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Conserved domains on  [gi|550822198|ref|NP_001272411|]
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5-hydroxytryptamine receptor 1D [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
32-364 7.64e-149

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15333:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 265  Bit Score: 421.13  E-value: 7.64e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  32 QALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIW 111
Cdd:cd15333    1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15333  161 ILYTVYSTVGAFYIPTLLLIALYGRIYVEAR------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15333  192 -------------------ARERKATKTLGIILGAFIVCWLPFFIISLVLPICKDACWFHLAIFDFFTWLGYLNSLINPI 252
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15333  253 IYTMSNEDFKQAF 265
 
Name Accession Description Interval E-value
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
32-364 7.64e-149

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 421.13  E-value: 7.64e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  32 QALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIW 111
Cdd:cd15333    1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15333  161 ILYTVYSTVGAFYIPTLLLIALYGRIYVEAR------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15333  192 -------------------ARERKATKTLGIILGAFIVCWLPFFIISLVLPICKDACWFHLAIFDFFTWLGYLNSLINPI 252
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15333  253 IYTMSNEDFKQAF 265
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
53-353 2.69e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.81  E-value: 2.69e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198   53 NAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYT-TTRTWNFGQILCDIWVSSDITCCTASILHLCVIAL 131
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYlNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  132 DRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMSDCL-----VNTSQISYTIYSTCGAFY 204
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfgWTLTVPEGNVTVCFidfpeDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  205 IPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikladSILE 284
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKS--------------------------------------------------------ASKQ 185
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822198  285 RKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:pfam00001 186 KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElsRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
34-218 2.45e-06

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 49.01  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  34 LRISLVVVLSVITLATVLSNAFVLTtILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVS 113
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV--NTSQ 191
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMfyNNKT 196
                        170       180       190
                 ....*....|....*....|....*....|.
gi 550822198 192 ISYTIYSTCG----AFYIPSILLIILYGRIY 218
Cdd:PHA03087 197 MNWKLFINFEiniiGMLIPLTILLYCYSKIL 227
 
Name Accession Description Interval E-value
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
32-364 7.64e-149

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 421.13  E-value: 7.64e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  32 QALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIW 111
Cdd:cd15333    1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15333  161 ILYTVYSTVGAFYIPTLLLIALYGRIYVEAR------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15333  192 -------------------ARERKATKTLGIILGAFIVCWLPFFIISLVLPICKDACWFHLAIFDFFTWLGYLNSLINPI 252
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15333  253 IYTMSNEDFKQAF 265
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
36-364 1.10e-125

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 362.03  E-value: 1.10e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNtSQISYT 195
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLIS-QDIGYT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15064  160 IFSTFGAFYIPLLLMLILYWKIYRA------------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15064  185 --------------AARERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSH-CWIPLALKSFFLWLGYFNSLINPLIYTF 249

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15064  250 FNKDFRKAF 258
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
36-365 2.84e-88

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 266.81  E-value: 2.84e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEmSDCLVNTSQISYT 195
Cdd:cd15334   81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRE-DECIIKHDHIVFT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15334  160 IYSTFGAFYIPLALILILYYKIYRA------------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15334  185 --------------ATRERKAATTLGLILGAFVICWLPFFVKEVIVNTC-DSCYISEEMSNFLTWLGYINSLINPLIYTI 249
                        330
                 ....*....|
gi 550822198 356 FNEDFRQAFQ 365
Cdd:cd15334  250 FNEDFKKAFQ 259
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
38-364 4.41e-87

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 263.65  E-value: 4.41e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd14967    2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC-LVNTSQISYTI 196
Cdd:cd14967   82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCeCEFTPNKIYVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 197 YSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvki 276
Cdd:cd14967  162 VSSVISFFIPLLIMIVLYARIFRVAR------------------------------------------------------ 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 kladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYTVF 356
Cdd:cd14967  188 ---------------RELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFC-PPDCVPPILYAVFFWLGYLNSALNPIIYALF 251

                 ....*...
gi 550822198 357 NEDFRQAF 364
Cdd:cd14967  252 NRDFRRAF 259
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
38-364 1.32e-86

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 262.55  E-value: 1.32e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15335    3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIY 197
Cdd:cd15335   83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDHVIYTIY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15335  163 STFGAFYIPLTLILILYYRIYHA--------------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPIcrDSCWIHPALFDFFTWLGYLNSLINPVIYTVFN 357
Cdd:cd15335  186 ------------ASRERKAARILGLILGAFILSWLPFFIKELIVGL--SVMTVSPEVADFLTWLGYVNSLVNPLLYTSFN 251

                 ....*..
gi 550822198 358 EDFRQAF 364
Cdd:cd15335  252 EDFKLAF 258
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
40-364 1.99e-86

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 262.29  E-value: 1.99e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15331    5 IILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDaLEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAH---EEMSDCLVNtSQISYT 195
Cdd:cd15331   85 TASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFgWKDEDDLdrvLKTGVCLIS-QDYGYT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15331  163 IFSTVGAFYVPLLLMIIIYWKIYQAAK----------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15331  190 ----------------RERKAARTLAIITGAFVVCWLPFFLVALVMPFC-GAWQISRFLESFFLWLGYFNSLLNPIIYTI 252

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15331  253 FSPDFRGAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
38-364 5.82e-84

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 256.04  E-value: 5.82e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15329    3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEmSDCLVnTSQISYTIY 197
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDP-GVCQV-SQDFGYQIY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15329  161 ATFGAFYIPLIVMLVLYYKIYRA--------------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPIC--RDSCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15329  184 ------------AKSERKAIKTLGIIMGAFTLCWLPFFILALLRPFLkpIKCSCIPLWLSRLFLWLGYANSFLNPIIYAK 251

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15329  252 FNREFRTPF 260
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
40-364 5.01e-77

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 238.34  E-value: 5.01e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15330    5 LFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWII-SICISIPPLFWRQATAHEEMSDCLVNTSQiSYTIYS 198
Cdd:cd15330   85 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIgFSISIPPMLGWRTPEDRSDPDACTISKDP-GYTIYS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikl 278
Cdd:cd15330  164 TFGAFYIPLILMLVLYGRIFKA---------------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNE 358
Cdd:cd15330  186 -----------AARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNK 254

                 ....*.
gi 550822198 359 DFRQAF 364
Cdd:cd15330  255 DFQSAF 260
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
38-364 9.29e-77

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 237.64  E-value: 9.29e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTT-RTWNFGQILCDIWVSSDI 116
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTgGYWLFGRDWCDVWHSFDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATA--HEEMSDCLVnTSQISY 194
Cdd:cd15067   82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDpgPSPPNQCLF-TDDSGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15067  161 LIFSSCVSFYIPLVVMLFTYYRIY-------------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA-LFDFFTWLGYLNSLINPVIY 353
Cdd:cd15067  185 -------------RAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPDiLFPLVTWLGYINSGMNPIIY 251
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15067  252 ACSSRDFRRAF 262
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
36-364 1.93e-73

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 228.85  E-value: 1.93e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVNTSQISY 194
Cdd:cd15060   81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIgWNDWPENFTETTPCTLTEEKGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15060  161 VIYSSSGSFFIPLLIMTIVYVKIFIA------------------------------------------------------ 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15060  187 ---------------TSKERRAARTLGIIMGVFVVCWLPFFLMYVILPFC-ETCSPSAKVVNFITWLGYVNSALNPVIYT 250
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15060  251 IFNLDFRRAF 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
36-364 8.47e-73

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 227.23  E-value: 8.47e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATA-HEEMSDCLVNTsQIS 193
Cdd:cd15059   81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFgWKDEQPwHGAEPQCELSD-DPG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnq 273
Cdd:cd15059  160 YVLFSSIGSFYIPLLIMIIVYARIYRAAKR-------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15059  190 ------------------KERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKT-CGVPELLFKFFFWLGYCNSALNPVIY 250
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15059  251 TIFNKDFRRAF 261
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
41-364 1.23e-68

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 218.07  E-value: 1.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTP-ANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQiLCDIWVSSDITCC 119
Cdd:cd15057    6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMCS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIP--PLFWRQATA-------HEEMSDCLVNTS 190
Cdd:cd15057   85 TASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIpvQLGWHRADDtsealalYADPCQCDSSLN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QIsYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGkrftTAQLITGSAGSslcslnpslheshthtvgsplf 270
Cdd:cd15057  165 RT-YAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALER----AAQESTNPDSS---------------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPIC-----RDSCwIHPALFDFFTWLGYLN 345
Cdd:cd15057  218 ---------------LRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCdlrtaQFPC-VPDTTFIVFVWLGWAN 281
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTvFNEDFRQAF 364
Cdd:cd15057  282 SSLNPIIYA-FNADFRKAF 299
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
41-364 2.22e-65

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 209.51  E-value: 2.22e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15065    5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WrqataHEEMSDCLVNTSQIS----- 193
Cdd:cd15065   85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlgW-----HRLSQDEIKGLNHASnpkps 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 --------YTIYSTCGAFYIPSILLIILYGRIYVAARSRILNppslygkrfTTAQLITGSAGSSLCSLNPSLHESHTHTv 265
Cdd:cd15065  160 caldlnptYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVN---------IKSQKLPSESGSKFQVPSLSSKHNNQGV- 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 gsplffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRdsCWIHPALFDFFTWLGYLN 345
Cdd:cd15065  230 --------------------------SDHKAAVTLGIIMGVFLICWLPFFIINIIAAFCK--TCIPPKCFKILTWLGYFN 281
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15065  282 SCLNPIIYSIFNSEFRRAF 300
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
40-364 5.47e-65

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 207.20  E-value: 5.47e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAY-TTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVeVNGGKWYLGPILCDIYIAMDVMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQisYTIYS 198
Cdd:cd15053   85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPD--FIIYS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikl 278
Cdd:cd15053  163 SISSFYIPCIVMLLLYYRIFRALR-------------------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPIC----RDSCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15053  187 -------------REKKATKTLAIVLGVFLFCWLPFFTLNILNAICpklqNQSCHVGPALFSLTTWLGYVNSFLNPIIYT 253
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15053  254 IFNIEFRKAF 263
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-364 1.01e-64

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 207.57  E-value: 1.01e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIP--PLFWRQATAH----EEMSDCLVNT 189
Cdd:cd15051   81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLpiHLGWNTPDGRvqngDTPNQCRFEL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQiSYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygKRFTTAQlitgsagsslCSLNPSlheshthtvgspl 269
Cdd:cd15051  161 NP-PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQA--------KRINALT----------PASTAN------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15051  209 --------------SSKSAATAREHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDN--INETALSVVLWLGYANSALN 272
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15051  273 PILYAFLNRDFRRAF 287
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
38-364 9.51e-64

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 204.13  E-value: 9.51e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15061    2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQiSYTIY 197
Cdd:cd15061   82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDK-GYRIY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIyvaarSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15061  161 SSMGSFFLPLLLMLFVYLRI-----FRV---------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICrdSCWIHPALFDFFTWLGYLNSLINPVIYTVFN 357
Cdd:cd15061  184 ------------IAKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFC--DCQFSEALSTAFTWLGYFNSVINPFIYAFYN 249

                 ....*..
gi 550822198 358 EDFRQAF 364
Cdd:cd15061  250 KDFRRAF 256
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
36-364 7.08e-63

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 202.78  E-value: 7.08e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPL-----FWRQATAHEEMSDCLVNTS 190
Cdd:cd15055   81 YILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLydnlnQPGLIRYNSCYGECVVVVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCgAFYIPSILLIILYGRIYVAARSRilnppslygkrfttAQLITGsagsslcslnpslHESHTHTVGSplf 270
Cdd:cd15055  161 FIWGVVDLVL-TFILPCTVMIVLYMRIFVVARSQ--------------ARAIRS-------------HTAQVSLEGS--- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsileRKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwihPALFDFFTWLGYLNSLINP 350
Cdd:cd15055  210 --------------SKKVSKKSERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYISTP----SSVFDVLIWLGYFNSCLNP 271
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15055  272 LIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
36-364 1.13e-61

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 199.39  E-value: 1.13e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD------CLVNT 189
Cdd:cd15314   81 ITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHvaceggCLVFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCgAFYIPSILLIILYGRIYVAARSRilnppslygkrfttAQLITGSAGSSlcslnpslheshthtvgspl 269
Cdd:cd15314  161 SKVSSVVGSVF-SFYIPAVIMLCIYLKIFLVAQRQ--------------ARSIQSARTKS-------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15314  206 ----------------GASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYS--IPPVLIEVLNWLGYSNSTLN 267
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15314  268 PFIYAFFYSWFRKAF 282
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
41-364 1.10e-59

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 193.75  E-value: 1.10e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMS-----DCLVNTSQIs 193
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlgWYTTEEHLQYRkthpdQCEFVVNKI- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnq 273
Cdd:cd15066  164 YALISSSVSFWIPCIVMIFTYYRIYLEAK--------------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15066  193 ------------------REHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDACPYPPILVSILFWIGYFNSTLNPLIY 254
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15066  255 AYFNRDFREAF 265
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
36-364 1.09e-58

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 191.30  E-value: 1.09e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15323    1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPL--FWRQaTAHEEMSDCLVNtSQIS 193
Cdd:cd15323   81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLisMYRD-PEGDVYPQCKLN-DETW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnq 273
Cdd:cd15323  159 YILSSCIGSFFAPCLIMILVYIRIY------------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15323  184 -------------RVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPEPLFKFFFWIGYCNSSLNPVIY 250
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15323  251 TIFNQDFRRSF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
38-364 2.09e-58

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 191.90  E-value: 2.09e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15058    3 LLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPL---FWRQATA-----HEEMSDCLVNT 189
Cdd:cd15058   83 CVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPImnqWWRANDPeandcYQDPTCCDFRT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQIsYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaQLITGSAGSSLCSLNPSLHESHTHTVGSPl 269
Cdd:cd15058  163 NMA-YAIASSVVSFYIPLLIMIFVYARVFLIATRQL--------------QLIDKRRLRFQSECPAPQTTSPEGKRSSG- 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsiLERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15058  227 -------------RRPSRLTVVKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNL--PPGEVFLLLNWLGYINSGLN 291
                        330
                 ....*....|....*
gi 550822198 350 PVIYtVFNEDFRQAF 364
Cdd:cd15058  292 PIIY-CRSPEFRTAF 305
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
53-353 2.69e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.81  E-value: 2.69e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198   53 NAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYT-TTRTWNFGQILCDIWVSSDITCCTASILHLCVIAL 131
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYlNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  132 DRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMSDCL-----VNTSQISYTIYSTCGAFY 204
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfgWTLTVPEGNVTVCFidfpeDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  205 IPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikladSILE 284
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKS--------------------------------------------------------ASKQ 185
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822198  285 RKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:pfam00001 186 KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElsRLLDKALSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
38-357 2.56e-55

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 182.87  E-value: 2.56e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV----NTSQIS 193
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLcwpdLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffNQ 273
Cdd:cd00637  161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLR-------------------------------------------------RH 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 VKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd00637  192 RRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIY 271

                 ....
gi 550822198 354 TVFN 357
Cdd:cd00637  272 AFFN 275
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
36-364 6.87e-54

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 178.61  E-value: 6.87e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTT-RTWNFGQILCDIWVSS 114
Cdd:cd15328    1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgRRWQLGRSLCQVWISF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISY 194
Cdd:cd15328   81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15328  161 TVFSTFGAFYLPLCVVLFVYWKIYKAAQ---------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrdSCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15328  189 -----------------KEKRAALMVGILIGVFVLCWIPFFLTELISPLC--SCDIPPIWKSIFLWLGYSNSFFNPLIYT 249
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15328  250 AFNKNYNNAF 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
38-364 1.98e-53

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 178.32  E-value: 1.98e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15312    3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE--------MSDCLVNT 189
Cdd:cd15312   83 LSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEdyvalvscTGSCVLIF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCgAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheSHTHTVGspl 269
Cdd:cd15312  163 NKLWGVIASLI-AFFIPGTVMIGIYIKIFFVAR-------------------------------------KHAKVIN--- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffNQVKIKLADsilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpaLFDFFTWLGYLNSLIN 349
Cdd:cd15312  202 --NRPSVTKGD---SKNKLSKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVD--LFDALVWLGYFNSTCN 274
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15312  275 PLIYGFFYPWFQKAF 289
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
37-364 3.69e-53

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 177.04  E-value: 3.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15321    8 AIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE--MSDCLVNtSQISY 194
Cdd:cd15321   88 LFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQggLPQCKLN-EEAWY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15321  167 ILSSSIGSFFAPCLIMILVYLRIYLIAKN--------------------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15321  196 -----------------REKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPHSLFQFFFWIGYCNSSLNPVIYT 258
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15321  259 IFNQDFRRAF 268
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
36-364 4.13e-53

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 176.85  E-value: 4.13e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15050    1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFW----RQATAHEEMSDClvNTSQ 191
Cdd:cd15050   81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWhhfaRGGERVVLEDKC--ETDF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGA---FYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsp 268
Cdd:cd15050  159 HDVTWFKVLTAilnFYIPSLLMLWFYAKIFKAVN---------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCwiHPALFDFFTWLGYLNSLI 348
Cdd:cd15050  193 -----------------------RERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCC--NENLHMFTIWLGYINSTL 247
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15050  248 NPFIYPLCNENFKKTF 263
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
36-364 5.92e-53

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 176.53  E-value: 5.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVNTS---- 190
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVgWNDGKDGIMDYSGSSSLPctce 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 ---QISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgs 267
Cdd:cd15063  161 ltnGRGYVIYSALGSFYIPMLVMLFFYFRIYRAAR--------------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 plffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSL 347
Cdd:cd15063  196 ------------------------METKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDC--IPPLLFSVFFWLGYCNSA 249
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15063  250 LNPCIYALFSRDFRFAF 266
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
35-364 1.69e-52

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 177.12  E-value: 1.69e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  35 RISLVVVLSVITLATVLSNAFVLTTILLTKKLHTP-ANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQiLCDIWVS 113
Cdd:cd15320    1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKvTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI--PPLFWRQA----------TAHEE 181
Cdd:cd15320   80 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFipVQLNWHKAkptsfldlnaSLRDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 182 MSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLygKRFTTAQLITGSAGSSLCSLNPSLHESH 261
Cdd:cd15320  160 TMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISAL--ERAAVHAKNCQNSTGNRGSGDCQQPESS 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 262 ThtvgsplffnqvkikladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDS-----CwIHPALFD 336
Cdd:cd15320  238 F------------------------KMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTstepfC-ISSTTFD 292
                        330       340
                 ....*....|....*....|....*...
gi 550822198 337 FFTWLGYLNSLINPVIYTvFNEDFRQAF 364
Cdd:cd15320  293 VFVWFGWANSSLNPIIYA-FNADFRKAF 319
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
36-364 4.96e-52

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 173.98  E-value: 4.96e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVNtSQISY 194
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLItIEKKSGQPEGPICKIN-DEKWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15322  160 IISSCIGSFFAPCLIMVLVYIRIY-------------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRdsCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15322  184 ------------QIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCD--CSVPETLFKFFFWFGYCNSSLNPVIYT 249
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15322  250 IFNHDFRRAF 259
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
39-364 4.11e-51

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 171.34  E-value: 4.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISI-AYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15052    4 ALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSIlTELFGGVWPLPLVLCLLWVTLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI--PPLFWRQATAHEEMSDCLVNTsqISYT 195
Cdd:cd15052   84 FCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSpiPVLGIIDTTNVLNNGTCVLFN--PNFV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYgriyvaarsrilnppslygkrFTTAQLITgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15052  162 IYGSIVAFFIPLLIMVVTY---------------------ALTIRLLS-------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRD-SCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15052  189 ----------------NEQKASKVLGIVFAVFVICWCPFFITNILTGLCEEcNCRISPWLLSVFVWLGYVSSTINPIIYT 252
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15052  253 IFNKTFRRAF 262
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
38-364 4.91e-51

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 171.21  E-value: 4.91e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15324    3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFwrqATAHEEMsDCLVNtSQISYTIY 197
Cdd:cd15324   83 FCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL---MTKHDEW-ECLLN-DETWYILS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15324  158 SCTVSFFAPGLIMILVYCKIY----------------------------------------------------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFN 357
Cdd:cd15324  179 ---------RVAKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFN 249

                 ....*..
gi 550822198 358 EDFRQAF 364
Cdd:cd15324  250 RDFRKAF 256
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-364 2.76e-50

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 169.30  E-value: 2.76e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVnTSQISYT 195
Cdd:cd15326   81 VLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEI-TEEPFYA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAArsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15326  160 LFSSLGSFYIPLIVILVMYCRVYIVA------------------------------------------------------ 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrISAARERKATKTLGIILGAFIICWLPFFvvsLVLPICRDSCWIHP--ALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15326  186 ------------LKFSREKKAAKTLGIVVGMFILCWLPFF---IALPLGSLFSHLKPpeTLFKIIFWLGYFNSCLNPIIY 250
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15326  251 PCSSKEFKRAF 261
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
41-364 3.97e-50

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 170.09  E-value: 3.97e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMSDCLVN------TSQI 192
Cdd:cd15959   86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMnqWWRDGADEEAQRCYDNprccdfVTNM 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaQLITGSAGSslcslnpslheshthtvgsplfFN 272
Cdd:cd15959  166 PYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQV--------------RLIRKDKVR----------------------FP 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 QVKIKLADSILERKR----ISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDscWIHPALFDFFTWLGYLNSLI 348
Cdd:cd15959  210 PEESPPAESRPACGRrpsrLLAIKEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRS--LVPDPAFLFLNWLGYANSAF 287
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVfNEDFRQAF 364
Cdd:cd15959  288 NPIIYCR-SPDFRSAF 302
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
36-364 8.11e-50

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 169.27  E-value: 8.11e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15957    1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI--PPLFWRQATAHE------EMSDCLV 187
Cdd:cd15957   81 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFlpIQMHWYRATHQEaincyaEETCCDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 NTSQiSYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaQLITGSAGSSLCSLNPSLHESHTHTVGS 267
Cdd:cd15957  161 FTNQ-AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQL--------------QKIDKSEGRFHNQNIDQNGSGGGGGNRR 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 PLFFnqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSL 347
Cdd:cd15957  226 RSKF------------------CLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL--IRKEVYILLNWIGYVNSG 285
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVfNEDFRQAF 364
Cdd:cd15957  286 FNPLIYCR-SPDFRIAF 301
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
36-364 1.37e-49

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 167.67  E-value: 1.37e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNtSQISYT 195
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVN-EEPGYV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAArsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15062  160 LFSSLGSFYLPLAIILVMYCRVYVVA------------------------------------------------------ 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15062  186 ------------FKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFST-LKPPEPVFKVVFWLGYFNSCLNPIIYPC 252

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15062  253 SSREFKRAF 261
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
36-364 6.74e-49

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 166.47  E-value: 6.74e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqATAHEEMSDCLVNTSQISYT 195
Cdd:cd15317   81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYT--GANDEGLEEYSSEISCVGGC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 I--------YSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttAQLITGSAGsslcSLNPSLHEShthtvgs 267
Cdd:cd15317  159 QllfnkiwvLLDFLTFFIPCLIMIGLYAKIFLVARRQ--------------ARKIQNMED----KFRSSEENS------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 plffnqvkikladsilerKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPIcrdSCWIHPAL-FDFFTWLGYLNS 346
Cdd:cd15317  214 ------------------SKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEY---SNFITPAIvFDAVIWLGYFNS 272
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15317  273 AFNPFIYAFFYPWFRKAF 290
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
40-364 3.62e-48

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 165.07  E-value: 3.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPL---FWR----QATAHEEMSDCLVNTSQI 192
Cdd:cd15958   85 TASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPImmhWWRdeddQALKCYEDPGCCDFVTNR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGkRFTTAQLITGSAGSSLCSlnpslheshthtvgsplffn 272
Cdd:cd15958  165 AYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEG-RFHNTLTGLGRKCKRRPS-------------------- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDscWIHPALFDFFTWLGYLNSLINPVI 352
Cdd:cd15958  224 --------------RILALREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRE--LVPDWLFVFFNWLGYANSAFNPII 287
                        330
                 ....*....|..
gi 550822198 353 YTVfNEDFRQAF 364
Cdd:cd15958  288 YCR-SPDFRKAF 298
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
36-364 6.57e-48

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 163.26  E-value: 6.57e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEMSD--CLVN-TSQ 191
Cdd:cd15049   81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLwAPAILGWQYFVGERTVPDgqCYIQfLDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15049  161 PAITFGTAIAAFYLPVLVMTILYWRIYRE--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15049  190 ------------------TARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKC--IPDTLWSFGYWLCYINSTINPF 249
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15049  250 CYALCNKTFRKTF 262
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
36-364 1.78e-47

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 163.04  E-value: 1.78e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAIT-DALEYskRRTAGHAAAMIAAVWIISICISIPPLF--WRQ-ATAHEEMSDCLVNTS- 190
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICcQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMqgWNHiGIEDLIAFNCASGSTs 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 -----QISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfTTAQLItgsagSSLCSLNPSLHESHTHtv 265
Cdd:cd15056  159 cvfmvNKPFAIICSTVAFYIPALLMVLAYYRIYVAAR--------------EQAHQI-----RSLQRAGSSNHEADQH-- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 gsplffNQVKIKladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICR----DSCWihpalfDFFTWL 341
Cdd:cd15056  218 ------RNSRMR--------------TETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGyrvpYLLW------TAFLWL 271
                        330       340
                 ....*....|....*....|...
gi 550822198 342 GYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15056  272 GYINSGLNPFLYAFFNKSFRRAF 294
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
43-364 5.38e-47

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 160.91  E-value: 5.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  43 SVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTR-TWNFGQILCDIWVSSDITCCTA 121
Cdd:cd15310    8 CALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGgVWNFSRICCDVFVTLDVMMCTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 122 SILHLCVIALDRYWAITDALEYSKRRTAGH---AAAMIAAVWIISICISIPPLFWRQATAheemSDCLVNTSQISYTIYS 198
Cdd:cd15310   88 SILNLCAISIDRYTAVVMPVHYQHGTGQSScrrVSLMITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikl 278
Cdd:cd15310  164 SVVSFYLPFGVTLLVYVRIYVV---------------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRdSCWIHPALFDFFTWLGYLNSLINPVIYTVFNE 358
Cdd:cd15310  186 -----------LLREKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQ-ACHVPPELYSATTWLGYVNSALNPVIYTTFNI 253

