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Conserved domains on  [gi|299758443|ref|NP_001177380|]
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decorin preproprotein [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13881376)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens lumican that binds to laminin

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
65-293 1.07e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  65 LGLDKVPWDFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPLVklERLYLSKNQLKELPEKMP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIK---TLYANSNQLTSI-PATLPDTI--QEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 145 RTLQELRVHENEITKLRKSDFNGLNnvlvielggnplknsgiengafqglkslsYIRISDTNITAIPQGLPTSLTEVHLD 224
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELR-----------------------------YLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 225 GNKITKVDA---PSLKGLI---------------NLSKLGLSFNSITVMENgSLAnvPHLRELHLDNNKLLRVPAGL-AQ 285
Cdd:PRK15370 313 SNSLTALPEtlpPGLKTLEagenaltslpaslppELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 299758443 286 HKYIQVVY 293
Cdd:PRK15370 390 LQIMQASR 397
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 1.80e-12

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 60.79  E-value: 1.80e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 299758443    48 MCPYRCQCHLRVVQCSDLGLDKVPWDFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-293 1.07e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  65 LGLDKVPWDFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPLVklERLYLSKNQLKELPEKMP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIK---TLYANSNQLTSI-PATLPDTI--QEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 145 RTLQELRVHENEITKLRKSDFNGLNnvlvielggnplknsgiengafqglkslsYIRISDTNITAIPQGLPTSLTEVHLD 224
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELR-----------------------------YLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 225 GNKITKVDA---PSLKGLI---------------NLSKLGLSFNSITVMENgSLAnvPHLRELHLDNNKLLRVPAGL-AQ 285
Cdd:PRK15370 313 SNSLTALPEtlpPGLKTLEagenaltslpaslppELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 299758443 286 HKYIQVVY 293
Cdd:PRK15370 390 LQIMQASR 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-300 5.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  78 TTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNkiskispEAFKPLVKLERLYLSKNQLKELPEkmprtlqelrvhenei 157
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE---------------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 158 tklrksdfnglnnvlvielggnplknsgiengAFQGLKSLSYIRISDTNITAIPQGLP--TSLTEVHLDGNKITKVDAPs 235
Cdd:COG4886  131 --------------------------------ELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE- 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 236 LKGLINLSKLGLSFNSITVMENgSLANVPHLRELHLDNNKLLRVPAGLAQHKYIQVVYLHNNNIS 300
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 1.80e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 60.79  E-value: 1.80e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 299758443    48 MCPYRCQCHLRVVQCSDLGLDKVPWDFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
79-136 1.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 299758443   79 TLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 204-276 1.23e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.23e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 204 DTNITAIPqGLP--TSLTEVHLDGNKITKVDapSLKGLINLSKLGLSFNSITVMENgsLANVPHLRELHLDNNKL 276
Cdd:cd21340   33 DNKITKIE-NLEflTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 48-75 2.34e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 54.94  E-value: 2.34e-10
                          10        20
                  ....*....|....*....|....*...
gi 299758443   48 MCPYRCQCHLRVVQCSDLGLDKVPWDFP 75
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-293 1.07e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  65 LGLDKVPWDFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPLVklERLYLSKNQLKELPEKMP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIK---TLYANSNQLTSI-PATLPDTI--QEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 145 RTLQELRVHENEITKLRKSDFNGLNnvlvielggnplknsgiengafqglkslsYIRISDTNITAIPQGLPTSLTEVHLD 224
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPEELR-----------------------------YLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 225 GNKITKVDA---PSLKGLI---------------NLSKLGLSFNSITVMENgSLAnvPHLRELHLDNNKLLRVPAGL-AQ 285
Cdd:PRK15370 313 SNSLTALPEtlpPGLKTLEagenaltslpaslppELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 299758443 286 HKYIQVVY 293
Cdd:PRK15370 390 LQIMQASR 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-300 5.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  78 TTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNkiskispEAFKPLVKLERLYLSKNQLKELPEkmprtlqelrvhenei 157
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE---------------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 158 tklrksdfnglnnvlvielggnplknsgiengAFQGLKSLSYIRISDTNITAIPQGLP--TSLTEVHLDGNKITKVDAPs 235
Cdd:COG4886  131 --------------------------------ELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE- 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 236 LKGLINLSKLGLSFNSITVMENgSLANVPHLRELHLDNNKLLRVPAGLAQHKYIQVVYLHNNNIS 300
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-300 9.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 9.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  75 PPDTTLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLKELPEKMPRTLQELRVHE 154
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 155 NEITKLRKSDFNGLNNVLVIELGGNPlknsgiengAFQGLKSLSYIRISDTNITAIPQGLP--TSLTEVHLDGNKITKVD 232
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 299758443 233 APsLKGLINLSKLGLSFNSITVMENgSLANVPHLRELHLDNNKLLRVPAGLAQHKYIQVVYLHNNNIS 300
Cdd:COG4886  153 EP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-290 1.01e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  56 HLRVVQCSDLGLDKVPWDFPPDTTL--LDLQNNKITEIKEgAFKNLKDLHTLILVNNKISKIsPEAFKPLVKLERLYLSK 133
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 134 NQLKELPE--KMPRtLQELRVHENEITKLrkSDFNGLNNVLVIELGGNPLKNSGIEN-GAFQGLKSLSYIRISDTNITAI 210
Cdd:COG4886  238 NQLTDLPElgNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKElELLLGLNSLLLLLLLLNLLELL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 211 PQGLPTSLTEVHLDGNKITKVDAPSLKGLINLSKLGLSFNSITVMENGSLANVPHLRELHLDNNKLLRVPAGLAQHKYIQ 290
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-283 1.43e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.65  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  42 DNPLISMcPYRCQCHLRVVQCSDLGLDKVPWDFPPDTTLLDLQNNKITEIKEgafKNLKDLHTLILVNNKISKIsPEAFK 121
Cdd:PRK15370 208 NNELKSL-PENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 122 PlvKLERLYLSKNQLKELPEKMPRTLQELRVHENEITKLRKSDFNGLNnvlVIELGGNPLknSGIENGAFQGLKSLSyir 201
Cdd:PRK15370 283 E--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENAL--TSLPASLPPELQVLD--- 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 202 ISDTNITAIPQGLPTSLTEVHLDGNkitkvdapslkGLINLSKlglsfnsitvmengslaNVP-HLRELHLDNNKLLRVP 280
Cdd:PRK15370 353 VSKNQITVLPETLPPTITTLDVSRN-----------ALTNLPE-----------------NLPaALQIMQASRNNLVRLP 404


