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Conserved domains on  [gi|215272345|ref|NP_001135823|]
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beta-galactoside alpha-2,6-sialyltransferase 2 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 245-514 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467714  Cd Length: 270  Bit Score: 604.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 245 GLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFN 324
Cdd:cd23986    1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 325 SAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQ 404
Cdd:cd23986   81 SAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 405 PFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHP 484
Cdd:cd23986  161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 215272345 485 LLYEKLLVQRLNMGTQGDLHRKGKVVLPGF 514
Cdd:cd23986  241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 245-514 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 604.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 245 GLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFN 324
Cdd:cd23986    1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 325 SAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQ 404
Cdd:cd23986   81 SAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 405 PFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHP 484
Cdd:cd23986  161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 215272345 485 LLYEKLLVQRLNMGTQGDLHRKGKVVLPGF 514
Cdd:cd23986  241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 278-508 1.51e-37

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 138.89  E-value: 1.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  278 RLVPAVplSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN--SQILTNPSHH 355
Cdd:pfam00777  30 ELLPKV--SPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  356 FIDSSLYKDV--ILVAWDPAPYsanlnLW-----YKKP-DYNLFTPYIQHRQRNPNQP--FYILHPKFIWQLWDIIQEnt 425
Cdd:pfam00777 108 GFSHPRDPFVefVLVPFKGRDL-----LWlpaflTKGNvSRSLRVLYTLKEVKIPVDPdkVLFLHPDFLRYVANFWLR-- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  426 KEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYhelYYDAAC--TLGAY--HPLLYEKLLVQRlnmgtqg 501
Cdd:pfam00777 181 SHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH---YYDNVLmkKGGFYgvHDMPFEFKLLQK------- 250


                  ....*..
gi 215272345  502 dLHRKGK 508
Cdd:pfam00777 251 -LHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 245-514 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 604.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 245 GLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFN 324
Cdd:cd23986    1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 325 SAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQ 404
Cdd:cd23986   81 SAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 405 PFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHP 484
Cdd:cd23986  161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 215272345 485 LLYEKLLVQRLNMGTQGDLHRKGKVVLPGF 514
Cdd:cd23986  241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 248-514 5.54e-155

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 442.87  E-value: 5.54e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 248 RAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPaVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP 327
Cdd:cd23968    1 SEDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPF-PESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 328 TRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFY 407
Cdd:cd23968   80 TKGFEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 408 ILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLY 487
Cdd:cd23968  160 LIDPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAA 239

                        250       260
                 ....*....|....*....|....*..
gi 215272345 488 EKLLVQRLNMGTQGDLHRKGKVVLPGF 514
Cdd:cd23968  240 EKLLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 248-514 1.30e-151

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 434.13  E-value: 1.30e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 248 RAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQlHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP 327
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLRE-EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 328 TRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFY 407
Cdd:cd23985   80 TAGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 408 ILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLY 487
Cdd:cd23985  160 ILHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLY 239

                        250       260
                 ....*....|....*....|....*..
gi 215272345 488 EKLLVQRLNMGTQGDLHRKGKVVLPGF 514
Cdd:cd23985  240 EKNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 296-495 4.74e-47

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 162.15  E-value: 4.74e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 296 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILT----NPSHHFIDSSLYKDVILVAWD 371
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGfylrGPRCGCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 372 PAPYSANLNLWYKKpdynlftpyiqhrqRNPNQPFYILH--PKFIWQLWDIIQ-ENTKEKIQPNPPSSGFIGILIMMSMC 448
Cdd:cd19952   81 AAAADFKRLKRRKK--------------RHDNAVLLLTDpaPDLLSYVRKRLEkLGLKSFFGGNAPSSGLLAVLLALQLC 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 215272345 449 REVHVYEYIPSVRQTELCHYHelYYDAACTLG--AYHPLLYEKLLVQRL 495
Cdd:cd19952  147 DSVDLYGFGVDSGHAPKVPYH--YYDLVEAEEgtAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 278-508 1.51e-37

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 138.89  E-value: 1.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  278 RLVPAVplSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN--SQILTNPSHH 355
Cdd:pfam00777  30 ELLPKV--SPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  356 FIDSSLYKDV--ILVAWDPAPYsanlnLW-----YKKP-DYNLFTPYIQHRQRNPNQP--FYILHPKFIWQLWDIIQEnt 425
Cdd:pfam00777 108 GFSHPRDPFVefVLVPFKGRDL-----LWlpaflTKGNvSRSLRVLYTLKEVKIPVDPdkVLFLHPDFLRYVANFWLR-- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345  426 KEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYhelYYDAAC--TLGAY--HPLLYEKLLVQRlnmgtqg 501
Cdd:pfam00777 181 SHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH---YYDNVLmkKGGFYgvHDMPFEFKLLQK------- 250


                  ....*..
gi 215272345  502 dLHRKGK 508
Cdd:pfam00777 251 -LHKEGV 256
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 294-495 1.01e-28

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 112.77  E-value: 1.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRiinsqiLTNPSHHFIDSSLYK---DVILVAW 370
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR------MFYPESAFRDPEEYDsdwLLVLVPF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 371 DPAPYS-----------ANLNLWYKKPDYNLftPYiqhrqrNPNQpFYILHPKFIWQL-WDIIQENTKEKIQPNPPSSGF 438
Cdd:cd23967   77 KSMDLLwlqavikgkkpNGKGGFWKKIATSV--PK------PPKK-IRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGI 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272345 439 IGILIMMSMCREVHV--YEYIPSVRQTelcHYHelYYDAACT----LGAYHPLLYEKLLVQRL 495
Cdd:cd23967  148 IAIVMALHYCDEVDIagFGYDPSDPNA---PLH--YYDSLTMkaikRSWTHNVTKEKKYLKKL 205
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 276-474 1.97e-28

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 114.28  E-value: 1.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 276 WRRLVPAVPLSQLHprgLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILtnpsHH 355
Cdd:cd23963   49 YELLPKTSPFSHKR---YKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL----KR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 356 FIDSSLYKDVILVAWDpapYSANLN---LWYKKPDYN-----LFTPYIQHRQRNPNQPFYILHPKF---IWQLWdiiqen 424
Cdd:cd23963  122 RYNSLKKNRDRDKFLN---RLKEYNgsiLWYPKFSFKsstnlLLKAARALKKNGLNLTVVYSNPEHflaVQKFW------ 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272345 425 tKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIP---SVRQTELcHYHelYYD 474
Cdd:cd23963  193 -KRRGLEKRPSTGLYLVSLALTFCDEIHLYGFWPfptDPNGRPV-PYH--YYD 241
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 294-494 3.43e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 109.25  E-value: 3.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN----SQILTNPshHFIDSSLYKDVILVA 369
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVShsslPRLLRNA--ILLLAGTRAPTVVVF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 370 WDPapysanlnlwYKKPDYNLFTPYIQHR---QRNPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILIM 444
Cdd:cd23965   80 WGP----------ETKMNKDGAGKYNLLRslsKKYPDVEFYSLTPEKMDYADELFEKETgKSRIKSGTwLSTGWFTMLLA 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272345 445 MSMCREVHVYEYIP----SVRQTELCHYHelYYDA----ACT--------LGAYHPLLYEKLLVQR 494
Cdd:cd23965  150 LDVCDEIKVYGMVPenycREHPNSKVPYH--YYEPgglkECTyynyhenaLKGGHRFITEKAVFAR 213
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 294-495 4.30e-26

