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Conserved domains on  [gi|409264681|ref|NP_001258528|]
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sortilin isoform 1 precursor [Mus musculus]

Protein Classification

VPS10 domain-containing protein( domain architecture ID 12217182)

VPS10 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
131-739 0e+00

VPS10 domain;


:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 734.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   131 PLVIVSFGQSKLYRSEDYGKNFKD---ITNLINNTFIRTEFGMAIGPENSGKviltaevsggsRGGRVFRSSDFAKNFVQ 207
Cdd:smart00602   1 SLLLGSAEESSVYISEDYGKTWKKideIEGVIIETVISDFFNSSANKFKTIL-----------VKGYIFISSDEGKSFQK 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   208 TDLPFHPLTQMMYSPQNSDYLLALSTEN---GLWVSKNFGEKWEEIHKAVCL--AKWGPNNIIFFTTHVNGSCKADLGAL 282
Cdd:smart00602  70 FTLPFPPLPSLLYHPKHPDYVLAYSKDCnykVLYVSKDFGKTWTEIQENVESceFSWGSMGVYDFPDLVHISVKENSGAL 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   283 -ELWRTSDLG--KTFKTIGVKIYSFGLGGRFLFASVMaDKDTTRRIHVSTDQGDTWSMAQLPS---VGQEQFYSILAANE 356
Cdd:smart00602 150 tELVSSIDFFqrYDQSTIFLDIVGFLLTDEYLFVAVT-DEDTTSRKLYVSNDRSTFAMAKFPKyhaLGKQQAYTILDSDE 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   357 DMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTtGGETDFTNVTSLRGVYITSTLS-EDNSIQSMITFDQGGRW 435
Cdd:smart00602 229 DSVFLHVSENNQNDTGNLYISDSRGTKFSLSLENVNRYT-GGYIDFYKVEGLKGIYIANIVSkVDKQLQTKITFDKGGDW 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   436 EHLRKPENS------KCDATAKNKNECSLHIHASYSISqklNVPMAPLSEPNAVGIVIAHGSVGDAISVmVPDVYISDDG 509
Cdd:smart00602 308 SLLKPPDVDnegkkfNCDLTSLEKCSLHLHLRYSESPY---SGDIASSKSAPGIIIASGNVGDGLASYW-EPSTFISSDG 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   510 GYSWAKMLEGPHYYTILDSGGIIVAIEHSNrPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTES 589
Cdd:smart00602 384 GLTWRLVFDGPHLYAYGDHGGIIVAIEYNS-PTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKE 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   590 FITrQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDykDGCILGYKEQFLRLRKSSVCQNGR-DYVVAKQPSVCPCSL 668
Cdd:smart00602 463 RGS-SWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSR--DGCLLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTR 539
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 409264681   669 EDFLCDFGYFRPE-NASECVEQPELKGHEL-EFCLYGK--EEHLTTNGYRKIPGDKCQGGMnpAREVKDLKKKCT 739
Cdd:smart00602 540 EDFECDFGFYRLSeGDSTCVPDPNLSGNPLsDDCKKGKsyTEYVKSLGYRKIPGDKCKGGV--KLEAEDIPHPCP 612
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
131-739 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 734.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   131 PLVIVSFGQSKLYRSEDYGKNFKD---ITNLINNTFIRTEFGMAIGPENSGKviltaevsggsRGGRVFRSSDFAKNFVQ 207
Cdd:smart00602   1 SLLLGSAEESSVYISEDYGKTWKKideIEGVIIETVISDFFNSSANKFKTIL-----------VKGYIFISSDEGKSFQK 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   208 TDLPFHPLTQMMYSPQNSDYLLALSTEN---GLWVSKNFGEKWEEIHKAVCL--AKWGPNNIIFFTTHVNGSCKADLGAL 282
Cdd:smart00602  70 FTLPFPPLPSLLYHPKHPDYVLAYSKDCnykVLYVSKDFGKTWTEIQENVESceFSWGSMGVYDFPDLVHISVKENSGAL 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   283 -ELWRTSDLG--KTFKTIGVKIYSFGLGGRFLFASVMaDKDTTRRIHVSTDQGDTWSMAQLPS---VGQEQFYSILAANE 356
Cdd:smart00602 150 tELVSSIDFFqrYDQSTIFLDIVGFLLTDEYLFVAVT-DEDTTSRKLYVSNDRSTFAMAKFPKyhaLGKQQAYTILDSDE 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   357 DMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTtGGETDFTNVTSLRGVYITSTLS-EDNSIQSMITFDQGGRW 435
Cdd:smart00602 229 DSVFLHVSENNQNDTGNLYISDSRGTKFSLSLENVNRYT-GGYIDFYKVEGLKGIYIANIVSkVDKQLQTKITFDKGGDW 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   436 EHLRKPENS------KCDATAKNKNECSLHIHASYSISqklNVPMAPLSEPNAVGIVIAHGSVGDAISVmVPDVYISDDG 509
Cdd:smart00602 308 SLLKPPDVDnegkkfNCDLTSLEKCSLHLHLRYSESPY---SGDIASSKSAPGIIIASGNVGDGLASYW-EPSTFISSDG 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   510 GYSWAKMLEGPHYYTILDSGGIIVAIEHSNrPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTES 589
Cdd:smart00602 384 GLTWRLVFDGPHLYAYGDHGGIIVAIEYNS-PTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKE 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   590 FITrQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDykDGCILGYKEQFLRLRKSSVCQNGR-DYVVAKQPSVCPCSL 668
Cdd:smart00602 463 RGS-SWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSR--DGCLLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTR 539
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 409264681   669 EDFLCDFGYFRPE-NASECVEQPELKGHEL-EFCLYGK--EEHLTTNGYRKIPGDKCQGGMnpAREVKDLKKKCT 739
Cdd:smart00602 540 EDFECDFGFYRLSeGDSTCVPDPNLSGNPLsDDCKKGKsyTEYVKSLGYRKIPGDKCKGGV--KLEAEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
140-570 1.47e-144

