NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|510025446|ref|NP_001265344|]
View 

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2Fe-2S_thioredx pfam01257
Thioredoxin-like [2Fe-2S] ferredoxin;
1-112 1.56e-74

Thioredoxin-like [2Fe-2S] ferredoxin;


:

Pssm-ID: 460139  Cd Length: 145  Bit Score: 218.88  E-value: 1.56e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446    1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:pfam01257  34 IEYVAELLGIPPARVYEVATFYTMFSLKPVGKYHIQVCTGTPCHLRGSDEILEALEKKLGIKPGETTPDGKFTLEEVECL 113

                          90       100       110
                  ....*....|....*....|....*....|..
gi 510025446   81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:pfam01257 114 GACDNAPVMQINDDYYGDLTPEKVDEILEELK 145
 
Name Accession Description Interval E-value
2Fe-2S_thioredx pfam01257
Thioredoxin-like [2Fe-2S] ferredoxin;
1-112 1.56e-74

Thioredoxin-like [2Fe-2S] ferredoxin;


Pssm-ID: 460139  Cd Length: 145  Bit Score: 218.88  E-value: 1.56e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446    1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:pfam01257  34 IEYVAELLGIPPARVYEVATFYTMFSLKPVGKYHIQVCTGTPCHLRGSDEILEALEKKLGIKPGETTPDGKFTLEEVECL 113

                          90       100       110
                  ....*....|....*....|....*....|..
gi 510025446   81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:pfam01257 114 GACDNAPVMQINDDYYGDLTPEKVDEILEELK 145
PRK07539 PRK07539
NADH-quinone oxidoreductase subunit NuoE;
1-112 1.33e-69

NADH-quinone oxidoreductase subunit NuoE;


Pssm-ID: 181024  Cd Length: 154  Bit Score: 206.93  E-value: 1.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:PRK07539  43 IEAVADYLGMPAIDVEEVATFYSMIFRQPVGRHVIQVCTSTPCWLRGGEAILAALKKKLGIKPGETTADGRFTLLEVECL 122

                         90       100       110
                 ....*....|....*....|....*....|..
gi 510025446  81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:PRK07539 123 GACDNAPVVMINDDTYEDLTPEKIDELLDELK 154
NuoE COG1905
NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]; ...
 1-113 3.58e-69

NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 441509  Cd Length: 159  Bit Score: 205.76  E-value: 3.58e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:COG1905   47 IEEIAEALGLPPAEVYGVATFYSMFRLKPVGKHVIRVCTGTACHLRGAEELLEALEEKLGIKPGETTADGKFTLEEVECL 126

                         90       100       110
                 ....*....|....*....|....*....|...
gi 510025446  81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELKA 113
Cdd:COG1905  127 GACGLAPVMMVNDDVYGRLTPEKVDEILDELRA 159
nuoE_fam TIGR01958
NADH-quinone oxidoreductase, E subunit; This model describes the E chain of complexes that ...
 4-112 6.30e-61

NADH-quinone oxidoreductase, E subunit; This model describes the E chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoB. This model does not identify proteins from chloroplast and cyanobacteria. [Energy metabolism, Electron transport]


Pssm-ID: 131013  Cd Length: 148  Bit Score: 184.50  E-value: 6.30e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446    4 VAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGAC 83
Cdd:TIGR01958  40 VAEMLGIPPVWVYEVATFYSMFDTEPVGRYHLQVCTNVPCALRGSEALLKYLENKLGIKPGETTPDGRFTLVEVECLGAC 119

                          90       100
                  ....*....|....*....|....*....
gi 510025446   84 VNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:TIGR01958 120 GNAPVMMINDDYYEFLTPEKLDELLERYE 148
TRX_Fd_NuoE cd03064
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E ...
 32-111 7.41e-45

TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes. It is a multisubunit complex with at least 14 core subunits. It catalyzes the electron transfer of NADH to quinone coupled with the transfer of protons across the membrane, providing the proton motive force required for energy-consuming processes. Electrons are transferred from NADH to quinone through a chain of iron-sulfur clusters in Nuo, including the [2Fe-2S] cluster present in NuoE core subunit, also called the 24 kD subunit of Complex 1. This subfamily also include formate dehydrogenases, NiFe hydrogenases and NAD-reducing hydrogenases, that contain a NuoE domain. A subset of these proteins contain both NuoE and NuoF in a single chain. NuoF, also called the 51 kD subunit of Complex 1, contains one [4Fe-4S] cluster and also binds the NADH substrate and FMN.


