  687 -------GLKSFfwDRLQLL----------------KH--LEILDLSHNQLT-KVPERLANcSKSLTTLILKHNQI---- 736
Cdd:PLN00113  320 ftgkipvALTSL--PRLQVLqlwsnkfsgeipknlgKHnnLTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLegei 396

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595582277  737 -------RQLTKYFLED------------ALQLRY-LDISSNKIQVIQKTSFPEnvLNNLEMLVLHHNRFL 787
Cdd:PLN00113  397 pkslgacRSLRRVRLQDnsfsgelpseftKLPLVYfLDISNNNLQGRINSRKWD--MPSLQMLSLARNKFF 465
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
545-740 2.68e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  545 LRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNS---HYfqAEGITHMLNFTKKLRLL-DKLMMNdndistsasrtmesd 620
Cdd:PRK15370  264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTlpaHL--PSGITHLNVQSNSLTALpETLPPG--------------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  621 sLRILEfrgnhldvlwrAGDNRYLDFFKNL-FNLEVLDISRNSLNSLPpevfEGMPPNLKNLSLAKNGLKSFfwdRLQLL 699
Cdd:PRK15370  327 -LKTLE-----------AGENALTSLPASLpPELQVLDVSKNQITVLP----ETLPPTITTLDVSRNALTNL---PENLP 387

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 595582277  700 KHLEILDLSHNQLTKVPERLANC---SKSLTTLILKHNQIRQLT 740
Cdd:PRK15370  388 AALQIMQASRNNLVRLPESLPHFrgeGPQPTRIIVEYNPFSERT 431
LRR_8 pfam13855
Leucine rich repeat;
497-555 4.44e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.44e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277   497 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIgQTLNGSELWPLRELRYLDFSNNRL 555
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
524-780 4.90e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  524 NLSGNTIGQTLNGSELWPLRE-----LRYLDFSNNRLDLLYstafEELQS-LEVLDLSSNSHYFQAEgithmlNFTKKLR 597
Cdd:PRK15370  217 NLQGNIKTLYANSNQLTSIPAtlpdtIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCLPE------NLPEELR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  598 LLDklmMNDNDISTSASRTMESDSlrilefrgnHLDVLwragdNRYLDFFKNLF--NLEVLDISRNSLNSLPpevfEGMP 675
Cdd:PRK15370  287 YLS---VYDNSIRTLPAHLPSGIT---------HLNVQ-----SNSLTALPETLppGLKTLEAGENALTSLP----ASLP 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  676 PNLKNLSLAKNglksffwdRLQLLKH-----LEILDLSHNQLTKVPErlaNCSKSLTTLILKHNQIRQLTK---YFLEDA 747
Cdd:PRK15370  346 PELQVLDVSKN--------QITVLPEtlpptITTLDVSRNALTNLPE---NLPAALQIMQASRNNLVRLPEslpHFRGEG 414

