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Conserved domains on  [gi|329663552|ref|NP_001192282|]
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GRAM domain-containing protein 4 isoform 2 [Mus musculus]

Protein Classification

GRAM domain-containing protein 4( domain architecture ID 10192382)

GRAM domain-containing protein 4 (GRAMD4) plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53

CATH:  2.30.29.30
Gene Ontology:  GO:0006915
PubMed:  11050430|18201690
SCOP:  4000903

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 490-593 2.55e-46

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


:

Pssm-ID: 270041  Cd Length: 104  Bit Score: 158.66  E-value: 2.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329663552 490 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLMDITDIQK--EESVLDEWGLASPLSL 567
Cdd:cd13221    1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKakPYSFLPGSGMSIEVSV 78

                         90       100
                 ....*....|....*....|....*.
gi 329663552 568 GEAGGPVAMVVLFHFSIKSCLSSLAQ 593
Cdd:cd13221   79 SSADKPLFFGAMFRRDEFFDIIALGA 104
 
Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 490-593 2.55e-46

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270041  Cd Length: 104  Bit Score: 158.66  E-value: 2.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329663552 490 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLMDITDIQK--EESVLDEWGLASPLSL 567
Cdd:cd13221    1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKakPYSFLPGSGMSIEVSV 78

                         90       100
                 ....*....|....*....|....*.
gi 329663552 568 GEAGGPVAMVVLFHFSIKSCLSSLAQ 593
Cdd:cd13221   79 SSADKPLFFGAMFRRDEFFDIIALGA 104
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 476-554 5.06e-12

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 62.77  E-value: 5.06e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 329663552  476 NFHEIFNLTENERPLAVCengwrCCLINRDRkmptdYIRNGVLYVTENYLCFESSKSGSSKRnKVIKLMDITDIQKEES 554
Cdd:pfam02893   2 LFRKKFKLPPEERLIASY-----SCYLNRDG-----GPVQGRLYLTNYRLCFRSLPKGWSTK-VVIPLVDIEEIEKLKG 69
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
482-552 1.67e-08

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.67e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329663552   482 NLTENERPLAVcengWRCCLINrdrkmptDYIRNGVLYVTENYLCFESSKSGSSKrNKVIKLMDITDIQKE 552
Cdd:smart00568   1 KLPEEEKLIAD----YSCYLSR-------TGPVQGRLYISNYRLCFRSNLPGKLT-KVVIPLADITRIEKS 59
 
Name Accession Description Interval E-value
PH-GRAM_GRAMDC4 cd13221
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 490-593 2.55e-46

GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270041  Cd Length: 104  Bit Score: 158.66  E-value: 2.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329663552 490 LAVCENGWRCCLINRDrKMPTDYIRNGVLYVTENYLCFESSKSgSSKRNKVIKLMDITDIQK--EESVLDEWGLASPLSL 567
Cdd:cd13221    1 LPVWENGWRCCLINRD-KMPTDYIRNGRLYLTENYLCFESSSS-SSKKNVVIPLTDITRIEKakPYSFLPGSGMSIEVSV 78

                         90       100
                 ....*....|....*....|....*.
gi 329663552 568 GEAGGPVAMVVLFHFSIKSCLSSLAQ 593
Cdd:cd13221   79 SSADKPLFFGAMFRRDEFFDIIALGA 104
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 476-554 5.06e-12

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 62.77  E-value: 5.06e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 329663552  476 NFHEIFNLTENERPLAVCengwrCCLINRDRkmptdYIRNGVLYVTENYLCFESSKSGSSKRnKVIKLMDITDIQKEES 554
Cdd:pfam02893   2 LFRKKFKLPPEERLIASY-----SCYLNRDG-----GPVQGRLYLTNYRLCFRSLPKGWSTK-VVIPLVDIEEIEKLKG 69
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
482-552 1.67e-08

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.67e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329663552   482 NLTENERPLAVcengWRCCLINrdrkmptDYIRNGVLYVTENYLCFESSKSGSSKrNKVIKLMDITDIQKE 552
Cdd:smart00568   1 KLPEEEKLIAD----YSCYLSR-------TGPVQGRLYISNYRLCFRSNLPGKLT-KVVIPLADITRIEKS 59
PH-GRAM cd10570
Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins ...
 493-551 1.76e-07

Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275393  Cd Length: 94  Bit Score: 49.30  E-value: 1.76e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 329663552 493 CENGWRCCLINRDRKMPtdyiRNGVLYVTENYLCFESSKSGsSKRNKVIKLMDITDIQK 551
Cdd:cd10570    2 EKLGVRFCCALRPRKLP----LEGTLYLSTYRLIFSSKADG-DETKLVIPLVDITDVEK 55
PH-GRAM_GRAMDC cd13220
GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 516-556 5.76e-05

GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; The GRAMDC proteins are membrane proteins. Nothing is known about its function. Members include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, GRAMDC4, and GRAMDC-like proteins. All of the members, except for GRAMDC4 are included in this hierarchy. Each contains a single PH-GRAM domain at their N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275406  Cd Length: 94  Bit Score: 42.11  E-value: 5.76e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 329663552 516 GVLYVTENYLCFESSKSGsSKRNKVIKLMDITDIQKEESVL 556
Cdd:cd13220   21 GRLYISENHLCFYSNIFG-WETKLVIPFKDITSIEKKKTAL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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