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Conserved domains on  [gi|358030301|ref|NP_001239587|]
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low-density lipoprotein receptor isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 1.60e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.96  E-value: 1.60e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 358030301  529 GFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.82e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.82e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  196 SPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
236-271 1.92e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.92e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 358030301  236 TCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC 271
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.90e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  107 KTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-526 8.22e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 8.22e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  486 RNIYWTDSVPG-SVSVADTKGVKRRTLFQEAGSRPRAIVVDP 526
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-184 1.33e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.33e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301  146 TTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEwpQNC 184
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 3.11e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.11e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 358030301   25 DSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 4.02e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 4.02e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 358030301   553 HSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-483 2.62e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 53.32  E-value: 2.62e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 358030301  440 NRIYWSDLSQKkiYSALMDQAPNLSYDTIISEDLHAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 3.52e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.93  E-value: 3.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  616 DKVYWTDVINEAIFSANRLTGSDV-NLVAENLLSPEDIVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 6.83e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 6.83e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301   66 VTCQSNQFSCGGRvsRCIPDSWRCDGQVDCENDSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.38e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.38e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 358030301  279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-389 5.46e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 5.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 358030301   355 DIDECQEPDTCSQ--LCVNLEGSYKCECQAGFHMDPH 389
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-347 3.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.53e-05
                          10        20
                  ....*....|....*....|....*....
gi 358030301  319 CLDNNGGCSHICKDLKIGSECLCPSGFRL 347
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 1.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 358030301   420 YTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMD 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 1.60e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.96  E-value: 1.60e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 358030301  529 GFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.82e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.82e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  196 SPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
236-271 1.92e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.92e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 358030301  236 TCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC 271
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.90e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  107 KTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-526 8.22e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 8.22e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  486 RNIYWTDSVPG-SVSVADTKGVKRRTLFQEAGSRPRAIVVDP 526
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-143 8.39e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 8.39e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 109 CSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHC 143
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-184 1.33e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.33e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301  146 TTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEwpQNC 184
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 2.43e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 2.43e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 198 CSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHC 232
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 3.11e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.11e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 358030301   25 DSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 4.02e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 4.02e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 358030301   553 HSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-508 9.13e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 9.13e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 358030301   467 TIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKR 508
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-140 9.89e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 9.89e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   108 TCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 573-615 1.33e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 358030301  573 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEnrLAHPFSLAIYE 615
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 1.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.82e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 237 CRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC 271
