BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292   81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292   81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014  135 NLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpewNECSKHVIELHEEACCSAVFPQFIKYLYVGQIeVTLQ 214
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSG---QESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*...
gi 442616014  215 TVMPMLALSDKYNIRDLIDLCVDYMNKH 242
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKS 106

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014   258 YTLSFTPTHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQmeatgsgg 337
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEK-------- 76

                           90       100
                   ....*....|....*....|..
gi 442616014   338 FMELIEQTVSHIRFGMMTPRQL 359
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYL 98

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014  260 LSFTPTHN--DLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEatgsgg 337
Cdd:pfam07707   5 YRFADAYGctELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRK------ 78

                          90       100
                  ....*....|....*....|....*.
gi 442616014  338 fmELIEQTVSHIRFGMMTPRQLSHLL 363
Cdd:pfam07707  79 --KHLPELLSAVRLPLLSPQYLLNLV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLY 205
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVFEKFLRYLY 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18292   81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 142 MSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIKYLYVGQIEVTLQTVMPMLA 221
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSS-GMKESSSSEIELDD--VSPEAFEALLDYIYTGELELSEENVEELLA 77

                 ....*
gi 442616014 222 LSDKY 226
Cdd:cd18186   78 AADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 133 IANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVML---MnpewNECSKHVIELHEEAccSAVFPQFIKYLYVGQI 209
Cdd:cd18287   13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggM----RESQQSEIELKDTN--AEAFKALLKYIYTGRL 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 442616014 210 EVTL---QTVMPMLALSDKYNIRDLIDLCVDY 238
Cdd:cd18287   87 TLTDlkeDVLLDVLGLAHQYGFEELEAAISDY 118

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLMnPEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18314    7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLT-GSMIESNLKEVTLEDVE--PEIFETVLKYMYTGQVTLSEENVLDLLML 83

                         90
                 ....*....|...
gi 442616014 223 SDKYNIRDLIDLC 235
Cdd:cd18314   84 ASKYQVPDLEKLC 96

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014   258 YTLSFTPTHNDLTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQmeatgsgg 337
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEK-------- 76

                           90       100
                   ....*....|....*....|..
gi 442616014   338 FMELIEQTVSHIRFGMMTPRQL 359
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 135 NLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQ 214
Cdd:cd18237   14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS-NMTESKSSEVELKDAE--PDIIELLVEFAYTARISVNSN 90

                         90       100
                 ....*....|....*....|....*....
gi 442616014 215 TVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18237   91 NVQSLLDAANQYQIEPVKKMCVDFLKEQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVielHEEACCSAVFPQFIKYLY 205
Cdd:cd18270   10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV---HLRNVDAATLQIIITYAY 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18270   87 TGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 136 LYAEQLMSDIVLLV--DGKEFPAHRVILCASSDVFQVMLMNPEW--NECSKHVIELHEEAccsaVFPQFIKYLYVGQIEV 211
Cdd:cd18294    8 LINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQkeSTQSPLVLSDIEPE----VFRAVLEFIYTNCVTL 83

                         90       100
                 ....*....|....*....|....*...
gi 442616014 212 TLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18294   84 SNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 143 SDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMPMLAL 222
Cdd:cd18265   24 TDVVLLVDGKDFPCHRATLSANSAYFRAMF-GGHLKESRQAVVEIQKVS--AAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                         90
                 ....*....|....*..
gi 442616014 223 SDKYNIRDLIDLCVDYM 239
Cdd:cd18265  101 SDLLQVSKLREACVRFL 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 131 NKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPeWNECSKHVIELHEEACcsAVFPQFIKYLYVGQIE 210
Cdd:cd18286    6 KDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGS-WAESNSSEITLTGVSH--AAVSFVLLFIYGGVLD 82