                 ...
gi 299758443 281 AGL 283
Cdd:PRK15370 405 ESL 407
LRRNT smart00013
Leucine rich repeat N-terminal domain;
48-80 1.80e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 60.79  E-value: 1.80e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 299758443    48 MCPYRCQCHLRVVQCSDLGLDKVPWDFPPDTTL 80
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
79-136 1.18e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 299758443   79 TLLDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 204-276 1.23e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.23e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 204 DTNITAIPqGLP--TSLTEVHLDGNKITKVDapSLKGLINLSKLGLSFNSITVMENgsLANVPHLRELHLDNNKL 276
Cdd:cd21340   33 DNKITKIE-NLEflTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-285 3.01e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.53  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  79 TLLDLQNNKITEIKEGAFKNL---KDLHTLILVNNKIS----KISPEAFKPLV-KLERLYLSKNQLKElpEKMPRTLQEL 150
Cdd:cd00116   84 QELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEG--ASCEALAKAL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 151 RVHeneiTKLRKsdfnglnnvlvIELGGNPLKNSGIENgAFQGLKSLSYIR--------ISDTNITAIPQGLPT--SLTE 220
Cdd:cd00116  162 RAN----RDLKE-----------LNLANNGIGDAGIRA-LAEGLKANCNLEvldlnnngLTDEGASALAETLASlkSLEV 225

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 299758443 221 VHLDGNKITKVDAPSL-----KGLINLSKLGLSFNSIT----VMENGSLANVPHLRELHLDNNKLLRVPAGLAQ 285
Cdd:cd00116  226 LNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITddgaKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-288 4.25e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 4.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  79 TLLDLQNNKITEIkeGAFKNLKDLHTLILVNNKISKIspEAFKPLVKLERLYLSKNQLKELP--EKMPRtLQELRVHENE 156
Cdd:cd21340    5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 157 ITKLrksdfNGLNNvlvielggnplknsgiengafqgLKSLSYIRISDTNI---------TAIPQGLPTSLTEVHLDGNK 227
Cdd:cd21340   80 ISVV-----EGLEN-----------------------LTNLEELHIENQRLppgekltfdPRSLAALSNSLRVLNISGNN 131

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 299758443 228 ITKVDapSLKGLINLSKLGLSFNSITVMEN--GSLANVPHLRELHLDNNKLLRvpaglaQHKY 288
Cdd:cd21340  132 IDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK------KPKY 186
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 48-75 2.34e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 54.94  E-value: 2.34e-10
                          10        20
                  ....*....|....*....|....*...
gi 299758443   48 MCPYRCQCHLRVVQCSDLGLDKVPWDFP 75
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
216-276 3.14e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 299758443  216 TSLTEVHLDGNKITKVDAPSLKGLINLSKLGLSFNSITVMENGSLANVPHLRELHLDNNKL 276
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-220 6.95e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  57 LRVVQCSDLGLDKVPWDFPPDTTLLDLQNNKITEIKEGAFKNLKdlhTLILVNNKISKIsPEAFKPlvKLERLYLSKNQL 136
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSL-PASLPP--ELQVLDVSKNQI 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 137 KELPEKMPRTLQELRVHENEITKLrksdfnglnnvlvielggnPlknsgiENGAfqglKSLSYIRISDTNITAIPQGLPT 216
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNALTNL-------------------P------ENLP----AALQIMQASRNNLVRLPESLPH 409


                 ....
gi 299758443 217 SLTE 220
Cdd:PRK15370 410 FRGE 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-312 6.90e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 6.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  70 VPWDFPPDTTLLDLQNNKIT-EIKE--GAFKNLKdlhTLILVNNKISKISPEAFKPLVKLERLYLSKNQLKElpeKMPRT 146
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSgEIPNdiGSFSSLK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG---QIPRE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 147 LQELRVheneiTKLRKSDFNGLNNVLVIELGGnplknsgiengafqgLKSLSYIRISDTNITA-IPQGLP--TSLTEVHL 223
Cdd:PLN00113 208 LGQMKS-----LKWIYLGYNNLSGEIPYEIGG---------------LTSLNHLDLVYNNLTGpIPSSLGnlKNLQYLFL 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 224 DGNKITKVDAPSLKGLINLSKLGLSFNS--------ITVMEN----------------GSLANVPHLRELHLDNNKLL-R 278
Cdd:PLN00113 268 YQNKLSGPIPPSIFSLQKLISLDLSDNSlsgeipelVIQLQNleilhlfsnnftgkipVALTSLPRLQVLQLWSNKFSgE 347

                        250       260       270
                 ....*....|....*....|....*....|....
gi 299758443 279 VPAGLAQHKYIQVVYLHNNNISAVGQNDFCRAGH 312
Cdd:PLN00113 348 IPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGN 381
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-220 1.58e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  34 SGIIPYDPDNPLISMCPYRCQCHLRVVQCSDLGLDKVPWDFPPDTTLLDLQNNKITeikegafknlkdlhtlilvnnkis 113
Cdd:PRK15370 304 SGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQIT------------------------ 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 114 kISPEAFKPlvKLERLYLSKNQLKELPEKMPRTLQELRVHENEITKLRKS--DFNGLN---NVLVIELggNPLKNSGIEN 188
Cdd:PRK15370 360 -VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESlpHFRGEGpqpTRIIVEY--NPFSERTIQN 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 299758443 189 -------GAFQG------LKSLSYIRISDTNITAIpQGLPTSLTE 220
Cdd:PRK15370 435 mqrlmssVGYQGprvlfaMGDFSIVRVTRPLHQAV-QGWLTNLEE 478
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 194-279 1.73e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 194 LKSLSYIRISDTNITAIP-QGLPTSLTEVHLDGNKITKVdaPSLKGLINLSKLGLSFNSITVMENgsLANVPHLRELHLD 272
Cdd:cd21340    1 LKRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76


                 ....*..
gi 299758443 273 NNKLLRV 279
Cdd:cd21340   77 GNRISVV 83
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-253 2.17e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.10  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  75 PPDTTLLDLQNNKITEikEGA------FKNLKDLHTLILVNNKISKISPEAFKPLVK----LERLYLSKNQLKE-----L 139
Cdd:COG5238  207 NTTVTTLWLKRNPIGD--EGAeilaeaLKGNKSLTTLDLSNNQIGDEGVIALAEALKnnttVETLYLSGNQIGAegaiaL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 140 PE--KMPRTLQELRVHENEITK---------LRKSdfnglNNVLVIELGGNPLKNSGIEnGAFQGLKSLSYI-------- 200
Cdd:COG5238  285 AKalQGNTTLTSLDLSVNRIGDegaialaegLQGN-----KTLHTLNLAYNGIGAQGAI-ALAKALQENTTLhsldlsdn 358

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 299758443 201 RISDTNITAIPQGL--PTSLTEVHLDGNKITKVDAPSLKGLIN---LSKLGLSFNSIT 253
Cdd:COG5238  359 QIGDEGAIALAKYLegNTTLRELNLGKNNIGKQGAEALIDALQtnrLHTLILDGNLIG 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-302 6.61e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 6.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 216 TSLTEVHLDGNKITKVDApsLKGLINLSKLGLSFNSITVMENgsLANVPHLRELHLDNNKLLRVPaGLAQHKYIQVVYLH 295
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76


                 ....*..
gi 299758443 296 NNNISAV 302
Cdd:cd21340   77 GNRISVV 83
LRR_8 pfam13855
Leucine rich repeat;
102-151 5.59e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.59e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 299758443  102 LHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLKELPekmPRTLQELR 151
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---PGAFSGLP 49
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-277 1.13e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  81 LDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLK-ELPEKMPRtLQELrvhenEITK 159
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQ-LQNL-----EILH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 160 LRKSDFNG--------LNNVLVIELGGNPL-----KNSGIENgafqglkSLSYIRISDTNITA-IPQGLPTS--LTEVHL 223
Cdd:PLN00113 315 LFSNNFTGkipvaltsLPRLQVLQLWSNKFsgeipKNLGKHN-------NLTVLDLSTNNLTGeIPEGLCSSgnLFKLIL 387

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 299758443 224 DGNKITKVDAPSLKGLINLSKLGLSFNSITVMENGSLANVPHLRELHLDNNKLL 277
Cdd:PLN00113 388 FSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
LRR_8 pfam13855
Leucine rich repeat;
241-299 3.24e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  241 NLSKLGLSFNSITVMENGSLANVPHLRELHLDNNKLLRVPAGLAQH-KYIQVVYLHNNNI 299
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 169-303 4.85e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 169 NNVLVIELGGNPLKNSGIEN--GAFQGLKSLSYIRISDTNIT-----AIPQGL--PTSLTEVHLDGNKIT----KVDAPS 235
Cdd:COG5238  208 TTVTTLWLKRNPIGDEGAEIlaEALKGNKSLTTLDLSNNQIGdegviALAEALknNTTVETLYLSGNQIGaegaIALAKA 287

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 299758443 236 LKGLINLSKLGLSFNSITvmENGSLANVPHLRelhldNNKLLRVpaglaqhkyiqvVYLHNNNISAVG 303
Cdd:COG5238  288 LQGNTTLTSLDLSVNRIG--DEGAIALAEGLQ-----GNKTLHT------------LNLAYNGIGAQG 336
LRR_8 pfam13855
Leucine rich repeat;
125-207 2.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  125 KLERLYLSKNQlkelpekmprtlqelrvheneITKLRKSDFNGLNNVLVIELGGNPLknSGIENGAFQGLKSLSYIRISD 204
Cdd:pfam13855   2 NLRSLDLSNNR---------------------LTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 299758443  205 TNI 207
Cdd:pfam13855  59 NRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-191 1.61e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  81 LDLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLK-ELP---EKMPrTLQELRVHENE 156
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMP-VLSQLDLSQNQ 558

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 299758443 157 ITKLRKSDFNGLNNVLVIELGGNPLKNSGIENGAF 191
Cdd:PLN00113 559 LSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAF 593
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-300 2.00e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  76 PDTTLLDLQNNKIT-EIKEGAFKNlKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLK-ELPEKMP--RTLQELR 151
Cdd:PLN00113 332 PRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVR 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 152 VHENEITKLRKSDFNGLNNVLVIELGGNPLknSGIENGAFQGLKSLSYIRISDTNITAipqGLPTS-----LTEVHLDGN 226
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNL--QGRINSRKWDMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRN 485

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 227 KITKVDAPSLKGLINLSKLGLSFNSITVMENGSLANVPHLRELHLDNNKLL-RVPAGLAQHKYIQVVYLHNNNIS 300
Cdd:PLN00113 486 QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS 560
LRR_9 pfam14580
Leucine-rich repeat;
67-152 2.39e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443   67 LDKVPWdFPPDTTLLdLQNNKITEIKEGAFKNLKDLHTLILVNNKISKISP-EAFKPLVKLERLYLSKNQLKELP---EK 142
Cdd:pfam14580  57 LDGFPL-LRRLKTLL-LNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTNKPhyrLY 134

                          90
                  ....*....|
gi 299758443  143 MPRTLQELRV 152
Cdd:pfam14580 135 VIYKVPQLRL 144
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-230 2.45e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  73 DFPPDTTLLDLQNNKIT----EIKEGAFKNLKDLHTLILVNNkisKISPEAFKPLVKlerlylsknQLKELPEkmprtLQ 148
Cdd:cd00116  134 DLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANN---GIGDAGIRALAE---------GLKANCN-----LE 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 149 ELRVHENEITKLRKSDFNG----LNNVLVIELGGNPLKNSGIE---NGAFQGLKSLSYIRISDTNITA-----IPQGLP- 215
Cdd:cd00116  197 VLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDAGAAalaSALLSPNISLLTLSLSCNDITDdgakdLAEVLAe 276

                        170
                 ....*....|....*.
gi 299758443 216 -TSLTEVHLDGNKITK 230
Cdd:cd00116  277 kESLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
173-228 5.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  173 VIELGGNPLknSGIENGAFQGLKSLSYIRISDTNITAIP----QGLPtSLTEVHLDGNKI 228
Cdd:pfam13855   5 SLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 81-117 6.86e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 6.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 299758443   81 LDLQNNKITEIkeGAFKNLKDLHTLILV-NNKISKISP 117
Cdd:pfam12799   6 LDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLSD 41
LRR_8 pfam13855
Leucine rich repeat;
264-307 7.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 299758443  264 PHLRELHLDNNKLLRVPAGLAQH-KYIQVVYLHNNNISAVGQNDF 307
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF 45
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-309 9.23e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443  99 LKDLHTLILVNNKISKISPEAFKPLVKLERLYLSKNQLKElpekmprtlqelrvheneitKLRKSDFnGLNNVLVIELGG 178
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG--------------------PIPPSIF-SLQKLISLDLSD 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758443 179 NPLknSGIENGAFQGLKSLSYIRISDTNITA-IPQGLPT--SLTEVHLDGNKITKVDAPSLKGLINLSKLGLSFNSITVM 255
Cdd:PLN00113 294 NSL--SGEIPELVIQLQNLEILHLFSNNFTGkIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGE 371

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 299758443 256 ENGSLANVPHLRELHLDNNKLL-RVPAGLAQHKYIQVVYLHNNNISAVGQNDFCR 309
Cdd:PLN00113 372 IPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTK 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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