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 2.26e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.26e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 358030301  27 CSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-483 2.62e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 53.32  E-value: 2.62e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 358030301  440 NRIYWSDLSQKkiYSALMDQAPNLSYDTIISEDLHAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-58 2.90e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.90e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 358030301    27 CSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 3.07e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.07e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   147 TCGPAHFRCNSSICIPSLWACDGDVDCVDGSDE 179
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 3.52e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.93  E-value: 3.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  616 DKVYWTDVINEAIFSANRLTGSDV-NLVAENLLSPEDIVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 6.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 6.83e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301   66 VTCQSNQFSCGGRvsRCIPDSWRCDGQVDCENDSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-180 7.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 7.39e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 358030301 148 CGPAHFRCNSSICIPSLWACDGDVDCVDGSDEW 180
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 198-229 1.10e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.10e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 358030301   198 CSSLEFHCGSSECIHRSWVCDGEADCKDKSDE 229
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 439-628 1.69e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 56.53  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 439 NNRIYWSDLSQKKIySALMDQAPNLSY--DTIISEDLHAPDGLAVDwiHRNIYWTDSVPGSVSVADTKGVKRRTlFQEAG 516
Cdd:cd14963   66 DGNIYVADLYNGRI-QVFDPDGKFLKYfpEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 517 SR------PRAIVVDPvHGFMYWTDWGTpAKI----KKGG----LNGVDIHSLVTENiqwPNGITLDlSSGRLYWVDSKL 582
Cdd:cd14963  142 SEpgelsyPNGIAVDE-DGNIYVADSGN-GRIqvfdKNGKfikeLNGSPDGKSGFVN---PRGIAVD-PDGNLYVVDNLS 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 358030301 583 HSISSIDVNGGNRKTIL---EDENRLAHPFSLAIYEDK-VYWTDVINEAI 628
Cdd:cd14963  216 HRVYVFDEQGKELFTFGgrgKDDGQFNLPNGLFIDDDGrLYVTDRENNRV 265
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 3.12e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 3.12e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 358030301  68 CQSNQFSCGGrvSRCIPDSWRCDGQVDCENDSDEQGC 104
Cdd:cd00112    1 CPPNEFRCAN--GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 4.32e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 4.32e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   236 TCRPDEFQCADGSCIHGSRQCDREHDCKDMSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.38e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.38e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 358030301  279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 1.51e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 358030301    67 TCQSNQFSCGGrvSRCIPDSWRCDGQVDCENDSDE 101
Cdd:smart00192   1 TCPPGEFQCDN--GRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-389 5.46e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 5.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 358030301   355 DIDECQEPDTCSQ--LCVNLEGSYKCECQAGFHMDPH 389
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
430-593 7.81e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 7.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 430 VVALDTEVTNNRIYWSDLSQKKIYsaLMDQAPNLSYDTIISEDlhAPDGLAVDWIHRNIYWTDSVPGSVSVADTK-GVKR 508
Cdd:COG3391   70 ADGADAGADGRRLYVANSGSGRVS--VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTAtGKVV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 509 RTLfqEAGSRPRAIVVDPVHGFMYWTDWGTP--AKIkkggLNGVDIHSL-VTENI---QWPNGITLDLSSGRLY------ 576
Cdd:COG3391  146 ATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI----VSVIDTATGkVVATIpvgGGPVGVAVSPDGRRLYvanrgs 219

                        170
                 ....*....|....*...
gi 358030301 577 -WVDSKLHSISSIDVNGG 593
Cdd:COG3391  220 nTSNGGSNTVSVIDLATL 237
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-549 2.06e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 2.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 358030301   509 RTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 549
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 3.18e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 3.18e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 358030301 279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 8.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.15e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 358030301 355 DIDECQEPDTCS--QLCVNLEGSYKCECQAGFH 385
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 1.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 1.47e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 358030301   279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-347 3.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.53e-05
                          10        20
                  ....*....|....*....|....*....
gi 358030301  319 CLDNNGGCSHICKDLKIGSECLCPSGFRL 347
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 1.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 358030301   420 YTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMD 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 596-639 3.03e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 3.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 358030301   596 KTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANrLTGSDV 639
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTNR 43
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 5.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 5.55e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 358030301  355 DIDEC-QEPDTCSQ--LCVNLEGSYKCECQAG 383
Cdd:pfam07645   1 DVDECaTGTHNCPAntVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 1.60e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.96  E-value: 1.60e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 358030301  529 GFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.82e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.82e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  196 SPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