                 ....*.
gi 550822198 359 DFRQAF 364
Cdd:cd15310  254 EFRRAF 259
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
36-364 2.26e-46

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 159.29  E-value: 2.26e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQAtAHEEMSDCLVnTSQISY 194
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFgWKEP-APEDETICQI-TEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAArsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15325  159 ALFSALGSFYLPLAIILVMYCRVYVVA----------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrISAARERKATKTLGIILGAFIICWLPFFvvsLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPVI 352
Cdd:cd15325  186 -------------LKFSREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSIFPAYKPSdtVFKITFWLGYFNSCINPII 249
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15325  250 YPCSSQEFKKAF 261
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
36-364 3.07e-46

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 159.78  E-value: 3.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATA--HEEMSDCLVntsQI 192
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGpAIIGWDLWTGysIVPTGDCEV---EF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGA----FYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsAGSSLCSLNPSLHESHTHTVGSP 268
Cdd:cd15048  158 FDHFYFTFITsvleFFIPFISVSFFNLLIYLNIRKR---------------------SRRRPLRSVPILPASQNPSRARS 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 LffnqvkikladsileRKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCwIHPALFDFFTWLGYLNSLI 348
Cdd:cd15048  217 Q---------------REQVKLRRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGSC-VDSYLYEFTFWLLWTNSAI 280
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15048  281 NPFLYAACHPRFRKAF 296
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
41-364 1.21e-44

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 156.27  E-value: 1.21e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTP-ANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQiLCDIWVSSDITCC 119
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMCS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI--PPLFWRQATAHEEMSDCLVNTSQIS---- 193
Cdd:cd15319   85 TASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFipVQLNWHKDSGDDWVGLHNSSISRQVeenc 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 -------YTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygKRFTTAQlitgSAGSSLCSLNPSLHESHTHTvg 266
Cdd:cd15319  165 dsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQIQI--------RRISSLE----RAAEHAQSCRSNRIDCHHHT-- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsileRKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA--------LFDFF 338
Cdd:cd15319  231 ------------------SLRTSIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPADPDAglpcvsetTFDVF 292
                        330       340
                 ....*....|....*....|....*.
gi 550822198 339 TWLGYLNSLINPVIYTvFNEDFRQAF 364
Cdd:cd15319  293 VWFGWANSSLNPIIYA-FNADFRKVF 317
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
36-364 2.14e-43

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 151.22  E-value: 2.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15327    1 VGVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEmSDCLVnTSQISY 194
Cdd:cd15327   81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLgWKEPPPPDE-SICSI-TEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAArsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15327  159 ALFSSLFSFYLPLMVILVMYFRVYVVA----------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrISAARERKATKTLGIILGAFIICWLPFFvvsLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPVI 352
Cdd:cd15327  186 -------------LKFSREKKAAKTLAIVVGVFILCWFPFF---FVLPLGSFFPALKPSemVFKVIFWLGYFNSCVNPII 249
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15327  250 YPCSSKEFKRAF 261
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
36-364 6.75e-40

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 142.25  E-value: 6.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15054    1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPL--------FWRQATAHEEMSD--- 184
Cdd:cd15054   81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIelgwhelgHERTLPNLTSGTVegq 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 185 CLVNTSqISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshtht 264
Cdd:cd15054  161 CRLLVS-LPYALVASCLTFFLPSGAICFTYCRILLAAR------------------------------------------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 265 vgsplffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrdSCwIHPALFDFFTWLGYL 344
Cdd:cd15054  198 ---------------------------KALKASLTLGILLGMFFVTWLPFFVANVVQAVC--DC-VSPGLFDVLTWLGYC 247
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd15054  248 NSTMNPIIYPLFMRDFKRAL 267
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
44-364 5.86e-38

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 136.89  E-value: 5.86e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIaYTTTR--TWNFGQILCDIWVSSDITCCTA 121
Cdd:cd15308    9 LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYV-YSEFQggVWTLSPVLCDALMTMDVMLCTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 122 SILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQisYTIYSTCG 201
Cdd:cd15308   88 SIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKLEDNN--YVVYSSVC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 202 AFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshtHTVGsplffnqvkiklads 281
Cdd:cd15308  166 SFFIPCPVMLVLYCAMF--------------------------------------------RGLG--------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 282 ilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFR 361
Cdd:cd15308  187 ----------RERKAMRVLPVVVGAFLFCWTPFFVVHITRALC-ESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255

                 ...
gi 550822198 362 QAF 364
Cdd:cd15308  256 NVF 258
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
36-363 1.06e-37

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 137.30  E-value: 1.06e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15316    1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFW-RQATAHEEMSDCL--VNTSQI 192
Cdd:cd15316   81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTgVNDDGLEELVNALncVGGCQI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYT---IYSTCGAFYIPSILLIILYGRIYVAARSRILnppslygKRFTTAQLITGSAgsslcslnpslhESHTHTVgspl 269
Cdd:cd15316  161 ILNqnwVLVDFLLFFIPTFAMIILYGKIFLVAKQQAR-------KIEMTSSKAESSS------------ESYKDRV---- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRdscWIHPAL-FDFFTWLGYLNSLI 348
Cdd:cd15316  218 --------------------ARRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMN---FITPPYiYEICCWCAYYNSAM 274
                        330
                 ....*....|....*
gi 550822198 349 NPVIYTVFNEDFRQA 363
Cdd:cd15316  275 NPLIYALFYPWFRKA 289
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
44-369 1.63e-37

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 136.19  E-value: 1.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPIS-IAYTTTRTWNFGQILCDIWVSSDITCCTAS 122
Cdd:cd15305    9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSlIAILYDYAWPLPRYLCPIWISLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPlfwrQATAHEEMSDCLVNTSQI----SYTIYS 198
Cdd:cd15305   89 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPI----PVIGLQDDEKVFVNGTCVlndeNFVLIG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYG-RIYVAARSRILNppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15305  165 SFVAFFIPLIIMVITYClTIQVLQRQQAIN-------------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15305  195 --------------NERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACdqKLMEELLNVFVWVGYVSSGINPLVYTL 260
                        330
                 ....*....|....
gi 550822198 356 FNEDFRQAFQKVVH 369
Cdd:cd15305  261 FNKTYRRAFSNYIR 274
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
40-364 3.41e-37

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 134.78  E-value: 3.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15309    5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKR-RTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEmsdCLVNTSqiSYTIYS 198
Cdd:cd15309   85 TASILNLCAISIDRYTAVAMPMLYNTRySSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQNE---CIIANP--AFVVYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikl 278
Cdd:cd15309  160 SIVSFYVPFIVTLLVYVQIYIVLQ-------------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrdSCWIHPALFDFFTWLGYLNSLINPVIYTVFNE 358
Cdd:cd15309  184 -------------KEKKATQMLAIVLGVFIICWLPFFITHILNMHC--DCNIPPALYSAFTWLGYVNSAVNPIIYTTFNI 248

                 ....*.
gi 550822198 359 DFRQAF 364
Cdd:cd15309  249 EFRKAF 254
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
36-364 4.67e-36

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 133.11  E-value: 4.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWR--QATAHEEMSDCLV------ 187
Cdd:cd14993   81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYelEEIISSEPGTITIyicted 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 ---NTSQISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsaGSSLCSLNPSLHESHTHT 264
Cdd:cd14993  161 wpsPELRKAYNVALFVVLYVLPLLIISVAYSLI-----------------------------GRRLWRRKPPGDRGSANS 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 265 VgsplffnqvkikladsilERKRISAAReRKATKTLGIILGAFIICWLPFFVVSLVL----PICRDSCWIHPALFDFFTW 340
Cdd:cd14993  212 T------------------SSRRILRSK-KKVARMLIVVVVLFALSWLPYYVLSILLdfgpLSSEESDENFLLILPFAQL 272
                        330       340
                 ....*....|....*....|....
gi 550822198 341 LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd14993  273 LGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
44-368 7.48e-36

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 132.00  E-value: 7.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15307    9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDclvNTSQISYTIYSTCGA- 202
Cdd:cd15307   89 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVN---GTCQIPDPVYKLVGSi 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 203 --FYIPSILLIILYGriyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikLAD 280
Cdd:cd15307  166 vcFYIPLGVMLLTYC--------------------------------------------------------------LTV 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 281 SILERKRISAAR----ERKATKTLGIILGAFIICWLPFFVVSlVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15307  184 RLLARQRSRHGRiirlEQKATKVLGVVFFTFVILWSPFFVLN-LLPTVCAECEERIShwVFDVVTWLGYASSMVNPIFYT 262
                        330
                 ....*....|....
gi 550822198 355 VFNEDFRQAFQKVV 368
Cdd:cd15307  263 IFNKVFRQAFKKVL 276
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
46-363 7.69e-34

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 126.51  E-value: 7.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  46 TLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILH 125
Cdd:cd15318   11 MLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 126 LCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWR---QATAHEEMSDCLVNTSQISYTI---YST 199
Cdd:cd15318   91 LCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKaveEGLAELLTSVPCVGSCQLLYNKlwgWLN 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttAQLITgsagsslcslnpslheshthtvgsplffnqvkikla 279
Cdd:cd15318  171 FPVFFIPCLIMIGLYVKIFIVAKRQ--------------ARAIA------------------------------------ 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 280 dSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVlpicrDSCW---IHPALFDFFTWLGYLNSLINPVIYTVF 356
Cdd:cd15318  201 -SLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMV-----DSLLnfiTPPLLFDIIIWFAYFNSACNPLIYVFS 274

                 ....*..
gi 550822198 357 NEDFRQA 363
Cdd:cd15318  275 YPWFRKA 281
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
44-364 5.06e-33

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 124.27  E-value: 5.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPIS-IAYTTTRTWNFGQILCDIWVSSDITCCTAS 122
Cdd:cd15304    9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSmLTILYGYRWPLPSKLCAVWIYLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISI--CISIPPLFWRQATAHEEMSDCLVntSQISYTIYSTC 200
Cdd:cd15304   89 IMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVgiSMPIPVFGLQDDSKVFKEGSCLL--ADENFVLIGSF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 201 GAFYIPSILLIILYgriyvaarsrilnppslygkrFTTAQlitgsagsslcslnpSLHEshthtvgsplffnqvkiklad 280
Cdd:cd15304  167 VAFFIPLTIMVITY---------------------FLTIK---------------SLQQ--------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 281 silerkriSAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIH--PALFDFFTWLGYLNSLINPVIYTVFNE 358
Cdd:cd15304  190 --------SISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKESCNEVviGGLLNVFVWIGYLSSAVNPLVYTLFNK 261

                 ....*.
gi 550822198 359 DFRQAF 364
Cdd:cd15304  262 TYRSAF 267
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
36-364 6.94e-32

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 121.08  E-value: 6.94e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF---WRQATAHEEMSDCLVN--TS 190
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYswpYIEGKRTVPAGTCYIQflET 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplf 270
Cdd:cd15301  161 NPYVTFGTALAAFYVPVTIMCILYWRIW---------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsiLERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15301  189 ------------RETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIPTELWDFSYYLCYINSTINP 256
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15301  257 LCYALCNAAFRRTY 270
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
38-364 8.57e-32

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 120.84  E-value: 8.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd17790    3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHE--EMSDCLVN-TSQIS 193
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLwAPAILFWQYLVGERtvLAGQCYIQfLSQPI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnq 273
Cdd:cd17790  163 ITFGTAIAAFYLPVTIMIILYWRIY------------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsileRKRIsaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd17790  188 -----------RETI---KEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC--VPKTLWELGYWLCYVNSTVNPMCY 251
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd17790  252 ALCNKSFRDTF 262
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
36-364 1.70e-31

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 119.85  E-value: 1.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPI-SIAYTTTRTWNFGQILCDIWVSS 114
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFyTVYVLNGDYWPLGWVLCDLWLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAH-----------EEM 182
Cdd:cd15302   81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFgWQYFTGQgrslpegecyvQFM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 183 SDCLVNTS-QISYtiystcgaFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslhesh 261
Cdd:cd15302  161 TDPYFNMGmYIGY--------YWTTLIVMLILYAGIYRAAN--------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 262 thtvgsplffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWL 341
Cdd:cd15302  194 ------------------------------RARKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVNETLYTISYYL 243
                        330       340
                 ....*....|....*....|...
gi 550822198 342 GYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15302  244 CYMNSPINPFCYALANQQFKKTF 266
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
37-368 4.61e-31

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 119.17  E-value: 4.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVItlATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPIS-IAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15306    4 ALLILMVII--PTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIAlLTILFEAMWPLPLVLCPIWLFLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMSDCLVNTSQIS 193
Cdd:cd15306   82 VLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIkgIETDVDNPNNITCVLTKERFG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 Y-TIYSTCGAFYIPSILLIILYgriyvaarsrilnppslygkrFTTAQLitgsagsslcslnpslheshthtvgsplffn 272
Cdd:cd15306  162 DfILFGSLAAFFTPLAIMIVTY---------------------FLTIHA------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsiLERKRISaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSC--WIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15306  190 ----------LRKQTIT--NEQRASKVLGIVFFLFLLMWCPFFITNITSVLC-DSCnqTTLQMLMEIFVWIGYVSSGVNP 256
                        330
                 ....*....|....*...
gi 550822198 351 VIYTVFNEDFRQAFQKVV 368
Cdd:cd15306  257 LVYTLFNKTFRDAFGRYI 274
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
38-364 7.47e-30

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 115.45  E-value: 7.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15297    3 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEMSD--CLVN-TSQIS 193
Cdd:cd15297   83 VSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILwAPAILFWQFIVGGRTVPEgeCYIQfFSNAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnq 273
Cdd:cd15297  163 VTFGTAIAAFYLPVIIMTVLYWQISRA----------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15297  190 ----------------SSREKKVTRTILAILLAFIITWTPYNVMVLINTFCASC--IPNTVWTIGYWLCYINSTINPACY 251
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15297  252 ALCNATFKKTF 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
39-364 4.03e-28

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 111.23  E-value: 4.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-----LVMPISIAYTTTR-TWNFgqILCDIWV 112
Cdd:cd14972    2 LVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIafvftFLSVLLVSLTPSPaTWLL--RKGSLVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SSditccTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEmsDCLVNTSQ 191
Cdd:cd14972   80 SL-----LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLgWNCVLCDQE--SCSPLGPG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTC-GAFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsSLCSLNPSLHESHTHTVGSPLf 270
Cdd:cd14972  153 LPKSYLVLIlVFFFIALVIIVFLYVRIFW-----------------------------CLWRHANAIAARQEAAVPAQP- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIhPALFDFFTWLGYLNSLINP 350
Cdd:cd14972  203 --------------------STSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDI-QAVFYYFLVLALLNSAINP 261
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd14972  262 IIYAFRLKEMRRAV 275
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
35-368 5.55e-28

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 110.81  E-value: 5.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  35 RISLVVVLS-VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVS 113
Cdd:cd15299    2 QVVLIAFLTgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEM--SDCLVN-T 189
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLwAPAILFWQYFVGKRTVppDECFIQfL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15299  162 SEPIITFGTAIAAFYLPVTIMTILYWRIYK-------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCwIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15299  192 -------------------ETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFC-DSC-IPKTYWNLGYWLCYINSTVN 250
                        330
                 ....*....|....*....
gi 550822198 350 PVIYTVFNEDFRQAFQKVV 368
Cdd:cd15299  251 PVCYALCNKTFRTTFKMLL 269
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
39-364 4.22e-27

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 108.50  E-value: 4.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFgqILCDIWVSSDITC 118
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF--HGCLFMACLVLVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-W-----RQATAHEEMSDCL-VNTSQ 191
Cdd:cd14968   82 TQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFgWnngapLESGCGEGGIQCLfEEVIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIY-STCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLitgsagsslcslnpslheshthtvgsplf 270
Cdd:cd14968  162 MDYMVYfNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRSTL----------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLNSLINP 350
Cdd:cd14968  213 --------------------QKEVKAAKSLAIILFLFALCWLPLHIINCITLFCPE-CKVPKILTYIAILLSHANSAVNP 271
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd14968  272 IVYAYRIRKFRQTF 285
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
38-364 1.09e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 107.52  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd14992    3 LGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVN--------T 189
Cdd:cd14992   83 SVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIfccqippvD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTC---GAFYIPSILLIILYGRIYVaarsrilnppSLYGKRfttaqlitgSAGSSLCSlnpslheshthtvg 266
Cdd:cd14992  163 NKTYEKVYFLLifvVIFVLPLIVMTLAYARISR----------ELWFRK---------VPGFSIKE-------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsiLERKRISAarERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPAL--FDFFTWLGYL 344
Cdd:cd14992  210 ----------------VERKRLKC--KRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKHTLqvYYFLHWIAMS 271
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd14992  272 NSMYNPIIYVTLNNNFRKNF 291
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
36-364 8.94e-26

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 104.68  E-value: 8.94e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSDCLV------N 188
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLpVIIFARTLQEEGGTISCNLqwpdppD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsp 268
Cdd:cd14970  160 YWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRS--------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnQVKIKLADSilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPALFDFFTWLGYLNSL 347
Cdd:cd14970  195 ----SRNLSTSGA-----REKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVrLLIDPPETLTVVGVFLFCIALSYANSC 265
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd14970  266 LNPILYAFLDENFRKSF 282
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
36-364 1.28e-25

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 103.95  E-value: 1.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE---MSDCLVN-TSQ 191
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRtvpERECQIQfLSE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15300  161 PTITFGTAIAAFYIPVSVMTILYCRIYK---------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15300  189 -----------------ETIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDC--IPLTLWHLGYWLCYVNSTVNPM 249
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15300  250 CYALCNKTFRKTF 262
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
36-364 1.49e-25

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 103.95  E-value: 1.49e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEMSD--CLVN-TSQ 191
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLwAPAILFWQFVVGKRTVPDnqCFIQfLSN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15298  161 PAVTFGTAIAAFYLPVVIMTVLYIHISLA--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRdSCwIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15298  190 ------------------SARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ-SC-IPDTVWSIGYWLCYVNSTINPA 249
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15298  250 CYALCNATFKKTF 262
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
38-367 1.84e-25

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 103.75  E-value: 1.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGH-AAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTI 196
Cdd:cd15295   83 LCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLrIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECEPEFFSNWYILA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 197 YSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvki 276
Cdd:cd15295  163 ITSVLEFLVPVILVAYFNTQIYWSLWKRL--------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 kladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPIC---RDSCWihpalFDFFTWLGYLNSLINPVIY 353
Cdd:cd15295  192 ---------------RDRKLAKSLAIILGTFAICWAPYSLFTIIRAACekhRGSPW-----YNFAFWLQWFNSFINPFLY 251
                        330
                 ....*....|....
gi 550822198 354 TVFNEDFRQAFQKV 367
Cdd:cd15295  252 PLCHKRFRKAFLKI 265
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
36-364 4.99e-25

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 103.07  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALeySKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD------CLVN- 188
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILpycgyfCTESw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 ---TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtv 265
Cdd:cd15203  159 pssSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRV---------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 gsplffnQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLV----LPICRDSCWIHpaLFDFFT-W 340
Cdd:cd15203  199 -------KKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLFNLLrdfePLPQIDGRHFY--LIFLIChL 269
                        330       340
                 ....*....|....*....|....
gi 550822198 341 LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15203  270 IAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
36-364 5.25e-24

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 99.87  E-value: 5.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15296    1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEY-SKRRTAGHAAAMIAAVWiisicisipplfwrqataheemsdclvntsqisy 194
Cdd:cd15296   81 YLLCTASVFNIVLISYDRFLSVTRAVSYrAQKGMTRQAVLKMVLVW---------------------------------- 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 tiystcgafyipsILLIILYGRI-----YVAARSrILNPPSLYGKRFTTAQLITgsAGSSLCSLNPSLheshthtvgSPL 269
Cdd:cd15296  127 -------------VLAFLLYGPAiisweYIAGGS-IIPEGECYAEFFYNWYFLM--TASTLEFFTPFI---------SVT 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 FFNqVKIKLAdsiLERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpALFDFFTWLGYLNSLIN 349
Cdd:cd15296  182 YFN-LSIYLN---IQKRRFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCVPD-YWYETSFWLLWVNSAIN 256
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15296  257 PVLYPLCHMSFRRAF 271
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
36-364 7.86e-24

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 99.59  E-value: 7.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDI---WV 112
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIygfAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SsdiTCCTASILHLCVIALDRYWAITDALEYsKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN--- 188
Cdd:cd14969   81 T---FLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFgWSSYVPEGGGTSCSVDwys 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 --TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvg 266
Cdd:cd14969  157 kdPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLR-------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScWIHPALFDFFTWLGYLNS 346
Cdd:cd14969  193 -----KMSKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGES-TIPPLLATIPALFAKSST 266
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd14969  267 IYNPIIYVFMNKQFRRAL 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
38-364 1.41e-22

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 96.15  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15207    3 FIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNT------SQ 191
Cdd:cd15207   83 SVAASVFTLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHIcvefwpSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTC---GAFYIPSILLIILYGRIYVaarsRILNPPSLYGkrfttaqlitgsagsslcslnpsLHESHthtvgsp 268
Cdd:cd15207  161 EYRKAYTTSlfvLCYVAPLLIIAVLYVRIGY----RLWFKPVPGG-----------------------GSASR------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCW----IHPALFDFFTWLGYL 344
Cdd:cd15207  207 ---------------EAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNqrevLYVYIYPIAHWLAYF 271
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd15207  272 NSCVNPIVYGYFNRNFRKGF 291
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
45-364 1.68e-22

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 96.27  E-value: 1.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  45 ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISI-AYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd14979   10 IFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELyNFWWQYPWAFGDGGCKLYYFLFEACTYATV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQA--------TAHEEMSDCLVNTSQISYT 195
Cdd:cd14979   90 LTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIqylngplpGPVPDSAVCTLVVDRSTFK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 I---YSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKrfttaqlitgsagsslcslnpslhesHTHTVGSPLffn 272
Cdd:cd14979  170 YvfqVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQ--------------------------GTRNVELSL--- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC----WIHPALFDFFTWLGYLNSLI 348
Cdd:cd14979  221 ----------------SQQARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSYASKEDtflfDFYQYLYPISGILFYLSSAI 284
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd14979  285 NPILYNLMSSRFRVAF 300
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
36-363 2.49e-22

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 95.48  E-value: 2.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN-----T 189
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSCSFDylsrdD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslYGKRFTTaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15083  161 ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR--------HEKAMKE------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikLADSILERKRISAARERKA-TKTLGIILG---AFIICWLPFFVVSLVlpicrdscwihpALFDFFTWLGYLN 345
Cdd:cd15083  202 --------MAKRFSKSELSSPKARRQAeVKTAKIALLlvlLFCLAWTPYAVVALI------------GQFGYLEVLTPLA 261
                        330       340
                 ....*....|....*....|....*....
gi 550822198 346 SLI-----------NPVIYTVFNEDFRQA 363
Cdd:cd15083  262 TAIpaafaktsaiyNPVIYAFSHPKFRRA 290
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
37-364 3.24e-20

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 89.35  E-value: 3.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKL-HTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15104    1 AAGVILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYT 195
Cdd:cd15104   81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLII-LYGRIYVAARsrilnppsLYGKRFTTAQLITGSAGsslcslNPSLHESHThtvgsplffnqv 274
Cdd:cd15104  161 LLVLSCMVFFPALLLFVfCYCDILKIAR--------VHSRAIYKVEHALARQI------HPRRTLSDF------------ 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15104  215 --------------------KAARTVAVLIGCFLLSWLPFQITGLVQALC-DECKLYDVLEDYLWLLGLCNSLLNPWIYA 273
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15104  274 FWQKEVRRAL 283
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
36-364 9.58e-20

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 88.20  E-value: 9.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd14986    1 VSRVAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMsDCLVNTSQISY- 194
Cdd:cd14986   81 VVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVH-QCWSSFYTPWQr 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFY---IPSILLIILYGRIY--VAARSRilnppslyGKRFTTAQLITGSAGSSLCSlnpslhESHTHTvgspl 269
Cdd:cd14986  160 KVYITWLATYvfvIPLIILSYCYGRILrtIWIRSR--------QKTDRPIAPTAMSCRSVSCV------SSRVSL----- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkrISAARERKATKTLGIILgAFIICWLPFFVVSLvLPICRDSCWIHPALFDFFTWLGYLNSLIN 349
Cdd:cd14986  221 ------------------ISRAKIKTIKMTLVIIL-AFILCWTPYFIVQL-LDVYAGMQQLENDAYVVSETLASLNSALN 280
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd14986  281 PLIYGFFSSHLSFEH 295
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
36-362 7.79e-19

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 85.58  E-value: 7.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISI-AYTTTRTWNFGQILCDIWVSS 114
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF-MLGMPFLIhQFAIDGQWYFGEVMCKIITAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPP-LFWRQATAHEEMSDCLVN----T 189
Cdd:cd15088   80 DANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVwVYSSLIYFPDGTTFCYVSlpspD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYGRIYvaarsrilnppslygkRFTTAQLITGsagsslcslNPSLHESHThtvgspl 269
Cdd:cd15088  160 DLYWFTIYHFILGFAVPLVVITVCYILIL----------------HRLARGVAPG---------NQSHGSSRT------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkrisaareRKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15088  208 ------------------------KRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFLSICLGYANSCLN 263
                        330
                 ....*....|...
gi 550822198 350 PVIYTVFNEDFRQ 362
Cdd:cd15088  264 PFVYILVSENFRK 276
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
39-364 1.18e-18

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 85.37  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQ---ILCDIWVSSd 115
Cdd:cd15068    4 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGclfIACFVLVLT- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 itccTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQA-----------TAHEEMS 183
Cdd:cd15068   83 ----QSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLgWNNCgqpkegknhsqGCGEGQV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 184 DCLV-NTSQISYTIYSTCGA-FYIPSILLIILYGRIYVAARSRIlnppslygkrfttaqlitgsagsslcslnpslhesh 261
Cdd:cd15068  159 ACLFeDVVPMNYMVYFNFFAcVLVPLLLMLGVYLRIFLAARRQL------------------------------------ 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 262 thtvgsplffNQVKIKLADSilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFT-W 340
Cdd:cd15068  203 ----------KQMESQPLPG--ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD-CSHAPLWLMYLAiV 269
                        330       340
                 ....*....|....*....|....
gi 550822198 341 LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15068  270 LSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
36-361 2.98e-17

