NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|270288788|ref|NP_001161875|]
View 

ankyrin repeat domain-containing protein 55 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 2.50e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666  164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 270288788 189 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 238
Cdd:COG0666  242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 5.75e-15

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 5.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  207 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 270288788  287 LL 288
Cdd:pfam12796  79 LL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 2.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666  164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 270288788 189 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 238
Cdd:COG0666  242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 5.97e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 102.41  E-value: 5.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   3 YQAASNGDVNSLTSVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095  98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGF---GDIINDLAKVP 225
Cdd:PHA03095 173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckrSLVLPLLIAGI 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270288788 226 ECNlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095 249 SIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-163 3.75e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 3.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 270288788  116 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 163
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 5.75e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 5.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  207 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 270288788  287 LL 288
Cdd:pfam12796  79 LL 80
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-288 8.90e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 8.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 198 DDESGKTCVHIAAASGFGDIINDLAKVpecNLQAlDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLA 274
Cdd:PLN03192 521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                         90
                 ....*....|....
gi 270288788 275 YALYCGHTACVRLL 288
Cdd:PLN03192 597 NAISAKHHKIFRIL 610
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 9.49e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 9.49e-06
                           10        20
                   ....*....|....*....|....*....
gi 270288788    31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 2.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 2.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 270288788   235 DDRTPLHWAAASGKAECVQSLLDLGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 7.45e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   5 AASNGDVNSLTSVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 66
Cdd:cd22192   58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  67 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 134
Cdd:cd22192  138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                        170       180
                 ....*....|....*....|.
gi 270288788 135 TPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192  214 TPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-238 2.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 2.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 109 PDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666  164 GNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 270288788 189 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQALDVDDRT 238
Cdd:COG0666  242 G---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-273 1.19e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.24  E-value: 1.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 109 PDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666  131 GNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 189 RqgpSIINYDDESGKTCVHIAAASGFGDIINDLAKVPEcNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDIN 268
Cdd:COG0666  209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                 ....*
gi 270288788 269 ESTPL 273
Cdd:COG0666  285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-298 5.15e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.93  E-value: 5.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  34 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRL 113
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 114 LIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqgps 193
Cdd:COG0666  103 VKLLLEAGA--DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA----- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 194 iinyddesgktcvhiaaasgfGDIINdlakvpecnlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPL 273
Cdd:COG0666  176 ---------------------GADVN-----------ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                        250       260
                 ....*....|....*....|....*
gi 270288788 274 AYALYCGHTACVRLLSREGRAEPAR 298
Cdd:COG0666  224 DLAAENGNLEIVKLLLEAGADLNAK 248
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
48-288 2.00e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 2.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  48 VKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEIN 127
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL--AGDLLVALLLLAAGADIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 128 HQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpsiinyddesgktcvh 207
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG------------------ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 208 iaaasgfgdiindlAKVpecNLQalDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRL 287
Cdd:COG0666  144 --------------ADV---NAQ--DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204


                 .
gi 270288788 288 L 288
Cdd:COG0666  205 L 205
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 5.97e-23

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 102.41  E-value: 5.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   3 YQAASNGDVNSLTSVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095  98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHRQGPSIINyddESGKTCVHIAAASGF---GDIINDLAKVP 225
Cdd:PHA03095 173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLHSMATGSSckrSLVLPLLIAGI 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270288788 226 ECNlqALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095 249 SIN--ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-288 2.17e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.48  E-value: 2.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  45 VDTVKLLLKMGANINTQDAYGRTSLC--LATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLHA----ATAEPDVRLLIvl 117
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLylynATTLDVIKLLI-- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 118 lqqSSLSEINHQDTEGMTPLH--WAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN------RILCsiilshR 189
Cdd:PHA03095 105 ---KAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanvellRLLI------D 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 190 QGPSIINYDDEsGKTCVHIAAAS--GFGDIINDLAkVPECNLQALDVDDRTPLHWAAA--SGKAECVQSLLDLGMDSNLR 265
Cdd:PHA03095 176 AGADVYAVDDR-FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINAR 253

                        250       260
                 ....*....|....*....|....
gi 270288788 266 DINESTPLAYA-LYCGHTACVRLL 288
Cdd:PHA03095 254 NRYGQTPLHYAaVFNNPRACRRLI 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-194 2.07e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 2.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  39 AVSGRQVDTVKLLLKMGANINTQDAYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIV 116
Cdd:PHA03100  80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 117 --LLQQ--------------SSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 180
Cdd:PHA03100 160 klLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                        170
                 ....*....|....
gi 270288788 181 LCSIILSHrqGPSI 194
Cdd:PHA03100 240 IFKLLLNN--GPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-163 3.75e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 3.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 270288788  116 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 163
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
170-266 4.01e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 4.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  170 LHWAVQSGNRILCSIILSHRQGPsiiNYDDESGKTCVHIAAASGFGDIINDLAKVPECNLQaldVDDRTPLHWAAASGKA 249
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 270288788  250 ECVQSLLDLGMDSNLRD 266
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-288 5.75e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 5.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  207 HIAAASGFGDIINDLAKvPECNLQALDVDDRTPLHWAAASGKAECVQSLLDlGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 270288788  287 LL 288
Cdd:pfam12796  79 LL 80
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-292 1.92e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.47  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDVR 112
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 113 LLIVLLQQSSLseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILS 187
Cdd:PHA03100  88 IVKLLLEYGAN--VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 188 HRqgpsiinyddesgktcVHIAAAsgfgDIINDLAKVpECNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDI 267
Cdd:PHA03100 165 KG----------------VDINAK----NRVNYLLSY-GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        250       260
                 ....*....|....*....|....*
gi 270288788 268 NESTPLAYALYCGHTACVRLLSREG 292
Cdd:PHA03100 224 YGDTPLHIAILNNNKEIFKLLLNNG 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-276 5.55e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   9 GDVNSLTsviREDPSILECcdsegctplmhAVSGRQVDTVKLLLKMGANINTQDaygrTSLCLATYLGWLEGCVSLLRNG 88
Cdd:PHA02876 202 ADVNIIA---LDDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  89 AKHNIPDKNGRLPLHAATAEPDV-RLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN-RPQHTQMLLKKGADPTLVDKDF 166
Cdd:PHA02876 264 FSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERG--ADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 167 KTALHWAvQSGNRILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFGDIINDLAKVpECNLQALDVDDRTPLHWA-AA 245
Cdd:PHA02876 342 ITPLHQA-STLDRNKDIVITLLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAlCG 418

                        250       260       270
                 ....*....|....*....|....*....|.
gi 270288788 246 SGKAECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:PHA02876 419 TNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 23-209 2.75e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.30  E-value: 2.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  23 SILECC------DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK 96
Cdd:PHA02874 109 TILDCGidvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  97 NGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPqhTQMLLKKGADPTLVDKDFKTALHWAVQS 176
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLLIDHG--NHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAINP 264

                        170       180       190
                 ....*....|....*....|....*....|....
gi 270288788 177 GNRI-LCSIILSHRQGPSIinyDDESGKTCVHIA 209
Cdd:PHA02874 265 PCDIdIIDILLYHKADISI---KDNKGENPIDTA 295
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 4-292 3.07e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.79  E-value: 3.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   4 QAASNGDVNslTSVIREDPSI-LECCDSEGCTPLMHAVSGRQVDT-VKLLLKMGANINTQDAYGRTSLCLATYLGW-LEG 80
Cdd:PHA02876 246 KAIRNEDLE--TSLLLYDAGFsVNSIDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYdTEN 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  81 CVSLLRNGAKHNIPDKNGRLPLH-AATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:PHA02876 324 IRTLIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGA--NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 160 TLVDKDFKTALHWAVQSGNRILcsiilshrqgpsiinyddeSGKTCVHIAAasgfgdiindlakvpecNLQALDVDDRTP 239
Cdd:PHA02876 402 EALSQKIGTALHFALCGTNPYM-------------------SVKTLIDRGA-----------------NVNSKNKDLSTP 445

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 270288788 240 LHWAAASG-KAECVQSLLDLGMDSNLRDINESTPLAYALycGHTACVRLLSREG 292
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYG 497
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-194 7.99e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 7.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  28 CDSEGCTPLMHAVSGRQVD--TVKLLLKMGANINTQDAYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLH 103
Cdd:PHA03095 148 LDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhHHLQSFKPRARIVReLIRAGCDPAATDMLGNTPLH 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 104 -AATAEPDVRLLIVLLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC 182
Cdd:PHA03095 228 sMATGSSCKRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306

                        170
                 ....*....|..
gi 270288788 183 SIILSHRqgPSI 194
Cdd:PHA03095 307 RAALAKN--PSA 316
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-264 1.51e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 69.63  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  36 LMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLI 115
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 116 VLLQQSS-LSEINHQDteGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgpSI 194
Cdd:PHA02875  86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 195 INYDDESGKTCVHIAAASG----------FGDIINDLAKVPecnlqaldvdDRTPLHWAAASGKAECVQSLLDLGMDSNL 264
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGdiaickmlldSGANIDYFGKNG----------CVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-277 1.80e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.61  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   8 NGDVNSLTSVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLG-------WLEG 80
Cdd:PHA02874  11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  81 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN 144
Cdd:PHA02874  91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 145 RPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHrqGPSIINyDDESGKTCVHIAaasgfgdIINDLAKV 224
Cdd:PHA02874 169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 270288788 225 P----ECNLQALDVDDRTPLHWA-AASGKAECVQSLLDLGMDSNLRDINESTPLAYAL 277
Cdd:PHA02874 239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-95 1.91e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788    4 QAASNGDVNSLTSVIREDPSIlECCDSEGCTPLMHAVSGRQVDTVKLLLKmGANINTQDaYGRTSLCLATYLGWLEGCVS 83
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 270288788   84 LLRNGAKHNIPD 95
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 32-196 2.59e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 2.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  32 GCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE-PD 110
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKD 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 111 VRLLIVLLQQSslSEINHQDT-EGMTPLHwAAFHNrPQHTQMLLKKGADPTLVDKDFKTALHWAVQS------GNRILCS 183
Cdd:PHA02878 248 YDILKLLLEHG--VDVNAKSYiLGLTALH-SSIKS-ERKLKLLLEYGADINSLNSYKLTPLSSAVKQylciniGRILISN 323

                        170
                 ....*....|...
gi 270288788 184 IILSHRQGPSIIN 196
Cdd:PHA02878 324 ICLLKRIKPDIKN 336
Ank_2 pfam12796
Ankyrin repeats (3 copies);
240-288 1.20e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 1.20e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 270288788  240 LHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-289 4.12e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.20  E-value: 4.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSL---CLA--------------------TYLGWLEGC-------- 81
Cdd:PHA02878  38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  82 VSLLRNGAKHN--IPDKNgrlpLHAATAEPDVRLLIVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGAD 158
Cdd:PHA02878 118 KIILTNRYKNIqtIDLVY----IDKKSKDDIIEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGAN 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 159 PTLVDKDFKTALHWAVQSGNRILCSIILshRQGPSiINYDDESGKTCVHIAAASGFG-DIINDLAKVPEC-NLQAlDVDD 236
Cdd:PHA02878 194 VNIPDKTNNSPLHHAVKHYNKPIVHILL--ENGAS-TDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILG 269

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 270288788 237 RTPLHWAAASGKAecVQSLLDLGMDSNLRDINESTPLAYAL--YCGHTACVRLLS 289
Cdd:PHA02878 270 LTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-188 4.67e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  102 LHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 270288788  182 CSIILSH 188
Cdd:pfam12796  77 VKLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
237-288 4.91e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 4.91e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270288788  237 RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-162 5.99e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   2 VYQAASNGDVNSLTSVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGC 81
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  82 VSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLqqSSLSEINHQDTEG-MTPLHWAAFHNRPQHTQMLLKKGADPT 160
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL--DSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCN 229