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 434.32  E-value: 1.47e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  140 SKLYRSEDYGKNFKDITNLINNTFIRTefgMAIGPENSGKVILTaevsggSRGGRVFRSSDFAKNFVQTDLPFHPLTQ-- 217
Cdd:pfam15902   1 SEVYRSHDYGKTWKKVKDVPDGEAILA---IYPHPYDNDRAYLL------TDGKKHYYTTDRGKTFRSFKLPFPPNLFgp 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  218 -MMYSPQNSDYLLAL-------STENGLWVSKNFGEKWEEIHKAVCLAKWG-----PNNIIFFTTHVNGSCKADLGALEL 284
Cdd:pfam15902  72 pLSFHPKDPDWLIWYggkcfsgDCHSVAYYSTDGGKSWKLLLEYVRRCEWAvsskaDENLIFCEVYENESGNADDVKLRL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  285 WRTSDLGKTFKTIGVK-IYSFGLGGRFLFASVMADKDTTRRIHVSTDqGDTWSMAQLPSVGQEQFYSILAANEDMVFMHV 363
Cdd:pfam15902 152 VSSDDFFKSDKVLFDDgVVGFAVVGEFIVVAVKSENTSELALYVSYD-GKTFARAQFPHVLEQQAYTVLESSTHSIFLHV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  364 DEPGDTGFGTIFTSDDRGIVYSKSLDrHLYTTTGGETDFTNVTSLRGVYITSTLS--------EDNSIQSMITFDQGGRW 435
Cdd:pfam15902 231 TTSSDNPYGSLYKSNSNGTYFVLSLE-NVNRNERGYVDFEKVAGLEGVYLANVVSnaeevgkgADKKLKTKITFNDGGTW 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  436 EHLRKPEN-SKCDATAKNKNECSLHIHASYSisQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMV-PDVYISDDGGYSW 513
Cdd:pfam15902 310 QPLKPPDKdSEYKCSGKGLEKCSLHLHGYTE--RLVNIGRDTFSSPSAPGLIMGVGNVGDSLGPYEdADTFISRDGGITW 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 409264681  514 AKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGL 570
Cdd:pfam15902 388 KEVLKGPHKWEFGDQGSIIVAVKDEGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
224-400 1.78e-09