                         250       260       270
                  ....*....|....*....|....*....|...
gi 595582277  748 LQlryldisSNKIqVIQKTSFPENVLNNLEMLV 780
Cdd:PRK15370  415 PQ-------PTRI-IVEYNPFSERTIQNMQRLM 439
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 498-786 9.34e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 9.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  498 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFeeLQSLEVLDLSSN 577
Cdd:PLN00113   73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  578 ShyfqaegithmlnFTKKLrlldklmmnDNDISTSAsrtmesdSLRILEFRGNHLdvlwragDNRYLDFFKNLFNLEVLD 657
Cdd:PLN00113  151 M-------------LSGEI---------PNDIGSFS-------SLKVLDLGGNVL-------VGKIPNSLTNLTSLEFLT 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  658 ISRNSL-NSLPPEVfeGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLT-KVPERLANCSKsLTTLILKHNQ 735
Cdd:PLN00113  195 LASNQLvGQIPREL--GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN-LQYLFLYQNK 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 595582277  736 IRQLTKYFLEDALQLRYLDISSNKIQviqkTSFPENV--LNNLEMLVLHHNRF 786
Cdd:PLN00113  272 LSGPIPPSIFSLQKLISLDLSDNSLS----GEIPELViqLQNLEILHLFSNNF 320
LRR_8 pfam13855
Leucine rich repeat;
275-326 1.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 595582277   275 NNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYL 326
Cdd:pfam13855   10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-784 2.47e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  640 DNR--YLDFFKNLFNLEVLDISRNSLNSLppEVFEGMPpNLKNLSLAKN------GLksffwdrlQLLKHLEILDLSHNQ 711
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKI--ENLENLV-NLKKLYLGGNrisvveGL--------ENLTNLEELHIENQR 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277  712 L------TKVPERLANCSKSLTTLILKHNQIRQLTkyFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHN 784
Cdd:cd21340   102 LppgeklTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
676-736 8.57e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 8.57e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595582277   676 PNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQI 736
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
75-139 2.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.86e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595582277    75 NHIPSISPDSFRRLNHLEEIDLRCNCVPVllgskanvctkrlqIRPGSFSGLSDLKALYLDGNQL 139
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 895-993 4.23e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 46.92  E-value: 4.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   895 FIVYDTKNSAVTEWVLQELvakledpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYL 974
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90
                   ....*....|....*....
gi 595582277   975 SHQRLLDEKvdVIILIFLE 993
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
605-786 7.18e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 7.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  605 NDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLA 684
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  685 KNGLKSFFWDRLQLLKHLEIL-----------------DLSHNQLTKVPERLANCsKSLTTLILKHNQIRQLTKyFLEDA 747
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELdlsgneelsnltnleslDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 595582277  748 LQLRYLDISSNKIqviqkTSFPENV--LNNLEMLVLHHNRF 786
Cdd:COG4886   159 TNLKSLDLSNNQL-----TDLPEELgnLTNLKELDLSNNQI 194
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 7.33e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.47  E-value: 7.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   754 DISSNKIQVIQKTSFpeNVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTI--PYLAtdvTCVGPGAHKGQSVISLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 595582277   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 pfam13855
Leucine rich repeat;
204-259 9.85e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 9.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 595582277   204 RNLKVLSLKDNNVTAVPTTL---PPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGN 259
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 453-720 1.79e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  453 DRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYG---QTLDLSRNNIFFIKP---SDFQHLSFLKCLNLS 526
Cdd:cd00116    37 EEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGcglQELDLSDNALGPDGCgvlESLLRSSSLQELKLN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  527 ----GNTIGQTLNGSELWPLRELRYLDFSNNRL------DLlySTAFEELQSLEVLDLSSNShyFQAEGITHMLNFTKKL 596
Cdd:cd00116   117 nnglGDRGLRLLAKGLKDLPPALEKLVLGRNRLegasceAL--AKALRANRDLKELNLANNG--IGDAGIRALAEGLKAN 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  597 RLLDKLMMNDNDIStsasrtmesdslrilefrgnhldvlwRAGDNRYLDFFKNLFNLEVLDISRNSLNSLP-PEVFEGMP 675
Cdd:cd00116   193 CNLEVLDLNNNGLT--------------------------DEGASALAETLASLKSLEVLNLGDNNLTDAGaAALASALL 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 595582277  676 ---PNLKNLSLAKNGLK-SFFWDRLQLLKH---LEILDLSHNQLTKVPERLA 720
Cdd:cd00116   247 spnISLLTLSLSCNDITdDGAKDLAEVLAEkesLLELDLRGNKFGEEGAQLL 298
LRR_8 pfam13855
Leucine rich repeat;
725-786 1.94e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.94e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595582277   725 SLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPEnvLNNLEMLVLHHNRF 786
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 399-428 2.17e-05

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 42.33  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 595582277   399 LEVLDLGTNFIKIADLNIFKHFENLKLIDL 428
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-259 3.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   75 NHIPSIsPDSFRRLNHLEEIDLRCNCVPVLlgskanvctkrlqirPGSFSGLSDLKALYLDGNQLLEIPqdlpsslhlls 154
Cdd:COG4886   169 NQLTDL-PEELGNLTNLKELDLSNNQITDL---------------PEPLGNLTNLEELDLSGNQLTDLP----------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  155 leannifsitkENLTELVNIETLYLGQNcyyrnpcNVSysiEKDAFLVMRNLKVLSLKDNNVTAVPTTLP-PNLLELYLY 233
Cdd:COG4886   222 -----------EPLANLTNLETLDLSNN-------QLT---DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLS 280

