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Conserved domains on  [gi|226442815|ref|NP_001140162|]
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cholinephosphotransferase 1 isoform 1 [Mus musculus]

Protein Classification

CDP-alcohol phosphatidyltransferase class-I family protein( domain architecture ID 2159)

CDP-alcohol phosphatidyltransferase class-I family protein such as CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase that catalyzes the committed step in the synthesis of acidic phospholipids

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK10832 super family cl00453
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
19-382 9.15e-37

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


The actual alignment was detected with superfamily member PTZ00307:

Pssm-ID: 469774  Cd Length: 417  Bit Score: 138.43  E-value: 9.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  19 EPLSAAQLRRLEEHRYTAVGESLFEP-PLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTY 97
Cdd:PTZ00307  18 EYIPPAYLPNLKKYKYSSTDSSIISRyVLQRYWNFIVNLVPMTVAPNCITFTGFLIGMSSAALLLYFYFFEEGVYPSWVL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  98 LLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAvrLGTHPDWLFFCSFVGMFMFYCAHWQ 177
Cdd:PTZ00307  98 YYAAFALFAYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLA--TYMTPVERFWLSTISSMSLFTAIWE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 178 TYVSGVLRFGRVD-VTEIQVALVIVFMLSTFGGATMWD------YTIPILEIKLKIVP------VLGVVGGLIF-----S 239
Cdd:PTZ00307 176 QFSTGTFDLGYVNgPTEGIILNCVLFIVSGVYGESIWDtpavgpYDVAYPPVLSSFFPgcsgtvHIESVRSVLFllflvS 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 240 C-----SNYFHVILHGGVGKNGSTiaGTSVLSPGLHIGLIIILAIMIYkksaTNMFEKHPCLYTLMFGCVFAKVAQKLVI 314
Cdd:PTZ00307 256 CpftilTNVVHVVLRPTVHASKVT--PMLAALPILTMTALHVHVFVVF----PNLHVKFPFALELSYGLLMSITVTRLTL 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 315 AHM------TKSELYLQDTVFIGPGLLFLDQYFNNFIDEYV--VLWIAMV-ISSFDMMIYF---TSLCLQISRHLHLNIF 382
Cdd:PTZ00307 330 ARLsampyrTFNWHIVITFLALTAASLMHYAGDASVEHKYVepSLGWALTgLAVFAAWQYGhmiLSAFTQIARYLSISIM 409
 
Name Accession Description Interval E-value
PTZ00307 PTZ00307
ethanolamine phosphotransferase; Provisional
19-382 9.15e-37

ethanolamine phosphotransferase; Provisional


Pssm-ID: 140328  Cd Length: 417  Bit Score: 138.43  E-value: 9.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  19 EPLSAAQLRRLEEHRYTAVGESLFEP-PLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTY 97
Cdd:PTZ00307  18 EYIPPAYLPNLKKYKYSSTDSSIISRyVLQRYWNFIVNLVPMTVAPNCITFTGFLIGMSSAALLLYFYFFEEGVYPSWVL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  98 LLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAvrLGTHPDWLFFCSFVGMFMFYCAHWQ 177
Cdd:PTZ00307  98 YYAAFALFAYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLA--TYMTPVERFWLSTISSMSLFTAIWE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 178 TYVSGVLRFGRVD-VTEIQVALVIVFMLSTFGGATMWD------YTIPILEIKLKIVP------VLGVVGGLIF-----S 239
Cdd:PTZ00307 176 QFSTGTFDLGYVNgPTEGIILNCVLFIVSGVYGESIWDtpavgpYDVAYPPVLSSFFPgcsgtvHIESVRSVLFllflvS 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 240 C-----SNYFHVILHGGVGKNGSTiaGTSVLSPGLHIGLIIILAIMIYkksaTNMFEKHPCLYTLMFGCVFAKVAQKLVI 314
Cdd:PTZ00307 256 CpftilTNVVHVVLRPTVHASKVT--PMLAALPILTMTALHVHVFVVF----PNLHVKFPFALELSYGLLMSITVTRLTL 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 315 AHM------TKSELYLQDTVFIGPGLLFLDQYFNNFIDEYV--VLWIAMV-ISSFDMMIYF---TSLCLQISRHLHLNIF 382
Cdd:PTZ00307 330 ARLsampyrTFNWHIVITFLALTAASLMHYAGDASVEHKYVepSLGWALTgLAVFAAWQYGhmiLSAFTQIARYLSISIM 409
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
34-208 8.52e-29

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 110.55  E-value: 8.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  34 YTAVGESLFEPPLQLY-WTWLLQWIPLWMAPNTITLIGLAINLVTTLVlifYCPTVTEEAPYWTylLCALGLFIYQSLDA 112
Cdd:COG5050    8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVG---YLASNGDTGAYLW--LAPVGLIVYWFGDS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 113 IDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGthPDWLFFCSFVGMFMFYCAHWQTYVSGVLRFG-RVDV 191
Cdd:COG5050   83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLSPYVR--LDVALLALLGYLLLSIHTFWETRVTGEFRLGyLIGP 160
                        170
                 ....*....|....*..
gi 226442815 192 TEIQVaLVIVFMLSTFG 208
Cdd:COG5050  161 TELRL-ILIALTAAMFS 176
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
60-163 3.80e-03

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 37.92  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815   60 WMAPNTITLIGLAinLVTTLVLIFYcptvteeAPYWTYLlcALGLFIYQSL-DAIDGKQARRTNSCSPLGELFDHGCDSL 138
Cdd:pfam01066   1 LNLPNLLTLLRIL--LVPVFVVLLL-------GPGNRIL--AAVVFALAALtDFLDGKIARKLNQVTDFGKFLDPLADKL 69
                          90       100
                  ....*....|....*....|....*
gi 226442815  139 STVFMAIGASIAVRLgthPDWLFFC 163
Cdd:pfam01066  70 LVAAALIALSILGLL---PWWFVVV 91
 
Name Accession Description Interval E-value
PTZ00307 PTZ00307
ethanolamine phosphotransferase; Provisional
19-382 9.15e-37

ethanolamine phosphotransferase; Provisional


Pssm-ID: 140328  Cd Length: 417  Bit Score: 138.43  E-value: 9.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  19 EPLSAAQLRRLEEHRYTAVGESLFEP-PLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTY 97
Cdd:PTZ00307  18 EYIPPAYLPNLKKYKYSSTDSSIISRyVLQRYWNFIVNLVPMTVAPNCITFTGFLIGMSSAALLLYFYFFEEGVYPSWVL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  98 LLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAvrLGTHPDWLFFCSFVGMFMFYCAHWQ 177
Cdd:PTZ00307  98 YYAAFALFAYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLA--TYMTPVERFWLSTISSMSLFTAIWE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 178 TYVSGVLRFGRVD-VTEIQVALVIVFMLSTFGGATMWD------YTIPILEIKLKIVP------VLGVVGGLIF-----S 239
Cdd:PTZ00307 176 QFSTGTFDLGYVNgPTEGIILNCVLFIVSGVYGESIWDtpavgpYDVAYPPVLSSFFPgcsgtvHIESVRSVLFllflvS 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 240 C-----SNYFHVILHGGVGKNGSTiaGTSVLSPGLHIGLIIILAIMIYkksaTNMFEKHPCLYTLMFGCVFAKVAQKLVI 314
Cdd:PTZ00307 256 CpftilTNVVHVVLRPTVHASKVT--PMLAALPILTMTALHVHVFVVF----PNLHVKFPFALELSYGLLMSITVTRLTL 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 315 AHM------TKSELYLQDTVFIGPGLLFLDQYFNNFIDEYV--VLWIAMV-ISSFDMMIYF---TSLCLQISRHLHLNIF 382
Cdd:PTZ00307 330 ARLsampyrTFNWHIVITFLALTAASLMHYAGDASVEHKYVepSLGWALTgLAVFAAWQYGhmiLSAFTQIARYLSISIM 409
PLN02359 PLN02359
ethanolaminephosphotransferase
29-317 1.44e-35