                 ..
gi 270288788 161 LV 162
Cdd:PHA02875 230 IM 231
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 49-276 3.54e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.69  E-value: 3.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  49 KLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINH 128
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--SNINK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 129 QDTEGMTplhwaAFHNRPQHTQMLL-KKGADPTLVDKDFKTALHWAVQSGNriLCSIILSHRQGPSIINYDDESGKTCVH 207
Cdd:PHA02876 240 NDLSLLK-----AIRNEDLETSLLLyDAGFSVNSIDDCKNTPLHHASQAPS--LSRLVPKLLERGADVNAKNIKGETPLY 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 270288788 208 IAAASGFgdiinDLAKVPECNLQALDVD--DR---TPLHWAAASGK-AECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:PHA02876 313 LMAKNGY-----DTENIRTLIMLGADVNaaDRlyiTPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-292 1.81e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.92  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  66 RTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINHQDTEgmTPLHWAAFHNR 145
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 146 PQHTQMLLKKGadpTLVD----KDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDesgKTCVHIAAASGFGDIINDL 221
Cdd:PHA02875  81 VKAVEELLDLG---KFADdvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELL 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 270288788 222 AKVPECnlqaLDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDIN-ESTPLAYALYCGHTACVRLLSREG 292
Cdd:PHA02875 155 IDHKAC----LDIEDccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRG 225
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 113-273 3.70e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 113 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRqgp 192
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 193 SIINYDDESGKTCVH--------IAAASGFgdiindlakvpecNLQALDVDDRTPLHWAA-ASGKAECVQSLLDLGMDSN 263
Cdd:PHA02876 235 SNINKNDLSLLKAIRnedletslLLYDAGF-------------SVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVN 301

                        170
                 ....*....|
gi 270288788 264 LRDINESTPL 273
Cdd:PHA02876 302 AKNIKGETPL 311
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-178 6.63e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 6.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 270288788  133 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 111-190 1.27e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 111 VRLLIvllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQ 190
Cdd:PTZ00322  98 ARILL-----TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_5 pfam13857
Ankyrin repeats (many copies);
227-276 3.83e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 3.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 270288788  227 CNLQALDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYA 276
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-62 4.77e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 4.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 270288788    3 YQAASNGDVNsltsVIREdpsILECCD----SEGCTPLMHAVSGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam12796  35 HLAAKNGHLE----IVKL---LLEHADvnlkDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
117-173 1.47e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 270288788  117 LLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 173
Cdd:pfam13857   1 LLEHGPID-LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 127-273 2.48e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 50.05  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 127 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINYDDESGktCV 206
Cdd:PHA02946  66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270288788 207 HIAAASGFGDIIndLAKVPECNLQALDVD----DRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPL 273
Cdd:PHA02946 144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-153 5.21e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 270288788   98 GRLPLHAATAEPDVRLLIVLLQqsSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLL 153
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
18-72 8.68e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 8.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 270288788   18 IREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLA 72
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-288 8.90e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 8.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 198 DDESGKTCVHIAAASGFGDIINDLAKVpecNLQAlDVDD---RTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLA 274
Cdd:PLN03192 521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                         90
                 ....*....|....
gi 270288788 275 YALYCGHTACVRLL 288
Cdd:PLN03192 597 NAISAKHHKIFRIL 610
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 9.49e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 9.49e-06
                           10        20
                   ....*....|....*....|....*....
gi 270288788    31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02798 PHA02798
ankyrin-like protein; Provisional
 45-185 4.47e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  45 VDTVKLLLKMGANINTQDAYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdvrllivLLQ 119
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270288788 120 QSSLseinhqdtegmtplhwaafhNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 185
Cdd:PHA02798 119 NGYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEII 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-62 5.66e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 5.66e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 270288788   31 EGCTPLMHAV-SGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-164 5.83e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 5.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 270288788  132 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 164
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 152-292 7.39e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 7.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 152 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGpsiINYDDESGKTCVHIAAASGFGDIINDL-----AKVPE 226
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFRILyhfasISDPH 620

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270288788 227 CnlqALDVddrtpLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSREG 292
Cdd:PLN03192 621 A---AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-159 1.05e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*...
gi 270288788  132 EGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-85 1.10e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270288788   34 TPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEgCVSLL 85
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 233-290 1.14e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 1.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 270288788 233 DVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLLSR 290
Cdd:PTZ00322 112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 132-161 1.34e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 270288788   132 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 161
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02791 PHA02791
ankyrin-like protein; Provisional
 95-178 1.63e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.88  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  95 DKNGRLPLHAATAEPDVRLLIVLLQQSSLSEInhqdTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAV 174
Cdd:PHA02791  27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNL----LENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                 ....
gi 270288788 175 QSGN 178
Cdd:PHA02791 103 DSGN 106
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 21-127 2.07e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  21 DPSILECCDSEGCTplmHAVSGRQVDtVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PTZ00322  75 DPVVAHMLTVELCQ---LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                         90       100
                 ....*....|....*....|....*..
gi 270288788 101 PLHAAtAEPDVRLLIVLLQQSSLSEIN 127
Cdd:PTZ00322 151 PLELA-EENGFREVVQLLSRHSQCHFE 176
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 2.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 2.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 270288788   235 DDRTPLHWAAASGKAECVQSLLDLGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-266 2.73e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 270288788  235 DDRTPLHWAAAS-GKAECVQSLLDLGMDSNLRD 266
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-165 2.84e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   2 VYQAASNGDVNSLTSVIR--EDPSIlecCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLE 79
Cdd:PLN03192 529 LLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK 605