                         170       180
                  ....*....|....*....|....*.
gi 595582277  234 NNIIKKIQENDFNNLNELQVLDLSGN 259
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
621-688 3.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 3.75e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582277   621 SLRILEFRGNHLDVLwraGDnrylDFFKNLFNLEVLDISRNSLNSLPPEVFEGMpPNLKNLSLAKNGL 688
Cdd:pfam13855    2 NLRSLDLSNNRLTSL---DD----GAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 520-760 5.03e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 5.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  520 LKCLNLSGNTIGQT---LNGSELWPLRELRYLDFSNNRL-DLLYST-----AFEELQSLEVLDLSSNShyFQAEGITHML 590
Cdd:cd00116    25 LQVLRLEGNTLGEEaakALASALRPQPSLKELCLSLNETgRIPRGLqsllqGLTKGCGLQELDLSDNA--LGPDGCGVLE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  591 NFTKKLRLlDKLMMNDNDISTSASRTMeSDSLRILEFRGNHLdVLWR-----AGDNRYLDFFKNLFNLEVLDISRNSLN- 664
Cdd:cd00116   103 SLLRSSSL-QELKLNNNGLGDRGLRLL-AKGLKDLPPALEKL-VLGRnrlegASCEALAKALRANRDLKELNLANNGIGd 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  665 SLPPEVFEGMP--PNLKNLSLAKNGLK----SFFWDRLQLLKHLEILDLSHNQLTKVP-----ERLANCSKSLTTLILKH 733
Cdd:cd00116   180 AGIRALAEGLKanCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSC 259

                         250       260       270
                  ....*....|....*....|....*....|.
gi 595582277  734 NQIRQLT----KYFLEDALQLRYLDISSNKI 760
Cdd:cd00116   260 NDITDDGakdlAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
701-760 6.18e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   701 HLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKI 760
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 528-760 1.57e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  528 NTIGQTLNGSELWPLRELRYLDFSNN-----RLDLLYSTAFEELQSLEVLDLSSNshYFQAEGITHMLNFTKKLRLLDKL 602
Cdd:COG5238   136 ALPRRINLIQVLKDPLGGNAVHLLGLaarlgLLAAISMAKALQNNSVETVYLGCN--QIGDEGIEELAEALTQNTTVTTL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  603 MMNDNDISTSASRTM-----ESDSLRILEFRGNHLdvlwraGDNRYLDFFKNLFN---LEVLDISRNSLNSlppevfEGM 674
Cdd:COG5238   214 WLKRNPIGDEGAEILaealkGNKSLTTLDLSNNQI------GDEGVIALAEALKNnttVETLYLSGNQIGA------EGA 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  675 ppnlknLSLAKNglksffwdrLQLLKHLEILDLSHNQLT-----KVPERLANcSKSLTTLILKHNQIRQLTKYFLEDALQ 749
Cdd:COG5238   282 ------IALAKA---------LQGNTTLTSLDLSVNRIGdegaiALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQ 345

                         250
                  ....*....|....*
gi 595582277  750 ----LRYLDISSNKI 760
Cdd:COG5238   346 enttLHSLDLSDNQI 360
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-407 3.11e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277   85 FRRLNHLEEIDLRCNcvpVLLGSKANVCTKRLQIRPgsfsglsDLKALYLDGNQLLEIPQdlpsslhllsleannIFSIT 164
Cdd:cd00116    19 LPKLLCLQVLRLEGN---TLGEEAAKALASALRPQP-------SLKELCLSLNETGRIPR---------------GLQSL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  165 KENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLvmrnlKVLSLKDNN--------VTAVPTTLPPNLLELYL-YNN 235
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSL-----QELKLNNNGlgdrglrlLAKGLKDLPPALEKLVLgRNR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  236 IIKKIQE---NDFNNLNELQVLDLSGNCPRCYNVPYPCtpcennsplqihdNAFNSLTELKVLRLHSNSLQH-------- 304
Cdd:cd00116   149 LEGASCEalaKALRANRDLKELNLANNGIGDAGIRALA-------------EGLKANCNLEVLDLNNNGLTDegasalae 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  305 VPPTWfknmRNLQELDLSQNYL----AREIEEAkFLHFLPNLVELDFSFNYELQVyhASITLPHSLSSLENLKILRVKG- 379
Cdd:cd00116   216 TLASL----KSLEVLNLGDNNLtdagAAALASA-LLSPNISLLTLSLSCNDITDD--GAKDLAEVLAEKESLLELDLRGn 288

                         330       340
                  ....*....|....*....|....*....
gi 595582277  380 YVFKELKNSSLSVLH-KLPRLEVLDLGTN 407
Cdd:cd00116   289 KFGEEGAQLLAESLLePGNELESLWVKDD 317
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 521-760 6.28e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 6.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  521 KCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLD----LLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKL 596
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGeeaaKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  597 RLLDKLMMNDNDISTSASRTMES----DSLRILEFRGN-----HLDVLWRAGDNRYLDffknlfnLEVLDISRNSLNSLP 667
Cdd:cd00116    81 CGLQELDLSDNALGPDGCGVLESllrsSSLQELKLNNNglgdrGLRLLAKGLKDLPPA-------LEKLVLGRNRLEGAS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  668 PEVFEGMPP---NLKNLSLAKNGLKSFFWDRLQL----LKHLEILDLSHNQLT-----KVPERLANcSKSLTTLILKHNQ 735
Cdd:cd00116   154 CEALAKALRanrDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGLTdegasALAETLAS-LKSLEVLNLGDNN 232

                         250       260       270
                  ....*....|....*....|....*....|
gi 595582277  736 IRQLTKYFLEDAL-----QLRYLDISSNKI 760
Cdd:cd00116   233 LTDAGAAALASALlspniSLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 366-632 9.00e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  366 LSSLENLKILRVKGYVFKELKNSSL-SVLHKLPRLEVLDLGTNFIKIADLNI------FKHFENLKLIDLSVNKISPSEe 438
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEEAAKALaSALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDG- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  439 sreVGFCPNAQTSvdrhgpQVLEALHYFRYDEYARSCRFKNKEPPSfLPLNADchiygqTLDLSRNNIF----FIKPSDF 514
Cdd:cd00116    98 ---CGVLESLLRS------SSLQELKLNNNGLGDRGLRLLAKGLKD-LPPALE------KLVLGRNRLEgascEALAKAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  515 QHLSFLKCLNLSGNTIG----QTLnGSELWPLRELRYLDFSNNRL----DLLYSTAFEELQSLEVLDLSSNShyFQAEGI 586
Cdd:cd00116   162 RANRDLKELNLANNGIGdagiRAL-AEGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNN--LTDAGA 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 595582277  587 THMLN-FTKKLRLLDKLMMNDNDISTSASRTM-----ESDSLRILEFRGNHL 632
Cdd:cd00116   239 AALASaLLSPNISLLTLSLSCNDITDDGAKDLaevlaEKESLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-577 9.96e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 9.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  360 ITLPHSLSSLENLKILrvkgYVFKelkN--SSLSVLHKLPRLEVLDLGTNFI-KIADLNifkHFENLKLIDLSVNKISPS 436
Cdd:cd21340    14 ITKIDNLSLCKNLKVL----YLYD---NkiTKIENLEFLTNLTHLYLQNNQIeKIENLE---NLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  437 EesrevGFcpnaqtsvdrHGPQVLEALHYfrydEYARscrfknkeppsfLPLnadchiyGQTLDLSRNNIFFIKPSdfqh 516
Cdd:cd21340    84 E-----GL----------ENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS---- 121

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595582277  517 lsfLKCLNLSGNTIgQTLngSELWPLRELRYLDFSNNRLDLL--YSTAFEELQSLEVLDLSSN 577
Cdd:cd21340   122 ---LRVLNISGNNI-DSL--EPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 548-760 1.07e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  548 LDFSNNRLDL----LYSTAFEELQSLEVLDLSSNS-HYFQAEGITHMLNFTKKLRLLDklmMNDNDISTS-----ASRTM 617
Cdd:COG5238   185 VYLGCNQIGDegieELAEALTQNTTVTTLWLKRNPiGDEGAEILAEALKGNKSLTTLD---LSNNQIGDEgvialAEALK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  618 ESDSLRILEFRGNHLDVLWRAGDNRYLdffKNLFNLEVLDISRNSLNSlppEVFEGMPPNLKN------LSLAKNGLKSF 691
Cdd:COG5238   262 NNTTVETLYLSGNQIGAEGAIALAKAL---QGNTTLTSLDLSVNRIGD---EGAIALAEGLQGnktlhtLNLAYNGIGAQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  692 FWDRL----QLLKHLEILDLSHNQLT----KVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQ---LRYLDISSNKI 760
Cdd:COG5238   336 GAIALakalQENTTLHSLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQtnrLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 649-742 1.26e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  649 NLFNLEVLDISRNSLnsLPPEVFE-------GMPPNLKNLSLAKNGLKSFfwDRLQLLKHLEILDLSHNQLTKVPE--RL 719
Cdd:cd21340    88 NLTNLEELHIENQRL--PPGEKLTfdprslaALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDL 163

                          90       100
                  ....*....|....*....|...
gi 595582277  720 ANCSKSLTTLILKHNQIRQLTKY 742
Cdd:cd21340   164 LSSWPSLRELDLTGNPVCKKPKY 186
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-259 3.28e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  121 GSFSGLSDLKALYLDGNQLLEIP-------------QDlpsslhllsleaNNIFSItkENLTELVNIETLYLGQNC---- 183
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIEnlefltnlthlylQN------------NQIEKI--ENLENLVNLKKLYLGGNRisvv 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  184 ---------------YYRNPCNVSYSIEKDA-FLVMRNLKVLSLKDNNVTAVpTTLPP--NLLELYLYNNIIKKIQE--N 243
Cdd:cd21340    84 eglenltnleelhieNQRLPPGEKLTFDPRSlAALSNSLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDLEEllD 162

                         170
                  ....*....|....*.
gi 595582277  244 DFNNLNELQVLDLSGN 259
Cdd:cd21340   163 LLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-372 3.85e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  120 PGSFSGLSDLKALYLDGNQLL-EIPQDLPSSLHLLSLE--ANNIFSITKENLTELVNIETLYLGQNcyyrnpcNVSYSIE 196
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHlfSNNFTGKIPVALTSLPRLQVLQLWSN-------KFSGEIP 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  197 KDaFLVMRNLKVLSLKDNNVTA-VPTTL--PPNLLELYLYNNIIK----------------KIQENDF------------ 245
Cdd:PLN00113  350 KN-LGKHNNLTVLDLSTNNLTGeIPEGLcsSGNLFKLILFSNSLEgeipkslgacrslrrvRLQDNSFsgelpseftklp 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  246 ---------NNLN-----------ELQVLDLS-----GNCPRCYNvpypctpCENNSPLQIHDNAFN--------SLTEL 292
Cdd:PLN00113  429 lvyfldisnNNLQgrinsrkwdmpSLQMLSLArnkffGGLPDSFG-------SKRLENLDLSRNQFSgavprklgSLSEL 501

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582277  293 KVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIeEAKFLHFlPNLVELDFSFNyelqvyHASITLPHSLSSLENL 372
Cdd:PLN00113  502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI-PASFSEM-PVLSQLDLSQN------QLSGEIPKNLGNVESL 573
PLN03150 PLN03150
hypothetical protein; Provisional
 511-578 6.35e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 6.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582277  511 PSDFQHLSFLKCLNLSGNTIGQTLNGSeLWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNS 578
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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