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Conserved domains on  [gi|459642365|ref|NP_001264044|]
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dynein axonemal heavy chain 11 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
 1855-2181 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


:

Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 627.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320


                   ....*..
gi 459642365  2175 NAGTGKS 2181
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
 240-812 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


:

Pssm-ID: 462457  Cd Length: 560  Bit Score: 626.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385  233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385  311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385  387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385  466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544

                          570
                   ....*....|....*.
gi 459642365   798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385  545 PGLTTLTWNSLgIDEY 560
MT super family cl37598
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 3097-3441 1.07e-169

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


The actual alignment was detected with superfamily member pfam12777:

Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 526.95  E-value: 1.07e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777    1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777   81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777  161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777  240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319

                          330       340
                   ....*....|....*....|....*
gi 459642365  3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777  320 FISYLGFFTKKYRNELLDKFWIPYI 344
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
 1316-1721 2.04e-153

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


:

Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 482.91  E-value: 2.04e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394


                   ....*...
gi 459642365  1714 VRHSITEA 1721
Cdd:pfam08393  395 LRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
 4219-4514 8.11e-120

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 381.97  E-value: 8.11e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365  4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1543-4166 2.38e-111

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 401.29  E-value: 2.38e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245   706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245   769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245   845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245   924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245   992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245  1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245  1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245  1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245  1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245  1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245  1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245  1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245  1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245  1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245  1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245  1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245  1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245  1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245  1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245  2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245  2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245  2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245  2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245  2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245  2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532

                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245  2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611

                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245  2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691

                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245  2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760

                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245  2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827

                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245  2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888

                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245  2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951

                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245  2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025

                        2650      2660      2670      2680      2690      2700      2710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245  3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
 1855-2181 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 627.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320


                   ....*..
gi 459642365  2175 NAGTGKS 2181
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
 240-812 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 626.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385  233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385  311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385  387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385  466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544

                          570
                   ....*....|....*.
gi 459642365   798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385  545 PGLTTLTWNSLgIDEY 560
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 3097-3441 1.07e-169

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 526.95  E-value: 1.07e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777    1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777   81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777  161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777  240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319

                          330       340
                   ....*....|....*....|....*
gi 459642365  3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777  320 FISYLGFFTKKYRNELLDKFWIPYI 344
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
 1316-1721 2.04e-153

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 482.91  E-value: 2.04e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394


                   ....*...
gi 459642365  1714 VRHSITEA 1721
Cdd:pfam08393  395 LRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
 4219-4514 8.11e-120

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 381.97  E-value: 8.11e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365  4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1543-4166 2.38e-111

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 401.29  E-value: 2.38e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245   706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245   769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245   845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245   924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245   992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245  1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245  1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245  1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245  1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245  1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245  1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245  1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245  1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245  1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245  1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245  1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245  1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245  1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245  1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245  2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245  2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245  2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245  2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245  2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245  2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532

                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245  2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611

                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245  2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691

                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245  2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760

                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245  2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827

                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245  2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888

                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245  2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951

                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245  2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025

                        2650      2660      2670      2680      2690      2700      2710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245  3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
 3466-3684 2.80e-108

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 345.20  E-value: 2.80e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3466 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3544
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3545 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3622
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459642365  3623 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3684
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3312-3407 1.49e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3312 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3391
Cdd:COG4372    60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139

                          90
                  ....*....|....*.
gi 459642365 3392 RWGQSIKSFEAQEKTL 3407
Cdd:COG4372   140 ELQSEIAEREEELKEL 155
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 3104-3198 7.16e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 42.02  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3104 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3179
Cdd:TIGR04320  247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326

                           90
                   ....*....|....*....
gi 459642365  3180 LLKAEPALVAATAALNTLN 3198
Cdd:TIGR04320  327 LANAEARLAKAKEALANLN 345
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
 1855-2181 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 627.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320


                   ....*..
gi 459642365  2175 NAGTGKS 2181
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
 240-812 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 626.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385  233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385  311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385  387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365   718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385  466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544

                          570
                   ....*....|....*.
gi 459642365   798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385  545 PGLTTLTWNSLgIDEY 560
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 3097-3441 1.07e-169

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 526.95  E-value: 1.07e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777    1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777   81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777  161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777  240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319

                          330       340
                   ....*....|....*....|....*
gi 459642365  3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777  320 FISYLGFFTKKYRNELLDKFWIPYI 344
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
 1316-1721 2.04e-153

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 482.91  E-value: 2.04e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394


                   ....*...
gi 459642365  1714 VRHSITEA 1721
Cdd:pfam08393  395 LRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
 4219-4514 8.11e-120

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 381.97  E-value: 8.11e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365  4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1543-4166 2.38e-111

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 401.29  E-value: 2.38e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245   706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245   769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245   845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245   924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245   992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245  1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245  1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245  1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245  1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245  1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245  1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245  1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245  1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245  1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245  1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245  1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245  1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245  1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245  1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245  2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245  2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245  2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245  2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245  2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245  2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532

                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245  2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611

                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245  2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691

                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245  2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760

                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245  2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827

                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245  2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888

                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245  2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951

                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245  2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025

                        2650      2660      2670      2680      2690      2700      2710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245  3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
 3466-3684 2.80e-108

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 345.20  E-value: 2.80e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3466 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3544
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3545 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3622
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459642365  3623 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3684
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
 2825-3084 1.38e-105

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 339.20  E-value: 1.38e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2825 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 2904
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2905 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 2984
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2985 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 3064
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239

