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Conserved domains on  [gi|325121030|ref|NP_001191356|]
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small proline-rich protein 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cornifin super family cl25524
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-149 2.29e-20

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


The actual alignment was detected with superfamily member pfam02389:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 83.56  E-value: 2.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325121030   17 EQHQVKQPCQPPPQGKFVPiATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 325121030   97 PCSTNITEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTI-PGPSSTK 149
Cdd:pfam02389  80 PCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVtPGPAQQK 133
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-149 2.29e-20

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 83.56  E-value: 2.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325121030   17 EQHQVKQPCQPPPQGKFVPiATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 325121030   97 PCSTNITEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTI-PGPSSTK 149
Cdd:pfam02389  80 PCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVtPGPAQQK 133
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-149 2.29e-20

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 83.56  E-value: 2.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325121030   17 EQHQVKQPCQPPPQGKFVPiATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 325121030   97 PCSTNITEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTI-PGPSSTK 149
Cdd:pfam02389  80 PCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVtPGPAQQK 133
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 14-110 5.24e-08

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 50.44  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325121030   14 PQPEQHQVKQPCQPppqgkfvpiATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTT 93
Cdd:pfam02389  38 PEPCCPKVPEPCCP---------KVPEPCCPKVPEPCCPKVPEPCYPKVPEPCSPKVPEPCHPKAPEPCHPKVPEPCYPK 108

                          90
                  ....*....|....*..
gi 325121030   94 IPGPCSTNITEPDYTTI 110
Cdd:pfam02389 109 APEPCQPKVPEPCPSTV 125
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 14-87 1.42e-04

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 40.81  E-value: 1.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 325121030   14 PQPEQHQVKQPCQPppqgkfvpiATSEPCHTDVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNIT 87
Cdd:pfam02389  62 PEPCCPKVPEPCYP---------KVPEPCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVT 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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