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 224 NSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWG-----PNNIIFFTTHVNGsckadlgaleLWRTSDLGKTFKTIg 298
Cdd:COG4447    2 DGNRLWAVGASGGILRSTDGGKTWTPLSDGLPGLSLRavafsDPNTVWVGTGPGG----------IYRSTDGGKTWTEV- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 299 vkiySFGLGGRFLFASVMADKDT----TRRIHVSTDQGDTWSmaQLPSVGQEQFYSILAANEDMVFMHvdepgdTGFGTI 374
Cdd:COG4447   71 ----NSGPDNPRLFAIAFSDPNTgyaaVGGIYRTTDGGKTWT--KVSSGLPVDLNDVAFLDPGTLYAA------GEGGLI 138
                        170       180
                 ....*....|....*....|....*.
gi 409264681 375 FTSDDRGIvysksldrhLYTTTGGET 400
Cdd:COG4447  139 YRSTDGGE---------YRSTDGGKT 155
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
131-739 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 734.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   131 PLVIVSFGQSKLYRSEDYGKNFKD---ITNLINNTFIRTEFGMAIGPENSGKviltaevsggsRGGRVFRSSDFAKNFVQ 207
Cdd:smart00602   1 SLLLGSAEESSVYISEDYGKTWKKideIEGVIIETVISDFFNSSANKFKTIL-----------VKGYIFISSDEGKSFQK 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   208 TDLPFHPLTQMMYSPQNSDYLLALSTEN---GLWVSKNFGEKWEEIHKAVCL--AKWGPNNIIFFTTHVNGSCKADLGAL 282
Cdd:smart00602  70 FTLPFPPLPSLLYHPKHPDYVLAYSKDCnykVLYVSKDFGKTWTEIQENVESceFSWGSMGVYDFPDLVHISVKENSGAL 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   283 -ELWRTSDLG--KTFKTIGVKIYSFGLGGRFLFASVMaDKDTTRRIHVSTDQGDTWSMAQLPS---VGQEQFYSILAANE 356
Cdd:smart00602 150 tELVSSIDFFqrYDQSTIFLDIVGFLLTDEYLFVAVT-DEDTTSRKLYVSNDRSTFAMAKFPKyhaLGKQQAYTILDSDE 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   357 DMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTtGGETDFTNVTSLRGVYITSTLS-EDNSIQSMITFDQGGRW 435
Cdd:smart00602 229 DSVFLHVSENNQNDTGNLYISDSRGTKFSLSLENVNRYT-GGYIDFYKVEGLKGIYIANIVSkVDKQLQTKITFDKGGDW 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   436 EHLRKPENS------KCDATAKNKNECSLHIHASYSISqklNVPMAPLSEPNAVGIVIAHGSVGDAISVmVPDVYISDDG 509
Cdd:smart00602 308 SLLKPPDVDnegkkfNCDLTSLEKCSLHLHLRYSESPY---SGDIASSKSAPGIIIASGNVGDGLASYW-EPSTFISSDG 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   510 GYSWAKMLEGPHYYTILDSGGIIVAIEHSNrPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTES 589
Cdd:smart00602 384 GLTWRLVFDGPHLYAYGDHGGIIVAIEYNS-PTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEPGGSTLVFTLFGFTKE 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681   590 FITrQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDykDGCILGYKEQFLRLRKSSVCQNGR-DYVVAKQPSVCPCSL 668
Cdd:smart00602 463 RGS-SWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSR--DGCLLGHKTIFKRRKPTSQCLVGKsDYDLSLVSSPCSCTR 539
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 409264681   669 EDFLCDFGYFRPE-NASECVEQPELKGHEL-EFCLYGK--EEHLTTNGYRKIPGDKCQGGMnpAREVKDLKKKCT 739
Cdd:smart00602 540 EDFECDFGFYRLSeGDSTCVPDPNLSGNPLsDDCKKGKsyTEYVKSLGYRKIPGDKCKGGV--KLEAEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
140-570 1.47e-144

