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Conserved domains on  [gi|255958312|ref|NP_001157669|]
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matrix metalloproteinase-19 isoform 2 [Mus musculus]

Protein Classification

ZnMc_MMP and HX domain-containing protein( domain architecture ID 10136642)

ZnMc_MMP and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 33-185 1.67e-68

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


:

Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 215.15  E-value: 1.67e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  33 WRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGW-ADIRLSFHGRQSlYCSNTFDGPGKVLAHADI 111
Cdd:cd04278    2 WSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQeADIRISFARGNH-GDGYPFDGPGGTLAHAFF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255958312 112 P--ELGSIHFDKDELWTEGT-YQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYG 185
Cdd:cd04278   81 PggIGGDIHFDDDEQWTLGSdSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVPKFKLSQDDIRGIQALYG 157
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 214-399 1.12e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 193.68  E-value: 1.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 214 PNPCSGEV-DAMVLGpRGKTYAFKGDYVWTVTD-SGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDF 291
Cdd:cd00094    1 PDACDPLSfDAVTTL-RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 292 KMSPGFPMK-----FNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDG 366
Cdd:cd00094   80 NLEPGYPKPisdlgFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 255958312 367 QVYFFKGKEYWRLNQQLRVAK-GYPRNTTH-WMHC 399
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVRvGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 33-185 1.67e-68

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 215.15  E-value: 1.67e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  33 WRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGW-ADIRLSFHGRQSlYCSNTFDGPGKVLAHADI 111
Cdd:cd04278    2 WSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQeADIRISFARGNH-GDGYPFDGPGGTLAHAFF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255958312 112 P--ELGSIHFDKDELWTEGT-YQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYG 185
Cdd:cd04278   81 PggIGGDIHFDDDEQWTLGSdSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVPKFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 32-185 1.31e-62

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 200.15  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312   32 HWRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSF----HGRqslycSNTFDGPGKVLA 107
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFgrgdHGD-----GYPFDGPGGVLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  108 HADIPEL---GSIHFDKDELWTEGT--YQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPF-FKLHPDDVAGIQ 181
Cdd:pfam00413  76 HAFFPGPglgGDIHFDDDETWTVGSdpPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKkFRLSQDDIKGIQ 155


                  ....
gi 255958312  182 ALYG 185
Cdd:pfam00413 156 QLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 214-399 1.12e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 193.68  E-value: 1.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 214 PNPCSGEV-DAMVLGpRGKTYAFKGDYVWTVTD-SGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDF 291
Cdd:cd00094    1 PDACDPLSfDAVTTL-RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 292 KMSPGFPMK-----FNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDG 366
Cdd:cd00094   80 NLEPGYPKPisdlgFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 255958312 367 QVYFFKGKEYWRLNQQLRVAK-GYPRNTTH-WMHC 399
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVRvGYPLKISSdWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 33-186 7.03e-28

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 107.82  E-value: 7.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312    33 WRKKNLTFRIfnVPSTLSlPRVRAALHQAFKYWSSVAPLTFREVKAGwADIRLSFHGRQSlycsntfdgpGKVLAHADIP 112
Cdd:smart00235   5 WPKGTVPYVI--DSSSLS-PEEREAIAKALAEWSDVTCIRFVERTGT-ADIYISFGSGDS----------GCTLSHAGRP 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255958312   113 ElGSIHFDkDELWTEGTYqgvnlriIAAHEVGHALGLGHSRYTQA---LMAPVYAGYQPF-FKLHPDDVAGIQALYGK 186
Cdd:smart00235  71 G-GDQHLS-LGNGCINTG-------VAAHELGHALGLYHEQSRSDrdnYMYINYTNIDTRnFDLSEDDSLGIPYDYGS 139
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 265-308 1.08e-07

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.01  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 255958312   265 LDAAVYSPRTRrTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNL 308
Cdd:smart00120   1 IDAAFELRDGK-TYFFKGDKYWRFDPKRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 359-396 3.04e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 43.71  E-value: 3.04e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 255958312  359 AAMSWQDGQVYFFKGKEYWRLNQQlRVAKGYPRNTTHW 396
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQ-RVEPGYPKLISDF 39
 
Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 33-185 1.67e-68

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 215.15  E-value: 1.67e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  33 WRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGW-ADIRLSFHGRQSlYCSNTFDGPGKVLAHADI 111
Cdd:cd04278    2 WSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQeADIRISFARGNH-GDGYPFDGPGGTLAHAFF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255958312 112 P--ELGSIHFDKDELWTEGT-YQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYG 185
Cdd:cd04278   81 PggIGGDIHFDDDEQWTLGSdSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVPKFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 32-185 1.31e-62

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 200.15  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312   32 HWRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSF----HGRqslycSNTFDGPGKVLA 107
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFgrgdHGD-----GYPFDGPGGVLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  108 HADIPEL---GSIHFDKDELWTEGT--YQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPF-FKLHPDDVAGIQ 181
Cdd:pfam00413  76 HAFFPGPglgGDIHFDDDETWTVGSdpPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKkFRLSQDDIKGIQ 155


                  ....
gi 255958312  182 ALYG 185
Cdd:pfam00413 156 QLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 214-399 1.12e-59

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 193.68  E-value: 1.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 214 PNPCSGEV-DAMVLGpRGKTYAFKGDYVWTVTD-SGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDF 291
Cdd:cd00094    1 PDACDPLSfDAVTTL-RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 292 KMSPGFPMK-----FNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDG 366
Cdd:cd00094   80 NLEPGYPKPisdlgFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 255958312 367 QVYFFKGKEYWRLNQQLRVAK-GYPRNTTH-WMHC 399
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVRvGYPLKISSdWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 33-186 7.03e-28

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 107.82  E-value: 7.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312    33 WRKKNLTFRIfnVPSTLSlPRVRAALHQAFKYWSSVAPLTFREVKAGwADIRLSFHGRQSlycsntfdgpGKVLAHADIP 112
Cdd:smart00235   5 WPKGTVPYVI--DSSSLS-PEEREAIAKALAEWSDVTCIRFVERTGT-ADIYISFGSGDS----------GCTLSHAGRP 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255958312   113 ElGSIHFDkDELWTEGTYqgvnlriIAAHEVGHALGLGHSRYTQA---LMAPVYAGYQPF-FKLHPDDVAGIQALYGK 186
Cdd:smart00235  71 G-GDQHLS-LGNGCINTG-------VAAHELGHALGLYHEQSRSDrdnYMYINYTNIDTRnFDLSEDDSLGIPYDYGS 139
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 52-185 5.59e-12

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 63.63  E-value: 5.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  52 PRVRAALHQAFKYWSSVAPLTFREVKAGW--ADIRLSFHGRQSLYcsntfdGPGKVLAHADIPELGSIHFDK----DELW 125
Cdd:cd04279   20 QSWLQAVKQAAAEWENVGPLKFVYNPEEDndADIVIFFDRPPPVG------GAGGGLARAGFPLISDGNRKLfnrtDINL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255958312 126 TEGTYQGV-NLRIIAAHEVGHALGLGHSRYT-QALMAPVYAG---YQPffKLHPDDVAGIQALYG 185
Cdd:cd04279   94 GPGQPRGAeNLQAIALHELGHALGLWHHSDRpEDAMYPSQGQgpdGNP--TLSARDVATLKRLYG 156
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 35-184 1.63e-10

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 59.43  E-value: 1.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  35 KKNLTFRI-FNVPstlslPRVRAALHQAFKYWSSVAPLTFREVKAGW-ADIRLSFHGRQSLYCSNTFDGPGKVLahadiP 112
Cdd:cd04268    1 KKPITYYIdDSVP-----DKLRAAILDAIEAWNKAFAIGFKNANDVDpADIRYSVIRWIPYNDGTWSYGPSQVD-----P 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 113 ELGSIHFDKDELWTEGT-YQGVNLRIIAAHEVGHALGLGHSrYTQALMAPVYAG------------YQPF---------- 169
Cdd:cd04268   71 LTGEILLARVYLYSSFVeYSGARLRNTAEHELGHALGLRHN-FAASDRDDNVDLlaekgdtssvmdYAPSnfsiqlgdgq 149

                        170
                 ....*....|....*.
gi 255958312 170 -FKLHPDDVAGIQALY 184
Cdd:cd04268  150 kYTIGPYDIAAIKKLY 165
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 265-308 1.08e-07

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.01  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 255958312   265 LDAAVYSPRTRrTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNL 308
Cdd:smart00120   1 IDAAFELRDGK-TYFFKGDKYWRFDPKRVDPGYPKLISSFFPGL 43
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 60-185 1.34e-07

