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Conserved domains on  [gi|237858705|ref|NP_001153718|]
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RPA-interacting protein isoform d [Homo sapiens]

Protein Classification

RPA_interact_N and RPA_interact_M domain-containing protein( domain architecture ID 10632121)

RPA_interact_N and RPA_interact_M domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.66e-13

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


:

Pssm-ID: 464304  Cd Length: 39  Bit Score: 59.07  E-value: 1.66e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858705    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M super family cl20690
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-104 6.79e-04

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


The actual alignment was detected with superfamily member pfam14767:

Pssm-ID: 434193  Cd Length: 82  Bit Score: 35.47  E-value: 6.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 237858705   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQ 104
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQ 59
 
Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.66e-13

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 59.07  E-value: 1.66e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858705    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-104 6.79e-04

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 35.47  E-value: 6.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 237858705   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQ 104
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQ 59
 
Name Accession Description Interval E-value
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.66e-13

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 59.07  E-value: 1.66e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858705    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-104 6.79e-04

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 35.47  E-value: 6.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 237858705   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQ 104
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQ 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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