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 434.32  E-value: 1.47e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  140 SKLYRSEDYGKNFKDITNLINNTFIRTefgMAIGPENSGKVILTaevsggSRGGRVFRSSDFAKNFVQTDLPFHPLTQ-- 217
Cdd:pfam15902   1 SEVYRSHDYGKTWKKVKDVPDGEAILA---IYPHPYDNDRAYLL------TDGKKHYYTTDRGKTFRSFKLPFPPNLFgp 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  218 -MMYSPQNSDYLLAL-------STENGLWVSKNFGEKWEEIHKAVCLAKWG-----PNNIIFFTTHVNGSCKADLGALEL 284
Cdd:pfam15902  72 pLSFHPKDPDWLIWYggkcfsgDCHSVAYYSTDGGKSWKLLLEYVRRCEWAvsskaDENLIFCEVYENESGNADDVKLRL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  285 WRTSDLGKTFKTIGVK-IYSFGLGGRFLFASVMADKDTTRRIHVSTDqGDTWSMAQLPSVGQEQFYSILAANEDMVFMHV 363
Cdd:pfam15902 152 VSSDDFFKSDKVLFDDgVVGFAVVGEFIVVAVKSENTSELALYVSYD-GKTFARAQFPHVLEQQAYTVLESSTHSIFLHV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  364 DEPGDTGFGTIFTSDDRGIVYSKSLDrHLYTTTGGETDFTNVTSLRGVYITSTLS--------EDNSIQSMITFDQGGRW 435
Cdd:pfam15902 231 TTSSDNPYGSLYKSNSNGTYFVLSLE-NVNRNERGYVDFEKVAGLEGVYLANVVSnaeevgkgADKKLKTKITFNDGGTW 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  436 EHLRKPEN-SKCDATAKNKNECSLHIHASYSisQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMV-PDVYISDDGGYSW 513
Cdd:pfam15902 310 QPLKPPDKdSEYKCSGKGLEKCSLHLHGYTE--RLVNIGRDTFSSPSAPGLIMGVGNVGDSLGPYEdADTFISRDGGITW 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 409264681  514 AKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGL 570
Cdd:pfam15902 388 KEVLKGPHKWEFGDQGSIIVAVKDEGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
Sortilin_C pfam15901
Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of ...
572-738 6.03e-53

Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.


Pssm-ID: 464928 [Multi-domain]  Cd Length: 164  Bit Score: 181.36  E-value: 6.03e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  572 SEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDykdGCILGYKEQFLRLRKSSVCQN 651
Cdd:pfam15901   1 TEPDDTSLKFLLFGSSSSSRSDWEVVYTIDFSGLFDRKCTDDDYELWSPRHDQDGP---KCLLGHKQKYRRRKPDADCFN 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681  652 GRDYVVAKQPSVCPCSLEDFLCDFGYFRPENASECVEQPELKGHE--LEFCLYGKeEHLTTNGYRKIPGDKCQGGMnPAR 729
Cdd:pfam15901  78 GKDFKDPKIEENCECTREDFECDYGFERSANDGKCVLVPGLLPPDgpKEDCKPGT-YYLGSSGYRKIPGNTCEGGL-ELD 155

                  ....*....
gi 409264681  730 EVKDLKKKC 738
Cdd:pfam15901 156 KDEPVEHPC 164
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
224-400 1.78e-09