Pssm-ID: 239362 [Multi-domain]  Cd Length: 80  Bit Score: 141.50  E-value: 7.41e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  32 KYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDEL 111
Cdd:cd03064    1 KHVIRVCTGTACHLRGAEALLEALEKKLGIKPGETTPDGRFTLEEVECLGACDLAPVMMINDDVYGRLTPEKVDAILEAL 80
 
Name Accession Description Interval E-value
2Fe-2S_thioredx pfam01257
Thioredoxin-like [2Fe-2S] ferredoxin;
1-112 1.56e-74

Thioredoxin-like [2Fe-2S] ferredoxin;


Pssm-ID: 460139  Cd Length: 145  Bit Score: 218.88  E-value: 1.56e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446    1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:pfam01257  34 IEYVAELLGIPPARVYEVATFYTMFSLKPVGKYHIQVCTGTPCHLRGSDEILEALEKKLGIKPGETTPDGKFTLEEVECL 113

                          90       100       110
                  ....*....|....*....|....*....|..
gi 510025446   81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:pfam01257 114 GACDNAPVMQINDDYYGDLTPEKVDEILEELK 145
PRK07539 PRK07539
NADH-quinone oxidoreductase subunit NuoE;
1-112 1.33e-69

NADH-quinone oxidoreductase subunit NuoE;


Pssm-ID: 181024  Cd Length: 154  Bit Score: 206.93  E-value: 1.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:PRK07539  43 IEAVADYLGMPAIDVEEVATFYSMIFRQPVGRHVIQVCTSTPCWLRGGEAILAALKKKLGIKPGETTADGRFTLLEVECL 122

                         90       100       110
                 ....*....|....*....|....*....|..
gi 510025446  81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:PRK07539 123 GACDNAPVVMINDDTYEDLTPEKIDELLDELK 154
NuoE COG1905
NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]; ...
 1-113 3.58e-69

NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 441509  Cd Length: 159  Bit Score: 205.76  E-value: 3.58e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:COG1905   47 IEEIAEALGLPPAEVYGVATFYSMFRLKPVGKHVIRVCTGTACHLRGAEELLEALEEKLGIKPGETTADGKFTLEEVECL 126

                         90       100       110
                 ....*....|....*....|....*....|...
gi 510025446  81 GACVNAPMVQINDNYYEDLTPKDIEEIIDELKA 113
Cdd:COG1905  127 GACGLAPVMMVNDDVYGRLTPEKVDEILDELRA 159
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
3-139 6.04e-61

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 192.71  E-value: 6.04e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   3 KVAEVLQVPPMRVYEVATFYTMYNRKPVG-KYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLG 81
Cdd:PRK12373  60 KVADMLDMAYIRVLEVATFYTQFQLQPVGtRAHIQVCGTTPCMLRGSEALMAVCKSKIHAHPHELNADGTLSWEEVECLG 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  82 ACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKVP--KPGPRSGRFCCEPAGGLTSLTE 139
Cdd:PRK12373 140 ACVNAPMVQIGKDYYEDLTPERLEEIIDAFAAGKGPvvKPGPQIGRYASEPAGGLTSLTE 199
nuoE_fam TIGR01958
NADH-quinone oxidoreductase, E subunit; This model describes the E chain of complexes that ...
 4-112 6.30e-61

NADH-quinone oxidoreductase, E subunit; This model describes the E chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoB. This model does not identify proteins from chloroplast and cyanobacteria. [Energy metabolism, Electron transport]


Pssm-ID: 131013  Cd Length: 148  Bit Score: 184.50  E-value: 6.30e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446    4 VAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGAC 83
Cdd:TIGR01958  40 VAEMLGIPPVWVYEVATFYSMFDTEPVGRYHLQVCTNVPCALRGSEALLKYLENKLGIKPGETTPDGRFTLVEVECLGAC 119

                          90       100
                  ....*....|....*....|....*....
gi 510025446   84 VNAPMVQINDNYYEDLTPKDIEEIIDELK 112
Cdd:TIGR01958 120 GNAPVMMINDDYYEFLTPEKLDELLERYE 148
TRX_Fd_NuoE cd03064
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E ...
 32-111 7.41e-45

TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes. It is a multisubunit complex with at least 14 core subunits. It catalyzes the electron transfer of NADH to quinone coupled with the transfer of protons across the membrane, providing the proton motive force required for energy-consuming processes. Electrons are transferred from NADH to quinone through a chain of iron-sulfur clusters in Nuo, including the [2Fe-2S] cluster present in NuoE core subunit, also called the 24 kD subunit of Complex 1. This subfamily also include formate dehydrogenases, NiFe hydrogenases and NAD-reducing hydrogenases, that contain a NuoE domain. A subset of these proteins contain both NuoE and NuoF in a single chain. NuoF, also called the 51 kD subunit of Complex 1, contains one [4Fe-4S] cluster and also binds the NADH substrate and FMN.


Pssm-ID: 239362 [Multi-domain]  Cd Length: 80  Bit Score: 141.50  E-value: 7.41e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  32 KYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDEL 111
Cdd:cd03064    1 KHVIRVCTGTACHLRGAEALLEALEKKLGIKPGETTPDGRFTLEEVECLGACDLAPVMMINDDVYGRLTPEKVDAILEAL 80
PRK07571 PRK07571
bidirectional hydrogenase complex protein HoxE; Reviewed
 1-89 1.39e-28

bidirectional hydrogenase complex protein HoxE; Reviewed


Pssm-ID: 236053  Cd Length: 169  Bit Score: 103.29  E-value: 1.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   1 MNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECL 80
Cdd:PRK07571  57 LLYVARQLKLPLSRVYGVATFYHLFSLKPSGEHTCVVCTGTACYVKGSAAILEDLENELGIKAGETTADGKLSLLTARCL 136


                 ....*....
gi 510025446  81 GACVNAPMV 89
Cdd:PRK07571 137 GACGIAPAV 145
TRX_Fd_family cd02980
Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX ...
 33-111 6.45e-28

Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:ubiquinone oxidoreductase (NuoE). TRX-like Fds are soluble low-potential electron carriers containing a single [2Fe-2S] cluster. The exact role of TRX-like Fd is still unclear. It has been suggested that it may be involved in nitrogen fixation. Its homologous domains in large redox enzymes (such as Nuo and hydrogenases) function as electron carriers.


Pssm-ID: 239278 [Multi-domain]  Cd Length: 77  Bit Score: 98.47  E-value: 6.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  33 YHIQVCTTTPCMLRDSDSILETLQRKLGIKVGettpDKLFTLIEVECLGACVNAPMVQIN--DNYYEDLTPKDIEEIIDE 110
Cdd:cd02980    1 HHILVCTGTACGLRGAEELLEALEKELGIRGG----DGRVTVERVGCLGACGLAPVVVVYpdGVWYGRVTPEDVEEIVEE 76


                 .
gi 510025446 111 L 111
Cdd:cd02980   77 L 77
PRK05988 PRK05988
formate dehydrogenase subunit gamma; Validated
 4-113 1.22e-19

formate dehydrogenase subunit gamma; Validated


Pssm-ID: 180339  Cd Length: 156  Bit Score: 79.62  E-value: 1.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446   4 VAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGAC 83
Cdd:PRK05988  47 IAEALNLSRAEVHGVITFYHDFRTHPPGRHVLKLCRAEACQAMGGDALAAHAKARLGIDFHQTTADGAVTLEPVYCLGLC 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 510025446  84 VNAPMVQINDNYYEDLTPKDIEEIIDELKA 113
Cdd:PRK05988 127 ACSPAAMLDGEVHGRLDPQRLDALLAEARR 156
TRX_Fd_NuoE_FDH_gamma cd03081
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E ...
 32-111 3.04e-15

TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of formate to carbon dioxide accompanied by the reduction of NAD+ to NADH. FDH is a heteromeric enzyme composed of four nonidentical subunits (alpha, beta, gamma and delta). The FDH gamma subunit is closely related to NuoE, which is part of a multisubunit complex (Nuo) catalyzing the electron transfer of NADH to quinone coupled with the transfer of protons across the membrane. Electrons are transferred from NADH to quinone through a chain of iron-sulfur clusters in Nuo, including the [2Fe-2S] cluster present in NuoE. Similarly, the FDH gamma subunit is hypothesized to be involved in an electron transport chain involving other FDH subunits, upon the oxidation of formate.


