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Conserved domains on  [gi|226423850|ref|NP_001139777|]
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plexin domain-containing protein 2 precursor [Danio rerio]

Protein Classification

PSI domain-containing protein( domain architecture ID 10477607)

PSI domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 321-366 4.78e-11

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 58.10  E-value: 4.78e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226423850  321 TCLQFTSCTSCIASQiNFNCSWCHRLNRCS-----SGFDRHRQDWVDNS--CP 366
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASskCP 52
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 321-366 4.78e-11

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 58.10  E-value: 4.78e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226423850  321 TCLQFTSCTSCIASQiNFNCSWCHRLNRCS-----SGFDRHRQDWVDNS--CP 366
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASskCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
322-366 6.69e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 57.55  E-value: 6.69e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 226423850   322 CLQFTSCTSCIASQiNFNCSWCHRLNRCSSGF--DRHRQDWVDNSCP 366
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGCP 47
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 321-366 4.78e-11

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 58.10  E-value: 4.78e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226423850  321 TCLQFTSCTSCIASQiNFNCSWCHRLNRCS-----SGFDRHRQDWVDNS--CP 366
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASskCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
322-366 6.69e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 57.55  E-value: 6.69e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 226423850   322 CLQFTSCTSCIASQiNFNCSWCHRLNRCSSGF--DRHRQDWVDNSCP 366
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGCP 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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