ethanolaminephosphotransferase


Pssm-ID: 166000  Cd Length: 389  Bit Score: 134.52  E-value: 1.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  29 LEEHRYTAVGESLFEP-PLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTYLLCALGLFIY 107
Cdd:PLN02359  12 LHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFAHGLLLFLY 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 108 QSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGTHPDWLFFCSFVGmfmFYCAHWQTYVSGVLRFG 187
Cdd:PLN02359  92 QTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGRDTFWFWVISAVP---FYGATWEHFFTNTLILP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 188 RVD-VTEIQVALVIVFMLSTFGGATMWD----------------YTIPILEIKLKIVPVLGVVGGLIFSCSNYFHVILhg 250
Cdd:PLN02359 169 VINgPTEGLMLIYCAHFFTAIVGAEWWAqdfgksipflswvpfvSEIQTYRIVLFLMIAFAVIPTVAFNVSNVYKVVQ-- 246
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226442815 251 gvGKNGSTIAGTSVLSP-GLHIGLIIILAIMiykkSATNMFEKHPCLYTLMFGCVFAKVAQKLVIAHM 317
Cdd:PLN02359 247 --ARKGSMLLALAMLYPfVTLLGGVLIWDYL----SPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHL 308
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
34-208 8.52e-29

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 110.55  E-value: 8.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  34 YTAVGESLFEPPLQLY-WTWLLQWIPLWMAPNTITLIGLAINLVTTLVlifYCPTVTEEAPYWTylLCALGLFIYQSLDA 112
Cdd:COG5050    8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVG---YLASNGDTGAYLW--LAPVGLIVYWFGDS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 113 IDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGthPDWLFFCSFVGMFMFYCAHWQTYVSGVLRFG-RVDV 191
Cdd:COG5050   83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLSPYVR--LDVALLALLGYLLLSIHTFWETRVTGEFRLGyLIGP 160
                        170
                 ....*....|....*..
gi 226442815 192 TEIQVaLVIVFMLSTFG 208
Cdd:COG5050  161 TELRL-ILIALTAAMFS 176
PLN03039 PLN03039
ethanolaminephosphotransferase; Provisional
69-317 5.36e-22

ethanolaminephosphotransferase; Provisional


Pssm-ID: 166679  Cd Length: 337  Bit Score: 95.83  E-value: 5.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  69 IGLAINLVTTLVLIFYCPTVTEEAPYWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGAS 148
Cdd:PLN03039   1 MGFMFLLTSALLGYIYSPKLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFEAMAFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 149 IAVRLGTHPDWLFFCSFVGmfmFYCAHWQTYVSGVLRFGRVDVTEIQVALVIV-FMLSTFGGATMW----DYTIPIL--- 220
Cdd:PLN03039  81 STAMCGRDTFWFWVISAIP---FFGATWEHYFTNTLILPVINGPTEGLALIFCgHFFTAIVGAEWWaqpfGKSIPLFswv 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815 221 ---------EIKLKIVPVLGVVGGLIFSCSNYFHVILhggvGKNGSTIAGTSVLSPglhiGLIIILAIMIYKK-SATNMF 290
Cdd:PLN03039 158 pflneiqmsRAILFMMIAFAVIPTLAFNTSNVYKVVH----SRNGSMLLALAMLYP----FVTLIAGVLIWDYlSPIDLI 229
                        250       260
                 ....*....|....*....|....*..
gi 226442815 291 EKHPCLYTLMFGCVFAKVAQKLVIAHM 317
Cdd:PLN03039 230 ANYPHLVVLGTGLAFGFLVGRMILAHL 256
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
59-213 9.88e-12

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 62.95  E-value: 9.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815  59 LWMAPNTITLIGLAinLVTTLVLIFYCPtvteeapyWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSL 138
Cdd:COG0558    8 LLNIPNQLTLLRIL--LVPVFALLLLLG--------GALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKL 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226442815 139 STVFMAIGASIAVRLgthPDWLFFCSFVGMFM-FYCAHW-QTYVSGVLRFGRVDvTEIQVALVIVFMLSTFG-GATMW 213
Cdd:COG0558   78 LDAAALLGLVLLGLL---PAWLALLILLRELLvSYLRARaAALGVVASYLGKAK-TVLQLVAILLLLLGLPLlGVLLW 151
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
60-163 3.80e-03

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 37.92  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226442815   60 WMAPNTITLIGLAinLVTTLVLIFYcptvteeAPYWTYLlcALGLFIYQSL-DAIDGKQARRTNSCSPLGELFDHGCDSL 138
Cdd:pfam01066   1 LNLPNLLTLLRIL--LVPVFVVLLL-------GPGNRIL--AAVVFALAALtDFLDGKIARKLNQVTDFGKFLDPLADKL 69
                          90       100
                  ....*....|....*....|....*
gi 226442815  139 STVFMAIGASIAVRLgthPDWLFFC 163
Cdd:pfam01066  70 LVAAALIALSILGLL---PWWFVVV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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