                         90       100
                 ....*....|....*....|....*
gi 442616014 211 VTL-QTVMPMLALSDKYNIRDLIDL 234
Cdd:cd18286   83 LPDdVNLGELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18250    5 ALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAG-ELRESRADRVVLHGVS--AEILGLLLDFSY 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18250   82 TGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLmNPEWNECSKHVIELHEEAccSAVFPQFIKYLY 205
Cdd:cd18256    4 ASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQIHGVE--PDIFHILLDFIY 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 129 VLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEwNECSKHVIELHeeACCSAVFPQFIKYLYVGQ 208
Cdd:cd18264   15 VLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYT-QESKARVIHLP--VVSAAGLQRVLDFIYTSW 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 442616014 209 IEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18264   92 LSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 136 LYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKhviELHEEACCSAVFPQFIKYLYVGQIEVTLQT 215
Cdd:cd18269   21 LLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKK---EVVLEDVDPDVMGMILKYLYTSEIDLNDQN 97

                         90       100
                 ....*....|....*....|....*....
gi 442616014 216 VMPMLALSDKYNIRDLIDLCVDYMNKHVA 244
Cdd:cd18269   98 VQDIFALASRFQIPSIFTVCVSYLQKRLS 126

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 133 IANLYAEQLMSDIVLLVDGKE-FPAHRVILCASSDVFQVMLMnpewNECskhVIELHEEACCSAvFPQFIKYLYVGQIEV 211
Cdd:cd18299    3 LRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFL----MMT---VVTLDSDITPEA-FRRVLEFLYTGVLDE 74

                         90       100
                 ....*....|....*....|....*....
gi 442616014 212 TLQTVMPMLALSDKYNIRDLIDLCVDYMN 240
Cdd:cd18299   75 NEDDLKELKDAAELLELFDLVMMCTNVLN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheeaccSAVFPQ----FI 201
Cdd:cd18253    2 SESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCN-DHRESREMLVEI------NGILAEamdcFL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442616014 202 KYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNK 241
Cdd:cd18253   75 QYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 140 QLMSDIVLLVDGK----EFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELheEACCSAVFPQFIKYLYVGQIEVTLQT 215
Cdd:cd18248   19 QQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTS-GLRECGMEVVPI--EGVHPCVMSRLIEFAYTASISVGEKC 95

                         90       100
                 ....*....|....*....|....
gi 442616014 216 VMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18248   96 VLHVLPGAVMYQMDSVVKACCDFL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEACcsAVFPQFIKYLYVGQIEVT-LQTVM 217
Cdd:cd18300    6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGG-NFRESSAKEVELPGVSK--ETFLALLEYLYTDQAPILeDGDCV 82

                         90       100
                 ....*....|....*....|....*.
gi 442616014 218 PMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18300   83 GLIVLANRLCLPRLVALCEQYIVKEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 139 EQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEEAccSAVFPQFIKYLYVGQIEVTLQTVMP 218
Cdd:cd18272   29 DGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTS-NLKEARNRVIELKDVS--ESVFQLLVDYIYHGTVKLRVEELQE 105

                         90       100
                 ....*....|....*....|....*
gi 442616014 219 MLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18272  106 TYEVADMYQLTALFEECSRFLARTV 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 126 ANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIElheeacCSAVFPQFIKYLY 205
Cdd:cd18222    9 SNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIK------NPTVFEQLLSFCY 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 442616014 206 VGQIEVTLQTVMPMLALSDKYNIRDLIDLC 235
Cdd:cd18222   83 TGRICLQLADIISYLTAASFLQMQHIIDKC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 128 SVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVM----LMnpewnECSKHVIELHEEACCSAVFpqFIKY 203
Cdd:cd18276    7 TLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMftcgLM-----ECSQREVVLHDITAESVSI--ILNY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442616014 204 LYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHV 243
Cdd:cd18276   80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 123 MIDANSVLNKianLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVFQVMLMNpEWNECSKHVIELHEeaCCSAVFPQFIK 202
Cdd:cd18235    5 TQKAFDVMNE---LRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTG-DLSESRANRVTLQD--VDGKALLLLID 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 442616014 203 YLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
Cdd:cd18235   79 YVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616014 142 MSDIVLL-VDGKEFPAHRVILCASSDVFQVMLMN--PEWNECSKHVIELHeeaccSAVFPQFIKYLYVGQIEVTLQT--- 215
Cdd:cd18302    5 LYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSswIEASSCSALTMPIP-----SDILEIILDYLYTDEASAVKESqnv 79

                         90       100
                 ....*....|....*....|..
gi 442616014 216 --VMPMLALSDKYNIRDLIDLC 235
Cdd:cd18302   80 efLCNVLVIADQLLITRLKEIC 101