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Conserved domains on  [gi|288557351|ref|NP_001165696|]
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zinc finger protein 540 isoform a [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 9.86e-34

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.70  E-value: 9.86e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288557351     6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-620 1.19e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 241 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 317
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 318 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 391
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 392 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 471
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 472 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 538
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 539 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKP--------------------------------Y 579
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynC 419

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 288557351 580 KCKECGKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNS 620
Cdd:COG5048  420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 1.14e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557351  621 HLTEHQRIHTGEKPYECKVCRKAFRQ 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 9.86e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.70  E-value: 9.86e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288557351     6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 8.79e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 8.79e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 288557351    5 LVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.82e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.82e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 288557351   6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-620 1.19e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 241 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 317
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 318 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 391
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 392 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 471
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 472 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 538
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 539 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKP--------------------------------Y 579
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynC 419

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 288557351 580 KCKECGKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNS 620
Cdd:COG5048  420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 5.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 288557351  509 YLTEHQRIHTGEKPYKCKECGKAFIR 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557351  621 HLTEHQRIHTGEKPYECKVCRKAFRQ 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 9.86e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.70  E-value: 9.86e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288557351     6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 8.79e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 8.79e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 288557351    5 LVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.82e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.82e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 288557351   6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-620 1.19e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 241 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 317
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 318 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 391
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 392 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 471
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 472 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 538
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 539 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKP--------------------------------Y 579
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynC 419

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 288557351 580 KCKECGKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNS 620
Cdd:COG5048  420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-598 7.24e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 7.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 216 KCEKCGKVFSHSYQLTLHQRFHTGEKPYEC--QECGKTFTLYPQLNRHQKIHTGKKPYMCKKCDKGFFSrlELTQHKRIH 293
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS--KASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 294 TGKKSYE---CKECGKVFQLIFYFKEHERIHTGKKPYECKECGKAFSVCGQ-----------------------LTRHQK 347
Cdd:COG5048  113 SSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlslLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 348 IHTGVKPYECKECGKTFRLSFYLTEHRRTHAgKKPYECKECgkSFNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLR 427
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 428 VHSRIHTG---------EKPYECKECGKAFMLRSVLTEHQR--LHTG--VKPYECKE--CGKTFRVRSQISLHKKIHTDV 492
Cdd:COG5048  270 SQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 493 KPYKCV--RCGKTFRFGF--YLTEHQRIHTGEKPYKCKE-----CGKAFIRRGNLKEHLKIHSGLKPYDCK--ECGKSFS 561
Cdd:COG5048  350 SPAKEKllNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 288557351 562 RRGQFTEHQKIHTGVKPYKCKECGKAFSRSVDLRIHQ 598
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-658 9.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 9.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 296 KKSYECKECGKVFQLIFYFKEHERIHTGKKPYEC--KECGKAFSVCGQLTRHQKIHTGVKPYECKecgKTFRLSFYLTEH 373
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 374 R-RTHAGKKP-YECKECGKSFNvrgQLNRHKTIHTGIKP--FACKVCEKAFSYSGDLRVHSRIHtGEKPYECKeCGKAFM 449
Cdd:COG5048  108 SsLSSSSSNSnDNNLLSSHSLP---PSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 450 LRSVLTEHQRLHTGVKPYECKECGKTFRVRSQISLHKKIHtDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKCKECG 529
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 530 kafiRRGNLKEHLKIHSGLKPYdckecgkSFSRRGQFTehqkihtgvkPYKCKECGKAFSRSVDLRIHQR--IHTGE--K 605
Cdd:COG5048  262 ----RSSLPTASSQSSSPNESD-------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 288557351 606 PYEC--KQCGKAFRLNSHLTEHQRIHTGEKPYECK--VCRKAFRQYSHLYQHQKTHN 658
Cdd:COG5048  321 PFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-345 1.78e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 140 SQKKIVSKKMSTDRKRPSFTLNQRIHNSEKSCDSHLVQHG---KIDSDVKHDCKECGSTFNNVYQLTLHQ--KIHTGEK- 213
Cdd:COG5048  240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESl 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 214 ---SCKCEKCGKVFSHSYQLTLHQRFHTGEKPYEC--QECGKTFT-----LYPQLNRHQKIHTGKKPYMC--KKCDKGFF 281
Cdd:COG5048  320 kpfSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 288557351 282 SRLELTQHKRIHTGKKSYECK--ECGKVFQLIFYFKEHERIHTGKKPYECkECGKAFSVCGQLTRH 345
Cdd:COG5048  400 RDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 5.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 288557351  509 YLTEHQRIHTGEKPYKCKECGKAFIR 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-448 8.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|....
gi 288557351  425 DLRVHSRIHTGEKPYECKECGKAF 448
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557351  621 HLTEHQRIHTGEKPYECKVCRKAFRQ 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
593-616 1.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....
gi 288557351  593 DLRIHQRIHTGEKPYECKQCGKAF 616
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-337 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*
gi 288557351  313 YFKEHERIHTGKKPYECKECGKAFS 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-562 2.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557351  537 NLKEHLKIHSGLKPYDCKECGKSFSR 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-364 3.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.60e-03
                          10        20
                  ....*....|....*....|...
gi 288557351  342 LTRHQKIHTGVKPYECKECGKTF 364
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
568-590 5.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.54e-03
                          10        20
                  ....*....|....*....|...
gi 288557351  568 EHQKIHTGVKPYKCKECGKAFSR 590
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 579-601 7.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.85e-03
                          10        20
                  ....*....|....*....|...
gi 288557351  579 YKCKECGKAFSRSVDLRIHQRIH 601
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-253 8.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|....
gi 288557351  230 LTLHQRFHTGEKPYECQECGKTFT 253
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
483-573 8.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 8.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557351 483 SLHKKIHTDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKC--KECGKAFIRRGNLKEHLKIHSGLKPYDCKecgKSF 560
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSL 98

                         90
                 ....*....|...
gi 288557351 561 SRRGQFTEHQKIH 573
Cdd:COG5048   99 PLSNSKASSSSLS 111
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-280 9.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.33e-03
                          10        20
                  ....*....|....*....|...
gi 288557351  258 LNRHQKIHTGKKPYMCKKCDKGF 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 9.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|....*
gi 288557351  398 LNRHKTIHTGIKPFACKVCEKAFSY 422
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-308 9.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.71e-03
                          10        20
                  ....*....|....*....|....
gi 288557351  285 ELTQHKRIHTGKKSYECKECGKVF 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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