Pssm-ID: 239379  Cd Length: 80  Bit Score: 66.25  E-value: 3.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  32 KYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDEL 111
Cdd:cd03081    1 RHVLKLCRAEACQAMGAEALAAHIKARLGIDFHETTADGSVTLEPVYCLGLCACSPAAMIDGEVHGRVDPEKFDALLAEL 80
TRX_Fd_NuoE_hoxF cd03083
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E ...
 32-111 7.08e-10

TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, hoxF; composed of proteins similar to the NAD-reducing hydrogenase (hoxS) alpha subunit of Alcaligenes eutrophus H16. HoxS is a cytoplasmic hydrogenase catalyzing the oxidation of molecular hydrogen accompanied by the reduction of NAD. It is composed of four structural subunits encoded by the genes hoxF, hoxU, hoxY and hoxH. The hoxF protein (or alpha subunit) is a fusion protein containing an N-terminal NuoE-like domain and a C-terminal NuoF domain. NuoE and NuoF are components of Nuo, a multisubunit complex catalyzing the electron transfer of NADH to quinone coupled with the transfer of protons across the membrane. Electrons are transferred from NADH to quinone through a chain of iron-sulfur clusters in Nuo, including the [2Fe-2S] cluster in NuoE and the [4Fe-4S] cluster in NuoF. In addition, NuoF is also the NADH- and FMN-binding subunit. HoxF may be involved in the electron transport chain during the NAD-dependent oxidation of hydrogen through its NuoF domain. The NuoE-like domain of hoxF contains only one conserved cysteine in its putative active site, compared to four cysteines in NuoE, and may have lost the ability to bind [2Fe-2S] clusters.


Pssm-ID: 239381  Cd Length: 80  Bit Score: 52.41  E-value: 7.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  32 KYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDEL 111
Cdd:cd03083    1 KYRIYLSDSITDRMNGYKAVLDALCRELGIRFGEVDEDGMVGLFFTSCTGLCDQGPALLINNRVFTRLTPGRIDQIAELI 80
COG3411 COG3411
2Fe-2S ferredoxin [Energy production and conversion]; 2Fe-2S ferredoxin is part of the Pathway ...
 32-116 4.54e-09

2Fe-2S ferredoxin [Energy production and conversion]; 2Fe-2S ferredoxin is part of the Pathway/BioSystem: 2Fe2S


Pssm-ID: 442637  Cd Length: 96  Bit Score: 50.66  E-value: 4.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510025446  32 KYHIQVCTTTpCMLRDSDSILETLQ---RKLGIKVGettpdklFTLIEVECLGACVNAPMVQI--NDNYYEDLTPKDIEE 106
Cdd:COG3411    5 RHHVLVCTGS-CGAAGAEEVLDALKeelKERGLDGD-------VRVTKTGCLGRCEQGPVVVVypEGVWYGNVTPEDVPE 76

                         90
                 ....*....|.
gi 510025446 107 IIDE-LKAGKV 116
Cdd:COG3411   77 IVEEhLLGGRP 87
TRX_Fd_NuoE_W_FDH_beta cd03082
TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E ...
 35-109 7.89e-03

TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH is a heterodimeric NAD-dependent enzyme catalyzing the conversion of formate to carbon dioxide. The beta subunit is a fusion protein containing an N-terminal NuoE domain and a C-terminal NuoF domain. NuoE and NuoF are components of Nuo, a multisubunit complex catalyzing the electron transfer of NADH to quinone coupled with the transfer of protons across the membrane. Electrons are transferred from NADH to quinone through a chain of iron-sulfur clusters in Nuo, including the [2Fe-2S] cluster in NuoE and the [4Fe-4S] cluster in NuoF. In addition, NuoF is also the NADH- and FMN-binding subunit. Similarly, the beta subunit of W-FDH is most likely involved in the electron transport chain during the NAD-dependent oxidation of formate.


Pssm-ID: 239380 [Multi-domain]  Cd Length: 72  Bit Score: 33.53  E-value: 7.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 510025446  35 IQVCTTTPCMLRDSDSILETLQRKLG---IKVgettpdklftlIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIID 109
Cdd:cd03082    4 VRVCDSLSCAMAGAEELLAALEAGLGpegVRV-----------VRAPCVGRCERAPAALVGQRPVDGATPAAVAAAVE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH