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Conserved domains on  [gi|295789072|ref|NP_001171428|]
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neuronal membrane glycoprotein M6-b isoform 2 [Mus musculus]

Protein Classification

myelin proteolipid family protein( domain architecture ID 10472648)

myelin proteolipid family protein similar to human myelin proteolipid protein (PLP) that plays an important role in the formation or maintenance of the multilamellar structure of myelin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
63-298 1.90e-121

Myelin proteolipid protein (PLP or lipophilin);


:

Pssm-ID: 460144  Cd Length: 231  Bit Score: 347.36  E-value: 1.90e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072   63 FECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYG 142
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072  143 IILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNgtsgv 222
Cdd:pfam01275  81 LLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTN----- 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295789072  223 eQICVDVRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSR 298
Cdd:pfam01275 156 -QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
63-298 1.90e-121

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 347.36  E-value: 1.90e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072   63 FECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYG 142
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072  143 IILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNgtsgv 222
Cdd:pfam01275  81 LLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTN----- 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295789072  223 eQICVDVRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSR 298
Cdd:pfam01275 156 -QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
203-263 4.98e-32

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 113.35  E-value: 4.98e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295789072   203 NIWSTCEVIKSPQSNGTSgVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH 263
Cdd:smart00002   1 NTWTTCQSITFPEKTTTS-IGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
63-298 1.90e-121

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 347.36  E-value: 1.90e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072   63 FECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYG 142
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789072  143 IILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNgtsgv 222
Cdd:pfam01275  81 LLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTN----- 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295789072  223 eQICVDVRQYGIIPWNAFPGKICGSA-LENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSR 298
Cdd:pfam01275 156 -QLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
203-263 4.98e-32

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 113.35  E-value: 4.98e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295789072   203 NIWSTCEVIKSPQSNGTSgVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEFYMSYH 263
Cdd:smart00002   1 NTWTTCQSITFPEKTTTS-IGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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