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 81.02  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15391    1 PHLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV-------- 187
Cdd:cd15391   81 LVSVTASVLTNTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVlcgeswpg 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 -NTSQISYTIYSTCGAFYIPsiLLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvg 266
Cdd:cd15391  159 pDTSRSAYTVFVMLLTYIIP--LLILTSTYGYVGFR-------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 spLFFNQVKiklADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCW----IHPALFDFFTWLG 342
Cdd:cd15391  193 --LWNRTAP---GNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNmpqhTTRLIYGACHWIA 267
                        330
                 ....*....|....*....
gi 550822198 343 YLNSLINPVIYTVFNEDFR 361
Cdd:cd15391  268 MSNSFVNPIIYLFMNDSFR 286
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
40-364 4.23e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 80.79  E-value: 4.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCD-----IWVSS 114
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKfvnymMQVTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTasilhLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV------- 187
Cdd:cd15095   85 QATCLT-----LTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQTYcrevwps 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 NTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPslygkrfttaqlitgsagsslcSLNPSLHESHThtvgs 267
Cdd:cd15095  160 KAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGN----------------------NQSEQLSERAL----- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 plffnqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLvlpicrdscWIH--------PALFDFFT 339
Cdd:cd15095  213 -----------------------RQKRKVTRMVIVVVVLFAICWLPNHVLNL---------WQRfdpnfpetYATYALKI 260
                        330       340
                 ....*....|....*....|....*...
gi 550822198 340 W---LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15095  261 AalcLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
40-364 6.19e-17

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 80.03  E-value: 6.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF----WRQATAHEEMSDCLVNTSQI-SY 194
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFlhgvVSYGFSSEAYSYCTFLTEVGtAA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTC---GAFYIPSILLIILYGRIYVaarsRILNPPSLYGKRFTTAQlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15096  165 QTFFTSfflFSYLIPLTLICVLYMLMLR----RLRRQKSPGGRRSAESQ------------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLV-----LPICRDSCWIHPAlfdfFTWLGYLNS 346
Cdd:cd15096  210 -------------------RGKRRVTRLVVVVVVVFAICWLPIHIILLLkyygvLPETVLYVVIQIL----SNCLAYGNS 266
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15096  267 CVNPILYAFLSQNFRKAF 284
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
39-364 1.77e-16

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 78.94  E-value: 1.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPIS-IAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15392    4 ILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSfIALLILQYWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFW----RQATAHEEMSDCLVNTSQIS 193
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITsrlfEDSNASCGQYICTESWPSDT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YT-IYSTCGA---FYIPSILLIILYGRIYVAarsrilnppsLYGKRfttaqlITGSAGSSlcslnpslheshthtvgspl 269
Cdd:cd15392  162 NRyIYSLVLMilqYFVPLAVLVFTYTRIGIV----------VWAKR------TPGEAENN-------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsileRKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPI-CRDSCWIH-PALFDFFTWLGYLNSL 347
Cdd:cd15392  206 ---------------RDQRMAESKRKLVKMMITVVAIFALCWLPLNILNLVGDHdESIYSWPYiPYLWLAAHWLAMSHCC 270
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15392  271 YNPFIYCWMNAKFRNGF 287
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
38-364 3.92e-16

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 77.93  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15202    3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCL----------- 186
Cdd:cd15202   83 SVHVSAYTLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVrslcledwper 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 187 VNTSQISYTIYSTCGAFYIPSILLIILYGRiyVAARSRILNPPslygkrfttaqlitgsagsslcslnpslheshthtvg 266
Cdd:cd15202  161 ADLFWKYYDLALFILQYFLPLLVISFAYAR--VGIKLWASNMP------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkiklADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCW-IHPALFDFFTWLGYLN 345
Cdd:cd15202  202 ------------GDATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSKPDYLIkTINAVYFAFHWLAMSS 269
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15202  270 TCYNPFIYCWLNERFRIEF 288
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
36-364 1.78e-15

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 75.72  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSLLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSDCLVNTSQIS- 193
Cdd:cd15970   80 AINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILpIIIFSNTAPNSDGSVACNMQMPEPSq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 -----YTIYSTCGAFYIPSILLIILYgrIYVAARSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtvgsp 268
Cdd:cd15970  160 rwlavFVVYTFLMGFLLPVIAICLCY--ILIIVKMRV------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkIKLADSILERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwiHPALFDFFTWLGYLNSLI 348
Cdd:cd15970  195 -------VALKAGWQQRKR----SERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQH---DATVSQLSVILGYANSCA 260
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15970  261 NPILYGFLSDNFKRSF 276
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
36-364 2.95e-15

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 75.29  E-value: 2.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15092    1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNT-SQISY 194
Cdd:cd15092   80 YYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIpTPQDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 --TIYSTC---GAFYIPSILLIILYgriyvaarsrilnppSLYGKRFTTAQLITGSAgsslcslnpslheshthtvgspl 269
Cdd:cd15092  160 wdPVFGICvflFSFIIPVLIISVCY---------------SLMIRRLRGVRLLSGSK----------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPI-CRDSCWIHPALFDFFTWLGYLNSLI 348
Cdd:cd15092  202 --------------EKDR----NLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLgVQPSSETAVAILRFCTALGYVNSSL 263
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15092  264 NPVLYAFLDENFKACF 279
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
36-364 3.90e-15

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 75.02  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTR-TWNFGQILCDIWVSS 114
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWARePWLLGEFMCKLVPFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV------- 187
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVavcrtpa 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 -NTSQISYTIYSTCGAFYIPSILLIILYGRIyvaARsRILNPPSLYGKRFTTAQLitgsagsslcslnpslheshtHTVG 266
Cdd:cd14997  161 dTFWKVAYILSTIVVFFVVPLAILSGLYSVI---CR-RLVGHPALESRRADAANR---------------------HTLR 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 SplffnqvkikladsileRKRIsaarerkaTKTLGIILGAFIICWLPFFVVSL---------VLPICRDSCWIhpaLFDF 337
Cdd:cd14997  216 S-----------------RRQV--------VYMLITVVVLFFVCLLPFRVVTLwiifapdedLQALGLEGYLN---LLVF 267
                        330       340
                 ....*....|....*....|....*..
gi 550822198 338 FTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd14997  268 CRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-364 4.02e-15

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 74.81  E-value: 4.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15093    6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSDCLVNTSQ------IS 193
Cdd:cd15093   85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILpVVVFAGTRENQDGSSACNMQWPEpaaawsAG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPpslygkrfttaqlitgsaGSSlcslnpslheshthtvgsplffnq 273
Cdd:cd15093  165 FIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRA------------------GWQ------------------------ 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPAL---FDFFTWLGYLNSLINP 350
Cdd:cd15093  203 ----------QRKR----SERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLP--ETPALvgvYHFVVILSYANSCANP 266
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15093  267 ILYGFLSDNFKKSF 280
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
41-223 4.56e-15

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 74.75  E-value: 4.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15336    6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN-----TSQISY 194
Cdd:cd15336   86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFgWSAYVPEGLLTSCTWDymtftPSVRAY 165
                        170       180
                 ....*....|....*....|....*....
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAARS 223
Cdd:cd15336  166 TMLLFCFVFFIPLGIIIYCYLFIFLAIRS 194
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
36-364 4.64e-15

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 74.82  E-value: 4.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQAtahEEMSDCLVN------- 188
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQL---EVKYDFLYEkrhvccl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 ------TSQISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslyGKRFTTAQLItgSAGSSLCSLNPSLHESht 262
Cdd:cd15205  158 erwyspTQQKIYTTFILVILFLLPLTTMLFLYSRI---------------GYELWIKKRV--GDASVLQTIHGIEMSK-- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 263 htvgsplffnqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLV-----LPICRDSCWIHpALFDF 337
Cdd:cd15205  219 --------------------------ISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMMieysnLENKYDGVTIK-LIFAI 271
                        330       340
                 ....*....|....*....|....*..
gi 550822198 338 FTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15205  272 VQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
40-363 5.60e-15

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 74.45  E-value: 5.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDLYRLwRYRPWRFGDLLCRLMYFFSETC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--------WRQATAHEEMSDCLVNTS 190
Cdd:cd15928   84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVlvgvehiqGQQTPRGFECTVVNVSSG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGriyvaarsrilnppsLYGKRFTTAQLITGSAGSSLCSLNpslheshthtvgsplf 270
Cdd:cd15928  164 LLSVMLWVSTSFFFVPMVCLSLLYG---------------LIGRALWDRRQRSRTAGASRRDNN---------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerkrisaarERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLG----YLNS 346
Cdd:cd15928  213 ----------------------HRQTVRMLAVIVLAFVLCWLPFHVGRVIFNHSRASTKHLHYVSQYFNLVSfvlfYLSA 270
                        330
                 ....*....|....*..
gi 550822198 347 LINPVIYTVFNEDFRQA 363
Cdd:cd15928  271 AINPILYNLMSKRYRYA 287
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
44-364 6.60e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 74.54  E-value: 6.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15980    9 LIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITdaLEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQIS---------- 193
Cdd:cd15980   89 FTLVAIAVDRFRCIV--YPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSpvywcredwp 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 -------YTIYSTCGAFYIPSILLIILYGRIYVAArsrilnppslygkrFTTAQLITGSAgsslcslnpslHESHTHTVg 266
Cdd:cd15980  167 nqemrkiYTTVLFANIYLAPLSLIVIMYARIGITL--------------FKTAMPHTGKH-----------NQEQRHVV- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDS----CWIHPALFDFFTWLG 342
Cdd:cd15980  221 -----------------------SRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYANLSpnqlQIINIYIYPFAHWLA 277
                        330       340
                 ....*....|....*....|..
gi 550822198 343 YLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15980  278 FFNSSVNPIIYGFFNENFRRGF 299
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
39-364 6.71e-15

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 73.85  E-value: 6.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQIS----- 193
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAwpstl 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 ----YTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15001  163 ysrlYVVYLAIVIFFIPLIVMTFAYARD---------------------------------------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilERKRIsaarerkaTKTLGIILGAFIICWLPFFVVSLV---LPICRDSCWIHPALFDFFTWLGYLNS 346
Cdd:cd15001  191 --------------TRKQV--------IKMLISVVVLFAVCWGPLLIDNLLvsfDVISTLHTQALKYMRIAFHLLSYANS 248
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15001  249 CINPIIYAFMSKNFRSSF 266
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
40-362 8.22e-15

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 73.43  E-value: 8.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15214    4 IAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN-TSQISYTIY 197
Cdd:cd15214   84 SASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFgWSSLEFDRFKWMCVAAwHKEAGYTAF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15214  164 WQVWCALLPFVVMLVCYGFIF----------------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVslvlpICRDSCW----IHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15214  185 ---------RVARANQCKAFITILVVLGAFVTTWGPYMVV-----ISTEALWgknsVSPQLETLATWLSFTSAVCHPLIY 250

                 ....*....
gi 550822198 354 TVFNEDFRQ 362
Cdd:cd15214  251 GLWNKTVRK 259
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
38-357 1.08e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 73.23  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATA--HEEMSDCLVNTSQISYT 195
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPryNTLTGSCYLICTTIYLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd14964  161 WGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNT--------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd14964  202 ---------------DKNLKATKSLLILVITFLLCWLPFSIVFILHALVAA-GQGLNLLSILANLLAVLASTLNPFIYCL 265

                 ..
gi 550822198 356 FN 357
Cdd:cd14964  266 GN 267
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
44-364 2.43e-14

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 72.57  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15971    9 VVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELF-MLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVN---TSQISYT---IY 197
Cdd:cd15971   88 FCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIwpgESSAWYTgfiIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYVAARSRilnppslyGKRfttaqlitgsAGSSlcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15971  168 TFILGFFVPLTIICLCYLFIIIKVKSS--------GIR----------VGSS---------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVF 356
Cdd:cd15971  202 ------KRKK----SEKKVTRMVSIVVAVFVFCWLPFYIFNVSsVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFL 271

                 ....*...
gi 550822198 357 NEDFRQAF 364
Cdd:cd15971  272 SDNFKKSF 279
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
39-364 2.76e-14

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 72.43  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15195    4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF------WRQATAHEEMSDCLVNTSQI 192
Cdd:cd15195   84 MYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFsvlrkmPEQPGFHQCVDFGSAPTKKQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 S--YTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagssLCSLNPSLHESHTHTvgsplf 270
Cdd:cd15195  164 ErlYYFFTMILSFVIPLIITVTCYLLI--------------------------------LFEISKMAKRARDTP------ 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fNQVKIKLADSILERKRisaareRKATKTLGIILGAFIICWLPFFVVSLVLPIC-RDSCWIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15195  206 -ISNRRRSRTNSLERAR------MRTLRMTALIVLTFIVCWGPYYVLGLWYWFDkESIKNLPPALSHIMFLLGYLNPCLH 278
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15195  279 PIIYGVFMKEIRNWI 293
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
38-362 7.82e-14

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 71.14  E-value: 7.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPAN-YLIgSLATTDLLVsILVMPISIAYTTTRT-WNFGQILCDIWVSSD 115
Cdd:cd14982    3 FPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTiYMI-NLALADLLF-VLTLPFRIYYYLNGGwWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD-CLVN-----T 189
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTtCFEFlsewlA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagssLCSLNPSLHESHthtvgspl 269
Cdd:cd14982  161 SAAPIVLIALVVGFLIPLLIILVCYSLIIRA-----------------------------LRRRSKQSQKSV-------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPF----FVVSLVLPICRDSCWIHPALFDFF---TWLG 342
Cdd:cd14982  204 ----------------------RKRKALRMILIVLAVFLVCFLPYhvtrILYLLVRLSFIADCSARNSLYKAYritLCLA 261
                        330       340
                 ....*....|....*....|
gi 550822198 343 YLNSLINPVIYTVFNEDFRQ 362
Cdd:cd14982  262 SLNSCLDPLIYYFLSKTFRK 281
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
36-364 8.78e-14

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 70.79  E-value: 8.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTrTWNFGQILCDIWVSSD 115
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGNILCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISY- 194
Cdd:cd15090   80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWy 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 --TIYSTC---GAFYIPSILLIILYGRIYVaarsrilnppslygkRFTTAQLITGSAgsslcslnpslheshthtvgspl 269
Cdd:cd15090  160 weNLLKICvfiFAFIMPVLIITVCYGLMIL---------------RLKSVRMLSGSK----------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRdscwIHPALFDFFTW-----LGYL 344
Cdd:cd15090  202 --------------EKDR----NLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT----IPETTFQTVSWhfciaLGYT 259
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd15090  260 NSCLNPVLYAFLDENFKRCF 279
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
36-364 9.51e-14

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 70.79  E-value: 9.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISicisipplfwrqataheemsdCLVNTSQIsyt 195
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLAS---------------------FLLALPQL--- 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYipsilliilYGRIYVAARSRILNPPSLYGKRFTTAQ--LITGSAGSSLCSLnpslheSHTHT-VGSPLFFN 272
Cdd:cd15390  135 LYSTTETYY---------YYTGSERTVCFIAWPDGPNSLQDFVYNivLFVVTYFLPLIIM------AVAYTrVGVELWGS 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkiKLADSILERKRISAARERKATKTLGIILGAFIICWLP---FFVVSLVLPICRDSCWIHPALFDFFtWLGYLNSLIN 349
Cdd:cd15390  200 ----KTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPyhlYFILTYLYPDINSWKYIQQIYLAIY-WLAMSNSMYN 274
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15390  275 PIIYCWMNKRFRYGF 289
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
36-364 1.04e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 70.62  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV-------- 187
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIVYHLE--SKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIqacsekwp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 NTSQISYTIYSTCG---AFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaqlitgsagsslcslNPSLHESHTHT 264
Cdd:cd15399  159 NGTLNDGTIYSVSMlliQYVLPLAIISYAYIRIWTKLKNHV----------------------------SPGGGNDHYHQ 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 265 vgsplffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPIcrDSCWI----HPALFDFFTW 340
Cdd:cd15399  211 ---------------------------RRRKTTKMLVCVVVVFAVSWLPFHAFQLASDI--DSKVLdlkeYKLIYTIFHV 261
                        330       340
                 ....*....|....*....|....
gi 550822198 341 LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15399  262 IAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
36-364 1.08e-13

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 70.37  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15210    1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--WRQATAHEEMSDC--LVNTSQ 191
Cdd:cd15210   81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLgiWGRFGLDPKVCSCsiLRDKKG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRiyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15210  161 RSPKTFLFVFGFVLPCLVIIICYAR------------------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVlpicrDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15210  186 -------------------REDRRLTRMMLVIFLCFLVCYLPITLVNVF-----DDEVAPPVLHIIAYVLIWLSSCINPI 241
                        330
                 ....*....|...
gi 550822198 352 IYTVFNEDFRQAF 364
Cdd:cd15210  242 IYVAMNRQYRQAY 254
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
38-364 1.16e-13

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 70.58  E-value: 1.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIW-VSSDI 116
Cdd:cd15094    3 SAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYmVLTSI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILhLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVN-------T 189
Cdd:cd15094   82 NQFTSSFT-LTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVwpdssavN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYgrIYVAARSRILNPPSlygkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15094  161 GQKAFTLYTFLLGFAIPLLLISVFY--TLVILRLRTVGPKN--------------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsileRKRISAARERKATKTLGIILGAFIICWLPFFV--VSLV-LPICRDSCWIHPALFDFFTWLGYLNS 346
Cdd:cd15094  200 ---------------KSKEKRRSHRKVTRLVLTVISVYIICWLPYWAfqVHLIfLPPGTDMPKWEILMFLLLTVLSYANS 264
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15094  265 MVNPLLYAFLSENFRKSF 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-364 1.55e-13

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 70.50  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLatvLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15208    4 IALYILVFIVGL---VGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYskRRTAGHAAAMIAAVWIISICISIPPLFWRQATAH--------------EE 181
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVvplanktilltvcdER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 182 MSDclvNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqliTGSAGSSLCSLNPSLHESH 261
Cdd:cd15208  159 WSD---SIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCR------------------QIPGTSSVVQRKWNKPRKS 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 262 THTVgsplffnqvkikladsilERKRISAarERKATKTLGIILGAFIICWLPffvVSLvLPICR--------DSCWIHpA 333
Cdd:cd15208  218 AVAA------------------EEKQLRS--RRKTAKMLIVVVIMFAICYLP---VHL-LNILRyvfglftvDRETIY-A 272
                        330       340       350
                 ....*....|....*....|....*....|.
gi 550822198 334 LFDFFTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15208  273 WFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
32-364 1.98e-13

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 69.81  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  32 QALRISLVVVLSVItlatVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRTWNFGQILCDIW 111
Cdd:cd15102    1 GATSVVFVAICCFI----VLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGA-AYLANILLSGARTLRLSPAQWFLR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd15102   76 EGSMFVALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALDACSTVLPLYSK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 iSYTIYSTCgAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15102  156 -HYVLFCVT-IFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALL------------------------------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaarerkatKTLGIILGAFIICWLPFFVVSLVLPICRdsCWIHPALF--DFFTWLGYLNSLIN 349
Cdd:cd15102  204 --------------------------KTVLIVLLVFIACWGPLFILLLLDVACP--VKTCPILYkaDWFLALAVLNSALN 255
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15102  256 PIIYTLRSRELRRAV 270
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
39-364 2.34e-13

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 69.19  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN----TSQIS 193
Cdd:cd15196   84 MYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSIPQLFiFSYQEVGSGVYDCWATfeppWGLRA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRI-YVAARSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffN 272
Cdd:cd15196  163 YITWFTVAVFVVPLIILAFCYGRIcYVVWRAKI----------------------------------------------K 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 QVKIkladsilerkrisaarerkatkTLGIILgAFIICWLPFFVVSLVLPICRDSCWIHPAlFDFFTWLGYLNSLINPVI 352
Cdd:cd15196  197 TVKL----------------------TLVVVA-CYIVCWTPFFVVQMWAAWDPTAPIEGPA-FVIIMLLASLNSCTNPWI 252
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15196  253 YLAFSGNLRRAL 264
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
43-362 2.45e-13

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 69.77  E-value: 2.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  43 SVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYT-TTRTWNFGQILCDIWVSSDITCCTA 121
Cdd:cd15394    8 SLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAfEPRGWVFGRFMCYFVFLMQPVTVYV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 122 SILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIpplfwrQATAH--------EEMSDCL-----VN 188
Cdd:cd15394   88 SVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLAL------PAAAHtyyvefkgLDFSICEefwfgQE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkrfttaqlITGSAgsslcslnpslheshthtvgsp 268
Cdd:cd15394  160 KQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRV----------------VPGSM---------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkiklADSILERKRisaARERKATKTLGIILGAFIICWLPFFVVSLVLPIcrDSCWIHPALFDFFT----WLGYL 344
Cdd:cd15394  202 ----------TQSQAEWDR---ARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDI--DIDLIDKQYFNLIQllchWLAMS 266
                        330
                 ....*....|....*...
gi 550822198 345 NSLINPVIYTVFNEDFRQ 362
Cdd:cd15394  267 SACYNPFLYAWLHDSFRG 284
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
36-364 4.76e-13

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 68.82  E-value: 4.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15089    1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATS-TLPFQSAKYLMETWPFGELLCKAVLSID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFwrQATAHEEMSDCLVNTSQISY- 194
Cdd:cd15089   80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMV--MAVTKTPRDGAVVCMLQFPSp 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 -----TIYSTC---GAFYIPSILLIILYGRIYVaarsrilnppslygkRFTTAQLITGSAgsslcslnpslheshthtvg 266
Cdd:cd15089  158 swywdTVTKICvfiFAFVVPILVITVCYGLMIL---------------RLRSVRLLSGSK-------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsilERKRisaaRERKATKTLGIILGAFIICWLP---FFVVSLVLPICRDSCWIHPALfDFFTWLGY 343
Cdd:cd15089  203 -----------------EKDR----NLRRITRMVLVVVAAFIICWTPihiFVIVWTLVDIDRRNPLVVAAL-HLCIALGY 260
                        330       340
                 ....*....|....*....|.
gi 550822198 344 LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15089  261 ANSSLNPVLYAFLDENFKRCF 281
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
36-361 5.15e-13

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 68.88  E-value: 5.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTtILLTKKLHTPA--NYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVS 113
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLL-ILLRNRRRKRSrvNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALE--YSKRRtaghAAAMIAAVWIISICISIPPLFwrqaTAHEEMSDCLVNTSQ 191
Cdd:cd15382   80 FRAFGLYLSSFVLVCISLDRYFAILKPLRlsDARRR----GRIMLAVAWVISFLCSIPQSF----IFHVESHPCVTWFSQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 -------------ISYTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagSSLCslnpslh 258
Cdd:cd15382  152 cvtfnffpshdheLAYNIFNMITMYALPLIIIVFCYSLILCEISRK-----------------------SKEK------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 259 ESHTHTVGSPLFFNQVKIkladSILERkrisaARERKATKTLGIILgAFIICWLPFFVVSLVLPICRDSC-WIHPALFDF 337
Cdd:cd15382  202 KEDVSEKSSSVRLRRSSV----GLLER-----ARSRTLKMTIVIVL-VFIICWTPYFIMSLWYWFDRESAsKVDPRIQKG 271
                        330       340
                 ....*....|....*....|....
gi 550822198 338 FTWLGYLNSLINPVIYTVFNEDFR 361
Cdd:cd15382  272 LFLFAVSNSCMNPIVYGYFSIDLR 295
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
32-364 7.25e-13

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 67.92  E-value: 7.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  32 QALRISLVVVLSVItlatVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPiSIAYTTTRTWNFGQILCDIW 111
Cdd:cd15347    1 QVASIFIVILCCII----VLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIA-NILLSGSVTFRLTPVQWFIR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd15347   76 EGTAFITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGACWVISIVLGGLPILGWNCIGNLEDCSTVLPLYSK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 isYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslheSHTHTVGSPLFf 271
Cdd:cd15347  156 --HYILFVVTIFSIILLSIVILYVRIYCIVRS------------------------------------SHAEMAAPQTL- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICR-DSCwihPALF--DFFTWLGYLNSLI 348
Cdd:cd15347  197 -----------------------ALLKTVTIVLGVFIVCWLPAFIILLLDTSCKvKSC---PILYkaDYFFSVATLNSAL 250
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15347  251 NPVIYTLRSKDMRKEF 266
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 9.31e-13

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 68.12  E-value: 9.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIL----VMPISIAYtttRTWNFGQILCDIWVSSD 115
Cdd:cd15337    5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVngfpLKTISSFN---KKWIWGKVACELYGFAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDC----LVNT- 189
Cdd:cd15337   82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFgWGRYVPEGFQTSCtfdyLSRDl 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15337  162 NNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNH--------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffNQVKIKLADSILERKRISAARERKA----TKTLGIILGAFIICWLPFFVVSLvLPICRDSCWIHPALFDFFTWLGYLN 345
Cdd:cd15337  197 --EKEMTQTAKSGMGKDTEKNDARKKAeiriAKVAIILISLFLLSWTPYAVVAL-LGQFGPAYWITPYVSELPVMFAKAS 273
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15337  274 AIYNPIIYALSHPKFRAAL 292
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
50-362 1.19e-12

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 67.53  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  50 VLSNAFVLTTILLTKKLHTPANYlIGSLATTDLlVSILVMPISI-AYTTTRTWNFGQILCDIWVSSDITCCTASILHLCV 128
Cdd:cd15339   15 LVGNILVLFTIIRSRKKTVPDIY-VCNLAVADL-VHIIVMPFLIhQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 129 IALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE-MSDCLVNTSQ----ISYTIYSTCGAF 203
Cdd:cd15339   93 MSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDgLESCAFNLTSpddvLWYTLYQTITTF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 204 YIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagssLCSLNPSLHeshthtvgsplffnqvkiKLADSIL 283
Cdd:cd15339  173 FFPLPLILICYILI--------------------------------LCYTWEMYR------------------KNKKAGR 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 284 ERKRISAARERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPAlFDFFTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15339  203 YNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVnLSVSQPTLAFYVS-YYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
40-364 1.35e-12

