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2-oxoglutarate dehydrogenase complex component E1 isoform 2 [Mus musculus]
Protein Classification
2-oxoglutarate dehydrogenase subunit E1 ( domain architecture ID 11484076 )
2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.90
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 E pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 288 RF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 607 DGQ pr SMTCPS TG LEEDV L FHI G KVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH VRLS 685
Cdd:COG0567 541 GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP VRLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF N N M A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlqeenfdinqlydc N WI V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 846 P GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PE ng PAAQ DP H KVKR LLF C T GKVYYDL TR 925
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DD -- TDEL DP K KVKR VVL C S GKVYYDL LE 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 926 ER KA R NM e EE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR DPA A A 1004
Cdd:COG0567 834 ER RE R GR - DD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S 912
970 980
....*....|....*....|...
gi 356582479 1005 PATG NKKT H LT E LQRFLDT A FDL 1027
Cdd:COG0567 913 PATG YMSV H KA E QKALVEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.90
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 E pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 288 RF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 607 DGQ pr SMTCPS TG LEEDV L FHI G KVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH VRLS 685
Cdd:COG0567 541 GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP VRLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF N N M A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlqeenfdinqlydc N WI V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 846 P GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PE ng PAAQ DP H KVKR LLF C T GKVYYDL TR 925
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DD -- TDEL DP K KVKR VVL C S GKVYYDL LE 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 926 ER KA R NM e EE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR DPA A A 1004
Cdd:COG0567 834 ER RE R GR - DD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S 912
970 980
....*....|....*....|...
gi 356582479 1005 PATG NKKT H LT E LQRFLDT A FDL 1027
Cdd:COG0567 913 PATG YMSV H KA E QKALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1026
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1264.26
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplslsrss L A TMAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 A V QS LI R AY QV RGH HI A K LDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL H E S DLD KV F H lp T TTFIG G Q 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG L ------- WKRPDVPEL D P A ------------- FYGL T E A DLD RT F N -- T GSLAL G K 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 E P A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:PRK09404 140 E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 289 F G LEG C E V LIP A L KT II DMSSAN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGD M KYHLG m YHR 367
Cdd:PRK09404 218 F S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGD V KYHLG - FSS 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T 445
Cdd:PRK09404 297 -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 446 H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDVV V DLVCYRR N GHN 525
Cdd:PRK09404 375 G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHN 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 526 E M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F TRS K DEK ilh IKH WL DSP W PGFFT 605
Cdd:PRK09404 455 E G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLG 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 606 LDGQPR smtc PS TG LEEDV L FHIGKVASS VP v E N F TI H GGLSR IL KT RRE LV - TNRTV DW AL AE YM AF G SLL K EG IH VRL 684
Cdd:PRK09404 532 HEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED RRE MA e GEKPI DW GM AE AL AF A SLL D EG YP VRL 606
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 685 SGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF N N M 764
Cdd:PRK09404 607 SGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G 685
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 765 AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlqeenfdinqlydc N WI V V N CS 844
Cdd:PRK09404 686 AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 845 TP GNF FH V LRRQ I L L PFRKPL I V F TPKSLLRHP E A RT S FD E MLP G T h FQ R VI PE ng PAAQ DP H KVKR LLF C T GKVYYDL T 924
Cdd:PRK09404 746 TP AQY FH L LRRQ A L R PFRKPL V V M TPKSLLRHP L A VS S LE E LAE G S - FQ P VI GD -- IDEL DP K KVKR VVL C S GKVYYDL L 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 925 RE R KA R N m EEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTIDRAKPVW YAGR DPA A 1003
Cdd:PRK09404 823 EA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A 901
970 980
....*....|....*....|...
