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Conserved domains on  [gi|575501633|ref|NP_001276427|]
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pikachurin isoform 3 [Mus musculus]

Protein Classification

FN3 and LamG domain-containing protein( domain architecture ID 10812543)

protein containing domains FN3, LamG, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 241-391 2.88e-35

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 131.00  E-value: 2.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 241 FFGHSYVTFEPLKNSYQAFQVTLEFRAEAEDGLLLYCGESehGRGDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGA 320
Cdd:cd00110    4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575501633 321 WHTVTLYRDGLNGMLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVN 391
Cdd:cd00110   82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 718-843 3.71e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 124.07  E-value: 3.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  718 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALIFSYNLGSGVASIMVNGS-FSDGRWHRVKAVRDGQSGKITVDDYGA 796
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 575501633  797 RTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTL 843
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 468-615 2.80e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 2.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 468 SYAATPWPlepQHYLSFTEFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEAPLTLGQWHD 547
Cdd:cd00110    8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575501633 548 LRVSRTAKNGILQVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGILHPFSGSIQKIILN 615
Cdd:cd00110   85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 640-670 7.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 7.08e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 575501633 640 GAPCAHGGSCRPRKEGYECDCPLGFEGLNCQ 670
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 410-452 9.34e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.34e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 575501633 410 DVGECSSGicdeASCIHGGTCaaI-KADSYICLCPLGFRGRHCE 452
Cdd:cd00054    1 DIDECASG----NPCQNGGTC--VnTVGSYRCSCPPGYTGRNCE 38
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 30-86 5.08e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 5.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 575501633  30 WNSLDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFSPRSwPSNTVRT 86
Cdd:cd00063   38 YREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS-ESVTVTT 93
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 241-391 2.88e-35

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 131.00  E-value: 2.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 241 FFGHSYVTFEPLKNSYQAFQVTLEFRAEAEDGLLLYCGESehGRGDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGA 320
Cdd:cd00110    4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575501633 321 WHTVTLYRDGLNGMLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVN 391
Cdd:cd00110   82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 718-843 3.71e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 124.07  E-value: 3.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  718 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALIFSYNLGSGVASIMVNGS-FSDGRWHRVKAVRDGQSGKITVDDYGA 796
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 575501633  797 RTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTL 843
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 468-615 2.80e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 2.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 468 SYAATPWPlepQHYLSFTEFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEAPLTLGQWHD 547
Cdd:cd00110    8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575501633 548 LRVSRTAKNGILQVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGILHPFSGSIQKIILN 615
Cdd:cd00110   85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 690-839 5.36e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.76  E-value: 5.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 690 FIGRSYLTYDNPNILKRvsgsRSNAFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALIFSYNLGSGVASIMVNGS 769
Cdd:cd00110    4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 770 FSDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCIS 839
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
716-843 1.08e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 120.14  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   716 MRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALIFSYNLGSGVASIMV-NGSFSDGRWHRVKAVRDGQSGKITVDDY 794
Cdd:smart00282   4 FSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 575501633   795 GARTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTL 843
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG smart00282
Laminin G domain;
486-617 3.35e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.60  E-value: 3.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   486 EFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEA-PLTLGQWHDLRVSRTAKNGILQVDKQ 564
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 575501633   565 KVVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGILHPFSGSIQKIILNDR 617
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
260-393 4.73e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.51  E-value: 4.73e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   260 QVTLEFRAEAEDGLLLYCGEseHGRGDFMSLALIRRSLHFRFNCGTGIAIIISE-TKIKLGAWHTVTLYRDGLNGMLQLN 338
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGS--KGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 575501633   339 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVNGK 393
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 491-617 1.85e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  491 FRPDSGDGVLLYSYDtGSKDFLSINMAAGHVEFRFDCGSGTGVLRS-EAPLTLGQWHDLRVSRTAKNGILQVDKQKVVEG 569
Cdd:pfam02210   1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 575501633  570 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGILHPFSGSIQKIILNDR 617
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
265-396 2.89e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.18  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  265 FRAEAEDGLLLYCGESEHGrgDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGAWHTVTLYRDGLNGMLQLNNGTPVT 344
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 575501633  345 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLSVNGKKID 396
Cdd:pfam00054  79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 640-670 7.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 7.08e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 575501633 640 GAPCAHGGSCRPRKEGYECDCPLGFEGLNCQ 670
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 638-668 6.43e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 6.43e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 575501633  638 CVGAPCAHGGSCRPRKEGYECDCPLGFEGLN 668
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 410-452 9.34e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.34e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 575501633 410 DVGECSSGicdeASCIHGGTCaaI-KADSYICLCPLGFRGRHCE 452
Cdd:cd00054    1 DIDECASG----NPCQNGGTC--VnTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
640-670 1.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.59e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 575501633   640 GAPCAHGGSCRPRKEGYECDCPLGFE-GLNCQ 670
Cdd:smart00179   8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 30-86 5.08e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 5.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 575501633  30 WNSLDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFSPRSwPSNTVRT 86
Cdd:cd00063   38 YREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS-ESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 36-75 1.02e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 575501633    36 DKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFS 75
Cdd:smart00060  44 GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
49-78 3.52e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 575501633   49 DSMVIKGLDPDTNYQFAVKAMNAHGFSPRS 78
Cdd:pfam00041  56 TSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
EGF_CA smart00179
Calcium-binding EGF-like domain;
410-452 7.30e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 575501633   410 DVGECSSGicdeASCIHGGTCaaI-KADSYICLCPLGFR-GRHCE 452
Cdd:smart00179   1 DIDECASG----NPCQNGGTC--VnTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 419-450 2.07e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 575501633  419 CDEASCIHGGTCAAIKaDSYICLCPLGFRGRH 450
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 241-391 2.88e-35