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 67.21  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15346    5 VVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-AYTANLLLSGATTYKLTPTQWFLREGSMFVAL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheeMSDC--LVNTSQISYTIY 197
Cdd:cd15346   84 SASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISA---LSSCstVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCgAFYIPSILLIILYGRIYVAARSRilnppslyGKRFTTAQLITGSAGSSLCSLnpslheshthtvgsplffnqvkik 277
Cdd:cd15346  161 CTT-VFTLLLLSIVILYCRIYSLVRTR--------SRRLTFRKNIRKASRSSEKSM------------------------ 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICR-DSCwihPALF--DFFTWLGYLNSLINPVIYT 354
Cdd:cd15346  208 -----------------ALLKTVIIVLSVFIACWAPLFILLLLDVGCKvKTC---SILFkaEYFLVLAVLNSATNPIIYT 267
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15346  268 LTNKEMRRAF 277
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
38-364 1.61e-12

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 67.29  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15091    3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE--MSDCLVNTSQISYT 195
Cdd:cd15091   82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDvdSTECSLQFPDDDYS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYST-------CGAFYIPSILLIILYgriyvaarsrilnppSLYGKRFTTAQLITGSAgsslcslnpslheshthtvgsp 268
Cdd:cd15091  162 WWDTfmkicvfIFAFVIPVLIIIVCY---------------TLMILRLKSVRLLSGSR---------------------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHP-ALFDFFTWLGYLNSL 347
Cdd:cd15091  205 ---------------EKDR----NLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAvSSYYFCIALGYTNSS 265
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15091  266 LNPILYAFLDENFKRCF 282
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-364 1.72e-12

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 67.39  E-value: 1.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLT-KKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15383    4 VAVTFVLFVLSACSNLAVLWSATRNrRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRtaGHAAAMIAAVWIISICISIPPLF-WRQATAH--EEMSDCLVNTS---- 190
Cdd:cd15383   84 AMYSSAFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFlFHTVTATppVNFTQCATHGSfpah 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 --QISYTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitGSAGSSLCSLNPSLHESHTHtvgsp 268
Cdd:cd15383  162 wqETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRR-------------------MKEKKDSAKNEVALRSSSDN----- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilerkrISAARERKATKTLgIILGAFIICWLPFFVVSLVLpicrdscWIHPA-------------LF 335
Cdd:cd15383  218 -------------------IPKARMRTLKMTI-VIVSSFIVCWTPYYLLGLWY-------WFSPEmleqtvpeslshiLF 270
                        330       340
                 ....*....|....*....|....*....
gi 550822198 336 DFftwlGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15383  271 LF----GLLNACLDPLIYGLFTISFRRGL 295
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
33-364 2.46e-12

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 66.88  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  33 ALRISLVVVLSVITLAtvlSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQIL---CD 109
Cdd:cd15069    1 ATYVALELIIAALSVA---GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLflaCF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 110 IWVSSDitcctASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF---------------WR 174
Cdd:cd15069   78 VLVLTQ-----SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLgwnkamsatnnstnpAD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 175 QATAHeemSDCLV-----NTSQISYTIY-STCGAFYIPSILLIILYGRIYVAArSRILNPPSLYGKRFTTAQlitgsags 248
Cdd:cd15069  153 HGTNH---SCCLIsclfeNVVPMSYMVYfNFFGCVLPPLLIMLVIYIKIFLVA-CRQLQRTELMDHSRTTLQ-------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 249 slcslnpslheshthtvgsplffnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC 328
Cdd:cd15069  221 -------------------------------------------REIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFS 257
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 550822198 329 WIHPA-LFDFFTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15069  258 KSKPKwAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
38-363 2.59e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 66.59  E-value: 2.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15389    3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHE-----EMSDCLVN--TS 190
Cdd:cd15389   83 SVYVSTLTLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEysnerTRSRCLPSfpEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFyipsILLIILYGRIYVAARSRIlnppslyGKRFTTAQLItgsagsslcslnpslheshthtvgsplf 270
Cdd:cd15389  161 SDLFWKYLDLATF----ILQYVLPLLIIGVAYTRV-------AKKLWLRNAI---------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkiklaDSILERKRISAARERKAT-KTLGIILGAFIICWLPFFVVSLVL---PICRDScwihpALFDFFTWLGYLNS 346
Cdd:cd15389  202 ---------GDVTTEQYVAQRRKKKKTiKMLMLVVLLFAICWLPLNCYHVLLsshPIRSNS-----ALFFAFHWLAMSST 267
                        330
                 ....*....|....*..
gi 550822198 347 LINPVIYTVFNEDFRQA 363
Cdd:cd15389  268 CYNPFIYCWLNDSFRSE 284
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
40-364 3.35e-12

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 66.28  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPA--NYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARKGKPSliDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITD---ALEYSKRRTaghaAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV------N 188
Cdd:cd15002   84 CMAAKSFTIAVLAKACYMYVVNptkQVTIKQRRI----TAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILcipplaH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitGSAGSSLcslnpslheshthtvgsp 268
Cdd:cd15002  160 EFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRR-------------------GTKTQNL------------------ 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lfFNQvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFT-WLGYLNSL 347
Cdd:cd15002  203 --RNQ-----------------IRSRKLTHMLLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAqLLAFSISS 263
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15002  264 VNPIIFLLMSEEFREGF 280
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
40-362 4.08e-12

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 66.14  E-value: 4.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYwAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN-------TSQ 191
Cdd:cd15074   85 CCSINTLTAISIYRY-LKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVgWGSYGPEPFGTSCSIDwtgasasVGG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslyGKRFTTAQLITGSAgsslcslnpslheshthtvgsplff 271
Cdd:cd15074  164 MSYIISIFIFCYLLPVLIIVFSYVKIIRKVK----------SSRKRVAGFDSRSK------------------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 NQVKIkladsilerkrisaarERKATKTLGIILGAFIICWLPFFVVSlVLPICRDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15074  209 RQHKI----------------ERKVTKVAVLICAGFLIAWTPYAVVS-MWSAFGSPDSVPILASILPALFAKSSCMYNPI 271
                        330
                 ....*....|.
gi 550822198 352 IYTVFNEDFRQ 362
Cdd:cd15074  272 IYLLFSSKFRQ 282
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
38-145 4.53e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 66.06  E-value: 4.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15079    3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                         90       100
                 ....*....|....*....|....*...
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSK 145
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLNGNP 109
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
44-364 6.53e-12

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 65.21  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15972    9 VVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELF-MLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqATAHEEMSDCLV------NTSQISYTIY 197
Cdd:cd15972   88 FCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIF--SGVPGGMGTCHIawpepaQVWRAGFIIY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYVAARSRilnppslyGKRFTTAQlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15972  166 TATLGFFCPLLVICLCYLLIVVKVRSS--------GRRVRATS------------------------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladsilERKRISaarERKATKTLGIILGAFIICWLPFFV---VSLVLPICRDSCwiHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15972  201 ------TKRRGS---ERKVTRMVVIVVAAFVLCWLPFYAlniVNLVCPLPEEPS--LFGLYFFVVVLSYANSCANPIIYG 269
                        330
                 ....*....|
gi 550822198 355 VFNEDFRQAF 364
Cdd:cd15972  270 FLSDNFKQGF 279
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
36-364 6.78e-12

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 65.32  E-value: 6.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15401    1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC-LVNTSQISY 194
Cdd:cd15401   81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCtFAQTVSSSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplFFNQV 274
Cdd:cd15401  161 TITVVVVHFIVPLSIVTFCYLRIWV--------------------------------------------------LVIQV 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 KIKLADSIleRKRISAARERKATkTLGIILGAFIICWLPFFVVSLVLPI--CRDSCWIHPALFDFFTWLGYLNSLINPVI 352
Cdd:cd15401  191 KHRVRQDS--KQKLKANDIRNFL-TMFVVFVLFAVCWGPLNFIGLAVAInpLKVAPKIPEWLFVLSYFMAYFNSCLNAVI 267
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15401  268 YGVLNQNFRKEY 279
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-364 9.11e-12

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 64.96  E-value: 9.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTtILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTrtWNFGQILCDIWVSSD--- 115
Cdd:cd14978    4 GYVLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIA--DYSSSFLSYFYAYFLpyi 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ----ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE------MSDC 185
Cdd:cd14978   81 yplaNTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENcnnnsyYYVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 186 LVNTSQISYTIYSTCGAFY------IPSILLIILYGRIYVAARSRILNPPSLYGKRFTTaqlitgsagsslcslnpslhe 259
Cdd:cd14978  161 PTLLRQNETYLLKYYFWLYaifvvlLPFILLLILNILLIRALRKSKKRRRLLRRRRRLL--------------------- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 260 shthtvgsplffnqvkikladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDF 337
Cdd:cd14978  220 ---------------------------SRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFlsPIYQLLGDI 272
                        330       340
                 ....*....|....*....|....*..
gi 550822198 338 FTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd14978  273 SNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-364 9.25e-12

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 64.99  E-value: 9.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAY--TTTRTWNFGQILC----- 108
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYyvVRQRSWTHGDVLCavvny 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 109 ----DIWVSsditccTASILhlcVIALDRYWAITDALeySKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD 184
Cdd:cd15204   81 lrtvSLYVS------TNALL---VIAIDRYLVIVHPL--KPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 185 clVNTSQI----------SYTIYSTCGAFYIPSILLIILYGRIYVaarsrilnppSLYGKRFttaqlitgsagsslcsln 254
Cdd:cd15204  150 --IFCGQIwpvdqqayykAYYLFLFVLEFVLPVLIMTLCYLRIVR----------KVWFRRV------------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 255 pslheshthtvgsPLFFNqvkikladsilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVlpicRDscwIHPAL 334
Cdd:cd15204  200 -------------PGQQT-----------EQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIV----RD---FFPTL 248
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 550822198 335 FD--------FFT--WLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15204  249 LSkeklnttiFYIveALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
36-364 1.39e-11

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 64.66  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTR-TWNFGQILCDIWVSS 114
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI----------SIPPLFWRQATAHEEMSD 184
Cdd:cd15134   81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCalpfaiqtriVYLEYPPTSGEALEESAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 185 CLVNTSQISYT---IYSTCGAFYIPSILLIILYGRIYVAARSRILNppslygkrfttaqlitgsagsslcslnpslhesh 261
Cdd:cd15134  161 CAMLNEIPPITpvfQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLL---------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 262 thtvgsplffnqvkiKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLvlpICRDSCWIHPALFDFFTWL 341
Cdd:cd15134  207 ---------------RRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFICWAPFHAQRL---LTVYAKNMTPPYLFINRIL 268
                        330       340       350
                 ....*....|....*....|....*....|
gi 550822198 342 GY-------LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15134  269 FYisgvlyyVSSTVNPILYNVMSAKYRQAF 298
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
53-363 1.40e-11

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 64.18  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  53 NAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-LVMPISIAYTTTrtwnfGQILCDIWVSSDITCCTASILHLCVIAL 131
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCgLILNFVFQYVIQ-----SETISLITVGFLVASFTASVSSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 132 DRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWrqaTAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILL 210
Cdd:cd15962   93 DRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLgLLPVLGW---NCLEERASCSIVRPLTKSNVTLLSASFFFIFILM 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 211 IILYGRIyvaarsrilnppslygkrfttAQLITgsagsslcslnpslheSHTHtvgsplffnqvKIKLADSILERKRISA 290
Cdd:cd15962  170 LHLYIKI---------------------CKIVC----------------RHAH-----------QIALQQHFLTASHYVA 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550822198 291 AreRKATKTLGIILGAFIICWLPFFVVSLVlpicrdSCWIHPALFDFFTWL-GYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15962  202 T--KKGVSTLAIILGTFGASWLPFAIYCVV------GDHEYPAVYTYATLLpATYNSMINPIIYAYRNQEIQRS 267
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
37-364 1.76e-11

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 64.15  E-value: 1.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15402    2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQIS-YT 195
Cdd:cd15402   82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSaYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYV---AARSRILNPpslygkrfttaqlitgsagsslcslnpslheshthtvgsplffN 272
Cdd:cd15402  162 IAVVFFHFILPIIIVTFCYLRIWIlviQVRRRVKPD-------------------------------------------N 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 QVKIKLADSilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15402  199 KPKLKPHDF-------------RNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETIvpRIPEWLFVASYYMAYFNSCLNA 265
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15402  266 IIYGLLNQNFRREY 279
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
39-222 1.83e-11

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 63.71  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15215    3 SVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDC-LVNTSQISYTI 196
Cdd:cd15215   83 AFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYgWGQAAFDERNALCsVIWGSSYSYTI 162
                        170       180
                 ....*....|....*....|....*.
gi 550822198 197 YSTCGAFYIPSILLIILYGRIYVAAR 222
Cdd:cd15215  163 LSVVSSFVLPVIIMLACYSMVFRAAR 188
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
38-364 2.18e-11

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 63.56  E-value: 2.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15206    3 IIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATA---------HEEMSDCLVn 188
Cdd:cd15206   83 SVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPmsrpgghkcREVWPNEIA- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 tsQISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheSHThtvgsp 268
Cdd:cd15206  162 --EQAWYVFLDLMLLVIPGLVMSVAYGLI------------------------------------------SWT------ 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsILERKrisaareRKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIH--PALFDFFTWLGYLNS 346
Cdd:cd15206  192 -------------LLEAK-------KRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARYvsSTTISLIQLLAYISS 251
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15206  252 CVNPITYCFMNKRFRQAF 269
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
44-364 2.85e-11

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 63.58  E-value: 2.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15393    9 IISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV----------NTSQIS 193
Cdd:cd15393   89 FTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVkpfclpvgpsDDWWKI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVaarsrilnppSLYGKRfttaqlITGSAGSSlcslnpslheshthtvgsplffnq 273
Cdd:cd15393  167 YNLYLVCVQYFVPLVIICYAYTRIAV----------KIWGTK------APGNAQDV------------------------ 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsileRKRISAARERKATKTLGIILGAFIICWLP---FFVVSLVLPICRDSCWIHPALFdFFTWLGYLNSLINP 350
Cdd:cd15393  207 -----------RDDEILKNKKKVIKMLIIVVALFALCWLPlqtYNLLNEIKPEINKYKYINIIWF-CSHWLAMSNSCYNP 274
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15393  275 FIYGLYNEKFKREF 288
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
38-364 3.07e-11

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 63.28  E-value: 3.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLS-NAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15974    2 LIPVIYLLVCAIGLSgNTLVIYVVLRYAKMKTVTNIYILNLAVADELF-MLGLPFLATQNAISYWPFGSFLCRLVMTVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqATAHEEMSDCLVNTSQ----- 191
Cdd:cd15974   81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIF--SDVQPDLNTCNISWPEpvsvw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 -ISYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttAQLITGSAgsslcslnpslheshthtvgsplf 270
Cdd:cd15974  159 sTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKS---------------SGLRVGST------------------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsileRKRISaarERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15974  200 --------------KRRKS---ERKVTRMVVIIVVVFVFCWLPFYMLNIVnLIVILPEEPAFVGVYFFVVVLSYANSCAN 262
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15974  263 PILYGFLSDNFKQSF 277
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-364 3.84e-11

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 62.89  E-value: 3.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  45 ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVS-------ILVMPISIAYTTTRTwNFGQILCDIWVSSDIT 117
Cdd:cd15103   10 LGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaletIVIILLNNGYLVPRD-SFEQHIDNVIDSMICS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqataheemsdclvntSQISYTIY 197
Cdd:cd15103   89 SLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIY----------------SDSVPVII 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRfttaqlitgsagsslcslnpslheshthtvgsplffnqvkik 277
Cdd:cd15103  153 CLISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQR------------------------------------------ 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 ladSILERKRIsaarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15103  191 ---STRQRANM------KGAVTLTILLGVFIFCWAPFFLHLTLMISCPSNpyCACYMSHFNVYLILIMCNSVIDPLIYAF 261

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15103  262 RSQELRKTF 270
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-362 8.34e-11

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 62.07  E-value: 8.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYVSTYFLKKWYFGDVGCRLLFSLDF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISIC-----ISIPPLFWRQATAHEEMSDCLVNTSQ 191
Cdd:cd14999   80 LTMHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLltlpmAIMIRLVTVEDKSGGSKRICLPTWSE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTC---GAFYIPSILLIILYGRIyvaarsrilnppslyGKRFTTAQlitGSAGSSlcslnpslheshthtvgsp 268
Cdd:cd14999  159 ESYKVYLTLlfsTSIVIPGLVIGYLYIRL---------------ARKYWLSQ---AAASNS------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilERKRISaarERKATKTLGIILGAFIICWLPFFVVSLV------LPICRDScwiHPALFDFFTWLG 342
Cdd:cd14999  202 ---------------SRKRLP---KQKVLKMIFTIVLVFWACFLPFWIWQLLylyspsLSLSPRT---TTYVNYLLTCLT 260
                        330       340
                 ....*....|....*....|
gi 550822198 343 YLNSLINPVIYTVFNEDFRQ 362
Cdd:cd14999  261 YSNSCINPFLYTLLTKNYKE 280
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
40-363 1.00e-10

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 61.72  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-LVMPISIAYTTtrtwnFGQILCDIWVSSDITC 118
Cdd:cd15100    5 IVLCVSGTLIACENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLgLILHFVFRYCV-----YSEALSLVSVGLLVAA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWrqaTAHEEMSDCLVNTSQISYTIY 197
Cdd:cd15100   80 FSASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLgLLPVLGW---NCLREGSSCSVVRPLTKNHLA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYGRI-YVAARsrilnppslygkrfttaqlitgsagsslcslnpslhesHTHtvgsplffnqvKI 276
Cdd:cd15100  157 VLAVAFLLVFALMLQLYAQIcRIVLR--------------------------------------HAH-----------QI 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 KLADSILERKRISAAreRKATKTLGIILGAFIICWLPFFVVSLVlpicrdSCWIHPALFDFFTWL-GYLNSLINPVIYTV 355
Cdd:cd15100  188 ALQRHFLAPSHYVAT--RKGVSTLALILGTFAACWIPFAVYCLL------GDGSSPALYTYATLLpATYNSMINPIIYAF 259

                 ....*...
gi 550822198 356 FNEDFRQA 363
Cdd:cd15100  260 RNQDIQKV 267
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-363 1.04e-10

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 61.74  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWVSS 114
Cdd:cd15132    1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLYRLwKSRPWIFGEFLCRLYHYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCL-------- 186
Cdd:cd15132   80 SEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDfsreckht 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 187 ---VNTSQISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshth 263
Cdd:cd15132  160 pyaVSSGLLGIMIWVTTTYFFLPMLCLSFLYGFI---------------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 264 tvGSPLFFNQVKIkladsileRKRISAARE---RKATKTLGIILGAFIICWLPFFVVSLVLPICRDS-CWIHPALFDFFT 339
Cdd:cd15132  194 --GRKLWKSKNDL--------RGPNAAARErshRQTVRILAVVVLAFIICWLPFHIGRILFANTEDYrTMMFSQYFNIVA 263
                        330       340
                 ....*....|....*....|....*
gi 550822198 340 W-LGYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15132  264 MqLFYLSASINPILYNLISRKYRAA 288
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
41-364 1.18e-10

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 61.41  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELF-MLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSDCLV----NTSQISYT 195
Cdd:cd15973   85 TSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISpIIIFADTATRKGQAVACNLiwphPAWSAAFV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15973  165 IYTFLLGFLLPVLAIGLCYILIIGKMRA---------------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 IKLADSILERKRisaaRERKATKTLGIILGAFIICWLPFFVVSLV-LPICR-DSCWIHPALFdfftwLGYLNSLINPVIY 353
Cdd:cd15973  193 VALKAGWQQRRK----SEKKITRMVLMVVTVFVICWMPFYVVQLLnLFLPRlDATVNHASLI-----LSYANSCANPILY 263
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15973  264 GFLSDNFRRSF 274
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
42-363 1.58e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 61.29  E-value: 1.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  42 LSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTA 121
Cdd:cd15073    7 LIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 122 SILHLCVIALDRYWAITdALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVN-----TSQISYT 195
Cdd:cd15073   87 SIGLLTVVAVDRYLTIC-RPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVgWASYALDPTGATCTINwrkndSSFVSYT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPsiLLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplffnqVK 275
Cdd:cd15073  166 MSVIVVNFIVP--LAVMFYCYYNVSRF---------------------------------------------------VK 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 IKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDS---CWIH--PALFdfftwlGYLNSLINP 350
Cdd:cd15073  193 KVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKkipPWMAiiPPLF------AKSSTFYNP 266
                        330
                 ....*....|...
gi 550822198 351 VIYTVFNEDFRQA 363
Cdd:cd15073  267 CIYVIANKKFRRA 279
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
38-362 1.80e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 61.29  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDiwVSSDIT 117
Cdd:cd15397    3 LVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCK--MTPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 C--CTASILHLCVIALDRYWAITDALEYskRRTAGHAAAMIAAVWIISICISIPPLFWRQATAH---------EEMSDCL 186
Cdd:cd15397   81 CmsVTVSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLPFLAFHILTDEpyknlshffAPLADKA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 187 VNT----SQISYTIYSTC---GAFYIPSILLIILYGRIY--VAARSRILNPPSLYGKRfttaqlitgsagsslcslnpsl 257
Cdd:cd15397  159 VCTeswpSEHHKLAYTTWlllFQYCLPLLFILVCYLRIYlrLRRRKDMLERRGEYNRR---------------------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 258 heshthtvgsplffnqvkikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLV-------LPICRdscwi 330
Cdd:cd15397  217 --------------------------------AGHSKRINVMLVSLVAAFALCWLPLNVFNAIadwnheaIPHCQ----- 259
                        330       340       350
                 ....*....|....*....|....*....|..
gi 550822198 331 HPALFDFFTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15397  260 HNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-364 1.90e-10

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 61.03  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIaYTTTRTWN--FGQILCDIWVS 113
Cdd:cd15357    1 LPMSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEV-YEMWSNYPflFGPVGCYFKTA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWiisiciSIPPLFwrqataheemsdCLVNTSQIS 193
Cdd:cd15357   80 LFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLW------VLSVLF------------SIPNTSIHG 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYstcgafYIPSILLIILYGRIYVAARSRILNppslygkrfttaqlITGSAGSSLCSLNPSlheshthTVGSPLFFnQ 273
Cdd:cd15357  142 IKLQ------YFPNGTLIPDSATCTVVKPLWIYN--------------LIIQITSLLFYVLPM-------GVISVLYY-L 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 VKIKL-ADSILERKRISAARERKA----TKTLGIILGAFIICWLPF--------FVVSLVLPICRDSCWIHPALFDFFtw 340
Cdd:cd15357  194 MGLKLrGDKSLEADEMNVNIQRPSrksvTKMLFVLVLVFAICWAPFhvdrlffsFVVEWTEPLANVFNLIHVVSGVFF-- 271
                        330       340
                 ....*....|....*....|....
gi 550822198 341 lgYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15357  272 --YLSSAVNPIIYNLLSRRFRTAF 293
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
41-364 2.26e-10

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 60.69  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-----LVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVsngseTVVITLLNGNDTDAQSFTVNIDNVIDSVI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheeMSDCLVNTsqisyt 195
Cdd:cd15353   86 CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYSDSSV---VIICLISM------ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 iystcgaFYIPSILLIILYGRIYVAARSRILNPPSLYGkrfttaqliTGSagsslcslnpslheshthtvgsplffnqvk 275
Cdd:cd15353  157 -------FFTMLALMASLYVHMFLLARLHIKRIAVLPG---------TGP------------------------------ 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 ikladsilerkrISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15353  191 ------------IRQGANMKGAITLTILLGVFVVCWAPFFLHLIFYISCPRNpyCVCFMSHFNMYLILIMCNSVIDPLIY 258
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15353  259 AFRSQELRKTF 269
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
40-363 2.44e-10

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 60.61  E-value: 2.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMpISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15348    5 VAFLAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYA-ANILMSGANTLKLTPALWFLREGGVFITL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQiSYTIYST 199
Cdd:cd15348   84 TASVFSLLAIAIERHITMVRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWNCLGNLDACSTVLPLYAK-SYILFCI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CgAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRfttaqlitgsagsslcslnpslheshthtvgsplffnqvkikla 279
Cdd:cd15348  163 T-VFLAILAAIVVLYARIYRIVKANSQRLGALPTRK-------------------------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 280 dSILERKRISAArerkATKTLGIILGAFIICWLPFFVVSLVLPICR-DSCwihPALF--DFFTWLGYLNSLINPVIYTVF 356
Cdd:cd15348  198 -GRARRSQKYLA----LLKTVTIVLGTFVACWLPLFLLLLLDVSCPaQAC---PVLLkaDYFLGLAMINSLLNPIIYTLT 269

                 ....*..
gi 550822198 357 NEDFRQA 363
Cdd:cd15348  270 SRDMRRA 276
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-363 2.51e-10

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 60.93  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLS---NAFVLTTILLTK-KLHTPANYLIGSLATTDLLVsILVMPISIAYTTTR-TWNFGQILCDIw 111
Cdd:cd15190    9 SYALIPVIYMLVFVLGlsgNGLVLWTVFRSKrKRRRSADTFIANLALADLTF-VVTLPLWAVYTALGyHWPFGSFLCKL- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 vSSDITCCT--ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV-- 187
Cdd:cd15190   87 -SSYLVFVNmyASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICdm 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 -------NTSQISYT----IYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttAQLITgsagsslcslnps 256
Cdd:cd15190  166 dysgvvsNESEWAWIaglgLSSTVLGFLLPFLIMLTCYFFI---------------------GRTVA------------- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 257 lheSHTHTVGSPlffnqvkikladsilERKrisaaRERKATKTLGIILGAFIICWLPFFVVSLV-----LPICRDSCWIH 331
Cdd:cd15190  212 ---RHFSKLRRK---------------EDK-----KKRRLLKIIITLVVTFALCWLPFHLVKTLyalmyLGILPFSCGFD 268
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 550822198 332 P---ALFDFFTWLGYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15190  269 LflmNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
39-364 2.71e-10

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 60.65  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWiisicisipplfwrqataheemsdCLVNTSQISYTIYS 198
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATW------------------------CLSFTIMLPYPIYS 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TcgafyipsiLLIILYGRIYVAARSRILNPPSLYGKRFTTAQLItgsagssLCSLNPSLHESHTHTVGSPLFFNQVKIKL 278
Cdd:cd15978  140 N---------LVPFTRINNSTGNMCRLLWPNDVTQQSWYIFLLL-------ILFLIPGIVMMTAYGLISLELYRGIKFLM 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 AdsilerkrisaarERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPVIYTVF 356
Cdd:cd15978  204 A-------------KKRVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSAdrLLSGAPISFIHLLSYTSACVNPIIYCFM 270

                 ....*...
gi 550822198 357 NEDFRQAF 364
Cdd:cd15978  271 NKRFRMGF 278
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
36-363 2.84e-10

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 60.07  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEyskRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLV----NTS 190
Cdd:cd15213   81 WFFVLEGVAILLIISVDRYLIIVQRQD---KLNPHRAKILIAVSWVLSFCVSFPPLVgWGKYEFPPRAPQCVLgyteSPA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPsiLLIILYgriyvaarsrilnppslygkrfttaqlitgsagSSLCSLNpslheshthTVGSplf 270
Cdd:cd15213  158 DRIYVVLLLVAVFFIP--FLIMLY---------------------------------SYFCILN---------TVRS--- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerkrisaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDS---CWIHPALFdfftWLGYLNSL 347
Cdd:cd15213  191 ---------------------FKTRAFTTILILFIGFSVCWLPYTVYSLLSVFSRYSssfYVISTCLL----WLSYLKSA 245
                        330
                 ....*....|....*.
gi 550822198 348 INPVIYTVFNEDFRQA 363
Cdd:cd15213  246 FNPVIYCWRIKKFREA 261
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
40-364 3.64e-10

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 60.08  E-value: 3.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTR-TWNFGQILCDIWVSSDITC 118
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPLWATYTANQyDWPFGAFLCKVSSYVISVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD--CLVNTS----QI 192
Cdd:cd14985   84 MFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKtaCIMLYPheawHF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIyvaaRSRILNPPSLYGKRfttaqlitgsagsslcslnpslheshthtvgsplffn 272
Cdd:cd14985  164 GLSLELNILGFVLPLLIILTCYFHI----ARSLRKRYERTGKN------------------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsilERKRisaareRKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTW-------LGYLN 345
Cdd:cd14985  203 -----------GRKR------RKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAIRPCFWELFLDLglpiatcLAFTN 265
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd14985  266 SCLNPFIYVFVDRRFRQKV 284
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
36-364 3.77e-10

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 60.20  E-value: 3.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLatvLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISI------AYTTTRTWNFGQILCD 109
Cdd:cd15342    4 VALGLTVSVIVL---LTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFhtgpwtAKLSLYQWFLRQGLLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 110 iwvssdiTCCTASILHLCVIALDRYWAITdALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDC--L 186
Cdd:cd15342   81 -------TSLTASVANLLAIAVERHQTIF-TMQLHSKMSNQRVVILIFGIWMVALILGLIPAMgWNCLCDLKRCSTMapL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 187 VNTSQISYTIYSTCGAFyipsILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagSSLCSLNPSLHESHTHTVG 266
Cdd:cd15342  153 YSRSYLVFWALSNLLTF----LIMVAVYTRIFIYVRRK-----------------------SQRMSEHHSSHPRYRETVL 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 SPLffnqvkikladsilerkrisaarerkatKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpALFDFFTWLGYLNS 346
Cdd:cd15342  206 GLM----------------------------KTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVL-AYEKYFLLLAEINS 256
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15342  257 LVNPIVYSYRDKEMRKTF 274
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-364 3.95e-10

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 60.17  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWR---------QATAHEEMSDclvNTS 190
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHrlrnytpgnRTVCSEAWPS---RAH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRfttaqlitgsagsslcslnpslheshthtvgsplf 270
Cdd:cd14971  162 RRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR----------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDScwIHPALFDFFTW---LGYLNSL 347
Cdd:cd14971  207 --------------------RAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFP--LTYATYALRIWahcLAYSNSA 264
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd14971  265 VNPVLYAFLSEHFRKAF 281
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
38-364 4.87e-10

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 59.84  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15981    3 FILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDAleYSKRRTAGHAAAMIAAVWIISICISIPPLFwrQATAHEEMSDCLVNTSQISYTIY 197
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHP--FRQKLTLRKAIVTIVIIWVLALIIMCPSAV--TLTVTREEHHFMVDDYNNSYPLY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPS---ILLIILYGRIYVAARSRILnppSLYG----KRFTTAQLITGSAGSSlcslnpslheshthtvgsplf 270
Cdd:cd15981  159 SCWEAWPDTEmrkIYTTVLFSHIYLAPLTLIV---IMYAriafKLFKSSAPIRGSQGEE--------------------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsiLERKRISaARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCW----IHPALFDFFTWLGYLNS 346
Cdd:cd15981  215 ------------EEGRRVS-KRKIKVINMLIIVALFFTLSWLPLWTLMLLTDYGHLSEDqlnlVTVYVFPFAHWLAFFNS 281
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15981  282 SVNPIIYGYFNENFRRGF 299
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 5.31e-10

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 59.56  E-value: 5.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQisytiyST 199
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPG------GP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAFYIPSILLIILYgriyvaarsrilnppslygkrfttaqlitgsagsslcsLNPSLHESHTHT-VGSPLFFNQVKIKL 278
Cdd:cd16003  157 DQHFTYHIIVIVLVY--------------------------------------CLPLLVMGITYTiVGITLWGGEIPGDT 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 ADSILERKRIsaarERKATKTLGIILGAFIICWLPFFVVSLVLPICRD-SCW-----IHPALFdfftWLGYLNSLINPVI 352
Cdd:cd16003  199 SDKYHEQLRA----KRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQlNRWkyiqqVYLASF----WLAMSSTMYNPII 270
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd16003  271 YCCLNKRFRAGF 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
40-364 5.90e-10

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 59.55  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15123    5 VTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICIsipplfwrqATAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd15123   85 GVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLF---------AIPEAVFSDLYSFRDPEKNTTFEA 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAFYIPSILL-----IILYGRIYVAARSRIlnppSLYgkRFTTAQLITGSAGSSlcslnPSLHESHTHTvgsplffnqv 274
Cdd:cd15123  156 CAPYPVSEKILqeihsLLCFLVFYIIPLSII----SVY--YFLIARTLYKSTFNM-----PAEEHSHARK---------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladSILERKRISaarerkatKTLGIILGAFIICWLP----FFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15123  215 ------QIESRKRVA--------KTVLVLVALFAFCWLPnhilYLYRSFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNP 280
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15123  281 FALYWLSKSFRQHF 294
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
39-364 6.19e-10

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 59.86  E-value: 6.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVlSNAFVLTTILLTKK---LHTPANYLIGSLATTDLLVSILVMPISIaYT---TTRTWNFGQILCDIWV 112
Cdd:cd15355    5 AIYLALFVVGTV-GNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPVEL-YNfiwVHHPWAFGDAACRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-----WRQATAHEE-MSDCL 186
Cdd:cd15355   83 FLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFtmgeqNRSGTHPGGlICTPI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 187 VNTSQISYTI-YSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsAGSSLCSLNPSLHESHTHTV 265
Cdd:cd15355  163 VDTSTLKVVIqVNAFLSFLFPMLVISVLNTLI----------------------------ANQLTVMVNQAEQENQVCTI 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 GSPLFFNQVKIkladsilERKRISAAreRKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIhPALFDFFTW----- 340
Cdd:cd15355  215 GGQRTVLSVSM-------EPGRVQSL--RHGVLVLRAVVIAFVVCWLPYHVRRLMFCYVSDEQWT-TFLYDFYHYfymlt 284
                        330       340
                 ....*....|....*....|....*.
gi 550822198 341 --LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15355  285 nvLFYVSSAINPILYNLVSANFRQIF 310
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-357 6.73e-10

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 59.36  E-value: 6.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd15197   85 YASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNGEVQCWILWPEPWYWKVYMT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGA---FYIPSILLIILYGRIYVAARSRilnppslyGKRFTTaqlitgsagsslcslnpslheshthtvgspLFFNQVKI 276
Cdd:cd15197  165 IVAflvFFIPATIISICYIIIVRTIWKK--------SKIQVT------------------------------INKAGLHD 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 KLADSILERKRISAARERKATKTLGIILgAFIICWLPFFVVSL-----VLPICRDSCWIHPalfdFFTWLGYLNSLINPV 351
Cdd:cd15197  207 GSSRRSSSRGIIPRAKIKTIKMTFVIVT-VFIICWSPYFVFDLldvfgLLPRSKTKIAAAT----FIQSLAPLNSAINPL 281

                 ....*.
gi 550822198 352 IYTVFN 357
Cdd:cd15197  282 IYCLFS 287
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-364 6.87e-10

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 59.41  E-value: 6.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15209    1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVN-TSQISY 194
Cdd:cd15209   81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAqTVSTVY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYV---AARSRIlNPPSlygkrfttaqlitgsagsslcslnpslheshthtvgsplff 271
Cdd:cd15209  161 TITVVVIHFLLPLLIVSFCYLRIWVlvlQVRQRV-KPDQ----------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nQVKIKLADSilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCW--IHPALFDFFTWLGYLNSLIN 349
Cdd:cd15209  199 -RPKLKPADV-------------RNFLTMFVVFVLFAVCWAPLNFIGLAVAINPKEMApkIPEWLFVASYFMAYFNSCLN 264
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15209  265 AIIYGLLNQNFRKEY 279
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 7.12e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 59.47  E-value: 7.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIaYTTTRTWNF--GQILCDIWVSSDIT 117
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YELWQNYPFllGSGGCYFKTFLFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISicisipplfwrqataheeMSDCLVNTsqisytiy 197
Cdd:cd15133   84 VCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVS------------------MLCALPNT-------- 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPsilliilyGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLnpsLHESHTHTVGSPLFFNQVKIK 277
Cdd:cd15133  138 SLHGIKFLG--------SGVPASAQCTVRKPQAIYNMIPQHTGHLFFVLPMAVISV---LYLLMALRLARERGLDATGAG 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 LADSILE-RKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFF----TWLGYLNSLINPVI 352
Cdd:cd15133  207 SKIGTRTgQLLQHPRTRAQVTKMLFILVVVFAICWAPFHIDRLMWSFISDWTDNLHEVFQYVhiisGVFFYLSSAVNPIL 286
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15133  287 YNLMSTRFREMF 298
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-356 7.46e-10

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 59.37  E-value: 7.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15384    4 IVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQIS----- 193
Cdd:cd15384   84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVTYGFYTaewqe 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 --YTIYSTCGAFYIPSILLIILYGRIYVAARSRilnppslyGKRFTTAQLITGSAGsslcslnpslheshthtvgsplff 271
Cdd:cd15384  164 qlYNMLSLVFMFPIPLVIMVTCYVLIFITLSKS--------SRDFQGLEIYTRNRG------------------------ 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsiLERKRISAARERKATKTLGIILGAFIICWLPFFVVsLVLPICRDSCWIHPALFDFFTWLGYLNSLINPV 351
Cdd:cd15384  212 -----------PNRQRLFHKAKVKSLRMSAVIVTAFILCWTPYYVI-MIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPL 279

                 ....*
gi 550822198 352 IYTVF 356
Cdd:cd15384  280 IYGAF 284
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
41-364 7.53e-10

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 59.06  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLH---TPANYLIGSLATTDLLVsILVMPISI-AYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLF-LLGMPFLIhQLLGNGVWHFGETMCTLITALDT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMS-DCLV-----NTS 190
Cdd:cd15338   85 NSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSvGCALllpnpETD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPslygkrfttaqlitgsagsslcslnpslheshthtvgsplf 270
Cdd:cd15338  165 TYWFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLP----------------------------------------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvkikladsilerKRISAARERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPAlFDFFTWLGYLNSLIN 349
Cdd:cd15338  204 ---------------QRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAhLSIDRPSLAFLYA-YNVAISMGYANSCIN 267
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15338  268 PFLYIMLSETFKRQF 282
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
36-364 1.04e-09

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 58.60  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSiLVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFT-LVLPINIAEHLLQQWPFGELLCKLILSID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSK--RRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE-MSDCLVNTSQ- 191
Cdd:cd15087   80 HYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELgRKSCVLSFPSp 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 -----ISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSlygkrfttaqlitgsagsslcslnpslheshthtvg 266
Cdd:cd15087  160 eslwfKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNA------------------------------------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsilerKRISAAReRKATKTLGIILGAFIICWLPFF---VVSLVLPICRDSCWIhpALFDFFTWLGY 343
Cdd:cd15087  204 -------------------KALDKAK-KKVTLMVLVVLAVCLFCWTPFHlstVVALTTDLPQTPLVI--GISYFITSLSY 261
                        330       340
                 ....*....|....*....|.
gi 550822198 344 LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15087  262 ANSCLNPFLYAFLDDSFRKSF 282
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 1.22e-09

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 58.70  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVN-------TSQI 192
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFK--PRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAwpgdsggKHQL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsaGSSLCSLNPSLHESHTHtvgsplFFN 272
Cdd:cd16004  163 TYHLAVIVLIYLLPLAVMFVTYSII-----------------------------GITLWRSAVPGHQAHGA------YHR 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 QVKIKladsilerkrisaareRKATKTLGIILGAFIICWLPFFVVSLVLPICRD---SCWIHPALFDFFtWLGYLNSLIN 349
Cdd:cd16004  208 QLQAK----------------KKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDiycQKYIQQVYLAIF-WLAMSSTMYN 270
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd16004  271 PIIYCCLNQRFRSGF 285
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
39-363 1.30e-09

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 58.55  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIgSLATTDLLvSILVMPISIAYTTTR-TWNFGQILCDIWVSSDIT 117
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLL-NLSLSDLL-YILTLPLWIDYTANHhNWTFGPLSCKVVGFFFYT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPlFWRQATAHEEMSDCL------VNTSQ 191
Cdd:cd15160   83 NIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVF-LGHDELFRDEPNHTLcyekypMEGWQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslNPSLheshthtvgsplff 271
Cdd:cd15160  162 ASYNYARFLVGFLIPLSLILFFYRRVLRAVRQ------------------------------SPSL-------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLV----LPICRDSCWIHPALFD---FFTWLGYL 344
Cdd:cd15160  198 -----------------EREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVrsviELVQNGLCGFEKRVFTayqISLCLTSL 260
                        330
                 ....*....|....*....
gi 550822198 345 NSLINPVIYTVFNEDFRQA 363
Cdd:cd15160  261 NCVADPILYIFVTEDVRQD 279
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
39-364 1.55e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 58.62  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP-ISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15005    4 LTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCKVIAFLAVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDClvNTSQISYTI 196
Cdd:cd15005   84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFdVGTYTFIREEDQC--TFEHRSYKA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 197 YSTCGAFYIPSILLI---ILYGRIYVAARSR-----ILNPPSLYGKRFTTAQLITGSAGSSLCSLnpslheshthTVGSP 268
Cdd:cd15005  162 NDTLGFMLVLAVVIAathLVYLKLLIFLRHHrkmkpAQLVPAISQNWTFHGPGATGQAAANWTAG----------FGRGP 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 LFFNQVKIKLADSILERK---RISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDsCWIHPALFDFFTWLGYLN 345
Cdd:cd15005  232 TPPTLLGIRQAFHSGARRllvLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRG-YAVPQGFLTAAVWMTFAQ 310
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15005  311 AGVNPIVCFFFNRELRKCL 329
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
36-217 1.64e-09

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 58.23  E-value: 1.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLvSILVMPISIAYTTTRT-WNFGQILCDIWVSS 114
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLL-LVIWLPFKIAYHIHGNnWIFGEALCRLVTVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQA---------TAHEEMSDC 185
Cdd:cd15162   80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTiflpalditTCHDVLPEQ 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 550822198 186 LVNTSQISYTIYSTCGAFYIPSILLIILYGRI 217
Cdd:cd15162  160 LLVGDWFYYFLSLAIVGFLIPFILTASCYVAT 191
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
53-364 1.90e-09

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 57.73  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  53 NAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-LVMPISIAY----TTTRTWNFGQILCDIwvssditccTASILHLC 127
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIgLILNFIFAYllqsEAAKLVTVGLIVASF---------SASVCSLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 128 VIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WrqataheemsDCLVNTSQISYTIYSTCGAFYIP 206
Cdd:cd15961   89 AITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMgW----------NCLADESTCSVVRPLTKNNAAIL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 207 SILLIILYG---RIYVAARSRILNppslygkrfttaqlitgsagsslcslnpslhesHTHTVGSPLFFnqvkikLADSil 283
Cdd:cd15961  159 SVSFLLMFAlmlQLYIQICKIVMR---------------------------------HAHQIALQHHF------LATS-- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 284 erkriSAARERKATKTLGIILGAFIICWLPFFVVSLVlpicrdSCWIHPALFDFFTWL-GYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15961  198 -----HYVTTRKGVSTLAIILGTFAACWMPFTLYSLI------ADYTYPSIYTYATLLpATYNSIINPVIYAFRNQEIQK 266

                 ..
gi 550822198 363 AF 364
Cdd:cd15961  267 AL 268
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
40-362 2.35e-09

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 57.59  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI-LVMPISIAYTTTrtwnfGQILCDIWVSSDITC 118
Cdd:cd15963    5 VVLCISGTVISCENAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLgLILHFAFVYCIQ-----SAPVNLVTVGLLAPS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW-IISICISIPPLFWrqataheemsDCLVNTSQISYTIY 197
Cdd:cd15963   80 FTASVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWgASLCLGLLPVVGW----------NCLKDPSTCSVVKP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYG---RIYVAARSRILNppslygkrftTAQLITGSAGsslcslnpSLHESHTHTVgsplffnqv 274
Cdd:cd15963  150 LTKNHLVILSISFFMVFAlmlQLYAQICRIVCR----------HAHQIALQRH--------FLPTSHYVTT--------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaareRKATKTLGIILGAFIICWLPFFVVSLVlpicrdSCWIHPALFDFFTWL-GYLNSLINPVIY 353
Cdd:cd15963  203 -------------------RKGIATLAVILGTFASCWLPFAVYCLL------GDYTYPALYTYATLLpATYNSMINPIIY 257

                 ....*....
gi 550822198 354 TVFNEDFRQ 362
Cdd:cd15963  258 AFRNQEIQK 266
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
39-364 2.85e-09

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 57.52  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSV---ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVM-------PISiAYTTTRTWNFGQILC 108
Cdd:cd15101    1 VLVMGLgitVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFflmfntgPNT-RRLTVSTWFLRQGLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 109 DiwvssdiTCCTASILHLCVIALDRYWAITdALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEMSDC-- 185
Cdd:cd15101   80 D-------TSLTASVANLLAIAVERHISVM-RMQLHSRLSNRRVVVLIVLVWTMAIVMgAIPSVGWNCLCAIDACSNMap 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 186 LVNTSQISYTIYSTCGAFyipsILLIILYGRIYVAARSRILNppslygkrfttaqlitgsagsslcslnpslheSHTHTV 265
Cdd:cd15101  152 LYSRSYLVFWAISNLVTF----LVMVVVYARIFVYVRRRTNR--------------------------------MSPHTS 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 GSPlffnqvkikladsileRKRISAArerKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpALFDFFTWLGYLN 345
Cdd:cd15101  196 GSI----------------RNRDTMM---SLLKTVVIVLGAFVVCWTPGLVVLLLDGLCCRQCNVL-AVEKFFLLLAEFN 255
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15101  256 SAVNPIIYSYRDKEMSGTF 274
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 2.93e-09

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 57.57  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEysKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd16002   85 FASIYSMTAIALDRYMAIIHPLQ--PRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKYET 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 cgaFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKla 279
Cdd:cd16002  163 ---VYHVCVTVLIYFLPLLV--------------------------IGCAYTVVGITLWASEIPGDSSDRYHEQVSAK-- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 280 dsilerkrisaareRKATKTLGIILGAFIICWLPFFVVSLVLpicrdscWIHPALFD---------FFTWLGYLNSLINP 350
Cdd:cd16002  212 --------------RKVVKMMIVVVCTFAICWLPYHIYFLLQ-------YFHPELYEqkfiqqvylAIMWLAMSSTMYNP 270
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd16002  271 IIYCCLNDRFRVGF 284
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
40-364 4.30e-09

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 56.71  E-value: 4.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVS-------ILVMPISIAYTTTRTwNFGQILCDIWV 112
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSlyktlenILIILADMGYLNRRG-PFETKLDDIMD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheemsdclvntSQI 192
Cdd:cd15350   84 SLFCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMILFFHFVA-----------TVI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYstcgaFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslheSHTHTVGSplffn 272
Cdd:cd15350  153 CFTVL-----FFLMLVLILCLYVHMFLLAR-------------------------------------SHARKIAS----- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkIKLADSILERKRISAArerkatKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15350  186 ---LPNHHAQHQRSNMRGA------ITLTILLGVFVCCWAPFVLHLLLMMFCPMNpyCACYRSLFQVNGTLIMSHAVIDP 256
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15350  257 AIYAFRSPELRNTF 270
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-364 4.62e-09

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 56.84  E-value: 4.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLAT--VLSNAFVLTTILLTKKLHT-PANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCdIWVSS 114
Cdd:cd15340    1 LAIAVLSLTLGTftVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFL-FKLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDC--LVNTSQ 191
Cdd:cd15340   80 VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLgWNCKKLNSVCSDIfpLIDETY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCgafyipSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsslcslnpsLHESHTHTVGSPLFF 271
Cdd:cd15340  160 LMFWIGVTS------VLLLFIVYAYMYI-------------------------------------LWKAHHHAVRMLQRG 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 NQVKIKLADSilERKRISAARERKA------TKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpALFDFFTWLGYLN 345
Cdd:cd15340  197 TQKSIIVYTS--EDGKVQTTRPDQTrmdirlAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIK-TVFAFCSMLCLLN 273
                        330
                 ....*....|....*....
gi 550822198 346 SLINPVIYTVFNEDFRQAF 364
Cdd:cd15340  274 STVNPIIYALRSKDLRHAF 292
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-364 6.71e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 56.30  E-value: 6.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTR-TWNFGQILCDIWVSSDITC 118
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLF-LATLPLWATYYSYGyNWLFGSVMCKICGSLLTLN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISICISIPPLFWRqataheemsdclvNTSQISYTIYS 198
Cdd:cd15191   84 LFASIFFITCMSVDRYLAVVYPLR-SQRRRSWQARLVCLLVWVLACLSSLPTFYFR-------------DTYYIEELGVN 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYipsilliilygriyvaarsrilnPPSLYGKRFTTAQLITGSAG--SSLCSLNPSLHESHTHTVGSPLFfnqvki 276
Cdd:cd15191  150 ACIMAF-----------------------PNEKYAQWSAGLALMKNTLGflIPLIVIATCYFGIGRHLLKTKGF------ 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 kladsilerkRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICR----DSCWIHPA---LFDFFTWLGYLNSLIN 349
Cdd:cd15191  201 ----------GKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARmgviNNCWVITVidkALPFAICLGFSNSCIN 270
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15191  271 PFLYCFVGNHFREKL 285
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
47-363 6.85e-09

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 56.43  E-value: 6.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  47 LATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWVSSDITCCTASILH 125
Cdd:cd15131   12 VVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLYRLwQYRPWNFGDLLCKLFQFVSESCTYSTILN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 126 LCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWiISICISIPPLFWRQATAHE------EMSDC-----LVNTSQISY 194
Cdd:cd15131   91 ITALSVERYFAICFPLRAKVVVTKRRVKLVILVLW-AVSFLSAGPIFVLVGVEHEngtnpiDTNECkateyAVRSGLLTI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYgriyvaarsrilnppSLYGKRFTTAQLITGSAGSSLCSLNpslheshthtvgsplffnqv 274
Cdd:cd15131  170 MVWVSSVFFFLPVFCLTVLY---------------SLIGRKLWRRRRENIGPNASHRDKN-------------------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaarERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFF-----TWLGYLNSLIN 349
Cdd:cd15131  215 ------------------NRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGSLEIALISQYcnlvsFVLFYLSAAIN 276
                        330
                 ....*....|....
gi 550822198 350 PVIYTVFNEDFRQA 363
Cdd:cd15131  277 PILYNIMSKKYRVA 290
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
36-137 7.48e-09

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 56.36  E-value: 7.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIwvSSD 115
Cdd:cd15395    1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKL--NSM 78
                         90       100
                 ....*....|....*....|....
gi 550822198 116 ITCC--TASILHLCVIALDRYWAI 137
Cdd:cd15395   79 VQCIsiTVSIFSLVLIAIERHQLI 102
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
36-364 8.29e-09

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 56.09  E-value: 8.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTIL-LTKKLHTPANYLIGSLATTDLLVSILVMPISIA--YTTTRTWNFGQ-----IL 107
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHIsSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIAdqYYRGRYAQYSEewlrsPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 108 CDIWVSSDITCCTASILHLCVIALDRYWAITDALEYsKRRTAGHAAAMIAAVWIISICISIPPLFW-----RQATAHEEM 182
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSN-KRLSYKSAKIILILGWLFSIIFAAIPILYsinqpGDNRLYGYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 183 SDCL-VNTSQISYTIYST--CGAFYIPSILLIILYGRIYvaarsrilnppslygkrfttaqlitgsagsslcslnpslhe 259
Cdd:cd14980  160 SICMpSNVSNPYYRGWLIayLLLTFIAWIIICILYILIF----------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 260 shthtvgsplffnqvkIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPIcrDSCWIHPALFDFFT 339
Cdd:cd14980  199 ----------------ISVRKSRKSARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSGLL--TSTEIDIHVLQFIA 260
                        330       340
                 ....*....|....*....|....*.
gi 550822198 340 WLGY-LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd14980  261 ILALpLNSAINPYLYTLTTPTFKRDF 286
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
36-364 9.26e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 55.94  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15070    1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHFYSCLFMSCLLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITccTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WrqataHEEMSDCLVNTSQISY 194
Cdd:cd15070   81 FT--HASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFgW-----NRKPSLESVNTTPLQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFY-----------IPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagsslcslnpsLHESHTH 263
Cdd:cd15070  154 QFTSVMRMDYmvyfsfftwilIPLVIMCALYVDIFYIIRNK--------------------------------LSQNATG 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 264 TVGSPLFFnqvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICrdsCWIHPALFDFFTWLGY 343
Cdd:cd15070  202 FRETGAFY-------------------GREFKTAKSLALVLFLFAVCWLPLSIINCVVYFN---PKVPKIALYLGILLSH 259
                        330       340
                 ....*....|....*....|.
gi 550822198 344 LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15070  260 ANSMMNPIVYACKIKKFKETY 280
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
41-364 1.31e-08