236-271 1.92e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.92e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 358030301  236 TCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC 271
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.90e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 358030301  107 KTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-526 8.22e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 8.22e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  486 RNIYWTDSVPG-SVSVADTKGVKRRTLFQEAGSRPRAIVVDP 526
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-143 8.39e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 8.39e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 109 CSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHC 143
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-184 1.33e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.33e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301  146 TTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEwpQNC 184
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 2.43e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 2.43e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 198 CSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHC 232
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 3.11e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.11e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 358030301   25 DSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 4.02e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 4.02e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 358030301   553 HSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-508 9.13e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 9.13e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 358030301   467 TIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKR 508
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-140 9.89e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 9.89e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   108 TCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 573-615 1.33e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 358030301  573 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEnrLAHPFSLAIYE 615
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 1.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.82e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 358030301 237 CRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC 271
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 2.26e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.26e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 358030301  27 CSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-483 2.62e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 53.32  E-value: 2.62e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 358030301  440 NRIYWSDLSQKkiYSALMDQAPNLSYDTIISEDLHAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-58 2.90e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.90e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 358030301    27 CSRNEFQCRDGKCIASKWVCDGSPECPDGSDE 58
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 3.07e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.07e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   147 TCGPAHFRCNSSICIPSLWACDGDVDCVDGSDE 179
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 3.52e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.93  E-value: 3.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 358030301  616 DKVYWTDVINEAIFSANRLTGSDV-NLVAENLLSPEDIVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 6.83e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 6.83e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 358030301   66 VTCQSNQFSCGGRvsRCIPDSWRCDGQVDCENDSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-180 7.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 7.39e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 358030301 148 CGPAHFRCNSSICIPSLWACDGDVDCVDGSDEW 180
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 198-229 1.10e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.10e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 358030301   198 CSSLEFHCGSSECIHRSWVCDGEADCKDKSDE 229
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 439-628 1.69e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 56.53  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 439 NNRIYWSDLSQKKIySALMDQAPNLSY--DTIISEDLHAPDGLAVDwiHRNIYWTDSVPGSVSVADTKGVKRRTlFQEAG 516
Cdd:cd14963   66 DGNIYVADLYNGRI-QVFDPDGKFLKYfpEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 517 SR------PRAIVVDPvHGFMYWTDWGTpAKI----KKGG----LNGVDIHSLVTENiqwPNGITLDlSSGRLYWVDSKL 582
Cdd:cd14963  142 SEpgelsyPNGIAVDE-DGNIYVADSGN-GRIqvfdKNGKfikeLNGSPDGKSGFVN---PRGIAVD-PDGNLYVVDNLS 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 358030301 583 HSISSIDVNGGNRKTIL---EDENRLAHPFSLAIYEDK-VYWTDVINEAI 628
Cdd:cd14963  216 HRVYVFDEQGKELFTFGgrgKDDGQFNLPNGLFIDDDGrLYVTDRENNRV 265
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 3.12e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 3.12e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 358030301  68 CQSNQFSCGGrvSRCIPDSWRCDGQVDCENDSDEQGC 104
Cdd:cd00112    1 CPPNEFRCAN--GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 4.32e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 4.32e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 358030301   236 TCRPDEFQCADGSCIHGSRQCDREHDCKDMSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.38e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.38e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 358030301  279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 1.51e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 358030301    67 TCQSNQFSCGGrvSRCIPDSWRCDGQVDCENDSDE 101
Cdd:smart00192   1 TCPPGEFQCDN--GRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-389 5.46e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 5.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 358030301   355 DIDECQEPDTCSQ--LCVNLEGSYKCECQAGFHMDPH 389
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
430-593 7.81e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 7.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 430 VVALDTEVTNNRIYWSDLSQKKIYsaLMDQAPNLSYDTIISEDlhAPDGLAVDWIHRNIYWTDSVPGSVSVADTK-GVKR 508
