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Conserved domains on  [gi|427918099|ref|NP_001258790|]
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beta-adducin isoform 2 [Mus musculus]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 130-379 5.78e-72

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 230.51  E-value: 5.78e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVekGSSCFPVDTTGF 209
Cdd:PRK07044  14 EWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVV--DDSPYPVNPAGF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 210 SLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLV-GDMAYYDFNGEMEQEADRINLQKCLGPtCKILVLR 288
Cdd:PRK07044  92 TIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 289 NHGMVALGDTVEEAFYKVFHLQAACEVQVSALSsaGGTENLILleqekhrPHEVGSVQWAGSTFGPMQKSrlGEHEFEAL 368
Cdd:PRK07044 171 NHGLLTVGRTVAEAFLLMYTLERACEIQVAAQA--GGGELVLP-------PPEVAERTARQSLFDPGAGA--GELAWPAL 239

                        250
                 ....*....|...
gi 427918099 369 MRMLD--NLGYRT 379
Cdd:PRK07044 240 LRKLDriDPGYRD 252
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 130-379 5.78e-72

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 230.51  E-value: 5.78e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVekGSSCFPVDTTGF 209
Cdd:PRK07044  14 EWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVV--DDSPYPVNPAGF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 210 SLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLV-GDMAYYDFNGEMEQEADRINLQKCLGPtCKILVLR 288
Cdd:PRK07044  92 TIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 289 NHGMVALGDTVEEAFYKVFHLQAACEVQVSALSsaGGTENLILleqekhrPHEVGSVQWAGSTFGPMQKSrlGEHEFEAL 368
Cdd:PRK07044 171 NHGLLTVGRTVAEAFLLMYTLERACEIQVAAQA--GGGELVLP-------PPEVAERTARQSLFDPGAGA--GELAWPAL 239

                        250
                 ....*....|...
gi 427918099 369 MRMLD--NLGYRT 379
Cdd:PRK07044 240 LRKLDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 130-340 1.52e-70

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 225.32  E-value: 1.52e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRcKISSVYRLLDLYGWaqlsDTYVTLRVSKEQD---HFLISPKGVSCSEVTASSLIKVNILGEVVE--KGSSCFPv 204
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGW----VTGTGGNVSARDRdrgYFLITPSGVDYEEMTASDLVVVDAQGKVVEgkKPSSETP- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 205 dttgfsLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLV---GDMAYYDFNGEMeQEADRINLQKCLG-P 280
Cdd:cd00398   75 ------LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfP 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 427918099 281 TCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAGG--TENLILLEQEKHRPH 340
Cdd:cd00398  148 NSKAVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 135-317 5.80e-51

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 172.73  E-value: 5.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099  135 CKISSVYRLLDLYGWAQLSDTYVTLRVskEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKG---SSCFPvdttgfsL 211
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGGlkpSSETP-------L 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099  212 HSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNA--LLVGDMAYYDfNGEMEQEADRINLQKCLGPTCKILVLRN 289
Cdd:pfam00596  72 HLAIYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAadFLGGDIPIIP-YYTPGTEELGERIAEALGGDRKAVLLRN 150

                         170       180
                  ....*....|....*....|....*...
gi 427918099  290 HGMVALGDTVEEAFYKVFHLQAACEVQV 317
Cdd:pfam00596 151 HGLLVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 137-317 1.04e-46

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 161.65  E-value: 1.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099   137 ISSVYRLLDLYGWAQLSDTYVTLRVsKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscFPVDTTGFSLHSAIY 216
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGG--GPKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099   217 AARPDVRCAIHLHTPATAAVSAM--KCGLLPVSHNALLVG-DMAYYDFNGEMEQEADRI-NLQKCLGPT---CKILVLRN 289
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 427918099   290 HGMVALGDTVEEAFYKVFHLQAACEVQV 317
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 130-338 2.91e-45

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 158.45  E-value: 2.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVskEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscfpVDTTGF 209
Cdd:COG0235    3 EEELREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGDL----KPSSET 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 210 SLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHN--ALLVGDMAYYDFNG-EMEQEADRInlQKCLGpTCKILV 286
Cdd:COG0235   77 PLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGpGTEELAEAI--AEALG-DRPAVL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 427918099 287 LRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALsSAGGTENLILLEQEKHR 338
Cdd:COG0235  154 LRNHGVVVWGKDLAEAFDRAEVLEEAARIQLLAL-ALGGPLVLSDEEIDKLA 204
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 130-379 5.78e-72