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  80 gCVSLLRNGAKHNIPDKNGRLpLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:PLN03192 606 -IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681


                 ....*.
gi 270288788 160 TLVDKD 165
Cdd:PLN03192 682 DKANTD 687
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 150-231 3.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 150 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIInydDESGKTCVHIAAASGFGDIINDLAKVPECNL 229
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                 ..
gi 270288788 230 QA 231
Cdd:PTZ00322 176 EL 177
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-60 3.59e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.59e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 270288788   31 EGCTPLMHAVSGRQVDTVKLLLKMGANINT 60
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 220-288 1.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 1.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270288788 220 DLAKVPECNLQALDVDDRTPLHWA-------AASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:PTZ00322  59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
PHA02946 PHA02946
ankyin-like protein; Provisional
 23-230 1.68e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.19  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  23 SILECCDSEGCTPLMHA---VSGRQVDTVKLLLKMGANINTQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 99
Cdd:PHA02946  27 NMLQAIEPSGNYHILHAycgIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 100 LPLHAATAEPD-VRLLIVLLQQSSLSEINHQDTEGMTPLhWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:PHA02946 107 TPLYYLSGTDDeVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 270288788 179 RILCSIILSHRQGPSiINYDDESGKTCVHIAAASGFG--DIINDLAKVPECNLQ 230
Cdd:PHA02946 186 PKASTISWMMKLGIS-PSKPDHDGNTPLHIVCSKTVKnvDIINLLLPSTDVNKQ 238
PHA02798 PHA02798
ankyrin-like protein; Provisional
 29-138 2.03e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  29 DSEGCTPLMHAVSG-----RQVDTVKLLLKMGANINTQDAYGRTSLCLA---TYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PHA02798  68 DNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFT 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 270288788 101 PLHA---ATAEPDVRLLIVLLQQSslSEIN-HQDTEGMTPLH 138
Cdd:PHA02798 148 MLQVylqSNHHIDIEIIKLLLEKG--VDINtHNNKEKYDTLH 187
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-263 2.08e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....*....
gi 270288788  235 DDRTPLHWAAASGKAECVQSLLDLGMDSN 263
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 4.85e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 4.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270288788   65 GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLL 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-221 6.66e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 6.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270288788  168 TALHWAVQSGNRILCSIILSHRQgpsIINYDDESGKTCVHIAAASGFGDIINDL 221
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA---DINAVDGNGETALHFAASNGNVEVLKLL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 7.45e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788   5 AASNGDVNSLTSVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQDA--------------YGR 66
Cdd:cd22192   58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRAtgtffrpgpknliyYGE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788  67 TSLCLATYLGwLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdteGM 134
Cdd:cd22192  138 HPLSFAACVG-NEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ---GL 213

                        170       180
                 ....*....|....*....|.
gi 270288788 135 TPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192  214 TPFKLAAKEGNIVMFQHLVQK 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 100-178 8.33e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 100 LPLHAATAEPDVRLLIVLLQQSSlSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKkgADPTLVDK----DF---KTALHW 172
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPS-CDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsDLyqgETALHI 95


                 ....*.
gi 270288788 173 AVQSGN 178
Cdd:cd22192   96 AVVNQN 101
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 126-292 9.84e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.79  E-value: 9.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 126 INHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHRQGPSIINyddesgktc 205
Cdd:PHA02874  28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILP--------- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288788 206 vhiaaasgFGDIINDLAK-VPECNLQA--LDVDDRTPLHWAAASGKAECVQSLLDLGMDSNLRDINESTPLAYALYCGHT 282
Cdd:PHA02874  99 --------IPCIEKDMIKtILDCGIDVniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                        170
                 ....*....|
gi 270288788 283 ACVRLLSREG 292
Cdd:PHA02874 171 DIIKLLLEKG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH