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Conserved domains on  [gi|325296975|ref|NP_001191675|]
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cadherin-16 isoform 4 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-348 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 245 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 323
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296975 324 DlaGAEGGFSSTCEVEVAVTDINDH 348
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-235 2.06e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.06e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296975 167 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 235
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-123 4.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.04e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296975    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQA 123
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-558 7.86e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 7.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 471 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 325296975 547 PRLSASAPLVIH 558
Cdd:cd11304   80 PPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-461 5.81e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 5.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 360 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 439
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296975 440 kLV-----GPGPGPGATATVTVLVERV 461
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-348 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 245 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 323
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296975 324 DlaGAEGGFSSTCEVEVAVTDINDH 348
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-235 2.06e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.06e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296975 167 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 235
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 167-237 1.94e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.94e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325296975   167 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 237
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-123 4.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.04e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296975    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQA 123
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-558 7.86e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 7.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 471 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 325296975 547 PRLSASAPLVIH 558
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 262-350 1.57e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975   262 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 339
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 325296975   340 VAVTDINDHAP 350
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 2.68e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.68e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325296975  49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304   26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-461 5.81e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 5.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 360 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 439
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296975 440 kLV-----GPGPGPGATATVTVLVERV 461
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
244-343 1.59e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975  244 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 321
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 325296975  322 AMDLAGaeGGFSSTCEVEVAVT 343
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-459 2.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975  359 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 438
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 325296975  439 AKLVGPGPGPGATATVTVLVE 459
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
26-116 1.60e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975   26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 325296975  102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
175-229 8.76e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 8.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325296975  175 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 229
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-348 1.50e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 245 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 323
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296975 324 DlaGAEGGFSSTCEVEVAVTDINDH 348
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-235 2.06e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.06e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296975 167 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 235
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 167-237 1.94e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.94e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325296975   167 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 237
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-123 4.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 4.04e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296975    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQA 123
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-558 7.86e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 7.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 471 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 546
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 325296975 547 PRLSASAPLVIH 558
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 262-350 1.57e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975   262 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 339
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 325296975   340 VAVTDINDHAP 350
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 2.68e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.68e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325296975  49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304   26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-461 5.81e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 5.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975 360 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 439
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296975 440 kLV-----GPGPGPGATATVTVLVERV 461
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
244-343 1.59e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975  244 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 321
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 325296975  322 AMDLAGaeGGFSSTCEVEVAVT 343
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-459 2.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975  359 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 438
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 325296975  439 AKLVGPGPGPGATATVTVLVE 459
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
26-116 1.60e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975   26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 325296975  102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
175-229 8.76e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 8.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325296975  175 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 229
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-121 2.27e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296975  29 VPENYGGnfPLYLTKLPLPREGAEGQIV-LSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLW 107
Cdd:cd00031    6 AVEGRSR--GSFRVSIPTDLIASSGEIIkISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                         90
                 ....*....|....
gi 325296975 108 GPQPVLVHVKDEND 121
Cdd:cd00031   84 TSSVFSIEVYDEND 97
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 179-235 8.04e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 8.04e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 325296975 179 PPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 235
Cdd:cd00031   41 LPSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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