Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  31 FVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQE 110
Cdd:cd20419    1 FVEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 312283653 111 VEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20419   81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  31 FVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQE 110
Cdd:cd20419    1 FVEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 312283653 111 VEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20419   81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 312283653    81 IQPGHLCCVRIsEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLKC 134
Cdd:smart00333   3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  31 FVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQE 110
Cdd:cd20419    1 FVEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 312283653 111 VEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20419   81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653   26 SLIGVFVEYIISPSQFYIRiySRDSSELLEDMMIEMRRCYSNQLvsdryvmPECF-IQPGHLCCVRISEDKWWYRVIIHR 104
Cdd:pfam00567   1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKP-------PESLpPAVGDGCVAAFSEDGKWYRAKITE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 312283653  105 VLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLA 149
Cdd:pfam00567  72 SLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  30 VFVEYIISPSQFYIRIysRDSSELLEDMMIEMRRCYSNQLVSDRYVMPEcfiQPGHLCCVRISEDKWwYRVIIHRVLEKQ 109
Cdd:cd20422    4 AQVEFVKDPSEFWIRL--GEHAVPFSKLMRSMTAFYSQASKLDGVVLKP---QPGQLCCAKWKEDRY-YRAIVTAVKGKM 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312283653 110 eVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQK 168
Cdd:cd20422   78 -VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 312283653  83 PGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFL 132
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  28 IGVFVEYIISPSQFYIRiYSRDSSELLEDMMIEMRRcysnQLVSDRYVMPEcfIQPGHLCCVRISEDKWWYRVIIHRVLE 107
Cdd:cd20426    1 IEAYATAVDSPEYFWCQ-FATEKIQCLAVKVQEAGE----QVADRGNFIPS--IYVGDPCIVKYSEDNHWYRALVTKIND 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312283653 108 KQeVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQF 166
Cdd:cd20426   74 NL-VSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312283653  81 IQPGHLCCVRISEDKWWYRVIIHRVLE-KQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20423    3 SLPNPVCLAKYSEDGKWCRALIDNVYEpVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  30 VFVEYIISPSQFYIRIySRDSSelledmMIEMRRCYSNQLvSDRYVMPECFIQPGHLCCVRISeDKWWYRVIIhrVLEKQ 109
Cdd:cd20424   16 VYITYVNDPWTFYCQL-ARNAG------VLDQLASAISRL-SSEIRKLELSVNPGTLCLAKYS-DQHWYRGII--ITNKN 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 312283653 110 EVEVFYPDFGNIGIVQKSSLRFL---KCCYTKLPAQAIPCSL 148
Cdd:cd20424   85 STEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  26 SLIGVFVEYIISPSQFYIRIYSRdsSELLEDMMIEMRRCYSNQlvSDRYvmpecfiQPGHLCCV-RISEDKWWYRVIIHR 104
Cdd:cd20439   10 SVVDVKCSYVNSPGDFWCQLQTK--SSELKSLMKQIQSYYLIH--NDPY-------KHGQIACVaKYSKDGKWYRAAVLK 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 312283653 105 VLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20439   79 QVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  30 VFVEYIISPSQFYIRIySRDSSELLedMMIEmrrCYSNQLVSDRYVMPECFiQPGHLCCVRISEDKWWYRVIIHRVLEKQ 109
Cdd:cd20425    4 VYVSHVNSPSDFYVQL-AQDEDELS--MISE---KLNASKANDEEVECESL-QLGDLICAEYPEDGLWYRAVVKEKIPNN 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 312283653 110 EVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSL 148
Cdd:cd20425   77 LVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  37 SPSQFYIRIYS---------RDSSELLEDMMIEMRRCYSNQlvSDRyvMPECFIQPGHLCCVRISEDKWwYRVIIHRVLE 107
Cdd:cd20435    1 DATHYSARILEhrssdgevtKSMSSTYLKLSMKLNMYYSDP--SNR--ILHGKVKVGDLCAVEDENNLY-HRVKVLEITE 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312283653 108 K------QEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPV--EEHW 158
Cdd:cd20435   76 KddktkpREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVdnDTEW 134

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  52 ELLEDmmiEMRRCYSNqlvsDRYVMPECFIQPGHLCCVRISEDKWwYRVIIHRVLEKQeVEVFYPDFGNIGIVQKSSLRF 131
Cdd:cd20427    1 EQMED---EMKEFYSK----SSTAMCLRSPSVGQLVAVKAEEDAW-LRAQVIEVEEDK-VKVYYVDHGFSEVVERSKLFK 71

                         90       100
                 ....*....|....*....|..
gi 312283653 132 LKCCYTKLPAQAIPCSLAWVRP 153
Cdd:cd20427   72 LNKQFYSLPFQATKCKLAGLEP 93

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312283653  82 QPGHLCCVRISEDKWWYRVIIHRV------LEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRP 153
Cdd:cd20443   39 KKGELVLAQFSADNSWNRAMVVNAprqgtqSPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 312283653  87 CCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLK 133
Cdd:cd20416   25 CAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLE 71

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  54 LEDMMIEMRRCYSNQLVSDRYVMPecfiQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLK 133
Cdd:cd20433    5 LEKLMEKLRFEIASNPPLPGSYTP----RKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 312283653  83 PGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLR 130
Cdd:cd20409   28 VGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLR 75

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  54 LEDMMIEMRRCYSNQlvSDRYVMpecfIQPGHLCCVRIseDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLK 133
Cdd:cd20429    9 LEVLMEEMILYYNKT--EERPVA----IEKNKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLI 80

                         90
                 ....*....|.
gi 312283653 134 CCYTKLPAQAI 144
Cdd:cd20429   81 EKFRQLPFQAI 91

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283653  35 IISPSQFYIRI-----YSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECfIQPGHLCCVRISEDKWWYRVIIHRVLEKQ 109
Cdd:cd20434    6 IEDPGCFWGRIlkgsgDLVVNPEEYENLQDEMNQFYHKGYKDVEEIKPST-LEEGQVCVVFCEELKCWCRAVVESLMSSA 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312283653 110 E---VEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEH---------------WTSKAILQFQKL 169
Cdd:cd20434   85 DdylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVTLHvdlcedkakivparkWDSAAIQYFQNL 162