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 51.65  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  60 QAFKYWSSVAPLTFREVKAGW-ADIRLSfhgrqslycsNTFDGPGKVLAHADIP-------ELGSIHFDKDELW---TEG 128
Cdd:cd04277   41 DALEAWEDVADIDFVEVSDNSgADIRFG----------NSSDPDGNTAGYAYYPgsgsgtaYGGDIWFNSSYDTnsdSPG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312 129 TYQgvnlRIIAAHEVGHALGLGHS------------------RYTqaLMA---PVYAGYqPFFKLHPD-----DVAGIQA 182
Cdd:cd04277  111 SYG----YQTIIHEIGHALGLEHPgdynggdpvpptyaldsrEYT--VMSynsGYGNGA-SAGGGYPQtpmllDIAALQY 183


                 ...
gi 255958312 183 LYG 185
Cdd:cd04277  184 LYG 186
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 359-399 1.88e-07

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 47.24  E-value: 1.88e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 255958312   359 AAMSWQDGQVYFFKGKEYWRLNQQlRVAKGYPRNTTH---WMHC 399
Cdd:smart00120   3 AAFELRDGKTYFFKGDKYWRFDPK-RVDPGYPKLISSffpGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 221-263 1.09e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 45.31  E-value: 1.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 255958312   221 VDAMVLGPRGKTYAFKGDYVWTVTDS--GPGPLFQISALWEGLPG 263
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKrvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 359-396 3.04e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 43.71  E-value: 3.04e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 255958312  359 AAMSWQDGQVYFFKGKEYWRLNQQlRVAKGYPRNTTHW 396
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQ-RVEPGYPKLISDF 39
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 53-151 6.34e-06

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 46.36  E-value: 6.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  53 RVRAALHQAFKYWSSVAPLTFREVKAGW--ADIRLSFhgrqslyCSNTFDGPGkvLAHA-----DIPELGSIHFDKDELW 125
Cdd:cd00203   22 QIQSLILIAMQIWRDYLNIRFVLVGVEIdkADIAILV-------TRQDFDGGT--GGWAylgrvCDSLRGVGVLQDNQSG 92

                         90       100
                 ....*....|....*....|....*.
gi 255958312 126 TEgtyqgvNLRIIAAHEVGHALGLGH 151
Cdd:cd00203   93 TK------EGAQTIAHELGHALGFYH 112
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 265-299 1.95e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 41.78  E-value: 1.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 255958312  265 LDAAVYSPRtRRTHFFKGNKVWRYVDFKMSPGFPM 299
Cdd:pfam00045   1 IDAAFEDRD-GKTYFFKGRKYWRFDPQRVEPGYPK 34
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 308-354 3.87e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 40.69  E-value: 3.87e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 255958312   308 LDAALYWPvNQKVFLFKGSGYWQWDElaRTDLSRYPKPIKELFTGVP 354
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISSFFPGLP 44
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 54-151 2.44e-03

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 38.90  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255958312  54 VRAALHQAFKYWSSVAPLTFREVKAGWADIRLSF---HGrqslycSNTFDGPGKVLAHADIPelgSIHFDkdelWTEGTY 130
Cdd:cd04327   21 LKDKVRAAAREWLPYANLKFKFVTDADADIRISFtpgDG------YWSYVGTDALLIGADAP---TMNLG----WFTDDT 87

                         90       100
                 ....*....|....*....|.
gi 255958312 131 QGVNLRIIAAHEVGHALGLGH 151
Cdd:cd04327   88 PDPEFSRVVLHEFGHALGFIH 108
DUF4953 pfam16313
Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic ...
 135-151 6.45e-03

Met-zincin; This is a family of uncharacterized proteins that carry the highly characteriztic met-zincin mmotif HExxHxxGxxH, the extended zinc-binding domain of metallopeptidases.


Pssm-ID: 435269  Cd Length: 319  Bit Score: 38.39  E-value: 6.45e-03
                          10
                  ....*....|....*..
gi 255958312  135 LRIIAAHEVGHALGLGH 151
Cdd:pfam16313  13 LRFVSAHEVGHTLGLRH 29
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 308-349 7.51e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.46  E-value: 7.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 255958312  308 LDAALYWPVNqKVFLFKGSGYWQWDElaRTDLSRYPKPIKEL 349
Cdd:pfam00045   1 IDAAFEDRDG-KTYFFKGRKYWRFDP--QRVEPGYPKLISDF 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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