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 55.33  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSilvmpISIAYTTTRTW---NFGQILCDIWVSS--- 114
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVS-----VSNAWETITIYllnNRHLVIEDAFVRHidn 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 --DITCC---TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATaheemsdclvnt 189
Cdd:cd15354   81 vfDSLICisvVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSEST------------ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 sqisYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15354  149 ----YVIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPG------------------------------------ 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkiklADSILERKRISAArerkatKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSL 347
Cdd:cd15354  189 ---------YNSVRQRTSMKGA------VTLTILLGIFIVCWAPFFLHLILMISCPQNlyCVCFMSHFNMYLILIMCNSV 253
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15354  254 IDPLIYAFRSQEMRKTF 270
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
36-359 1.38e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 55.27  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVM-------PISIAYTTTRtWNFGQILC 108
Cdd:cd15343    1 IIVLCVGTFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVflmfntgPVSKTLTVNR-WFLRQGLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 109 DiwvssdiTCCTASILHLCVIALDRYWAITDALEYS---KRRTaghaAAMIAAVWIISICISIPPLFWRQATAHEEMSDC 185
Cdd:cd15343   80 D-------TSLSASLTNLLVIAVERHISIMRMKVHSnltKRRV----TLLIALVWAIAIFMGAVPTLGWNCICNISACSS 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 186 LVNTSQISYTIYSTCGAFYIPSILLIIlYGRIYVaarsrilnppslYGKRFTTAqlitgsagsslcsLNPslheshtHTV 265
Cdd:cd15343  149 LAPIYSRSYLVFWSVSNLVVFLIMVVV-YLRIYV------------YVQRKTNV-------------LSP-------HTS 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 266 GSplffnqvkikladsiLERKRISAarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHpALFDFFTWLGYLN 345
Cdd:cd15343  196 GS---------------INRRRTPI----KLMKTVMTVLGAFVICWTPGLVVLLLDGLNCTRCGVQ-HVKRWFLLLALLN 255
                        330
                 ....*....|....
gi 550822198 346 SLINPVIYTVFNED 359
Cdd:cd15343  256 SVMNPIIYSYKDEE 269
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
39-142 1.40e-08

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 55.21  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15979    4 ILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVS 83
                         90       100
                 ....*....|....*....|....
gi 550822198 119 CTASILHLCVIALDRYWAITDALE 142
Cdd:cd15979   84 VSVSTFSLVAIAIERYSAICNPLQ 107
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
38-139 1.87e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 55.22  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15396    3 LIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSV 82
                         90       100
                 ....*....|....*....|..
gi 550822198 118 CCTASILHLCVIALDRYWAITD 139
Cdd:cd15396   83 SVSVSIFSLVLIAIERYQLIVN 104
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
40-362 2.15e-08

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 54.84  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAavWIISICISIPPLFWRQATAHEEMSDCLVNT-SQISYTIYS 198
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAAS--WLFDAAFVSPALFFYGSNWGPHCNFFLPDSwDGAAYAIIH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAFYIPSILLIILYGRIyVAARSRIlnppslygkrfttaqlitGSAGSSlcslnpslheshthtvgsplffnqvkIKL 278
Cdd:cd15008  162 LLVGFLVPSILIILFYQKV-IKYIWRI------------------GTDGRT--------------------------VRR 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 ADSILERKRIsaarerKATKTLGIILGAFIICWLPFFVVSLVLP---ICRDSCwihpALFDFFTWLGYLNSLINPVIYTV 355
Cdd:cd15008  197 TMNIVPRTKV------KTIKMFLMLNSMFLLSWLPFYVVQLWHPresDYRQSS----LVFLAVTWISFSSSASKPTLYSV 266

                 ....*..
gi 550822198 356 FNEDFRQ 362
Cdd:cd15008  267 YNANFRR 273
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-364 2.16e-08

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 54.73  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKL--HTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD---CLVN----TS 190
Cdd:cd15098   85 SMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNqtfCWENwpekQQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagsslcslnpsLHESHThtvgsplf 270
Cdd:cd15098  165 KPVYVVCTFVFGYLLPLLLITFCYAKV---------------------------------------LNHLHK-------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 271 fnqvKIKladsilERKRISAARERKATKTLGIILGAFIICWLPFFVVSLvlpicrdscWIHPALFDF----FTW------ 340
Cdd:cd15098  198 ----KLK------NMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHL---------WVEFGDFPLtqasFVLritahc 258
                        330       340
                 ....*....|....*....|....
gi 550822198 341 LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15098  259 LAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
37-364 4.03e-08

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 54.09  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15400    2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC-LVNTSQISYT 195
Cdd:cd15400   82 LSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCtFVQTASSSYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYIPSILLIILYGRIYVaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsplFFNQVK 275
Cdd:cd15400  162 IAVVVIHFIVPITVVSFCYLRIWV--------------------------------------------------LVIQVR 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 IKLADSILERKRISAARErkaTKTLGIILGAFIICWLPFFVVSLVLPICRD--SCWIHPALFDFFTWLGYLNSLINPVIY 353
Cdd:cd15400  192 RKVKSESKPRLKPSDFRN---FLTMFVVFVIFAICWAPLNLIGLAVAINPQemAPKVPEWLFVVSYFMAYFNSCLNAIIY 268
                        330
                 ....*....|.
gi 550822198 354 TVFNEDFRQAF 364
Cdd:cd15400  269 GLLNQNFRKEY 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
42-362 6.77e-08

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 53.23  E-value: 6.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  42 LSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTA 121
Cdd:cd15381    7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 122 SILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEE--MSDCLVNTSQISYTIYST 199
Cdd:cd15381   87 SIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEynITACVLDYPSEGWHVALN 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 C----GAFYIPsiLLIILYgriyvaarsrilnppslygkrfttaqlitgsagsslCSlnpslheshthtvgsplfFNQVK 275
Cdd:cd15381  167 IllnvVGFLIP--LSIITF------------------------------------CS------------------TQIIQ 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 IKLADSILERKRISaaRERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFF-------TWLGYLNSLI 348
Cdd:cd15381  191 VLRNNKMQKFKEIQ--TERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISGCRWEDILdigtqiaTFLAYSNSCL 268
                        330
                 ....*....|....
gi 550822198 349 NPVIYTVFNEDFRQ 362
Cdd:cd15381  269 NPLLYVIVGKHFRK 282
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
39-224 7.16e-08

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 53.26  E-value: 7.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd14975    4 CTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACKGCVYVCAVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTS----QISY 194
Cdd:cd14975   83 MYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHYsdgqLVFH 162
                        170       180       190
                 ....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIYVAARSR 224
Cdd:cd14975  163 LLLETVVGFAVPFTAVVLCYSCLLRRLRRR 192
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
40-364 8.56e-08

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 52.89  E-value: 8.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHT--PANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWiisicisipplfwrqataheemsdCLVNTSQISYTIY 197
Cdd:cd14976   85 NMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIW------------------------AAAALAAIPEAIF 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 STCGAFYIPSILLIILYgriyvaarsrilnPPSLYGKRFTTaqlITGSAGSSLCSLNPSLheshthtvgsPLFFNQVKIK 277
Cdd:cd14976  141 STDTWSSVNHTLCLLRF-------------PKNSSVTRWYN---WLGMYQLQKVVLGFFL----------PLGIITLSYL 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 LADSILERKRISAAR-ERKATKTLGIILGAFIICWLPFFVVSL--------VLPICRDSCWIHPALFDFFTWLGYLNSLI 348
Cdd:cd14976  195 LLLRFLQRKRGGSKRrKSRVTKSVFIVVLSFFICWLPNQALSLwsalikfdDVPFSDAFFAFQTYAFPVAICLAHSNSCL 274
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd14976  275 NPVLYCLVRREFRDAL 290
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
36-364 9.66e-08

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 52.77  E-value: 9.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIL-VMP-ISIAYTTTRTWNFGQILCDIWVS 113
Cdd:cd14995    1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAaGLPnEIESLLGPDSWIYGYAGCLLITY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqATAHEEMSD------CLV 187
Cdd:cd14995   81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFL--LDLSIKHYGddivvrCGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 NTSQISYTIY--STCGAFY-IPSILLIILYGRIyvaarSRIlnppsLYGKRfttaqlitgsagsslcslnpslheshtht 264
Cdd:cd14995  159 KVSRHYYLPIylADFVLFYvIPLLLAIVLYGLI-----GRI-----LFSSR----------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 265 vgsplffnqvkikladsilerkrisaareRKATKTLGIILGAFIICWLPFFVVSLVLPICRDScWIHPALFDFFTWLGYL 344
Cdd:cd14995  200 -----------------------------KQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPP-YLDLWFLLFCRTCIYL 249
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd14995  250 NSAINPILYNLMSQKFRAAF 269
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
41-209 1.19e-07

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 52.55  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLF-VFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSD--CLVNTSQISY---- 194
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSetCFENFSSKTWktyl 164
                        170
                 ....*....|....*...
gi 550822198 195 ---TIYSTCGAFYIPSIL 209
Cdd:cd15156  165 skiVIFIEIVGFFIPLIL 182
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
39-364 1.44e-07

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 52.42  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLAT-VLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd14977    3 IMSLSLVIFAVgIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQaTAHEEMSD------CLVNTSQ 191
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLST-VARESSLDnssltvCIMKPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSI--LLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITgsagsslcslnpslheshthtvgspl 269
Cdd:cd14977  162 PFAETYPKARSWWLFGCyfCLPLAFTAVCYLLMARTLIRAAKEYTRGTKKHMKQ-------------------------- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkrisaarERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALF----DFFT-WLGYL 344
Cdd:cd14977  216 -----------------------RRQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTRSTldilDLIGqFLSFF 272
                        330       340
                 ....*....|....*....|
gi 550822198 345 NSLINPVIYTVFNEDFRQAF 364
Cdd:cd14977  273 NSCVNPIALYLLSEPFRRAF 292
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
36-364 2.14e-07

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 52.11  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVL-TTILLTKK---LHTPANYLIgSLATTDLLVSILVMPISI--AYTTTRTWNFGQILCD 109
Cdd:cd15135    1 ITLTLLYSLILVAGILGNSATIkVTQVLQKKgylQKSVTDHMV-SLACSDLLVLLLGMPVELysAIWDPFATPSGNIACK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 110 IWVSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTaghaAAMIAAVWIISICISIPPLF-------------- 172
Cdd:cd15135   80 IYNFLFEACSYATILNVATLSFERYIAICHPFKYkalSGSRV----RLLICFVWLTSALVALPLLFamgtedpleafpsy 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 173 ----WRQATAHEEMSDCLVNTSQISYTIYSTCGAFyipsILLIILYGRIYVAARSRIlnppslygkrfttaQLITGSAGS 248
Cdd:cd15135  156 rgtrHHCQDQKSNLTICTSLSSKWTVFQASIFSAF----VLYLLVLASVAFMCRRMM--------------RALMGSKKG 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 249 SLCSLNPSLHESHTHTVGSPlffnqvkikladsilerkRISAAReRKATKTLGIILGAFIICWLPFFVVSLVLPICRDSC 328
Cdd:cd15135  218 AVAVKGPGGSVQLLRKHESA------------------EGKTAR-KQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPKDD 278
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 550822198 329 W----------IHPALFDFFtwlgYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15135  279 WtrsyfrayiiLLPIADTFF----YLSSVLNPLLYNLSSQQFRSVF 320
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-362 2.26e-07

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 51.72  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  47 LATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTrtwNFGQILCDIW-------VSSDITCC 119
Cdd:cd15351   12 LVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLL---EHGVLVCRAPmlqhmdnVIDTMICS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 T--ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheeMSDCLVntsqisytiy 197
Cdd:cd15351   89 SvvSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYNSNA---VILCLI---------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 198 stcGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttAQLITgsagsslcslnpSLHESH-THTVGSPLffnqvki 276
Cdd:cd15351  156 ---VFFLFMLVLMLVLYIHMFILACRH--------------SQSIS------------SQQRRQcPHQQTASL------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 277 kladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15351  200 ------------------KGAITLTILLGIFFLCWGPFFLHLTLIVTCPTHpfCLCYFKYFNLFLILIICNSIIDPLIYA 261

                 ....*...
gi 550822198 355 VFNEDFRQ 362
Cdd:cd15351  262 FRSQELRK 269
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
39-137 2.82e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 51.31  E-value: 2.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPIS-IAYTTTRTWNFGQILCdiWVSSDIT 117
Cdd:cd15212    4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAfLTLFSRPGWLFGDRLC--LANGFFN 81
                         90       100
                 ....*....|....*....|..
gi 550822198 118 CC--TASILHLCVIALDRYWAI 137
Cdd:cd15212   82 ACfgIVSTLTMTLISFDRYYAI 103
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
40-160 3.51e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 51.11  E-value: 3.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:cd15927   85 GVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIW 125
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-364 3.54e-07

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 51.28  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTR-TWNFGQILCDIWVSSDITC 118
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCF-LITLPLWAAYTAMEyHWPFGNFLCKIASALVSFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQAtaheemsdclVNTSQISYTIys 198
Cdd:cd15192   84 LYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDV----------FFIENTNITV-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 tCGAFYiPSILLIILYGRIYVAarsrilnppSLYGKRFTTAQLITgsagsSLCSLNPSLHESHThtvgsplffnqvkikl 278
Cdd:cd15192  152 -CAFHY-PSQNSTLLVGLGLMK---------NLLGFLIPFLIILT-----CYTLIGKALKKAYE---------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICR----DSCWIhPALFD----FFTWLGYLNSLINP 350
Cdd:cd15192  200 -------IQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQlkviQDCHI-ADIVDtampFTICIAYFNSCLNP 271
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15192  272 ILYGFVGKNFRKKF 285
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
35-223 4.13e-07

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 50.93  E-value: 4.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  35 RISLVVVLSVITLAtVLSNAFVL-TTILLTKKLHTPANYLIgSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWV 112
Cdd:cd15365    1 YLFPFVYIFVIVIS-IPSNCISLyVSCLQIRKKNELGVYLF-NLSLSDLLY-IVILPLWIDYLwNGDNWTLSGFVCIFSA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQaTAHEEMSDCL------ 186
Cdd:cd15365   78 FLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWED-SFHESSSHTLcydkfp 156
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 550822198 187 VNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARS 223
Cdd:cd15365  157 LEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRS 193
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
36-364 6.17e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 50.39  E-value: 6.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRT-WNFGQILCDIWVSS 114
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLY-LLSLPFLIYYYANGDhWIFGDFMCKLVRFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ--- 191
Cdd:cd15168   80 FYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPeel 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGA---FYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagssLCSLNPSLHEShthtvgsp 268
Cdd:cd15168  160 NDYVIYSMVLTglgFLLPLLIILACYGLI--------------------------------VRALIRKLGEG-------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilerkrISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGY----- 343
Cdd:cd15168  200 -------------------VTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLSGTASCATLNGIYVAYkvtrp 260
                        330       340
                 ....*....|....*....|....
gi 550822198 344 ---LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15168  261 lasLNSCLNPLLYFLAGDKFRRRL 284
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
41-364 6.96e-07

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 50.27  E-value: 6.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI------LVMPISIAYTTTRTWNFGQILCDIWVSS 114
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVsnsletIMIAVLNSGYLVISDQFIQHMDNVFDSM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheeMSDCLVNTsqisy 194
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESKT---VIVCLITM----- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 tiystcgaFYIPSILLIILYGRIYVAARsrilnppsLYGKRFTTAQLITGSAGSSLCSLnpslheshthtvgsplffnqv 274
Cdd:cd15352  158 --------FFAMLVLMATLYVHMFLFAR--------LHVKRIAALPPAVDGAPQQRSCM--------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICRDS--CWIHPALFDFFTWLGYLNSLINPVI 352
Cdd:cd15352  201 --------------------KGAVTITILLGVFIVCWAPFFLHLILIISCPHNpyCLCYTSHFNTYLVLIMCNSVIDPLI 260
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15352  261 YAFRSLEMRKTF 272
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
36-363 7.29e-07

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 50.23  E-value: 7.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15403    1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAItdaLEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDCLVNTSQIS- 193
Cdd:cd15403   81 WFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVgWTLVEVPARAPQCVLGYTESPa 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 ---YTIYSTCGAFYIPsiLLIILYgriyvaarsrilnppslygkrfttaqlitgsagSSLCSLNPSLHES---HTHTvgS 267
Cdd:cd15403  158 drvYAVLLVVAVFFVP--FSIMLY---------------------------------SYLCILNTVRRNAvriHNHA--D 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 PLFFNQVKiKLADSILERK---RISAARERKATKTLGIILGAFIICWLPFFVVSLvLPICRDSCWIHPALFDFFT---WL 341
Cdd:cd15403  201 SLCLSQVS-KLGLMGLQRPhqmNVDMSFKTRAFTTILILFVGFSLCWLPHTVFSL-LSVFSRRFYYSSSFYPISTcvlWL 278
                        330       340
                 ....*....|....*....|..
gi 550822198 342 GYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15403  279 SYLKSVFNPVIYCWRIKKFREA 300
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
38-363 8.11e-07

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 50.14  E-value: 8.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQ-------ATAHEEM---SDCLV 187
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQtveilvtQDGQEEEicvLDREM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 NTSQIsYTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgs 267
Cdd:cd15012  162 FNSKL-YDTINFIVWYLIPLLIMTVLYSKISIV----------------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 plffnqvkIKLADSILERkrisaareRKATKTLGIILGAFIICWLPFFVVSL----VLPICRDSCWihPALFDFFTWL-G 342
Cdd:cd15012  194 --------LWKSSSIEAR--------RKVVRLLVAVVVSFALCNLPYHARKMwqywSEPYRCDSNW--NALLTPLTFLvL 255
                        330       340
                 ....*....|....*....|.
gi 550822198 343 YLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15012  256 YFNSAVNPLLYAFLSKRFRQS 276
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
40-364 1.22e-06

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 49.43  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15345    5 IFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGI-AYKVNILMSGKKTFSLSPTQWFLREGSMFVAL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWrqaTAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd15345   84 GASTFSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGW---NCLDNLPDCSTILPLYSKKYVAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAFYIPSILLI-ILYGRIYVaarsrilnppslygkrfttaqlITGSAGSSLCSLNPSlheshthtvgsplffnqvkikl 278
Cdd:cd15345  161 CISIFIAILVAIvILYARIYI----------------------LVKSSSRRVTNHRNS---------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVLPICR-DSCwihPALF--DFFTWLGYLNSLINPVIYTV 355
Cdd:cd15345  197 ------------ERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEvKQC---PILYkaDWFIALAVLNSAMNPIIYTL 261

                 ....*....
gi 550822198 356 FNEDFRQAF 364
Cdd:cd15345  262 ASKEMRRAF 270
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
40-364 1.24e-06

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 49.51  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSditcC 119
Cdd:cd15960    5 IALCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTLCSAGLLLAA----F 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICI-SIPPLFWRQATAHEEMSDCLVNTSQISYTIYS 198
Cdd:cd15960   81 SASVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIgLLPAMGWNCLRAPASCSVLRPVTKNNAAVLAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TcgaFYIPSILLIILYGRIYVAArsrilnppslygkrFTTAQLITgsagsslcslnpslheSHTHTVGSPLffnqvkikl 278
Cdd:cd15960  161 S---FLLLFALMMQLYLQICRIA--------------FRHAQQIA----------------VQHQFVNFCL--------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 279 adsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVlpicRDSCWihPALFDFFTWL-GYLNSLINPVIYTVFN 357
Cdd:cd15960  199 -----------ASSTRKGVSTLSLILATFAFCWVPFAVYSMV----ADSSY--PMIYTYYLVLpAACNSVINPIIYAFRN 261

                 ....*..
gi 550822198 358 EDFRQAF 364
Cdd:cd15960  262 PDIQKSL 268
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-364 1.25e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 49.43  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15385    4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAIT---DALEYSKRRTAGHAAAMiaavWIISICISIPPLF---WRQATAHEEMSDCLVNTSQI 192
Cdd:cd15385   84 MFASTYMLVMMTADRYIAIChplKTLQQPTKRSYLMIGSA----WALSFILSTPQYFifsLSEIENGSGVYDCWANFIVP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 ----SYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlnppslygkRFTTAQLITGSAGSslcslnpslheshthtvgsp 268
Cdd:cd15385  160 wgikAYITWITISIFVVPVIILLTCYGFICYNIWRNI---------KCKTRRGLSDNALK-------------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvKIKLADSILERKRISAARERKATKTLGIILgAFIICWLPFFVVSLVLPICRDSCWIHP--ALFDFFTWLGYLNS 346
Cdd:cd15385  211 ------NILLAVCVSSVKTISRAKIRTVKMTFVIVL-AYIVCWAPFFTIQMWSVWDQNFPWDESenTAVTITALLASLNS 283
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15385  284 CCNPWIYMFFSGHLLQDF 301
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
36-364 1.29e-06

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 49.22  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLttILLTKKLHTPAN---YLigSLATTDLLvSILVMPISIAYTTT-RTWNFGQILCDIW 111
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVI--WVAGFKMKRTVNtvwFL--NLALADFL-FCLFLPFLIVYIAMgHHWPFGSVLCKLN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 112 VSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC------ 185
Cdd:cd14974   76 SFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCnltcve 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 186 ---LVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARsrilnppslygkrfttaqlitgsagsslcslnpslhesht 262
Cdd:cd14974  156 dydLRRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLR---------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 263 htvgsplffnqvkikladsileRKRIsaARERKATKTLGIILGAFIICWLPFFVVSLVLpicrdscwIHPALFD------ 336
Cdd:cd14974  196 ----------------------RKRL--AKSSKPLRVLLAVVVAFFLCWLPYHVFALLE--------LVAAAGLpevvll 243
                        330       340       350
                 ....*....|....*....|....*....|.
gi 550822198 337 ---FFTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd14974  244 glpLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
39-160 1.34e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.55  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANY--LIGSLATTDLLVSILVMPISIA-YTTTRTWNFGQILCDI--WVS 113
Cdd:cd14981    4 PAPPALMFVFGVLGNLLALIVLARSSKSHKWSVFyrLVAGLAITDLLGILLTSPVVLAvYASNFEWDGGQPLCDYfgFMM 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 550822198 114 SDITCCTASILhlCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:cd14981   84 SFFGLSSLLIV--CAMAVERFLAITHPFFYNSHVKKRRARLMLGAVW 128
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
38-217 1.44e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 49.14  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRtWNFGQILCDIWVSSDIT 117
Cdd:cd14984    3 LPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLF-VLTLPFWAVYAADG-WVFGSFLCKLVSALYTI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIY 197
Cdd:cd14984   81 NFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATTW 160
                        170       180
                 ....*....|....*....|....*..
gi 550822198 198 ST-------CGAFYIPSILLIILYGRI 217
Cdd:cd14984  161 KTllrllqnILGFLLPLLVMLFCYSRI 187
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
40-364 1.44e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 49.35  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCdIWVSSDITCC 119
Cdd:cd15086    5 VFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGC-RWYGFANSLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 -TASILHLCVIALDRYWAIT-----DALEYSKRRTAGHAAAMIAAVWiisicISIPPLFWRQATAHEEMSDCLVN----- 188
Cdd:cd15086   84 gIVSLISLAVLSYERYCTLLrpteaDVSDYRKAWLGVGGSWLYSLLW-----TLPPLLGWSSYGPEGPGTTCSVQwtsrs 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 TSQISYTIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgsp 268
Cdd:cd15086  159 ANSISYIICLFIFCLLLPFLVMVYCYGRLLYA------------------------------------------------ 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkIKLADSIleRKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCwIHPALFDFFTWLGYLNSLI 348
Cdd:cd15086  191 -------IKQVGKI--NKSTARKREQHVLLMVVTMVICYLLCWLPYGVMALLATFGKPGL-VTPVASIVPSILAKSSTVV 260
                        330
                 ....*....|....*.
gi 550822198 349 NPVIYTVFNEDFRQAF 364
Cdd:cd15086  261 NPIIYVFMNKQFYRCF 276
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
36-145 1.53e-06

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 49.19  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80
                         90       100       110
                 ....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSK 145
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAV 110
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
36-361 2.31e-06

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 48.59  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLlVSILVMPI-SIAYTTTRTWNFGQILCDIwvSS 114
Cdd:cd15193    1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFwAASTALGGQWLFGEGLCKL--SS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCT--ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQI 192
Cdd:cd15193   78 FIIAVNrcSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCVEDSSSRFFQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslHESHTHTVGsplffn 272
Cdd:cd15193  158 GISLATLFLTFVLPLIVILFCYCSILVRLRR----------------------------------HFHGAKRTG------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsilerkrisaARERKATKTLGIILGAFIICWLPFFVVSLVL---------PICRDSCWIHPALfDFFTWLGY 343
Cdd:cd15193  198 ------------------RRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRlllelgggvLPCHTTVAIRQGL-TITACLAF 258
                        330
                 ....*....|....*...
gi 550822198 344 LNSLINPVIYTVFNEDFR 361
Cdd:cd15193  259 VNSCVNPLIYSLLDRHFR 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
40-364 2.36e-06

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 48.76  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLF-VFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKTYLS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAFYIPSILLIIlygriyvaarsrilnppslygkrfttaQLITGSAGSSLCslnpslheshTHTVGSPLFFNQVkikla 279
Cdd:cd15155  164 KITIFIEVVGFII---------------------------PLLLNLTCSSLV----------LRTLRKPATLSQI----- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 280 dsilerkrisAARERKATKTLGIILGAFIICWLPF----FVVSLVLPICRDSCWIH---PALFDFFTWLGYLNSLINPVI 352
Cdd:cd15155  202 ----------GTNKEKVLKMILVHVAIFVVCFVPYnsilFLYALVRSQAIANCGVErfaRTMYPITLCLATLNCCFDPFV 271
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15155  272 YYFTSESFQKSF 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
34-218 2.45e-06

