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Conserved domains on  [gi|261824011|ref|NP_001159853|]
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DNA repair protein RAD52 homolog isoform 1 [Mus musculus]

Protein Classification

RAD52 family DNA repair protein( domain architecture ID 10015712)

RAD52 family DNA repair protein similar to DNA repair and recombination protein RAD52 that is involved in DNA double-strand break (DSB) repair and recombination, by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

CATH:  3.30.390.80
Gene Ontology:  GO:0006281|GO:0006310|GO:0003677
PubMed:  30428330|11914131

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
39-200 1.83e-107

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 129695  Cd Length: 161  Bit Score: 313.67  E-value: 1.83e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011   39 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLKD 118
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  119 GSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPrQLPLDVDLTKTKREDFE 198
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRNFGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDE 159

                  ..
gi 261824011  199 PS 200
Cdd:TIGR00607 160 PS 161
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
39-200 1.83e-107

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 313.67  E-value: 1.83e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011   39 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLKD 118
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  119 GSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPrQLPLDVDLTKTKREDFE 198
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRNFGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDE 159

                  ..
gi 261824011  199 PS 200
Cdd:TIGR00607 160 PS 161
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
36-173 2.36e-70

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 218.35  E-value: 2.36e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011   36 EYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVK 113
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKVAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVR 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  114 VQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYL 173
Cdd:pfam04098  81 VTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRALRQFGNVLGNCLYDKEYL 140
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
38-306 7.17e-21

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 92.06  E-value: 7.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  38 QAIQKALRQRLGPEYISSRmAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLK 117
Cdd:COG5055    5 NPQRRILEQPLKPEQIKTR-EGNGEELSYIEGWNVIQEANRIFGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011 118 DgSYHEDV----GYGVSEGlRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDylrSLNKLPRQlPLDVDLTKTK 193
Cdd:COG5055   84 S-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRAATTFGNQFGLALYDDN---RQNDFLRG-AVNGGLVVRG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011 194 REdfepSVEQARYNSCRQNEALGLPKPqeVTSPCRSSPPHDSNIKLQGAKDISSSCSLAATLESDATHQRKLRKLRQKQL 273
Cdd:COG5055  158 DL----LEYTIYFLSIVEGDASKLKIC--DVIPTYTTFIPTAFNGSTPLDGGLSTANLGIAIAADSTNYPKNPTAYITNV 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 261824011 274 QQQFREQMETRRQSHAPAEEVAAKHAAVLPAPP 306
Cdd:COG5055  232 KDSDRGETFSALETPPIACSRSNNNGAVVVNIV 264
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
39-200 1.83e-107

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 313.67  E-value: 1.83e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011   39 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLKD 118
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  119 GSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPrQLPLDVDLTKTKREDFE 198
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRNFGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDE 159

                  ..
gi 261824011  199 PS 200
Cdd:TIGR00607 160 PS 161
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
36-173 2.36e-70

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 218.35  E-value: 2.36e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011   36 EYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVK 113
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKVAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVR 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  114 VQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYL 173
Cdd:pfam04098  81 VTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRALRQFGNVLGNCLYDKEYL 140
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
38-306 7.17e-21

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 92.06  E-value: 7.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011  38 QAIQKALRQRLGPEYISSRmAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLK 117
Cdd:COG5055    5 NPQRRILEQPLKPEQIKTR-EGNGEELSYIEGWNVIQEANRIFGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011 118 DgSYHEDV----GYGVSEGlRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDylrSLNKLPRQlPLDVDLTKTK 193
Cdd:COG5055   84 S-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRAATTFGNQFGLALYDDN---RQNDFLRG-AVNGGLVVRG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261824011 194 REdfepSVEQARYNSCRQNEALGLPKPqeVTSPCRSSPPHDSNIKLQGAKDISSSCSLAATLESDATHQRKLRKLRQKQL 273
Cdd:COG5055  158 DL----LEYTIYFLSIVEGDASKLKIC--DVIPTYTTFIPTAFNGSTPLDGGLSTANLGIAIAADSTNYPKNPTAYITNV 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 261824011 274 QQQFREQMETRRQSHAPAEEVAAKHAAVLPAPP 306
Cdd:COG5055  232 KDSDRGETFSALETPPIACSRSNNNGAVVVNIV 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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