Cdd:COG3391   70 ADGADAGADGRRLYVANSGSGRVS--VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTAtGKVV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 509 RTLfqEAGSRPRAIVVDPVHGFMYWTDWGTP--AKIkkggLNGVDIHSL-VTENI---QWPNGITLDLSSGRLY------ 576
Cdd:COG3391  146 ATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI----VSVIDTATGkVVATIpvgGGPVGVAVSPDGRRLYvanrgs 219

                        170
                 ....*....|....*...
gi 358030301 577 -WVDSKLHSISSIDVNGG 593
Cdd:COG3391  220 nTSNGGSNTVSVIDLATL 237
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 439-621 1.35e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 50.66  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 439 NNRIYWSDLSQKKIYSAlmdqAPNLSYDTIISEDLHAPDGLAVDWiHRNIYWTDSVPGsVSVADTKGVKRRTLFQEAG-- 516
Cdd:COG3386   18 DGRLYWVDIPGGRIHRY----DPDGGAVEVFAEPSGRPNGLAFDP-DGRLLVADHGRG-LVRFDPADGEVTVLADEYGkp 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 517 -SRPRAIVVDPvHGFMYWTDwgTPAKIKKGGL-----NGvDIHsLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDV 590
Cdd:COG3386   92 lNRPNDGVVDP-DGRLYFTD--MGEYLPTGALyrvdpDG-SLR-VLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDL 166

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 358030301 591 NG----GNRKTILEDENRLAHPFSLAIYEDKVYWT 621
Cdd:COG3386  167 DAdgtlGNRRVFADLPDGPGGPDGLAVDADGNLWV 201
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 470-652 1.64e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.39  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 470 SEDLHAPDGLAVDwIHRNIYWTDSVPGSVSVADTKGvKRRTLFQEAGS------RPRAIVVDPvHGFMYWTDWGTpAKIK 543
Cdd:cd05819    4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSgdgqfnEPAGVAVDS-DGNLYVADTGN-HRIQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 544 KGGLNGVDIHSLVT-----ENIQWPNGITLDlSSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDENRLAHPFSLAIY- 614
Cdd:cd05819   80 KFDPDGNFLASFGGsgdgdGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDs 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 358030301 615 EDKVYWTDVINEAI--FSAN----RLTGSDVNLVAEnLLSPEDI 652
Cdd:cd05819  159 DGNIYVADTGNHRIqvFDPDgnflTTFGSTGTGPGQ-FNYPTGI 201
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-549 2.06e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 2.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 358030301   509 RTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 549
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 471-632 2.84e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 49.51  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 471 EDLHAPDGLAVDWIHRnIYWTDSVPGSVSVADTKGVKRRTLFQEAG---SRPRAIVVDPvHGFMYWTDwGTPAKIKKGGL 547
Cdd:cd14962    9 EALTRPYGVAADGRGR-IYVADTGRGAVFVFDLPNGKVFVIGNAGPnrfVSPIGVAIDA-NGNLYVSD-AELGKVFVFDR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 548 NGVDIHSLVTENIQW-PNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILED---ENRLAHPFSLAI-YEDKVYWTD 622
Cdd:cd14962   86 DGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAVdRDGNLYVTD 165

                        170
                 ....*....|..
gi 358030301 623 VINE--AIFSAN 632
Cdd:cd14962  166 TMNFrvQIFDAD 177
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 3.18e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 3.18e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 358030301 279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 8.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.15e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 358030301 355 DIDECQEPDTCS--QLCVNLEGSYKCECQAGFH 385
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 1.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 1.47e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 358030301   279 GPNKFKCHSGECISLDKVCDSARDCQDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-347 3.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.53e-05
                          10        20
                  ....*....|....*....|....*....
gi 358030301  319 CLDNNGGCSHICKDLKIGSECLCPSGFRL 347
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
475-628 1.58e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 44.24  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 475 APDGlavdwihrNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPvHGFMYWTDWGTpAKIkkGGLNG----V 550
Cdd:COG4257   25 DPDG--------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGN-NRI--GRIDPktgeI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 551 DIHSLVTENIQwPNGITLDlSSGRLYWVDSKLHSISSIDVNGGnrkTILEDENRLAH--PFSLAIYED-KVYWTDVINEA 627
Cdd:COG4257   93 TTFALPGGGSN-PHGIAFD-PDGNLWFTDQGGNRIGRLDPATG---EVTEFPLPTGGagPYGIAVDPDgNLWVTDFGANA 167


                 .
gi 358030301 628 I 628
Cdd:COG4257  168 I 168
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 1.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 358030301   420 YTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMD 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 596-639 3.03e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 3.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 358030301   596 KTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANrLTGSDV 639
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-585 3.98e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 3.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030301 473 LHAPDGLAVDwIHRNIYWTDSVPGSVSVADTKGvKRRTLFQEAG------SRPRAIVVDPvHGFMYWTDWGT------PA 540
Cdd:cd05819  148 FNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG-NFLTTFGSTGtgpgqfNYPTGIAVDS-DGNIYVADSGNnrvqvfDP 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 358030301 541 KIKKGGLNGVDIHSLvtENIQWPNGITLDlSSGRLYWVDSKLHSI 585
Cdd:cd05819  225 DGAGFGGNGNFLGSD--GQFNRPSGLAVD-SDGNLYVADTGNNRI 266
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 353-392 5.52e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 39.29  E-value: 5.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 358030301 353 CEDIDECQE-PDTCSQLCVNLEGSYKCECQAGFHMDPHTRV 392
Cdd:cd01475  184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 5.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 5.55e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 358030301  355 DIDEC-QEPDTCSQ--LCVNLEGSYKCECQAG 383
Cdd:pfam07645   1 DVDECaTGTHNCPAntVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 358-389 9.29e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 9.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 358030301 358 ECQEPDTCS--QLCVNLEGSYKCECQAGFHMDPH 389
Cdd:cd00053    1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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