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 230.51  E-value: 5.78e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVekGSSCFPVDTTGF 209
Cdd:PRK07044  14 EWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVV--DDSPYPVNPAGF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 210 SLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLV-GDMAYYDFNGEMEQEADRINLQKCLGPtCKILVLR 288
Cdd:PRK07044  92 TIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 289 NHGMVALGDTVEEAFYKVFHLQAACEVQVSALSsaGGTENLILleqekhrPHEVGSVQWAGSTFGPMQKSrlGEHEFEAL 368
Cdd:PRK07044 171 NHGLLTVGRTVAEAFLLMYTLERACEIQVAAQA--GGGELVLP-------PPEVAERTARQSLFDPGAGA--GELAWPAL 239

                        250
                 ....*....|...
gi 427918099 369 MRMLD--NLGYRT 379
Cdd:PRK07044 240 LRKLDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 130-340 1.52e-70

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 225.32  E-value: 1.52e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRcKISSVYRLLDLYGWaqlsDTYVTLRVSKEQD---HFLISPKGVSCSEVTASSLIKVNILGEVVE--KGSSCFPv 204
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGW----VTGTGGNVSARDRdrgYFLITPSGVDYEEMTASDLVVVDAQGKVVEgkKPSSETP- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 205 dttgfsLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLV---GDMAYYDFNGEMeQEADRINLQKCLG-P 280
Cdd:cd00398   75 ------LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfP 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 427918099 281 TCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAGG--TENLILLEQEKHRPH 340
Cdd:cd00398  148 NSKAVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 135-317 5.80e-51

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 172.73  E-value: 5.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099  135 CKISSVYRLLDLYGWAQLSDTYVTLRVskEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKG---SSCFPvdttgfsL 211
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGGlkpSSETP-------L 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099  212 HSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNA--LLVGDMAYYDfNGEMEQEADRINLQKCLGPTCKILVLRN 289
Cdd:pfam00596  72 HLAIYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAadFLGGDIPIIP-YYTPGTEELGERIAEALGGDRKAVLLRN 150

                         170       180
                  ....*....|....*....|....*...
gi 427918099  290 HGMVALGDTVEEAFYKVFHLQAACEVQV 317
Cdd:pfam00596 151 HGLLVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 137-317 1.04e-46

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 161.65  E-value: 1.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099   137 ISSVYRLLDLYGWAQLSDTYVTLRVsKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscFPVDTTGFSLHSAIY 216
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGG--GPKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099   217 AARPDVRCAIHLHTPATAAVSAM--KCGLLPVSHNALLVG-DMAYYDFNGEMEQEADRI-NLQKCLGPT---CKILVLRN 289
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 427918099   290 HGMVALGDTVEEAFYKVFHLQAACEVQV 317
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 130-338 2.91e-45

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 158.45  E-value: 2.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVskEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscfpVDTTGF 209
Cdd:COG0235    3 EEELREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGDL----KPSSET 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 210 SLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHN--ALLVGDMAYYDFNG-EMEQEADRInlQKCLGpTCKILV 286
Cdd:COG0235   77 PLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGpGTEELAEAI--AEALG-DRPAVL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 427918099 287 LRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALsSAGGTENLILLEQEKHR 338
Cdd:COG0235  154 LRNHGVVVWGKDLAEAFDRAEVLEEAARIQLLAL-ALGGPLVLSDEEIDKLA 204
PRK06661 PRK06661
hypothetical protein; Provisional
 141-374 1.41e-37

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 138.81  E-value: 1.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 141 YRLLDLYGWAQLSDTYVTLRvSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscFPVDTTGFSLHSAIYAARP 220
Cdd:PRK06661  11 YRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILEGEE--YQYNKTGYFIHGSIYKTRP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 221 DVRCAIHLHTPATAAVSAMKCGLLPVSHNAL-LVGDMAYYDFNG---EMEQEADRinLQKCLGPTcKILVLRNHGMVALG 296
Cdd:PRK06661  88 DISAIFHYHTPASIAVSALKCGLLPISQWALhFYDRISYHNYNSlalDADKQSSR--LVNDLKQN-YVMLLRNHGAITCG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 297 DTVEEAFYKVFHLQAACEVQVSALSSAggtenlillEQEKHRPhevgSVQWAGSTFGPMQ--KSRLGEHEFEALMRMLDN 374
Cdd:PRK06661 165 KTIHEAMFYTYHLEQACKTQCLLNSTK---------KQELIIP----SVEICKKTVKDLLsfEEDLGKRDWAAWLRLIKM 231
PRK06208 PRK06208
class II aldolase/adducin family protein;
86-354 2.51e-29