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 131.00  E-value: 2.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 241 FFGHSYVTFEPLKNSYQAFQVTLEFRAEAEDGLLLYCGESehGRGDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGA 320
Cdd:cd00110    4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575501633 321 WHTVTLYRDGLNGMLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVN 391
Cdd:cd00110   82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 718-843 3.71e-33

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 124.07  E-value: 3.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  718 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALIFSYNLGSGVASIMVNGS-FSDGRWHRVKAVRDGQSGKITVDDYGA 796
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 575501633  797 RTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTL 843
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 468-615 2.80e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 2.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 468 SYAATPWPlepQHYLSFTEFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEAPLTLGQWHD 547
Cdd:cd00110    8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575501633 548 LRVSRTAKNGILQVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGILHPFSGSIQKIILN 615
Cdd:cd00110   85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 690-839 5.36e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.76  E-value: 5.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 690 FIGRSYLTYDNPNILKRvsgsRSNAFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALIFSYNLGSGVASIMVNGS 769
Cdd:cd00110    4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633 770 FSDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCIS 839
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
716-843 1.08e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 120.14  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   716 MRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALIFSYNLGSGVASIMV-NGSFSDGRWHRVKAVRDGQSGKITVDDY 794
Cdd:smart00282   4 FSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 575501633   795 GARTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTL 843
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG smart00282
Laminin G domain;
486-617 3.35e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.60  E-value: 3.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   486 EFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEA-PLTLGQWHDLRVSRTAKNGILQVDKQ 564
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 575501633   565 KVVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGILHPFSGSIQKIILNDR 617
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
260-393 4.73e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 115.51  E-value: 4.73e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633   260 QVTLEFRAEAEDGLLLYCGEseHGRGDFMSLALIRRSLHFRFNCGTGIAIIISE-TKIKLGAWHTVTLYRDGLNGMLQLN 338
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGS--KGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 575501633   339 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVNGK 393
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 491-617 1.85e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  491 FRPDSGDGVLLYSYDtGSKDFLSINMAAGHVEFRFDCGSGTGVLRS-EAPLTLGQWHDLRVSRTAKNGILQVDKQKVVEG 569
Cdd:pfam02210   1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 575501633  570 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGILHPFSGSIQKIILNDR 617
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
265-396 2.89e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.18  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  265 FRAEAEDGLLLYCGESEHGrgDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGAWHTVTLYRDGLNGMLQLNNGTPVT 344
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 575501633  345 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLSVNGKKID 396
Cdd:pfam00054  79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
718-838 7.40e-27