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 224 NSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWG-----PNNIIFFTTHVNGsckadlgaleLWRTSDLGKTFKTIg 298
Cdd:COG4447    2 DGNRLWAVGASGGILRSTDGGKTWTPLSDGLPGLSLRavafsDPNTVWVGTGPGG----------IYRSTDGGKTWTEV- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 299 vkiySFGLGGRFLFASVMADKDT----TRRIHVSTDQGDTWSmaQLPSVGQEQFYSILAANEDMVFMHvdepgdTGFGTI 374
Cdd:COG4447   71 ----NSGPDNPRLFAIAFSDPNTgyaaVGGIYRTTDGGKTWT--KVSSGLPVDLNDVAFLDPGTLYAA------GEGGLI 138
                        170       180
                 ....*....|....*....|....*.
gi 409264681 375 FTSDDRGIvysksldrhLYTTTGGET 400
Cdd:COG4447  139 YRSTDGGE---------YRSTDGGKT 155
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
133-247 2.44e-03

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 39.60  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 133 VIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRtefgmAIGPENSGKVILTAevsggsrgGRVFRSSDFAKNF--VQTDL 210
Cdd:COG4447   48 VWVGTGPGGIYRSTDGGKTWTEVNSGPDNPRLF-----AIAFSDPNTGYAAV--------GGIYRTTDGGKTWtkVSSGL 114
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 409264681 211 PFHpLTQMMYSPQNSDYL------LALSTENGLWVSKNFGEKW 247
Cdd:COG4447  115 PVD-LNDVAFLDPGTLYAagegglIYRSTDGGEYRSTDGGKTW 156
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
189-335 2.97e-03

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 39.21  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 189 GSRGGrVFRSSDFAKNF--VQTDLPFHPLTQMmySPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAV------CLAKWG 260
Cdd:COG4447   10 GASGG-ILRSTDGGKTWtpLSDGLPGLSLRAV--AFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPdnprlfAIAFSD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 261 PNNIIfftthvngsckADLGALelWRTSDLGKTFKTIGVKIY------SFGLGGRFLFASvmadkdTTRRIHVSTDQ--- 331
Cdd:COG4447   87 PNTGY-----------AAVGGI--YRTTDGGKTWTKVSSGLPvdlndvAFLDPGTLYAAG------EGGLIYRSTDGgey 147

                 ....*....
gi 409264681 332 -----GDTW 335
Cdd:COG4447  148 rstdgGKTW 156
BNR_6 pfam15899
BNR-Asp box repeat; This BNR repeat is found in proteins such as human sortilin. The model ...
142-155 4.26e-03

BNR-Asp box repeat; This BNR repeat is found in proteins such as human sortilin. The model complements family BNR_5.


Pssm-ID: 406351  Cd Length: 14  Bit Score: 35.20  E-value: 4.26e-03
                          10
                  ....*....|....
gi 409264681  142 LYRSEDYGKNFKDI 155
Cdd:pfam15899   1 LFRSSDFGKNFKQI 14
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
131-294 6.82e-03

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 38.06  E-value: 6.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 131 PLVIVSFGQS-KLYRSEDYGKNFKDITnliNNTFIRTEFGMAIGPENSGKViltaevsgGSRGGRVFRSSDFAKNFVQTD 209
Cdd:COG4447    3 GNRLWAVGASgGILRSTDGGKTWTPLS---DGLPGLSLRAVAFSDPNTVWV--------GTGPGGIYRSTDGGKTWTEVN 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409264681 210 LP--FHPLTQMMYSpqNSDYLLAlsTENGLWVSKNFGEKWEEIHKAV-----CLAKWGPNNI--------IFFTThvngs 274
Cdd:COG4447   72 SGpdNPRLFAIAFS--DPNTGYA--AVGGIYRTTDGGKTWTKVSSGLpvdlnDVAFLDPGTLyaagegglIYRST----- 142
                        170       180
                 ....*....|....*....|
gi 409264681 275 ckaDLGAlelWRTSDLGKTF 294
Cdd:COG4447  143 ---DGGE---YRSTDGGKTW 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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