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 117.01  E-value: 2.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099  86 ALRQIADFMASTSHAVFPASSMNFSMMTPINDlhtadslnlAKGERLMR-CKISSVYRLLDLYGWAQLSDTYVTLRVSKE 164
Cdd:PRK06208   4 VLSRAADTAAALSIPQPPREGLWFPRPPPFAT---------VAEERLHRkQRLAAAFRLFARFGFDEGLAGHITARDPEL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 165 QDHFLISPKGVSCSEVTASSLIKVNILGEVVEkGSscFPVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLL 244
Cdd:PRK06208  75 PDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE-GD--RPLNRAAFAIHSAIHEARPDVVAAAHTHSTYGKAWSTLGRPLD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 245 PVSHNAL-LVGDMAYYD-FNGEM--EQEADRInlQKCLGPTcKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVsaL 320
Cdd:PRK06208 152 PITQDACaFYEDHALFDdFTGVVvdTSEGRRI--AAALGTH-KAVILQNHGLLTVGPSVDAAAWWFIALERACQTQL--L 226

                        250       260       270
                 ....*....|....*....|....*....|....
gi 427918099 321 SSAGGTENLILLEQEKHRPHEVGSVQWAGSTFGP 354
Cdd:PRK06208 227 AEAAGPPQPIDHETARHTRSQVGSEYGGWFNFQP 260
PRK06486 PRK06486
aldolase;
165-373 1.22e-23

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 100.56  E-value: 1.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 165 QDHFLISPKGVSCSEVTASSLIKVNILGEVVEkGSScfPVDTTGFSLHSAIYAARPDVRCAIHLHTP-ATAAVSAMKCGL 243
Cdd:PRK06486  59 DDLFLVNPYGYAFSEITASDLLICDFDGNVLA-GRG--EPEATAFFIHARIHRAIPRAKAAFHTHMPyATALSLTEGRPL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 244 LPVSHNAllvgdMAYY-------DFNGEM--EQEADRInlQKCLGpTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACE 314
Cdd:PRK06486 136 TTLGQTA-----LKFYgrtavdeDYNGLAldAAEGDRI--ARAMG-DADIVFLKNHGVMVCGPRIAEAWDDLYYLERACE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 427918099 315 VQVSALSSAggtenlillEQEKHRPHEVgsvqwAGSTFGPMqksRLGEHE-----FEALMRMLD 373
Cdd:PRK06486 208 VQVLAMSTG---------RPLVPVDPAI-----AAAVARQM---REGDREsarlhLEALRRTLD 254
PRK07490 PRK07490
hypothetical protein; Provisional
 130-322 1.12e-21

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 94.40  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 130 ERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNilgevvEKGSSCFP----VD 205
Cdd:PRK07490   8 EEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLD------ADDPSTAErpdvPD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 206 TTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCG-LLPVSHNALLVGDMAYYDFN-GEMEQEADRINLQKCLGpTCK 283
Cdd:PRK07490  82 ATAWAIHGQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNTARFFNRVAVDTLyGGMALEEEGERLAGLLG-DKR 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 427918099 284 ILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSS 322
Cdd:PRK07490 161 RLLMGNHGVLVTGDTVAEAFDDLYYFERACQTYITALST 199
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 150-324 3.88e-14

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 72.75  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 150 AQLSDTYVTLRVskeqdhflispkGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDttgfSLHSAIYAARPDVRCAIHLH 229
Cdd:PRK07090  59 AEAPGTYYTQRL------------GLGFDEITASNLLLVDEDLNVLDGEGMPNPAN----RFHSWIYRARPDVNCIIHTH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 230 TPATAAVSAMKCGLLpVSH--NALLVGDMAYY---------DFNGEMEQEAdrinlqkcLGPTCKILvLRNHGMVALGDT 298
Cdd:PRK07090 123 PPHVAALSMLEVPLV-VSHmdTCPLYDDCAFLkdwpgvpvgNEEGEIISAA--------LGDKRAIL-LSHHGQLVAGKS 192