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 106.25  E-value: 7.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  718 FKTTAKDGLLLWRGdspMRPNSDFISLGLRDGALIFSYNLGSGVASIMVNGSFSDGRWHRVKAVRDGQSGKITVDDYGAR 797
Cdd:pfam00054   1 FRTTEPSGLLLYNG---TQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 575501633  798 TGKSP-GLMRQLNINGALYVGGMKEIALHTNRQ-YLRGLVGCI 838
Cdd:pfam00054  78 TGESPlGATTDLDVDGPLYVGGLPSLGVKKRRLaISPSFDGCI 120
Laminin_G_1 pfam00054
Laminin G domain;
491-620 5.98e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 100.85  E-value: 5.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  491 FRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEAPLTLGQWHDLRVSRTAKNGILQVDKQKVVEGM 570
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 575501633  571 AEGGFTQ-IKCNTDIFIGGVPNYDDVKKNSGILHPFSGSIQKIILNDRTIH 620
Cdd:pfam00054  81 SPLGATTdLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 265-393 3.19e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.65  E-value: 3.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575501633  265 FRAEAEDGLLLYCGEsehGRGDFMSLALIRRSLHFRFNCGTG-IAIIISETKIKLGAWHTVTLYRDGLNGMLQLNNGTPV 343
Cdd:pfam02210   1 FRTRQPNGLLLYAGG---GGSDFLALELVNGRLVLRYDLGSGpESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 575501633  344 TGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLSVNGK 393
Cdd:pfam02210  78 SSLPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 640-670 7.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 7.08e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 575501633 640 GAPCAHGGSCRPRKEGYECDCPLGFEGLNCQ 670
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 638-668 6.43e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 6.43e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 575501633  638 CVGAPCAHGGSCRPRKEGYECDCPLGFEGLN 668
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 410-452 9.34e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.34e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 575501633 410 DVGECSSGicdeASCIHGGTCaaI-KADSYICLCPLGFRGRHCE 452
Cdd:cd00054    1 DIDECASG----NPCQNGGTC--VnTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
640-670 1.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.59e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 575501633   640 GAPCAHGGSCRPRKEGYECDCPLGFE-GLNCQ 670
Cdd:smart00179   8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 30-86 5.08e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 5.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 575501633  30 WNSLDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFSPRSwPSNTVRT 86
Cdd:cd00063   38 YREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS-ESVTVTT 93
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 642-670 5.85e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.92  E-value: 5.85e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 575501633 642 PCAHGGSCRPRKEGYECDCPLGFEG-LNCQ 670
Cdd:cd00053    7 PCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 36-75 1.02e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 575501633    36 DKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFS 75
Cdd:smart00060  44 GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
49-78 3.52e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 575501633   49 DSMVIKGLDPDTNYQFAVKAMNAHGFSPRS 78
Cdd:pfam00041  56 TSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
EGF_CA smart00179
Calcium-binding EGF-like domain;
410-452 7.30e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 575501633   410 DVGECSSGicdeASCIHGGTCaaI-KADSYICLCPLGFR-GRHCE 452
Cdd:smart00179   1 DIDECASG----NPCQNGGTC--VnTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 419-450 2.07e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 575501633  419 CDEASCIHGGTCAAIKaDSYICLCPLGFRGRH 450
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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