                          250       260
                   ....*....|....*....|
gi 459642365  3065 RHNYTTPKSFLEQISLFKNL 3084
Cdd:pfam12780  240 RKNYVTPKSYLELLRLYKNL 259
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 2474-2649 1.00e-89

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 290.45  E-value: 1.00e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2474 DPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLS-EDYIVSRVPFNYYTTSTALQKILE 2552
Cdd:pfam12775    2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2553 KPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGS-F 2631
Cdd:pfam12775   82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161

                          170
                   ....*....|....*...
gi 459642365  2632 TINPRLQRHFTVFAFNFP 2649
Cdd:pfam12775  162 DITPRLLRHFNVFNITFP 179
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
 4077-4213 6.87e-66

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 220.40  E-value: 6.87e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  4077 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS-KVPWEDLRYLFGEIMYGGHITDDWDRK 4155
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 459642365  4156 LCRVYLEEFMNPSLTEDELMLAPG-FAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNA 4213
Cdd:pfam18198   81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
 3924-4045 2.91e-49

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 171.86  E-value: 2.91e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3924 SPATPIFFILSPGVDALKDLEILGKRLGFTidsGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEK 4003
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 459642365  4004 LLERF-SQGSHRDYRVFMSAEsaPTPDehiIPQGLLENSIKIT 4045
Cdd:pfam03028   78 ILEELpEETLHPDFRLWLTSE--PSPK---FPISILQNSIKIT 115
AAA_lid_1 pfam17857
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
 2682-2779 2.28e-37

AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.


Pssm-ID: 465535 [Multi-domain]  Cd Length: 100  Bit Score: 137.37  E-value: 2.28e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2682 LIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQR 2761
Cdd:pfam17857    1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80

                           90
                   ....*....|....*...
gi 459642365  2762 RMLETAYKYFEGIDSHML 2779
Cdd:pfam17857   81 IQMASLKKFFDDIEDELE 98
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
 2349-2466 6.81e-30

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 117.00  E-value: 6.81e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2349 LFDKYVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTP-------ENVPSDSPKEVYEVYFVFACIWAFGGTLLQD 2421
Cdd:pfam17852    4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 459642365  2422 QisdyQADFSRWWQKEMKAVKFP--SQGTIFDYYVDHKTKKLLPWAD 2466
Cdd:pfam17852   84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 2169-2313 5.30e-10

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 60.38  E-value: 5.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2169 SVFVVGNAGTGKSKILRTLNRTYVNmkqKPVWNDLNPKAVTTDELFGFIHHATR--EWKDGKIVYSyfiglfssiLREqa 2246
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSN---RPVFYVQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRA---------ARE-- 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459642365  2247 nlkhdgpKWIVLDGDID---PMWIESLNTVMDDNKVLTLASNERI-ALTPFMRLLFEIHHLR----SATPATVSR 2313
Cdd:pfam07728   67 -------GEIAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVkAAPDGFRLIATMNPLDrglnELSPALRSR 134
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 2505-2641 3.84e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 49.21  E-value: 3.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  2505 PLMLVGNAGVGKTvFVGDTLASLSEDYIVSRVPFNYYTTSTALQKILEkPLEKKAGHNYGP---GGNKKLIYFIDDMNMP 2581
Cdd:pfam07728    1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459642365  2582 EVDLYGTVqpHTLI---RQHIDYGHWydrqkVMLKEIHNCQYVACMNP-MVGSFTINPRLQRHF 2641
Cdd:pfam07728   79 NPDVLNSL--LSLLderRLLLPDGGE-----LVKAAPDGFRLIATMNPlDRGLNELSPALRSRF 135
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1893-2013 2.29e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.21  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  1893 GPAGTGKTETTKDLGRAL-GMMVYVFNCSEQM---DYKSIGNIYKGL-----------VQTGAWGCFDEFNRISVEVLSV 1957
Cdd:pfam07728    6 GPPGTGKTELAERLAAALsNRPVFYVQLTRDTteeDLFGRRNIDPGGaswvdgplvraAREGEIAVLDEINRANPDVLNS 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 459642365  1958 VavqvkmiHDAIRNRKKRFVFLGEAITLKP-SVGIFITMNPGYAGRTELPENLKALF 2013
Cdd:pfam07728   86 L-------LSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRGLNELSPALRSRF 135
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 3323-3387 8.51e-04

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 42.47  E-value: 8.51e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459642365  3323 ANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELE 3387
Cdd:pfam06009    1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3312-3407 1.49e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3312 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3391
Cdd:COG4372    60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139

                          90
                  ....*....|....*.
gi 459642365 3392 RWGQSIKSFEAQEKTL 3407
Cdd:COG4372   140 ELQSEIAEREEELKEL 155
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 3319-3389 2.51e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 2.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365 3319 ALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAK 3389
Cdd:COG3883    10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3317-3407 2.83e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3317 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3396
Cdd:COG4372    51 REELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130

                          90
                  ....*....|.
gi 459642365 3397 IKSFEAQEKTL 3407
Cdd:COG4372   131 RKQLEAQIAEL 141
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3317-3407 5.90e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3317 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3396
Cdd:COG4372    79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158

                          90
                  ....*....|.
gi 459642365 3397 IKSFEAQEKTL 3407
Cdd:COG4372   159 LESLQEELAAL 169
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 3104-3198 7.16e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 42.02  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365  3104 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3179
Cdd:TIGR04320  247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326

                           90
                   ....*....|....*....
gi 459642365  3180 LLKAEPALVAATAALNTLN 3198
Cdd:TIGR04320  327 LANAEARLAKAKEALANLN 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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