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Conserved domains on  [gi|253735886|ref|NP_001156718|]
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zinc finger protein isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.30e-26

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.29  E-value: 3.30e-26
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 253735886      5 LSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFLGLTSSKPYLVTCLEQIQEP 63
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-879 4.64e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  466 KPYKCEVCGKAFCFPPSLSKHKRIHTGEKPYKC--KECGKAFRFPSSLSAHKKIHTGEKPYKCevCGKAFHYPSLLSKHK 543
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  544 IIHTGEKPYKCDICDQafHVPSKLSHHKIIHTGEKPYK-----CEVCGKAFHYSSLLSKHKIIHTGkkpykcEVCDKAFH 618
Cdd:COG5048   110 LSSSSSNSNDNNLLSS--HSLPPSSRDPQLPDLLSISNlrnnpLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  619 YPSRLFSHTKMHTGEKPYKCEVCGKAFCSPSSLSKHKRIHKVEKAYSCEICGKTF------CIPLLLSKHKIIHTGENHY 692
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  693 NSEVCSKFFVYPSrlPKHKKIYKRE---KPYNCDVCGKAFDYPSRLSKHK--KIHTRE--KPYKCDV--CGKAFHIASLL 763
Cdd:COG5048   262 RSSLPTASSQSSS--PNESDSSSEKgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  764 LVHKGIHTGEKPYKC--EDCGKAFY------YPSFLSKHKRIHTgEKPYQCEV--CGKAFHVSSSLSKHRIIHTGERP-- 831
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 253735886  832 YKCEVCGKAFRFSSSLSKHKRIHTGKKPYKCEECGKAFHFPSLLSKHK 879
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-643 5.06e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  214 KPYKCEVCGKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  291 KKIHSVEKPYKCEICGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCEKAFRSLS 369
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  370 SLSKHRRIHMGDNYYNSELCSNAFVYPSRLSKHKKiCRGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 449
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  450 YYPSRLSTHKRIHTGE-------KPYKCEVCGKAFCFPPSLSKHKR--IHTGE--KPYKCKE--CGKAFRFPSSLSAHKK 516
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  517 IHTGEKPYKCevcgkafHYPSLLSKHKIIHTGEKPykcdicdqAFHVPSKLSHHKIIHTGEKPYKCEVCGKafhySSLLS 596
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLS 405

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 253735886  597 KHKIIHTGKKP--YKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEVCGK 643
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 86-197 7.50e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886   86 EWSKVFQNHQIIDLEVKP-YRSEERAKSFHIPSLSSEEST---IHAGEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENl 159
Cdd:COG5189   300 EIRGGISTGEMIDVRKLPcTNSSSNGKLAHGGERNIDTPSrmlKVKDGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN- 377

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 253735886  160 ykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 197
Cdd:COG5189   378 ------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 940-1019 8.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  940 GEKPYKCEV--CGNVFRFPSSLSEHKKtHTGENPYKCEVCGKafcsasllSKHKIIHIGKKPYKCEVCGKAFHYPSRLSK 1017
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886 1018 HK 1019
Cdd:COG5189   417 HR 418
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.30e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.29  E-value: 3.30e-26
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 253735886      5 LSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFLGLTSSKPYLVTCLEQIQEP 63
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 9.65e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 9.65e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 253735886     4 MLSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFLG 45
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 1.24e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.43  E-value: 1.24e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 253735886    5 LSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-879 4.64e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  466 KPYKCEVCGKAFCFPPSLSKHKRIHTGEKPYKC--KECGKAFRFPSSLSAHKKIHTGEKPYKCevCGKAFHYPSLLSKHK 543
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  544 IIHTGEKPYKCDICDQafHVPSKLSHHKIIHTGEKPYK-----CEVCGKAFHYSSLLSKHKIIHTGkkpykcEVCDKAFH 618
Cdd:COG5048   110 LSSSSSNSNDNNLLSS--HSLPPSSRDPQLPDLLSISNlrnnpLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  619 YPSRLFSHTKMHTGEKPYKCEVCGKAFCSPSSLSKHKRIHKVEKAYSCEICGKTF------CIPLLLSKHKIIHTGENHY 692
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  693 NSEVCSKFFVYPSrlPKHKKIYKRE---KPYNCDVCGKAFDYPSRLSKHK--KIHTRE--KPYKCDV--CGKAFHIASLL 763
Cdd:COG5048   262 RSSLPTASSQSSS--PNESDSSSEKgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  764 LVHKGIHTGEKPYKC--EDCGKAFY------YPSFLSKHKRIHTgEKPYQCEV--CGKAFHVSSSLSKHRIIHTGERP-- 831
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 253735886  832 YKCEVCGKAFRFSSSLSKHKRIHTGKKPYKCEECGKAFHFPSLLSKHK 879
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-643 5.06e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  214 KPYKCEVCGKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  291 KKIHSVEKPYKCEICGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCEKAFRSLS 369
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  370 SLSKHRRIHMGDNYYNSELCSNAFVYPSRLSKHKKiCRGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 449
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  450 YYPSRLSTHKRIHTGE-------KPYKCEVCGKAFCFPPSLSKHKR--IHTGE--KPYKCKE--CGKAFRFPSSLSAHKK 516
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  517 IHTGEKPYKCevcgkafHYPSLLSKHKIIHTGEKPykcdicdqAFHVPSKLSHHKIIHTGEKPYKCEVCGKafhySSLLS 596
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLS 405

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 253735886  597 KHKIIHTGKKP--YKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEVCGK 643
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 86-197 7.50e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886   86 EWSKVFQNHQIIDLEVKP-YRSEERAKSFHIPSLSSEEST---IHAGEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENl 159
Cdd:COG5189   300 EIRGGISTGEMIDVRKLPcTNSSSNGKLAHGGERNIDTPSrmlKVKDGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN- 377

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 253735886  160 ykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 197
Cdd:COG5189   378 ------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 940-1019 8.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  940 GEKPYKCEV--CGNVFRFPSSLSEHKKtHTGENPYKCEVCGKafcsasllSKHKIIHIGKKPYKCEVCGKAFHYPSRLSK 1017
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886 1018 HK 1019
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-505 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.74e-03
                           10        20
                   ....*....|....*....|....
gi 253735886   482 SLSKHKRIHTGEKPYKCKECGKAF 505
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-253 2.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|...
gi 253735886   231 LSKHKRIHTGEKPYKCEECGKAF 253
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 3.30e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.29  E-value: 3.30e-26
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 253735886      5 LSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFLGLTSSKPYLVTCLEQIQEP 63
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 9.65e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 9.65e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 253735886     4 MLSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFLG 45
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 1.24e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.43  E-value: 1.24e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 253735886    5 LSFKDVAIDFSAEERECLDPAQWKLYRNVMLENYDNLVFL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-879 4.64e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  466 KPYKCEVCGKAFCFPPSLSKHKRIHTGEKPYKC--KECGKAFRFPSSLSAHKKIHTGEKPYKCevCGKAFHYPSLLSKHK 543
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  544 IIHTGEKPYKCDICDQafHVPSKLSHHKIIHTGEKPYK-----CEVCGKAFHYSSLLSKHKIIHTGkkpykcEVCDKAFH 618
Cdd:COG5048   110 LSSSSSNSNDNNLLSS--HSLPPSSRDPQLPDLLSISNlrnnpLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  619 YPSRLFSHTKMHTGEKPYKCEVCGKAFCSPSSLSKHKRIHKVEKAYSCEICGKTF------CIPLLLSKHKIIHTGENHY 692
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  693 NSEVCSKFFVYPSrlPKHKKIYKRE---KPYNCDVCGKAFDYPSRLSKHK--KIHTRE--KPYKCDV--CGKAFHIASLL 763
Cdd:COG5048   262 RSSLPTASSQSSS--PNESDSSSEKgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  764 LVHKGIHTGEKPYKC--EDCGKAFY------YPSFLSKHKRIHTgEKPYQCEV--CGKAFHVSSSLSKHRIIHTGERP-- 831
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 253735886  832 YKCEVCGKAFRFSSSLSKHKRIHTGKKPYKCEECGKAFHFPSLLSKHK 879
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-643 5.06e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  214 KPYKCEVCGKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  291 KKIHSVEKPYKCEICGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCEKAFRSLS 369
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  370 SLSKHRRIHMGDNYYNSELCSNAFVYPSRLSKHKKiCRGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 449
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  450 YYPSRLSTHKRIHTGE-------KPYKCEVCGKAFCFPPSLSKHKR--IHTGE--KPYKCKE--CGKAFRFPSSLSAHKK 516
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  517 IHTGEKPYKCevcgkafHYPSLLSKHKIIHTGEKPykcdicdqAFHVPSKLSHHKIIHTGEKPYKCEVCGKafhySSLLS 596
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLS 405

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 253735886  597 KHKIIHTGKKP--YKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEVCGK 643
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
522-991 1.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  522 KPYKCEVCGKAFHYPSLLSKHKIIHTGEKPYKC--DICDQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFHYSSLLSK-H 598
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  599 KIIHTGKKPYKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEVCGKAFC-SPSSLSKHKRIHKVEkaysceICGKTFCIPL 677
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANS------LSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  678 LLSKHKIIHTGENHYNSEVCSKFFVYPSRLPKHKKIYKREK-PYNCDVCGKAFDYPSRL-----SKHKKIHTREKPYKC- 750
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSlPLTTNSQLSPKSLLSQSpsslsSSDSSSSASESPRSSl 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  751 --DVCGKAFHIASLLLVHKGIHTgekPYKCEDCGKAFYYPSFLSKHKR--IHTGE--KPYQC--EVCGKAFHVSSSLSKH 822
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  823 RIIHTGERPYKCevcgkafRFSSSLSKHKRIHTGKKPykceecgkafhfpSLLSKHKISHTREKFYNCD-LCSKTFHYPS 901
Cdd:COG5048   343 ILLHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSnSCIRNFKRDS 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  902 LLSKHKMIHMEGKPHKCdvcgkafhypsklsnhkkihtgekpyKCEVCGNVFRFPSSLSEHKKTHTGENPYKCEVCGKAF 981
Cdd:COG5048   403 NLSLHIITHLSFRPYNC--------------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456

                         490
                  ....*....|
gi 253735886  982 CSASLLSKHK 991
Cdd:COG5048   457 RDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
605-1022 2.32e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  605 KKPYKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEV--CGKAFCSPSSLSKHKRIHKVEKAYSCEICGKtfcipllLSKH 682
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP-------LSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  683 KIIHTGENHYNSEVCSKFFVYPSRLPKHKKIYKREKPYNCDVCGKAFDYPSRLSKHKKIHTREKPYKCDV---CGKAFHI 759
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  760 ASLLLVHKGIHTGEKPYKCEDCGKAFYYPSFLSKHKRihtgekpyqcevcgkaFHVSSSLSKHRIIHTGERPYKCEvcgk 839
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ---- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  840 afRFSSSLSKHKRIHTGKKPYKC---EECGKAFHFPSLLSKHKISHTRekfYNCDLCSKTFHYPSLLSKHK--MIH--ME 912
Cdd:COG5048   244 --SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLrsVNHsgES 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  913 GKPHKCDV--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVFRFPS-----SLSEHKKTHTGENPYKCEV--CGKAF 981
Cdd:COG5048   319 LKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCIRNF 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 253735886  982 CSASLLSKHKIIHIGKKP--YKCEVCGKAFHYPSRLSKHKAIH 1022
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-600 3.51e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  172 PSRLSRHKKIHSEEKPYKCEVCGKAFHFPSLLLVHKRVHTGEKPYKCEV--CGKAFHYPSILSKHKRIHTGEKPYKCE-E 248
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  249 CGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSVEKPYKCEICGKAFRILSLLSKHKIIHTEENPY 328
Cdd:COG5048    98 LPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  329 KCEVCGKAFDYPSRLSTHAK-------MHTGEKPYKCEVCEKAFRSLSSLSKHRRIHMGDnyYNSELCSNAFVYPSRLSK 401
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPsssenspLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP--KSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  402 HKKICrGEKPYKCEVCGKAFHVSSLLSKHRTIHTgekLYKCEVCGKAFYYPSRLSTHKR--IHTGE--KPYKC--EVCGK 475
Cdd:COG5048   256 SASES-PRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGK 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  476 AFCFPPSLSKHKRIHTGEKPYKCK--ECGKAFRFPS-----SLSAHKKIHTGEKPYKCEV--CGKAFHYPSLLSKHKIIH 546
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITH 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 253735886  547 TGEKP--YKCDICDQAFHVPSKLSHHKIIHTGEKPYKCEVCGKaFHYSSLLSKHKI 600
Cdd:COG5048   412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 338-432 2.15e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  338 DYPSRLsthaKMHTGEKPYKCEV--CEKAFRSLSSLskhrRIHMGDNYYNSELCSNafvyPSRlSKHKKICRGEKPYKCE 415
Cdd:COG5189   336 DTPSRM----LKVKDGKPYKCPVegCNKKYKNQNGL----KYHMLHGHQNQKLHEN----PSP-EKMNIFSAKDKPYRCE 402

                          90
                  ....*....|....*..
gi 253735886  416 VCGKAFHVSSLLSKHRT 432
Cdd:COG5189   403 VCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 297-375 2.91e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  297 EKPYKCEI--CGKAFRILSLLSKHKIiHTEENPykcevcgKAFDYPSRLSTHAkMHTGEKPYKCEVCEKAFRSLSSLSKH 374
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEKMNI-FSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  .
gi 253735886  375 R 375
Cdd:COG5189   418 R 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 772-851 5.62e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  772 GEKPYKCE--DCGKAfYYPSFLSKHKRIHTGekpyqcevCGKAFHVSSSLSKHRIIHTGERPYKCEVCGKAFRFSSSLSK 849
Cdd:COG5189   346 DGKPYKCPveGCNKK-YKNQNGLKYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886  850 HK 851
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
703-1002 9.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 9.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  703 YPSRLPKHKKIYKREKPYNCDVCGKAFDYPSRLSKHKKIHTREKPYKCDV--CGKAFHIASLLLVHKGIHTGEKPYKCED 780
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  781 -CGKAFYYPSFLSKHKRIHTGEKPYQCEVCGKAFHVSSSLSKHRIIHTGERPYKCEVC---------------------- 837
Cdd:COG5048    97 sLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpansl 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  838 -GKAFRFSSSLSKHKRIHTGKKPYKCEECGKAFHFPSLLSKHKISHTREkFYNCDLCSKTFHYPSLLSKHKMIHMEGKPH 916
Cdd:COG5048   177 sKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  917 KCDVCGKAFHYPSKLSNHKKIHTGE-------KPYKCEVCGNVFRFPSSLSEHKKT--HTGEN--PYKC--EVCGKAFCS 983
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCpySLCGKLFSR 335

                         330
                  ....*....|....*....
gi 253735886  984 ASLLSKHKIIHIGKKPYKC 1002
Cdd:COG5048   336 NDALKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-295 1.36e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  212 GEKPYKCEV--CGKAFHYPSILSKHKrihtgekpyKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSN 289
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 253735886  290 HKKiHS 295
Cdd:COG5189   417 HRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 576-655 3.73e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  576 GEKPYKCEV--CGKAFHYSSLLSKHKIiHTGKKPYKCEVCDKAfhypsrlfSHTKMHTGEKPYKCEVCGKAFCSPSSLSK 653
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886  654 HK 655
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 548-617 4.75e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 4.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 253735886  548 GEKPYKCDI--CDQAFHVPSKLSHHKIihTGEkpykcevCGKAFHYSSLLSKHKIIHTGKKPYKCEVCDKAF 617
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML--HGH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 520-599 4.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  520 GEKPYKCEV--CGKAFHYPSLLSKHKiihtgekpyKCDICDQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFHYSSLLSK 597
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886  598 HK 599
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-351 5.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  268 GEKPYKCEV--CGKAFHYPSRLSNHKKiHSVEKPYKCEICGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLST 345
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 253735886  346 HAKMHT 351
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 86-197 7.50e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886   86 EWSKVFQNHQIIDLEVKP-YRSEERAKSFHIPSLSSEEST---IHAGEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENl 159
Cdd:COG5189   300 EIRGGISTGEMIDVRKLPcTNSSSNGKLAHGGERNIDTPSrmlKVKDGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN- 377

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 253735886  160 ykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 197
Cdd:COG5189   378 ------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 940-1019 8.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735886  940 GEKPYKCEV--CGNVFRFPSSLSEHKKtHTGENPYKCEVCGKafcsasllSKHKIIHIGKKPYKCEVCGKAFHYPSRLSK 1017
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 253735886 1018 HK 1019
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-505 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.74e-03
                           10        20
                   ....*....|....*....|....
gi 253735886   482 SLSKHKRIHTGEKPYKCKECGKAF 505
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-253 2.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|...
gi 253735886   231 LSKHKRIHTGEKPYKCEECGKAF 253
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
846-869 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.30e-03
                           10        20
                   ....*....|....*....|....
gi 253735886   846 SLSKHKRIHTGKKPYKCEECGKAF 869
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-477 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.84e-03
                           10        20
                   ....*....|....*....|....
gi 253735886   454 RLSTHKRIHTGEKPYKCEVCGKAF 477
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
791-813 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.84e-03
                           10        20
                   ....*....|....*....|...
gi 253735886   791 LSKHKRIHTGEKPYQCEVCGKAF 813
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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