gi 356582479 1004 A PA T G NKKT H LTELQRFLDT A FD 1026
Cdd:PRK09404 902 S PA V G YMSL H KKQQEALVED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1025
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 980.13
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LSLSRSS LA TM A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 AV Q s LIRAY QV RGH HI A K LDPLG iscv NFD dap VTVSSNV DL A vfkerlrmltvgg FYGL H E S DL DKV F HLPTTTFIGGQ 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG ---- LKQ --- QDKVPEL DL S ------------- FYGL T E A DL QET F NIGSFVSGKDA 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 EPA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:TIGR00239 138 TMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 289 F G LEG CEV L I P A LK T II DM S SAN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GD M KYH L G MYHR 367
Cdd:TIGR00239 218 F S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GD V KYH M G RFSS 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 RIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH 446
Cdd:TIGR00239 298 DFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 447 GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W RNTF HK DV VV DLV C YRR N GHNE 526
Cdd:TIGR00239 377 GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y RNTF KR DV FI DLV G YRR H GHNE 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 527 M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FTRSKD e KILHIKHWLDSPWPGFFT L 606
Cdd:TIGR00239 457 A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 607 D g QPRSMTC P ST g L E EDV L FHIG K VA S S VP v E NFTI H GGLSR I LKT R RELVT -- NRTV DW AL AE YM AF GS L LKE GI H VRL 684
Cdd:TIGR00239 532 N - HEWDEEY P NK - V E MKR L QELA K RI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI P VRL 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 685 SG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF N N M 764
Cdd:TIGR00239 609 SG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G 687
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 765 AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlqeenfdinqlydc N WI V VNCS 844
Cdd:TIGR00239 688 AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT 747
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 845 TP GNF FH V LRRQ I L LPF R K PL I V FT PKSLLRHP E A RT S FD E MLP GT h FQ R VI P -- E NGPAAQ DP HK VKRL LF C T GKVYYD 922
Cdd:TIGR00239 748 TP AQV FH I LRRQ A L RGM R R PL V V MS PKSLLRHP L A VS S LE E LAE GT - FQ P VI G ei E ESGLSL DP EG VKRL VL C S GKVYYD 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 923 L TRE R KARN m EEE VAI T RIEQL S PFP FDLLLKEA Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I DRAKP V W YAGR DP 1001
Cdd:TIGR00239 827 L HEQ R RKNG - QKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PA 905
970 980
....*....|....*....|....
gi 356582479 1002 A A A PA T G NKKT H LTEL Q RF L DT A F 1025
Cdd:TIGR00239 906 S A S PA V G YMSL H QKQQ Q DL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
275-538
1.07e-177
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 517.85
E-value: 1.07e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 275 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID MSSAN GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 352
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAAEL GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 353 EGSGD M KYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 432
Cdd:cd02016 81 EGSGD V KYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 433 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDV 512
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 356582479 513 V V DLVCYRR N GHNE M DEP M FTQPLMY 538
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
267-593
1.05e-108
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 339.69
E-value: 1.05e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 267 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DMSSAN G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 346
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAALEP G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 347 KLE aad E G S G DMKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 426
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 427 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRN 506
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 507 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF TRSK 585
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 356582479 586 DEKIL H IK 593
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
728-875
6.30e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.55
E-value: 6.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 728 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F NNM A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 806
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 807 E - RFLQM cnddpdvlpdlqeenfdinqlyd CNWI VV NC S T P GNFFHV LR RQ I LLP f RKPL I VFTP KSL L R 875
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.90
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 E pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 288 RF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 607 DGQ pr SMTCPS TG LEEDV L FHI G KVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH VRLS 685
Cdd:COG0567 541 GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP VRLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF N N M A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlqeenfdinqlydc N WI V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 846 P GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PE ng PAAQ DP H KVKR LLF C T GKVYYDL TR 925
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DD -- TDEL DP K KVKR VVL C S GKVYYDL LE 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 926 ER KA R NM e EE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR DPA A A 1004
Cdd:COG0567 834 ER RE R GR - DD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S 912
970 980
....*....|....*....|...
gi 356582479 1005 PATG NKKT H LT E LQRFLDT A FDL 1027
Cdd:COG0567 913 PATG YMSV H KA E QKALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1026
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1264.26
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplslsrss L A TMAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 A V QS LI R AY QV RGH HI A K LDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL H E S DLD KV F H lp T TTFIG G Q 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG L ------- WKRPDVPEL D P A ------------- FYGL T E A DLD RT F N -- T GSLAL G K 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 E P A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:PRK09404 140 E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 289 F G LEG C E V LIP A L KT II DMSSAN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGD M KYHLG m YHR 367
Cdd:PRK09404 218 F S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGD V KYHLG - FSS 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T 445
Cdd:PRK09404 297 -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 446 H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDVV V DLVCYRR N GHN 525
Cdd:PRK09404 375 G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHN 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 526 E M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F TRS K DEK ilh IKH WL DSP W PGFFT 605
Cdd:PRK09404 455 E G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLG 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 606 LDGQPR smtc PS TG LEEDV L FHIGKVASS VP v E N F TI H GGLSR IL KT RRE LV - TNRTV DW AL AE YM AF G SLL K EG IH VRL 684
Cdd:PRK09404 532 HEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED RRE MA e GEKPI DW GM AE AL AF A SLL D EG YP VRL 606
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 685 SGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF N N M 764
Cdd:PRK09404 607 SGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G 685
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 765 AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlqeenfdinqlydc N WI V V N CS 844
Cdd:PRK09404 686 AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 845 TP GNF FH V LRRQ I L L PFRKPL I V F TPKSLLRHP E A RT S FD E MLP G T h FQ R VI PE ng PAAQ DP H KVKR LLF C T GKVYYDL T 924
Cdd:PRK09404 746 TP AQY FH L LRRQ A L R PFRKPL V V M TPKSLLRHP L A VS S LE E LAE G S - FQ P VI GD -- IDEL DP K KVKR VVL C S GKVYYDL L 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 925 RE R KA R N m EEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTIDRAKPVW YAGR DPA A 1003
Cdd:PRK09404 823 EA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A 901
970 980
....*....|....*....|...
gi 356582479 1004 A PA T G NKKT H LTELQRFLDT A FD 1026
Cdd:PRK09404 902 S PA V G YMSL H KKQQEALVED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1027
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1014.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 117 QPNVDKL V EDHLA V QS LI R AY Q VRGH HI A KL DPL GI scvnfddapv TVS S NV DL A V fkerlrmltvg GFY GL HES DLD KV 196
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY R VRGH LM A DT DPL EY ---------- RQR S HP DL D V ----------- LTH GL TLW DLD RE 434
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 197 F hl P TTT F i GG Q e PALP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L VRSTR FE 276
Cdd:PRK12270 435 F -- P VGG F - GG K - ERMK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L NAAEA FE 509
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 277 E FLQ R K WSSE KRF G LEG C E V LIP A L KTII D MSSAN G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E - AADE GS 355
Cdd:PRK12270 510 T FLQ T K YVGQ KRF S LEG G E S LIP L L DAVL D QAAEH G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D p RSAQ GS 589
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 356 GD M KYHLG --- MYHR rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAAFAGQG I V 431
Cdd:PRK12270 590 GD V KYHLG aeg TFTQ ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAAFAGQG V V 665
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 432 Y ET FH LS D L PS Y T T H GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W R NT FHKD 511
Cdd:PRK12270 666 A ET LN LS Q L RG Y R T G GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y R QR FHKD 745
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 512 VV V DLVCYRR N GHNE M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F TRSKDEK ilh 591
Cdd:PRK12270 746 VV I DLVCYRR R GHNE G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEVREAE --- 822
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 592 i K H wl DSPW P GFFTL D GQ P rs MTCPS T GLEED VL FH IG KVASSV P v E N FT I H GG L SRI L KT RRE LVTNRTV DWA LA E YM A 671
Cdd:PRK12270 823 - K K -- PPEP P ESVES D QG P -- PAGVD T AVSAE VL ER IG DAHVNL P - E G FT V H PK L KPL L EK RRE MAREGGI DWA FG E LL A 896
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 672 FGSLL K EG IH VRLSGQD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FAMAS P N AL 751
Cdd:PRK12270 897 FGSLL L EG TP VRLSGQD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YSVER P D AL 975
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 752 VLWEAQFGDF N N M AQ C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpdlqeenfdin 831
Cdd:PRK12270 976 VLWEAQFGDF A N G AQ T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG --------------- 1040
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 832 qlydc N WI V VNC STP G N F FH V LRRQ I L LPF R K PL I VFTPKS L LR HPE A RTSFDEMLP G T h F QR VI PE ng P AAQ D PH KV K R 911
Cdd:PRK12270 1041 ----- N MT V AQP STP A N Y FH L LRRQ A L SGP R R PL V VFTPKS M LR LKA A VSDVEDFTE G K - F RP VI DD -- P TVD D GA KV R R 1112
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 912 L L F C T GK V YYDL TRE R KARN m EEEV AI T R I EQL S P F P FDL L LKEAQK YPNA - E LA W C QEE HK NQG YYDYVKPR L RTTIDR 990
Cdd:PRK12270 1113 V L L C S GK L YYDL AAR R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN L PELLPD 1191
890 900 910
....*....|....*....|....*....|....*..
gi 356582479 991 AKPVWYAG R DPA A A PATG NK K T H LT E L Q RF LD T AF DL 1027
Cdd:PRK12270 1192 GRRLRRVS R PAS A S PATG SA K V H AV E Q Q EL LD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1025
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 980.13
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LSLSRSS LA TM A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 129 AV Q s LIRAY QV RGH HI A K LDPLG iscv NFD dap VTVSSNV DL A vfkerlrmltvgg FYGL H E S DL DKV F HLPTTTFIGGQ 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG ---- LKQ --- QDKVPEL DL S ------------- FYGL T E A DL QET F NIGSFVSGKDA 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 209 EPA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:TIGR00239 138 TMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 289 F G LEG CEV L I P A LK T II DM S SAN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GD M KYH L G MYHR 367
Cdd:TIGR00239 218 F S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GD V KYH M G RFSS 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 368 RIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH 446
Cdd:TIGR00239 298 DFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 447 GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W RNTF HK DV VV DLV C YRR N GHNE 526
Cdd:TIGR00239 377 GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y RNTF KR DV FI DLV G YRR H GHNE 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 527 M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FTRSKD e KILHIKHWLDSPWPGFFT L 606
Cdd:TIGR00239 457 A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 607 D g QPRSMTC P ST g L E EDV L FHIG K VA S S VP v E NFTI H GGLSR I LKT R RELVT -- NRTV DW AL AE YM AF GS L LKE GI H VRL 684
Cdd:TIGR00239 532 N - HEWDEEY P NK - V E MKR L QELA K RI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI P VRL 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 685 SG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF N N M 764
Cdd:TIGR00239 609 SG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G 687
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 765 AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlqeenfdinqlydc N WI V VNCS 844
Cdd:TIGR00239 688 AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT 747
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 845 TP GNF FH V LRRQ I L LPF R K PL I V FT PKSLLRHP E A RT S FD E MLP GT h FQ R VI P -- E NGPAAQ DP HK VKRL LF C T GKVYYD 922
Cdd:TIGR00239 748 TP AQV FH I LRRQ A L RGM R R PL V V MS PKSLLRHP L A VS S LE E LAE GT - FQ P VI G ei E ESGLSL DP EG VKRL VL C S GKVYYD 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 923 L TRE R KARN m EEE VAI T RIEQL S PFP FDLLLKEA Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I DRAKP V W YAGR DP 1001
Cdd:TIGR00239 827 L HEQ R RKNG - QKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PA 905
970 980
....*....|....*....|....
gi 356582479 1002 A A A PA T G NKKT H LTEL Q RF L DT A F 1025
Cdd:TIGR00239 906 S A S PA V G YMSL H QKQQ Q DL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
275-538
1.07e-177
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 517.85
E-value: 1.07e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 275 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID MSSAN GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 352
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAAEL GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 353 EGSGD M KYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 432
Cdd:cd02016 81 EGSGD V KYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 433 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDV 512
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 356582479 513 V V DLVCYRR N GHNE M DEP M FTQPLMY 538
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
267-593
1.05e-108
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 339.69
E-value: 1.05e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 267 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DMSSAN G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 346
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAALEP G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 347 KLE aad E G S G DMKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 426
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 427 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRN 506
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 507 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF TRSK 585
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 356582479 586 DEKIL H IK 593
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
880-1025
2.71e-79
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 255.06
E-value: 2.71e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 880 R T S FD E ML PGTHFQRVIP ENG P A a Q DP H KVKR LLF C T GKVYYDL TR ER KA R NMEEE VAI T RIEQL S PFPFDLL LK E AQ KY 959
Cdd:pfam16870 1 R S S LE E FT PGTHFQRVIP DPE P L - V DP E KVKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 356582479 960 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TIDRA - KPVW YAGR D P A A A PATG N K KT HL T E LQRF LD T AF 1025
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEAL LD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
660-875
4.35e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.14
E-value: 4.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 660 RTVDWAL A EYM A FGS L L K EGIH V RLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 739
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPR V VGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 740 EL G F A MAS P N a L VLW EA Q F G DF N N M A qcii D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 818
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N R A ---- D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 356582479 819 vlpdlqeenfdinqlydc NWI VV NC S TPGNFFHV LR RQ I LLPF RKP LIVFT P KS LLR 875
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
728-875
6.30e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.55
E-value: 6.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 728 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F NNM A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 806
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 807 E - RFLQM cnddpdvlpdlqeenfdinqlyd CNWI VV NC S T P GNFFHV LR RQ I LLP f RKPL I VFTP KSL L R 875
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.26e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.26e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 356582479 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
411-583
5.85e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 64.44
E-value: 5.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 411 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 485
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356582479 486 V NSD D PE AV MYVC K V A A E W - R NT f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 559
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 356582479 560 VVNQP E YEEEISKYDKIC EEA FTR 583
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