                        170       180
                 ....*....|....*....|....*.
gi 427918099 299 VEEAFYKVFHLQAACEVQVSAlSSAG 324
Cdd:PRK07090 193 IEEACVLALLIERAARLQLLA-MAAG 217
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 157-302 1.76e-08

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 55.01  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 157 VTLRVsKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEkGSSCFPVDTtgfSLHSAIYAARPDVRCAIHLHTP-ATA- 234
Cdd:PRK06557  35 VSARD-PGTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDT---ASHLYVYRHMPDVGGVVHTHSTyATAw 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 235 ---------AVSAMK---CGLLPVSHNAlLVGDmayydfngemeqeaDRIN---LQKCLGPTCKILVLRNHGMVALGDTV 299
Cdd:PRK06557 110 aargepipcVLTAMAdefGGPIPVGPFA-LIGD--------------EAIGkgiVETLKGGRSPAVLMQNHGVFTIGKDA 174


                 ...
gi 427918099 300 EEA 302
Cdd:PRK06557 175 EDA 177
PRK08130 PRK08130
putative aldolase; Validated
 167-304 2.39e-08

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 54.50  E-value: 2.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 167 HFLISPKGVSCSEVTASSLIKVNILGEVVEKGSscfPVDTTgfSLHSAIYAARPDVRCAIHLHTPATAAVS--------- 237
Cdd:PRK08130  38 GWLVTPTGSCLGRLDPARLSKVDADGNWLSGDK---PSKEV--PLHRAIYRNNPECGAVVHLHSTHLTALSclggldptn 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 427918099 238 ---------AMKCGLLPVshnallvgdMAYY---DfngemEQEADRInlqKCLGPTCKILVLRNHGMVALGDTVEEAFY 304
Cdd:PRK08130 113 vlppftpyyVMRVGHVPL---------IPYYrpgD-----PAIAEAL---AGLAARYRAVLLANHGPVVWGSSLEAAVN 174
PRK08333 PRK08333
aldolase;
166-305 6.49e-08

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 52.90  E-value: 6.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 166 DHFLISPKGVSCSEVTASSLIKVNILGEVVekgSSCFPvdTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLP 245
Cdd:PRK08333  34 NLVFIKATGSVMDELTREQVAVIDLNGNQL---SSVRP--SSEYRLHLAVYRNRPDVRAIAHLHPPYSIVASTLLEEELP 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 427918099 246 V--SHNALLVGDMAYYDFngemeQEADRINLQKCLGPTCK---ILVLRNHGMVALGDTVEEAFYK 305
Cdd:PRK08333 109 IitPEAELYLKKIPILPF-----RPAGSVELAEQVAEAMKeydAVIMERHGIVTVGRSLREAFYK 168
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
163-306 3.72e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 50.90  E-value: 3.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 163 KEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEkGSScfpVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCG 242
Cdd:PRK06833  35 REQGLMAITPSGIDYFEIKPEDIVIMDLDGKVVE-GER---KPSSELDMHLIFYRNREDINAIVHTHSPYATTLACLGWE 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 427918099 243 LLPVSHNALLVGD---MAYYDFNG--EMEQEA-----DRinlqkclgptcKILVLRNHGMVALGDTVEEAFYKV 306
Cdd:PRK06833 111 LPAVHYLIAVAGPnvrCAEYATFGtkELAENAfeameDR-----------RAVLLANHGLLAGANNLKNAFNIA 173
PRK08660 PRK08660
aldolase;
165-315 9.83e-07

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 49.18  E-value: 9.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 165 QDHFLISPKGVSCSEVTASSLIKVNIL--GEVVEKGSSCFPVdttgfslHSAIYAaRPDVRCAIHLHTPATAAVSAMKCG 242
Cdd:PRK08660  30 GDGLLITRTGSMLDEITEGDVIEVGIDddGSVDPLASSETPV-------HRAIYR-RTSAKAIVHAHPPYAVALSLLEDE 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 427918099 243 LLPV-SHNALLVGDMAYYDFNGEMEQEADriNLQKCLGPTcKILVLRNHGMVALGDTVEEAFYKVFHLQAACEV 315
Cdd:PRK08660 102 IVPLdSEGLYFLGTIPVVGGDIGSGELAE--NVARALSEH-KGVVVRGHGTFAIGKTLEEAYIYTSQLEHSCKV 172
PRK05874 PRK05874
L-fuculose-phosphate aldolase; Validated
 167-314 1.94e-05

