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Conserved domains on  [gi|270341364|ref|NP_001161978|]
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zinc finger protein 574 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048  188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 270341364 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048  188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 270341364 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-781 3.65e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.65e-05
                          10        20
                  ....*....|....*....|....*.
gi 270341364  756 SLQVHRRIHTGERPYPCPDCGKAFRQ 781
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-852 8.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 498 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 575
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 576 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 649
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 650 SSLRLRehrcaaaaaQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 729
Cdd:COG5048  188 ISSNVS---------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 730 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 803
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 270341364 804 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 852
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-781 3.65e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.65e-05
                          10        20
                  ....*....|....*....|....*.
gi 270341364  756 SLQVHRRIHTGERPYPCPDCGKAFRQ 781
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 761-846 4.45e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 761 RRIHT-GERPYPCP--DCGKAFRQSTHLKDHRrLHTGERPFACEVCGKAfaismrlaEHRRIHTGERPYSCPDCGKSYRS 837
Cdd:COG5189  340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*....
gi 270341364 838 FSNLWKHRK 846
Cdd:COG5189  411 LNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
768-840 4.59e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 4.59e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 270341364 768 RPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGKAFAISMRLA--EHRRIHTGERPYSCPDCGKSYRSFSN 840
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
468-588 5.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 468 SYRCLLCSREFGKALQLTRHQRFV-HRLE--RRHKC--SICGKMFKKKSHVRNHLRTHTGERPFPC-------------- 528
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSVnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfsplln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 529 -----------------------PDCSKPFNSPANLARHRLTHTGERP--YRCGDCGKAFTQSSTLRQHRLVHAQHFPYR 583
Cdd:COG5048  369 neppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                 ....*
gi 270341364 584 CQECG 588
Cdd:COG5048  449 CSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-565 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 270341364  540 NLARHRLTHTGERPYRCGDCGKAFTQ 565
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
784-808 2.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.62e-04
                          10        20
                  ....*....|....*....|....*
gi 270341364  784 HLKDHRRLHTGERPFACEVCGKAFA 808
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 522-605 3.43e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 522 GERPFPCP--DCSKPFNSPANLARHRLThtgerpyrcGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLM 599
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 270341364 600 HRYHHT 605
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
812-837 6.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 270341364  812 RLAEHRRIHTGERPYSCPDCGKSYRS 837
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 498-520 7.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|...
gi 270341364  498 HKCSICGKMFKKKSHVRNHLRTH 520
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 826-848 8.98e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.98e-04
                          10        20
                  ....*....|....*....|...
gi 270341364  826 YSCPDCGKSYRSFSNLWKHRKTH 848
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 770-792 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 270341364  770 YPCPDCGKAFRQSTHLKDHRRLH 792
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-537 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 270341364  512 HVRNHLRTHTGERPFPCPDCSKPFNS 537
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 554-576 2.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|...
gi 270341364  554 YRCGDCGKAFTQSSTLRQHRLVH 576
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
796-853 4.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 4.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 270341364 796 RPFACEVCGKAFAISMRLAEHRRIHTGERPYSCPD--CGKSYRSFSNLWKHRKTHQQQHQ 853
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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