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 49.01  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  34 LRISLVVVLSVITLATVLSNAFVLTtILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVS 113
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV--NTSQ 191
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMfyNNKT 196
                        170       180       190
                 ....*....|....*....|....*....|.
gi 550822198 192 ISYTIYSTCG----AFYIPSILLIILYGRIY 218
Cdd:PHA03087 197 MNWKLFINFEiniiGMLIPLTILLYCYSKIL 227
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-138 3.01e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 48.36  E-value: 3.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15977    5 ILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASV 84
                         90
                 ....*....|....*....
gi 550822198 120 TASILHLCVIALDRYWAIT 138
Cdd:cd15977   85 GITVLSLCALSIDRYRAVA 103
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
38-361 3.04e-06

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 48.21  E-value: 3.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAY-TTTRTWNFGQILCDIWVSSDI 116
Cdd:cd14991    3 LPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL-LICLPFRIDYyLRGEHWIFGEAWCRVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLvntSQISYTI 196
Cdd:cd14991   82 VNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCH---SFSSYTK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 197 YST---------CGAFYIPSILLIILYGRIYVAARSRilnppslygkrfttaqlitgsagsslcslnpslheshthtvgs 267
Cdd:cd14991  159 PSLsirwhnalfLLEFFLPLGLIVFCSVRIACNLRIR------------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 268 plffnqvkikladSILERKRisaaRERKATKTLGIILGAFIICWLP------FFVVSLVLPICRDSCWIHpALFDFFTWL 341
Cdd:cd14991  196 -------------QSLGKQA----RVQRAIRLVFLVVIVFVLCFLPsiiaglLALVFKNLGSCRCLNSVA-QLFHISLAF 257
                        330       340
                 ....*....|....*....|
gi 550822198 342 GYLNSLINPVIYTVFNEDFR 361
Cdd:cd14991  258 TYLNSALDPVIYCFSSPWFR 277
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
26-368 3.50e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 48.32  E-value: 3.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  26 WDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQ 105
Cdd:cd15084    1 WPHLAPRSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 106 ILCDIWVSSDITCCTASILHLCVIALDRYWAITDAL---EYSKRRTaghaAAMIAAVWIISICISIPPLF-WRQATAHEE 181
Cdd:cd15084   81 TMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMgdfRFQQRHA----VSGCAFTWGWSLLWTSPPLFgWSSYVPEGL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 182 MSDCLVN-----TSQISY--TIYSTCgaFYIPSILLIILYGRIYVAARSrilnppslygkrfTTAQlitgsagsslcsln 254
Cdd:cd15084  157 RTSCGPNwytggTNNNSYilALFVTC--FALPLSTIIFSYSNLLLTLRA-------------VAAQ-------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 255 psLHESHThtvgsplffnqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCwIHPAL 334
Cdd:cd15084  208 --QKESET--------------------------TQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVV-IQPTL 258
                        330       340       350
                 ....*....|....*....|....*....|....
gi 550822198 335 FDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVV 368
Cdd:cd15084  259 ASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELL 292
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-356 3.82e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 47.89  E-value: 3.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIL-VMPISIAYTTTRTWNfGQILCDIWVSSDIT 117
Cdd:cd15387    4 VTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFqVLPQLIWDITFRFYG-PDFLCRLVKYLQVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAheEMSDCLVNTSQ----IS 193
Cdd:cd15387   83 GMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLFSWLLSLVFSIPQVHIFSLREVGN--GVYDCWADFIQpwgpKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 YTIYSTCGAFYIPSILLIILYGRIYVaarsRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLheshthtvgsplffnq 273
Cdd:cd15387  161 YITWITLSVYIIPVLILSVCYGLISF----KIWQNVKLKTRRETKTPLSSAASGGAALARVSSV---------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 vkikladsilerKRISAARERKATKTLGIILgAFIICWLPFFVVSLVlpicrdSCWIHPA-----LFDFFTWLGYLNSLI 348
Cdd:cd15387  221 ------------KLISKAKIRTVKMTFVIVL-AYIVCWTPFFFVQMW------SVWDPNApkeasPFIIAMLLASLNSCC 281

                 ....*...
gi 550822198 349 NPVIYTVF 356
Cdd:cd15387  282 NPWIYMFF 289
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
38-141 5.72e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 47.46  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15398    3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                         90       100
                 ....*....|....*....|....
gi 550822198 118 CCTASILHLCVIALDRYWAITDAL 141
Cdd:cd15398   83 SVMVSTLMLMSIAIVRYHMIKHPL 106
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
36-256 6.14e-06

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 47.48  E-value: 6.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLvSILVMPISIAY-TTTRTWNFGQILCDIWVSS 114
Cdd:cd15370    1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLL-FVIWFPLKIAYhINGNNWIYGEALCKVLIGF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTaGHAAAMIAAVWIISICISIPPLFWRQA---------TAHEEMSDC 185
Cdd:cd15370   80 FYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKA-NIAIGISLAIWLLILLVTIPLYLVKQTvfipalditTCHDVLPEQ 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822198 186 LVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRIlNPPSLYGKRFTTAQLITGSAGSSLCSLNPS 256
Cdd:cd15370  159 LLVGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSI-NDESIEKKRKRAIKLIVTVLVMYLICFTPS 228
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
294-364 6.26e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 47.25  E-value: 6.26e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822198 294 RKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPaLFDFFTW-------LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15130  205 RRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTF-LFDFYHYfymltnaLFYVSSAINPILYNLVSANFRQVF 281
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
39-356 6.63e-06

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 47.46  E-value: 6.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDAL-EYSKRRTAGHAAAMIAavWIISICISIPPLF-WRQATAHEEMSDCLVNTSQI---- 192
Cdd:cd15388   84 MFASSYMIVAMTFDRHQAICRPMvTFQKGRARWNGPVCVA--WAISLILSLPQVFiFSKVEVAPGVYECWACFIEPwglk 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCslnpslheshthtvgsplffn 272
Cdd:cd15388  162 AYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQLLSSRASSVAE--------------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qvkikladsilerkrISAARERKATKTLGIILgAFIICWLPFFVVSLVlpicrdSCW-----IHPALFDFFTWLGYLNSL 347
Cdd:cd15388  221 ---------------VSKAMIKTVKMTLVIVL-VYVLCWAPFFLVQLW------SVWdpkapTEGATFTILMLLASLNSC 278

                 ....*....
gi 550822198 348 INPVIYTVF 356
Cdd:cd15388  279 TNPWIYMAF 287
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-364 7.12e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 47.46  E-value: 7.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  45 ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIaYTTTRTWNF--GQILCDIWVSSDITCCTAS 122
Cdd:cd15358   10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YEMWSNYPFllGAGGCYFKTLLFETVCFAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISIC-----ISIPPLFWRQATAHEEMSD---CLVNTSQISY 194
Cdd:cd15358   89 ILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILcsipnTSLHGIFQLTVPCRGPVPDsatCMLVKPRWMY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIY---STCGAFYIPSILLIILYGRIyvaarsrilnppSLYGKRFTTAQLITGSAGSSLcslnpslhESHTHTVgsplff 271
Cdd:cd15358  169 NLIiqiTTLLFFFLPMGTISVLYLLI------------GLQLKREKMLLVLEAKGSKAG--------DSYQHRR------ 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 nqvkikladsILERKRisaaRERKATKTLGIILGAFIICWLPF--------FVVSLVLPICRDSCWIHPALFDFFtwlgY 343
Cdd:cd15358  223 ----------IQQEKR----RRRQVTKMLFVLVVVFGICWAPFhtdrlmwsFISQWTGELHLAFQYVHIISGVFF----Y 284
                        330       340
                 ....*....|....*....|.
gi 550822198 344 LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15358  285 LSSAANPVLYNLMSTRFREMF 305
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
37-364 1.01e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 46.82  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  37 SLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDI 116
Cdd:cd15124    2 AIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 117 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSdclvNTSQISYT 195
Cdd:cd15124   82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIpEAVFSDLHPFYDKST----NKTFVSCA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 196 IYSTCGAFYiPSILLIILYGRIYVAARSRIlnppSLYgKRFTTAQLITGSAGSSLcslnpslhESHTHTvgsplffnqvk 275
Cdd:cd15124  158 PYPHSNELH-PKIHSMASFLIFYVIPLSII----SVY-YYFIAKNLIRSAYNLPV--------EGNVHV----------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 iklADSILERKRISaarerkatKTLGIILGAFIICWLPFFVVSLVLPICR---DSCWIHPALFDFFTWLGYLNSLINPVI 352
Cdd:cd15124  213 ---RRQIESRKRLA--------KTVLVFVGLFAFCWLPNHIIYLYRSYHYsevDTSMLHFVSSICARILAFTNSCVNPFA 281
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15124  282 LYLLSKSFRKQF 293
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
45-364 1.14e-05

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 46.65  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  45 ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASIL 124
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 125 HLCVIALDRYWAITdaLEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQ------ATAHEEMsdCLVNTSQISYTIYS 198
Cdd:cd15000   89 ALCAVSYDRLTAIV--LPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSyrerqwKNFLETY--CAENTQVLPIYWHV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCGAF-YIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagssLCSLNpslheshthtvgsplffnqvkiK 277
Cdd:cd15000  165 IITVLvWLPLGIMLICYSAI--------------------------------FWKLD----------------------K 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 278 LADSILERK-RISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFT-------WLGYLNSLIN 349
Cdd:cd15000  191 YERRVLRREhPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRYKLVPNDNTQNSVSGSFHilwfaskYLMFLNAAVN 270
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15000  271 PLIYGFTNENFRKAF 285
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
38-217 1.20e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 46.33  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISiAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15187    3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLF-VFSLPFQ-AYYLLDQWVFGNAMCKIVSGAYYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCL--VNTSQISYT 195
Cdd:cd15187   81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIpfYPGQGNSWK 160
                        170       180
                 ....*....|....*....|....*.
gi 550822198 196 IYSTCGA----FYIPSILLIILYGRI 217
Cdd:cd15187  161 VFTNFEVnilgLLIPFSILIFCYHNI 186
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
42-174 1.42e-05

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 46.35  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  42 LSVITLATVLS---NAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15121    4 IAILSLAFILGfpgNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWR 174
Cdd:cd15121   83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYR 138
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
40-363 1.66e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 45.90  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPAnyLIGSLATTDLLVSILVMPISIAYTTT--RTWNFGQILCDIWVSSDIT 117
Cdd:cd15220    4 FCMVLLDLTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILSSSPffLGVVFGEAECRVYIFLSVC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-W----RQATAHEemSDCLVNTSQI 192
Cdd:cd15220   82 LVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLgWpsygGPAPIAA--RHCSLHWSHS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 193 SY----TIYSTCGAFYIPSILLIILYGRIYVAarsrilnppslygkrfttaqLITGsagsslcslnpslheshthtvgsp 268
Cdd:cd15220  160 GHrgvfVVLFALVCFLLPLLLILVVYCGVFKV--------------------FGGG------------------------ 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 lffnqvkikladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSLI 348
Cdd:cd15220  196 --------------------------KAALTLAAIVGQFLCCWLPYFAFHLYSALA-ASPVSGGEAEEVVTWLAYSCFAV 248
                        330
                 ....*....|....*
gi 550822198 349 NPVIYTVFNEDFRQA 363
Cdd:cd15220  249 NPFFYGLLNRQIREE 263
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
36-144 1.82e-05

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 45.73  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAY--TTTRTWNFGQILCDIWVS 113
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHllSEHKTISFVGCAAQMFFF 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 550822198 114 sdITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15237   81 --LALGVTECVLLAVMAYDRYVAICNPLRYS 109
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
41-223 1.86e-05

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 45.92  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  41 VLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPIsIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15177    6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLL-LLTLPF-AAAETLQGWIFGNAMCKLIQGLYAINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRR--TAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC-------LVNTSQ 191
Cdd:cd15177   84 SGFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCrmifpevVSRTVK 163
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 550822198 192 ISYTIYSTCGAFYIPSILLIILY---GRIYVAARS 223
Cdd:cd15177  164 GATALTQVVLGFAIPLIVMAVCYaaiGRTLLAARG 198
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
289-363 1.94e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 45.55  E-value: 1.94e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822198 289 SAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15349  196 SRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGMEWVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
36-361 2.18e-05

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 45.53  E-value: 2.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKlHTPANYLIGSLATTDLLVSiLVMPISIAYTTTRT-WNFGQILCDIWVSS 114
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADLLCC-LSLPFSIAHLLLNGhWPYGRFLCKLLPSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSqISY 194
Cdd:cd15115   79 IVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFL-VAI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrftTAQLITGSAgsslcslnpslheshthtvgsplffnqv 274
Cdd:cd15115  158 TITRAVFGFLLPLLIIAACYSFI--------------------AFRMQRGRF---------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 275 kikladsilerkrisAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTW-LGYLNSLINPVIY 353
Cdd:cd15115  190 ---------------AKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLMSWDHLSIaLAYANSCLNPVLY 254

                 ....*...
gi 550822198 354 TVFNEDFR 361
Cdd:cd15115  255 VFMGKDFK 262
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-362 2.46e-05

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 45.54  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASI 123
Cdd:cd15189    9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEM--SDCLVNTSQisytiystcG 201
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLniTACVLLYPH---------E 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 202 AFYIPSILLIILYGriyvaarsrilnppslygkrFTTAQLITgsagsslcslnpslheshthtvgspLFFNQVKIKLADS 281
Cdd:cd15189  160 AWHFAHIVLLNIVG--------------------FLLPLLVI-------------------------TFCNYNILQALRT 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 282 ILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICR----DSC-WIH--PALFDFFTWLGYLNSLINPVIYT 354
Cdd:cd15189  195 REESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDvgvlDECfWEHfiDIGLQLAVFLAFSNSCLNPVLYV 274

                 ....*...
gi 550822198 355 VFNEDFRQ 362
Cdd:cd15189  275 FVGRYFRR 282
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
36-364 2.77e-05

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 45.52  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIgSLATTDLLVSIlVMPISIAYTTTRT-WNFGQILCDIWVSS 114
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFL-NLAVADFLFTF-FLPFSIAYTAMDFhWPFGRFMCKLNSFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRqataheemsdclvNTSQISY 194
Cdd:cd15116   79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFR-------------DTAPSQN 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYSTCgafyipsilliilygriyvaarsrilnppslygkrFTTAQLITGSAGSSLCSLNPSLHESHTHT---VGSPLFF 271
Cdd:cd15116  146 NNKIIC-----------------------------------FNNFSLSGDNSSPEVNQLRNMRHQVMTITrflLGFLIPF 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 272 NQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLV-LPICRDSCWIHPALFDFFTWLGYLNSLINP 350
Cdd:cd15116  191 TIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLeMEATRSPASVFKIGLPITSSLAFINSCLNP 270
                        330
                 ....*....|....
gi 550822198 351 VIYTVFNEDFRQAF 364
Cdd:cd15116  271 ILYVFMGQDFKKFK 284
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
39-357 2.93e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 45.17  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIL-VMPISIAYTTTRtWNFGQILCDIWVSSDIT 117
Cdd:cd15386    4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPQLIWEITYR-FQGPDLLCRAVKYLQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISICISIPPLF---WRQATAHEEMSDCL----VNTS 190
Cdd:cd15386   83 SMFASTYMLIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSLPQVFifsLREVDQGSGVLDCWadfgFPWG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRI-YVAARsrilnppSLYGKrfttaqliTGSAGSSLCSLNPSLHESHTHTVgspl 269
Cdd:cd15386  162 AKAYITWTTLSIFVLPVAILIVCYSLIcYEICK-------NLKGK--------TQTSRSEGGGWRTQGMPSRVSSV---- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerKRISAARERKATKTLGIILgAFIICWLPFFVVSLVlpicrdSCWIHPA--------LFDFFTWL 341
Cdd:cd15386  223 ----------------RTISRAKIRTVKMTFVIVL-AYIACWAPFFSVQMW------SVWDENApdedssdfAFTITMLL 279
                        330
                 ....*....|....*.
gi 550822198 342 GYLNSLINPVIYTVFN 357
Cdd:cd15386  280 ASLSSCCNPWIYMFFS 295
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
36-144 3.14e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 44.91  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAY------TTTRTWNFGQILCD 109
Cdd:cd15431    1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNclsdrpTISYSRCLAQMYIS 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 550822198 110 IWVSsdITCCtasiLHLCVIALDRYWAITDALEYS 144
Cdd:cd15431   81 LFLG--ITEC----LLLAVMAYDRFVAICNPLRYT 109
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
34-144 3.32e-05

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 45.05  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  34 LRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVS 113
Cdd:cd15943   13 LQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMY 92
                         90       100       110
                 ....*....|....*....|....*....|.
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15943   93 FFVAFATTECFLLAVMAYDRYVAICNPLLYT 123
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
38-160 4.01e-05

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 44.56  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFG----QILCDIW 111
Cdd:cd15232    3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPklLQNLLTERKTISFGgcmaQLYFFTW 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 550822198 112 VSSditcctASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:cd15232   83 SLG------SELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVW 125
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-137 4.59e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 44.84  E-value: 4.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15976    5 VVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASV 84
                         90
                 ....*....|....*...
gi 550822198 120 TASILHLCVIALDRYWAI 137
Cdd:cd15976   85 GITVLSLCALSIDRYRAV 102
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
36-364 5.09e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 44.57  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSiLVMPISIAYTTTRtWNFGQILCDIwVSS- 114
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFA-LTLPFWAVSVVKG-WIFGTFMCKL-VSLl 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 -DITCCTaSILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISICISIPPLFWRQataheemsdclvntsqis 193
Cdd:cd15178   78 qEANFYS-GILLLACISVDRYLAIVHATR-ALTQKRHLVKFVCAGVWLLSLLLSLPALLNRD------------------ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 194 ytiystcgAFYIPSILLIILYGRiyvaarsriLNPPSLYGKRFTTAQLitgsagsslcslnpslheshTHTVGsplFFNQ 273
Cdd:cd15178  138 --------AFKPPNSGRTVCYEN---------LGNESADKWRVVLRIL--------------------RHTLG---FLLP 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 274 VKIKLADSILERKRISAARERKATKTLGIILG---AFIICWLPFFVVSLVLPICR-----DSCWIHPAL---FDFFTWLG 342
Cdd:cd15178  178 LVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAvvlAFLLCWLPYNVTVLIDTLMRtklitETCELRNHVdvaLYVTQILG 257
                        330       340
                 ....*....|....*....|..
gi 550822198 343 YLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15178  258 FLHSCINPVLYAFIGQKFRNNL 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
36-144 5.63e-05

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 44.34  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15424   81 LSLGSTECLLLGAMAYDRYLAICHPLLYA 109
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
38-144 6.75e-05

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 44.12  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIA--YTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15226    3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICdlLREHKTISFGGCMAQIFFLHF 82
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCctASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15226   83 FGG--SEMVLLIAMAFDRYVAICKPLHYL 109
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-364 7.65e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 44.06  E-value: 7.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYL-IGSLATTDLLVS-ILVMPISIAYTTTRTWNFGQILCDIwvS 113
Cdd:cd15099    1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRRRPSYLfIGSLALADMLASvIFTISFLDFHVFHQRDSRNLFLFKL--G 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 114 SDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WRQATAHEEMSDC---LVNT 189
Cdd:cd15099   79 GVTMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMgWRCKTWDSPCSRLfpyIDRH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 190 SQISYTIYSTCGAFYIpsillIILYGRIYVAARSRILNppslYGKRFTTAQLITGSAGSSLcslnpslheshthtvgspl 269
Cdd:cd15099  159 YLASWTGLQLVLLFLI-----IYAYPYILWKAHRHEAN----MGGPKLGRQQVKGQARMRM------------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvKIKLAdsilerkrisaarerkatKTLGIILGAFIICWLP---FFVVSLVLPICRdscwIHPALFDFFTWLGYLNS 346
Cdd:cd15099  211 -----DIRLA------------------KTLSLILLVLAICWLPvlaFMLVDVRVTLTN----KQKRMFAFCSMLCLVNS 263
                        330
                 ....*....|....*...
gi 550822198 347 LINPVIYTVFNEDFRQAF 364
Cdd:cd15099  264 CVNPIIYALRSRELRGAM 281
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
38-217 7.80e-05

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 43.99  E-value: 7.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPIsIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15175    3 LPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILF-LLTLPF-WAASAAKKWVFGEEMCKAVYCLYKM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRR--TAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNT-SQISY 194
Cdd:cd15175   81 SFFSGMLLLMCISIDRYFAIVQAASAHRHRsrAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTnNKQTL 160
                        170       180
                 ....*....|....*....|....*..
gi 550822198 195 TIYSTCG----AFYIPSILLIILYGRI 217
Cdd:cd15175  161 SVKIQISqmvlGFLVPLVVMSFCYSVI 187
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-364 8.22e-05

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 43.79  E-value: 8.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLAtVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCC 119
Cdd:cd15125    6 LYLLIITVG-LLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 120 TASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQaTAHEEMSDCLVNTSQISYTIYST 199
Cdd:cd15125   85 GVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSE-VAHIMPDDNTTFTACIPYPQTDE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 200 CGAfYIPSILLIILYGRIYVAArsrilnpPSLYgkRFTTAQLITGSAGSSlcslnPSLHESHThtvgsplffnqvkikla 279
Cdd:cd15125  164 MHP-KIHSVLIFLVYFLIPLAI-------ISIY--YYHIAKTLIKSAHNI-----PGEYSEHS----------------- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 280 dsilerKRISAARERKAtKTLGIILGAFIICWLPFFVVSLVLPICR---DSCWIHPALFDFFTWLGYLNSLINPVIYTVF 356
Cdd:cd15125  212 ------KRQMETRKRLA-KIVLVFVGLFAFCWFPNHVLYMYRSFNYneiDSSLGHMIVTLVARVLSFCNSCVNPFALYLL 284

                 ....*...
gi 550822198 357 NEDFRQAF 364
Cdd:cd15125  285 SESFRRHF 292
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
40-364 8.45e-05

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 43.66  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKL-HTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYS 198
Cdd:cd15097   85 MYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWEEARRKAMD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 199 TCG---AFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagsslcslnpslheshthtvgspLFFNQVK 275
Cdd:cd15097  165 TCTfafGYLIPVLVVSLSYTRT---------------------------------------------------IKYLWTA 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 276 IKLADSILERKRIsaarERKATKTLGIILGAFIICWLPFFVVslVLPICRDSCWIHPALFDFFTW---LGYLNSLINPVI 352
Cdd:cd15097  194 VDPLEAMSESKRA----KRKVTKMIIIVTALFCLCWLPHHVV--ILCYLYGDFPFNQATYAFRLLshcMAYANSCLNPIV 267
                        330
                 ....*....|..
gi 550822198 353 YTVFNEDFRQAF 364
Cdd:cd15097  268 YALVSKHFRKGF 279
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
53-224 8.57e-05

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 43.64  E-value: 8.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  53 NAFVLTTIL--LTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRTWNFGQILCDIwvsSDITCCT---ASILHLC 127
Cdd:cd15122   18 NGFIIWSILwkMKARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKA---VYYLCCLsmyASIFIIG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 128 VIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ------ISYTIYSTCG 201
Cdd:cd15122   94 LMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHasrghaIFHYTFETLV 173
                        170       180
                 ....*....|....*....|...
gi 550822198 202 AFYIPSILLIILYGRIYVAARSR 224
Cdd:cd15122  174 AFVLPFGVILFSYSVILVRLKGA 196
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
287-364 8.61e-05

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 43.95  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 287 RISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIH-----PALFDFFTWLGYLNSLINPVIYTVFNEDFR 361
Cdd:cd15117  206 REGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELVVILNQKEDlnpllILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285

                 ...
gi 550822198 362 QAF 364
Cdd:cd15117  286 ERL 288
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
298-364 1.26e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 43.09  E-value: 1.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550822198 298 KTLGIILGAFIICWLPFFVVsLVLPICRDSCWIHpALFDFFTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15344  209 KTVVIVLGAFIICWTPGLVL-LLLDVCCPQCDVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
36-144 1.27e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 43.20  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVS 113
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPkmLSDLLSEEKTISFNGCVTQLFFL 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 550822198 114 SDITCctASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15940   81 HLFAC--TEIFLLTIMAYDRYVAICNPLHYP 109
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
42-144 1.72e-04

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 43.02  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  42 LSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPisiaytttrtwnfgQILCDIWV-SSDIT--- 117
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVP--------------KALCIFWFnLKEITfsg 72
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 550822198 118 CCT-------ASILH---LCVIALDRYWAITDALEYS 144
Cdd:cd15953   73 CLTqmffihtLSIMEsavLVAMAFDRYVAICNPLRYA 109
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
36-364 1.79e-04

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 42.96  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTtILLTKK--LHTPANYLIGSLATTDLLVsILVMPI-SIAYTTTRTWNFGQILCDIWV 112
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVLY-LMKSKQgwKKSSINLFVTSLAVTDFQF-VLTLPFwAVENALDFTWLFGKAMCKIVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 113 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSdCLVNTSQ 191
Cdd:cd15926   79 YVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLpNAIFSTTATVSNEEL-CLVKFPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ISYTIYSTCGAFYIPSILL--IILYGRIYVAarsrilnppSLYGKRFTTAQLITGSagsslcslnpslheshthtvgspl 269
Cdd:cd15926  158 NRGNAQFWLGLYHAQKVLLgfLIPLGIISLC---------YLLLVRFITDKNITGS------------------------ 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSL--------VLPICRDSCWIHPALFDFFTWL 341
Cdd:cd15926  205 -------------------STKRRSKVTKSVTIVVLSFFLCWLPNQALTTwgiliklnVVHFSYEYFTTQVYIFPITVCL 265
                        330       340
                 ....*....|....*....|...
gi 550822198 342 GYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15926  266 AHSNSCLNPILYCLMRREFRKAL 288
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
40-219 2.10e-04

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 42.76  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLsNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAY-TTTRTWNFGQILCDIWVSSDITC 118
Cdd:cd15967    6 VYILVFVVGLVG-NVWGLKSLLANWKKLGNINVFVLNLGLADLLY-LLTLPFLVVYyLKGRKWIFGQVFCKITRFCFNLN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEmsDCLVNTSQ------I 192
Cdd:cd15967   84 LYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSNGT--KCFDTTFNdylesyL 161
                        170       180
                 ....*....|....*....|....*....
gi 550822198 193 SYTIYSTCGAFYIPsiLLIIL--YGRIYV 219
Cdd:cd15967  162 TYSLGWTVTGFVIP--LLIILgcYGHVVV 188
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
38-160 2.22e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 42.44  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSiLVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15154    3 HLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSGSIFQM 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:cd15154   82 NMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVW 124
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
36-144 2.38e-04

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 42.39  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAY--TTTRTWNFGQILCDIWVS 113
Cdd:cd15429    1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHflAEHKTISFASCVAQLFIS 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 550822198 114 sdITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15429   81 --LALGGTEFILLAVMAYDRYVAVCHPLRYT 109
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
281-363 2.55e-04

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 42.55  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 281 SILERKRISA---ARERKATKTLGIILGAFIICWLPFFVVSL--VLPICRDSCW------IHPALFDFFTWLGYLNSLIN 349
Cdd:cd15925  189 SFLQQHKVNQnnrQRQSVIARSVRLVVASFFLCWFPNHVVTFwgVLVKFRAVPWnstfyfIHTYVFPVTTCLAHSNSCLN 268
                         90
                 ....*....|....
gi 550822198 350 PVIYTVFNEDFRQA 363
Cdd:cd15925  269 PVLYCLMRREFRQA 282
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
36-219 3.30e-04

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 42.09  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSiLVMPISIAYtttRTWNFGQILCDIWVSSD 115
Cdd:cd15920    1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLV-LCLPFRVAY---QNTAGPLSFCKIVGAFF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFW-RQATAHEEMSDCLVNTSQISY 194
Cdd:cd15920   77 YLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFEsRNEGPCDNKCFHFRSKGLTAG 156
                        170       180
                 ....*....|....*....|....*.
gi 550822198 195 TI-YSTCGAFYIPSILLIILYGRIYV 219
Cdd:cd15920  157 GInLTAVVIFYILSLLFLYFYAKISH 182
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
36-137 3.85e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 41.75  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100
                 ....*....|....*....|..
gi 550822198 116 ITCCTASILHLCVIALDRYWAI 137
Cdd:cd15404   81 WLFVMEGVAILLIISIDRFLII 102
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
38-364 3.97e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 41.71  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15082   16 LAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTF 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEySKRRTAGHAAAMIAAVWIISICISI-PPLFWRQATAHEEMSDCLVNTSQISY-- 194
Cdd:cd15082   96 FGIVALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIpPVLGWSSYTVSKIGTTCEPNWYSGNMhd 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 -----TIYSTCgaFYIPSILLIILYGRIYVAARSrilnppslygkrfttaqlitgsagsslcslnpslhESHTHtvgspl 269
Cdd:cd15082  175 htyiiTFFTTC--FILPLGVIFVSYGKLLQKLRK-----------------------------------VSNTQ------ 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkikladsilerKRISAAR--ERKATKTLGIILGAFIICWLPFFVVSLVLPICrDSCWIHPALFDFFTWLGYLNSL 347
Cdd:cd15082  212 ----------------GRLGNARkpERQVTRMVVVMIVAFMVCWTPYAAFSILVTAH-PTIHLDPRLAAIPAFFSKTAAV 274
                        330
                 ....*....|....*..
gi 550822198 348 INPVIYTVFNEDFRQAF 364
Cdd:cd15082  275 YNPIIYVFMNKQFRKCL 291
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
36-144 4.42e-04

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 41.54  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDL----------LVSILVMPISIAYTttrtwnfgq 105
Cdd:cd15413    1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLgystavtpkmLVNFVVEQNTISFY--------- 71
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 550822198 106 iLCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15413   72 -ACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYT 109
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
47-144 4.43e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 41.63  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  47 LATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVSSDITCCTASIl 124
Cdd:cd15950   12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPkmLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV- 90
                         90       100
                 ....*....|....*....|
gi 550822198 125 hLCVIALDRYWAITDALEYS 144
Cdd:cd15950   91 -LLAMAFDRYVAICHPLRYS 109
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
44-364 4.77e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 41.37  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQilCDIWVSSDITCCTASI 123
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 124 LHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-W------RQATAHEEMSDCLVNTSQ----- 191
Cdd:cd15071   87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFgWnnlnavERAWAANSSMGELVIKCQfetvi 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 -ISYTIYSTCGAFYIPSILL-IILYGRIYVAARSRIlnppslygkrfttaqlitgsagsslcslnpslheshthtvgspl 269
Cdd:cd15071  167 sMEYMVYFNFFVWVLPPLLLmLLIYLEVFYLIRKQL-------------------------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 270 ffnqvkIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRdSCWIHPALFDFFTWLGYLNSLIN 349
Cdd:cd15071  203 ------NKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCP-SCKKPMILTYIAIFLTHGNSAMN 275
                        330
                 ....*....|....*
gi 550822198 350 PVIYTVFNEDFRQAF 364
Cdd:cd15071  276 PIVYAFRIKKFRTTF 290
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
36-144 5.06e-04

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 41.31  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15428    1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15428   81 LSFGITECALLSVMSYDRYVAICLPLRYS 109
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
38-144 5.41e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 41.24  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP------------ISIAYTTTRTWNFGq 105
Cdd:cd15409    3 LFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPkmlvnflsknkmISFSGCAAQFFFFG- 81
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 550822198 106 ilcdiwvssdiTCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15409   82 -----------FSATTECFLLAAMAYDRYVAICNPLLYP 109
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
39-217 5.75e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 41.29  E-value: 5.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLS---NAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWVSS 114
Cdd:cd15369    1 RFVPSVYTIVFVISlplNILALVVFLRKMRVKKPAVIYMLNLACADLLF-VLLLPFKIAYHfSGNDWLFGEAMCRVVTAA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQA---------TAHEEMSDC 185
Cdd:cd15369   80 FYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTiqipdlgitTCHDVLNEQ 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 550822198 186 LVNTSQISYTIYSTCGAFYIPSILLIILYGRI 217
Cdd:cd15369  160 LLMGYYVYYFSIFSCLFFFVPLIITTVCYVSI 191
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
39-143 6.04e-04

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 41.38  E-value: 6.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLAT-VLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15127    3 VMCLSVVIFGIgIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                         90       100
                 ....*....|....*....|....*.
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEY 143
Cdd:cd15127   83 SLGVTTFTLCALCIDRFRAATNVQMY 108
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
38-144 6.52e-04

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 41.12  E-value: 6.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15223    3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPkmLAIFWFDANTISLPGCFAQMFFIHF 82
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASIlhLCVIALDRYWAITDALEYS 144
Cdd:cd15223   83 FTAMESSI--LLVMALDRYVAICKPLRYP 109
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
40-137 7.10e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 41.00  E-value: 7.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTW-----NFGQILCDIWVSS 114
Cdd:cd15975    5 VLSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWpfddsSFGVFLCKLVPFL 84
                         90       100
                 ....*....|....*....|...
gi 550822198 115 DITCCTASILHLCVIALDRYWAI 137
Cdd:cd15975   85 QKASVGITVLNLCALSVDRYRAV 107
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
60-217 7.77e-04

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 40.89  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  60 ILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYT-TTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAIT 138
Cdd:cd15372   24 VLATQVKRLPSTIFLINLAVADLLL-ILVLPFKISYHfLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 139 DALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMS-----DCLVNTSQISYTIYS-TCGA---FYIPSIL 209
Cdd:cd15372  103 HPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNitlchDVLPLDEQDTYLFYYfACLAvlgFLLPLVV 182

                 ....*...
gi 550822198 210 LIILYGRI 217
Cdd:cd15372  183 ILFCYGSV 190
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
76-227 8.91e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 40.66  E-value: 8.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  76 SLATTDLLVsILVMPISIAYTTTRT-WNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAA 154
Cdd:cd15377   41 NLALADFLY-VLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAIC 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 155 MIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQI----SYTIYSTCGA---FYIPSILLIILYGRIYVAARSRILN 227
Cdd:cd15377  120 ISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDeylrSYFIYSMCTTvamFCVPFILILGCYGLIVRALIYKDMK 199
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
43-144 9.69e-04

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 40.44  E-value: 9.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  43 SVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15952    8 CAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPkmLGIFWFNLREISFGGCLAQMFFIHTFTGME 87
                         90       100
                 ....*....|....*....|....
gi 550822198 121 ASIlhLCVIALDRYWAITDALEYS 144
Cdd:cd15952   88 SAV--LVAMAFDRYVAICNPLRYT 109
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
77-361 9.81e-04

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 40.50  E-value: 9.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  77 LATTDLlVSILVMPISIAYTTTR-TWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAM 155
Cdd:cd15119   41 LAIADF-VFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALIL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 156 IAAVWIISICISIPPLFWRQATAheemsdcLVNTSQISYTIYSTcgafyipsilliilYGRIYVAARSRILnppslygkr 235
Cdd:cd15119  120 CGIVWLSAAAISGPALYFRDTME-------LSINVTICFNNFHK--------------HDGDLIVMRHTIL--------- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 236 fTTAQLITGsagsslcSLNPSLHESHThtvGSPLFFNQvkikladsilerKRISAARERKATKTLGIILGAFIICWLPFF 315
Cdd:cd15119  170 -VWVRFFFG-------FLFPLLTMVVC---YSLLAIKV------------KRRTLLISSKFFWTISAVIVAFFVCWTPYH 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822198 316 VVSLVLPICRDSCWIHPAL---FDFFTWLGYLNSLINPVIYTVFNEDFR 361
Cdd:cd15119  227 IFSILELSIHHSSYLHNVLragIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-137 1.19e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 40.20  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTW-----NFGQILCDIWVSS 114
Cdd:cd15128    5 VVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWpfgdqPFGQFLCKLVPFI 84
                         90       100
                 ....*....|....*....|...
gi 550822198 115 DITCCTASILHLCVIALDRYWAI 137
Cdd:cd15128   85 QKASVGITVLNLCALSVDRYRAV 107
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
42-165 1.21e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.40  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  42 LSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISI-AYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15218    7 LGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFtSVKNGSTWTYGTLTCKVIAFLGVLSCF 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 550822198 121 ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISIC 165
Cdd:cd15218   87 HTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVA 131
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
294-364 1.22e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 40.23  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822198 294 RKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPaLFDFFTW-------LGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15356  209 QHSVQVLRAIVIAYVICWLPYHARRLMFCYVPDDAWTDS-LYNFYHYfymltntLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
39-362 1.24e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 40.32  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  39 VVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP-ISIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPfVLVSIRNGSAWTYSVLSCKIVAFMAVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAH-EEMSDCLVNTSQisYTI 196
Cdd:cd15217   84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFiREEDQCIFEHRY--FKA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 197 YSTCGAFYIPSILLI---ILYGRIYV-AARSRILNP----PSL------YGKRFTTAQLITGSAGSSLCSLNPSLH--ES 260
Cdd:cd15217  162 NDTLGFMLMLAVLIVathIVYGKLLLfEYRHRKMKPvqmvPAIsqnwtfHGPGATGQAAANWIAGFGRGPMPPTLLgiRQ 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 261 HTHTvgsplffnqvkikladsilERKRISAARERKATKTLG----IILGAFIICWLPfFVVSLVLPICRDSCWIHPALFD 336
Cdd:cd15217  242 NAHT-------------------ANRRLLGMEEFKAEKRLGrmfyVITLSFLVLWSP-YIVACYWRVFVKACSIPHRYLS 301
                        330       340
                 ....*....|....*....|....*.
gi 550822198 337 FFTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15217  302 TAVWMSFAQAGVNPIVCFLLNKDLKK 327
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
287-364 1.26e-03

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 40.08  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 287 RISAARERKATKTLGIILGA---FIICWLPFFVVSLVLPICRDSCWIHP---ALFDFFTWLGYLNSLINPVIYTVFNEDF 360
Cdd:cd15114  191 RTWSRRRQKSRRTLKVVTAVvvgFFLCWTPYHVVGLIIAASAPNSRLLAnalKADPLTVSLAYINSCLNPIIYVVAGRGF 270

                 ....
gi 550822198 361 RQAF 364
Cdd:cd15114  271 RKSL 274
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
28-160 1.28e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 40.38  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  28 PEVLQALRISLVVVLsvitLATVLSNAFVLTtILLTKKLHTPANYLIGSLATTDLLVsILVMPIsIAYTTTRTWNFGQIL 107
Cdd:PHA02638  95 PSISEYIKIFYIIIF----ILGLFGNAAIIM-ILFCKKIKTITDIYIFNLAISDLIF-VIDFPF-IIYNEFDQWIFGDFM 167
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822198 108 CDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:PHA02638 168 CKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISW 220
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
36-364 1.43e-03

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 40.08  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTT-RTWNFGQILCDIWVSS 114
Cdd:cd15922    1 PAIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAII-TPAAPLLIAYFSLgSHWPFGQFLCQLKVFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLvntsqisy 194
Cdd:cd15922   80 LSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCL-------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 195 TIYST--CGAFYIPSILLIILygriyvaarsRILNPpslygkrFTTAQLITGSAGSSLCSLNPSLHESHThtvgsplffn 272
Cdd:cd15922  152 SIHQSelSLLYFVWNFVLLIL----------GFLLP-------FGVSLTCYALLGASIAKMNSNNARGRA---------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 273 qVKIkladsilerkrisaarerKATKTLGIILGAFIICWLPFFVVSLVLPICR----DSC----WIHPALfdFFTW-LGY 343
Cdd:cd15922  205 -MKA------------------KSLQMIGISLVIFIICFVPLHVTRTVGVVVKlfypESCtllhKVEVAY--YISWvLTG 263
                        330       340
                 ....*....|....*....|.
gi 550822198 344 LNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15922  264 VNCCLDPLLYCFASEKFRKSF 284
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
36-160 1.47e-03

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 40.14  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPIsIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLF-VLTLPF-WAVDAAANWYFGNFLCKAVHVIY 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW 160
Cdd:cd15179   79 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVW 123
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
36-144 1.54e-03

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 39.99  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15411    1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYT 109
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
34-146 1.59e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  34 LRISLVVVLsvitLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSI--LVMPISIAYTTTRTWNFGqilcdIW 111
Cdd:cd15136    3 LRIGVWFVF----LLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIylGLLAIVDAKTLGEYYNYA-----ID 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 550822198 112 VSSDITCCTA----------SILHLCVIALDRYWAITDALEYSKR 146
Cdd:cd15136   74 WQTGAGCKTAgflavfsselSVFTLTVITLERWYAITHAMHLNKR 118
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
289-362 1.79e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 1.79e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550822198 289 SAARERKATKTLGIILGAFIICWLPFFVVSLVLpICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15085  206 CPEEEERAVIMVLAMVIAFLICWLPYTVFALIV-VVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
38-220 1.89e-03

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 39.73  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPIsIAYTTTRTWNFGQILCDIWVSSDIT 117
Cdd:cd15176    3 LPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPF-WAADAVNGWVLGTAMCKITSALYTM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 118 CCTASILHLCVIALDRYWAITDAleYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDC-------LVNTS 190
Cdd:cd15176   81 NFSCGMQFLACISVDRYVAITKA--TSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRClpvfppsLVTSA 158
                        170       180       190
                 ....*....|....*....|....*....|
gi 550822198 191 QISYTIYSTCGAFYIPSILLIILYGRIYVA 220
Cdd:cd15176  159 KATIQILEVLLGFVLPFLVMVFCYSRVARA 188
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-164 1.90e-03

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 39.65  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  43 SVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILvMPISIAYTTTRtWNFGQILCDIWVSSDITCCTAS 122
Cdd:cd15182    8 YLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFT-LPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSS 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 550822198 123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISI 164
Cdd:cd15182   86 ILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISI 127
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
40-186 2.06e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 39.41  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAYTTTRT-WNFGQILCDIWVSSDITC 118
Cdd:cd15921    5 TAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYYVLNShWPFGDIACRIILYVLYVN 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCL 186
Cdd:cd15921   84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCL 151
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
36-316 2.08e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 39.37  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIA-YTTTRTWNFGQILCDIWVSS 114
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLY-ALSLPLLIYnYAMRDRWLFGDFMCRLVRFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQ--- 191
Cdd:cd15968   80 FYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPalf 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 192 ---ISYTIYSTCGAFYIPSILLIILYGRIyvaarsrilnppslygkrfttaqlitgsagssLCSLNPSLHESHThtvgsp 268
Cdd:cd15968  160 phyVPYGMALTVSGFLLPFSIILWCYCLV--------------------------------VRTLCRTLGPAEP------ 201
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822198 269 lffnqvkikladsilerkrISAARERKATKTLGIILGAFIICWLPFFV 316
Cdd:cd15968  202 -------------------PAQARRRKSIRTIVTVTLLFALCFLPFHI 230
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
44-142 2.12e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 39.47  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  44 VITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRT---WNFGQILCDIWVSSDITCCT 120
Cdd:cd15006    8 VIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCS 87
                         90       100
                 ....*....|....*....|..
gi 550822198 121 ASILHLCVIALDRYWAITDALE 142
Cdd:cd15006   88 VTVLSFAAIALDRYYSVLYPLE 109
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
293-361 2.12e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 39.43  E-value: 2.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550822198 293 ERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWiHPALFDFFTWLGYLNSLINPVIYTVFNEDFR 361
Cdd:cd15080  210 EKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDF-GPIFMTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
294-364 2.56e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 39.39  E-value: 2.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550822198 294 RKATKTLGIILGAFIICWLPFFVVSLVLPICR--DSCWIHPA---LFDFFTWLGYLNSLINPVIYTVFNEDFRQAF 364
Cdd:cd15199  203 QRAMALVTSVVVVFGFCFLPCFLARVLMLIFQnkESCNALNIavhTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
38-144 2.59e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 39.19  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15917    3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPkmLGIFWFNAREISFDACLAQMFFIHS 82
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASILhLCvIALDRYWAITDALEYS 144
Cdd:cd15917   83 FTAMESGVL-LA-MAFDRYVAICYPLRYT 109
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
43-144 2.88e-03

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 38.98  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  43 SVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWVSSDITCCT 120
Cdd:cd15955    8 CIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPkmLAIFWFQLREISFNACLAQMFFIHTLQAFE 87
                         90       100
                 ....*....|....*....|....
gi 550822198 121 ASIlhLCVIALDRYWAITDALEYS 144
Cdd:cd15955   88 SGI--LLAMALDRYVAICHPLRHS 109
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
73-145 2.95e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 39.02  E-value: 2.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822198  73 LIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSK 145
Cdd:cd15142   40 LVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLSIICAMSIERYLAINHAYFYNH 112
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
40-362 3.31e-03

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 38.96  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVL---TTILLTKKLHTPANYLIgSLATTDLLVsILVMPISIAYTTTR-TWNFGQILCDIWVSSD 115
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLwvfARLYPSKKLNEIKIFMV-NLTIADLLF-LITLPFWIVYYHNEgNWILPKFLCNVAGCLF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV-------- 187
Cdd:cd15147   83 FINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVKIDSGNFTrcfegyek 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 188 -NTSQISYTIYSTCGAFYIpsILLIILYGRIYVAarsRILNPPSLYGKRfttaqlitgsagsslcslnpslheshthtvg 266
Cdd:cd15147  163 dNSKPVLIIHFIIIGLFFL--VFLLILVCNLVIA---RTLLSQPVQGQR------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 267 splffnqvkikladsilerkriSAARERKATKTLGIILGAFIICWLPFFVVSL-----VLPICR-DSCWIHPALFD---F 337
Cdd:cd15147  207 ----------------------NAGVKRRALWMVCTVLAVFVICFVPHHVVQGpwtlaVLQQWRyWDCQFRQALNDahqI 264
                        330       340
                 ....*....|....*....|....*
gi 550822198 338 FTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15147  265 TLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
36-147 4.04e-03

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 38.60  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSIlVMPISIAYTTTRT-WNFGQILCDIWVSS 114
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIQRNhWIFGKPLCNVVTVL 79
                         90       100       110
                 ....*....|....*....|....*....|...
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDALEYSKRR 147
Cdd:cd15368   80 FYANMYSSILTMTCISIERYLGVVYPMRSMRWR 112
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
34-144 4.12e-03

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 38.50  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  34 LRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP------------ISIAYTTTRTW 101
Cdd:cd15406    8 LQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPkmlvnfvsekniISYPECMTQLF 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 550822198 102 NFgqilcdiwvssdITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15406   88 FF------------CVFAIAECYMLTAMAYDRYVAICNPLLYN 118
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
36-361 4.90e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 38.22  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15075    1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 116 ITCCTASILHLCVIALDRYWAITD---ALEYSKRRTAGHAaamiAAVWIISICISIPPLF-WRQATAHEEMSDCLVN--- 188
Cdd:cd15075   81 AFFGIAALCTVAVIAVDRLFVVCKplgTLTFQTRHALAGI----ASSWLWSLIWNTPPLFgWGSYQLEGVMTSCAPDwys 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 189 --TSQISYTI--YSTCgaFYIPSILLIILYGRiyvaarsrilnppslygkrfttaqlitgsagsslcsLNPSLHESHTHT 264
Cdd:cd15075  157 rdPVNVSYILcyFSFC--FAIPFAIILVSYGY------------------------------------LLWTLRQVAKLG 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 265 VGSPLFFNQVKIKLADSILerkrisaarerkatktlgIILGAFIICWLPFFVVSLVLpICRDSCWIHPALFDFFTWLGYL 344
Cdd:cd15075  199 VAEGGSTAKAEVQVARMVV------------------VMVMAFLLCWLPYAAFALTV-VSKPDVYINPLIATVPMYLAKS 259
                        330
                 ....*....|....*..
gi 550822198 345 NSLINPVIYTVFNEDFR 361
Cdd:cd15075  260 STVYNPIIYIFMNKQFR 276
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
36-144 5.19e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 38.18  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIA--YTTTRTWNFGQILCDIWVS 113
Cdd:cd15942    1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAgfLSGGRIISFGGCVTQLFFF 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 550822198 114 SDITCctASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15942   81 HFLGC--AECFLYTVMAYDRFLAICKPLHYS 109
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
36-144 5.41e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 38.12  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                         90       100
                 ....*....|....*....|....*....
gi 550822198 116 ITCCTASILHLCVIALDRYWAITDALEYS 144
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYS 109
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
36-143 5.54e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 38.07  E-value: 5.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLA-------TTD---LLVSILVMPISIAYTTTrtwnFGQ 105
Cdd:cd15913    1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSfleicyvTSTvpnMLVNFLSETKTISFSGC----FLQ 76
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 550822198 106 ILCDIwvssdiTCCTASILHLCVIALDRYWAITDALEY 143
Cdd:cd15913   77 FYFFF------SLGTTECFFLSVMAFDRYLAICRPLHY 108
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
38-144 5.58e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 38.20  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  38 LVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTT---RTWNFGQILCDIWvSS 114
Cdd:cd15916    3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpggKVISFGGCVAQLY-FF 81
                         90       100       110
                 ....*....|....*....|....*....|
gi 550822198 115 DITCCTASILHlCVIALDRYWAITDALEYS 144
Cdd:cd15916   82 HFLGSTECFLY-TLMAYDRYLAICHPLHYP 110
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
269-362 5.59e-03

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 38.24  E-value: 5.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 269 LFFNQVKIKladSILERKRISAAR--ERKATKTLGIIL---GAFIICWLPFFVVSLV-----LPICRDSCWIHPALF--D 336
Cdd:cd15380  182 VFFNFHIIA---SLRERTEESRKRcgGLKDTKATRLILtlvLMFLVCWTPYHFFAFLdflfqVEVIQGCFWEEFIDLglQ 258
                         90       100
                 ....*....|....*....|....*.
gi 550822198 337 FFTWLGYLNSLINPVIYTVFNEDFRQ 362
Cdd:cd15380  259 LANFFAFANSCLNPVIYVFAGKLFRT 284
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
295-363 6.19e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 37.90  E-value: 6.19e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822198 295 KATKTLGIILGAFIICWLPFFVVSLVLPICRDscWIHPALF----DFFTWLGYLNSLINPVIYTVFNEDFRQA 363
Cdd:cd15404  194 RAFTTILILFIVFTVCWAPFTTYSLVATFNSH--FYHKHNFfeisTWLLWLCYLKSALNPLIYYWRIKKFRDA 264
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
35-144 7.22e-03

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 37.84  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  35 RISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMP--ISIAYTTTRTWNFGQILCDIWV 112
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPkiLADCISKDKSISFAGCAAQFFF 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 550822198 113 SSDIT---CCTasilhLCVIALDRYWAITDALEYS 144
Cdd:cd15418   81 SAGLAyseCFL-----LAAMAYDRYVAICNPLLYS 110
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
40-164 7.39e-03

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 37.81  E-value: 7.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  40 VVLSVITLATVLSNAFVLTTILLTKK-LHTPANYLIgSLATTDLLVsILVMPISIAYTTTrTWNFGQILCDIWVSSDITC 118
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTILLRRRRsRRTTENYLL-HLALADLLL-LLTFPFSVVESIA-GWVFGTFLCKLVGAIHKLN 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 550822198 119 CTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISI 164
Cdd:cd15181   82 FYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCF 127
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
36-141 7.76e-03

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 37.93  E-value: 7.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISI-AYTTTRTWNFGQILCDIWVSS 114
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLY-VCSLPLLIyNYTQKDYWPFGDFTCRLVRFQ 79
                         90       100
                 ....*....|....*....|....*..
gi 550822198 115 DITCCTASILHLCVIALDRYWAITDAL 141
Cdd:cd15379   80 FYTNLHGSILFLTCISVQRYLGICHPL 106
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
50-217 7.85e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 37.77  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  50 VLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVsILVMPISIAY-TTTRTWNFGQILCDIWVSSDITCCTASILHLCV 128
Cdd:cd15161   15 FPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYhLSGNHWPFGEVPCRLAGFLFYLNMYASLYFLAC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198 129 IALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLV----NTSQisYTIYSTCGAFY 204
Cdd:cd15161   94 ISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQlyreKASR--GALVSLAVAFT 171
                        170
                 ....*....|...
gi 550822198 205 IPSILLIILYGRI 217
Cdd:cd15161  172 IPFVTTVTCYLLI 184
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
36-137 9.10e-03

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 37.49  E-value: 9.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822198  36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLlVSILVMPISIAYTTTRTWNFGQILCDIWVSSD 115
Cdd:cd15166    1 IAALVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDL-IFILSLPFRMVYYAKDEWPFGDYFCRILGALT 79
                         90       100
                 ....*....|....*....|..
gi 550822198 116 ITCCTASILHLCVIALDRYWAI 137
Cdd:cd15166   80 VFYPSIALWLLAFISADRYMAI 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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