L-fuculose-phosphate aldolase; Validated


Pssm-ID: 102036 [Multi-domain]  Cd Length: 217  Bit Score: 46.17  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 167 HFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPvdTTGFSLHSAIYAARPDVRCAIHLHtPATAAVSAMKCGLLPV 246
Cdd:PRK05874  39 NVVITPSSVDYAEMLLHDLVLVDAGGAVLHAKDGRSP--STELNLHLACYRAFDDIGSVIHSH-PVWATMFAVAHEPIPA 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 427918099 247 SHNALLV---GDMAYYDFNGEMEQEADRINLQKCLGPTCKILVlrNHGMVALGDTVEeafyKVFHLQAACE 314
Cdd:PRK05874 116 CIDEFAIycgGDVRCTEYAASGTPEVGRNAVRALEGRAAALIA--NHGLVAVGPRPD----QVLRVTALVE 180
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
165-319 4.95e-05

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 44.73  E-value: 4.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 165 QDHFLISPKGVSCSEVTASSLIKVNILGEVvEKGSscFPvdTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGlL 244
Cdd:PRK08087  35 QDGMLITPTGIPYEKLTESHIVFVDGNGKH-EEGK--LP--SSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRP-I 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 245 PVSHNALLV--GD----MAYYDFNGEMEQEADRINLQKclgptCKILVLRNHGMVALGDTVEEAfykvfhLQAACEVQVS 318
Cdd:PRK08087 109 PAIHYMIAAagGNsipcAPYATFGTRELSEHVALALKN-----RKATLLQHHGLIACEVNLEKA------LWLAHEVEVL 177


                 .
gi 427918099 319 A 319
Cdd:PRK08087 178 A 178
araD PRK13145
L-ribulose-5-phosphate 4-epimerase; Provisional
 161-304 2.15e-04

L-ribulose-5-phosphate 4-epimerase; Provisional


Pssm-ID: 183870 [Multi-domain]  Cd Length: 234  Bit Score: 42.90  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 161 VSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVE---KGSSCFPVdttgfslHSAIYAARPDVRCAIHLHTpaTAAVS 237
Cdd:PRK13145  33 VCRELGRIVIKPSGVDYDELTPENMVVTDLDGNVVEgdlNPSSDLPT-------HVELYKAWPEVGGIVHTHS--TEAVG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 238 AMKCGL-LP---VSHNALLVGD------MAYYDFNGEMEQEADRINLQ----KCLGP-TCKILVLRNHGMVALGDTVEEA 302
Cdd:PRK13145 104 WAQAGRdIPfygTTHADYFYGPipcarsLTKDEVNGAYEKETGSVIIEefekRGLDPmAVPGIVVRNHGPFTWGKNPEQA 183


                 ..
gi 427918099 303 FY 304
Cdd:PRK13145 184 VY 185
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 141-304 6.15e-04

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 41.71  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 141 YRLLdLYGWAQLSDtyvtlrVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVE---KGSScfpvDTtgfSLHSAIYA 217
Cdd:PRK12348  18 YGLV-TFTWGNVSA------IDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEgeyRPSS----DT---ATHLELYR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 427918099 218 ARPDVRCAIHLHTP-ATA-AVSAMKCGLLPVSHNALLVGD------MAYYDFNGEMEQEADRINLQKcLGPTCKI----L 285
Cdd:PRK12348  84 RYPSLGGIVHTHSThATAwAQAGLAIPALGTTHADYFFGDipctrgLSEEEVQGEYELNTGKVIIET-LGNAEPLhtpgI 162

                        170
                 ....*....|....*....
gi 427918099 286 VLRNHGMVALGDTVEEAFY 304
Cdd:PRK12348 163 VVYQHGPFAWGKDAHDAVH 181
araD PRK08193
L-ribulose-5-phosphate 4-epimerase AraD;
161-234 2.68e-03

L-ribulose-5-phosphate 4-epimerase AraD;


Pssm-ID: 236181  Cd Length: 231  Bit Score: 39.43  E-value: 2.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 427918099 161 VSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVE---KGSScfpvDT-TgfslHSAIYAARPDVRCAIHLHTP-ATA 234
Cdd:PRK08193  32 IDRERGLFVIKPSGVDYDKMTAEDMVVVDLEGNVVEgklKPSS----DTpT----HLVLYKAFPEIGGIVHTHSRhATA 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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