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 105.52  E-value: 4.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRII-------NSQILTNPSHHFidsslykdvI 366
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesaqfDPGIENDPDTLL---------V 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 367 LVAWDPAPYSANLNLWY--KKPDYNLFTPYIQHRQRNPNQpFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIM 444
Cdd:cd23982   74 LVPFKPLDFYWLYEILSneKRVRKGFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITLA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272345 445 MSMCREVHV--YEYIPSVRQTELCHyhelYYDAAcTL----GAYHPLLYEKLLVQRL 495
Cdd:cd23982  153 LHLCDEVHIagFGYPDNGNSNQPIH----YYNQI-TLksmaNSGHNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 294-495 4.03e-23

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 97.12  E-value: 4.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ-ILTNPSHHFIDSSlykdVILVAWDP 372
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPEsIFSDPSHYDPNTT----VVLIPFKP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 373 APY----------SANLNLWYKKPDYNLftpyiqhrQRNPNQpFYILHPKFI----WQLWDIIQENTKEKIqPNPPSSGF 438
Cdd:cd23984   79 HDLrwlldllmgkKVSAKGFWKKPALNL--------IYKPNQ-IRILNPFILriaaYELLHFPKRFPKEKK-PKHPTTGI 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272345 439 IGILIMMSMCREVHV--YEYIPSVRQTELcHYHELYYDAACTLGAYHPLLYEKLLVQRL 495
Cdd:cd23984  149 IAITLALHICNEVHIagFKYDFSNLNSTL-HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 294-454 1.10e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 87.99  E-value: 1.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPSHHFIDSslyKDVILVA 369
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQQS---RDTKYVI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 370 WDPapySANLNLWYKKPDYNLFtpyIQHRQRNPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILIMMSM 447
Cdd:cd23977   79 WGP---ERNMDRDGGGKTYRAL---LTLAKMYPHLQVYTLTEEKMAYCDGVFQNETgKNRMKSGSfLSTGWFTMILALEL 152


                 ....*..
gi 215272345 448 CREVHVY 454
Cdd:cd23977  153 CEEILVY 159
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 290-470 1.13e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 89.24  E-value: 1.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 290 PRGLRSCAVVmSAGAILNSS-LGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI--INSQILTNPSHHFIDSSL-YKDV 365
Cdd:cd23964   79 RPRCIRCAVV-GNGGILNGSgKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTffPESLHNSLLKHVPQDKDTkYLFI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 366 ILVAWDpAPYSANLNLWYKKPDYNLFTPYiQHRQRNP---NQPFYILHPKFI------WQlwdiiqeNTKeKIqpNPPSS 436
Cdd:cd23964  158 PFKIRD-YDYLDAVLSGKPVPDGCDKGKR-PPPLFGPklnATNVRLLHPDFIrylfnrWL-------NSS-TS--YRPTT 225

                        170       180       190
                 ....*....|....*....|....*....|....
gi 215272345 437 GFIGILIMMSMCREVHVYEYIPSVRQTElcHYHE 470
Cdd:cd23964  226 GALMLLTALHTCDQVSVYGFGYDPRFSL--HYYD 257
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 295-494 3.67e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 86.45  E-value: 3.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 295 SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN----SQILTNPsHHFIdsSLYKDVILVAW 370
Cdd:cd23978    3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRP-QEFL--NRTPETTLIFW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 371 DPApysanlNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPP--SSGFIGILIMMSMC 448
Cdd:cd23978   80 GPP------NKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELC 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272345 449 REVHVYEYIP----SVRQTEL---CHYHELYYDAACTL---------GAYHPLLYEKLLVQR 494
Cdd:cd23978  154 DNVHVYGMVPpnycSKRPTPKkmpYHYYEPKGPDECVTyiqnehgrrGNHHRFITEKRVFAR 215
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 279-511 7.64e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 86.70  E-value: 7.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 279 LVPAVplSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFID 358
Cdd:cd23969   52 LLPEV--SPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 359 SSLYK----------DVILvaWDPAPYSANLNlwykkpDYNLFTPYIQHRQrnpNQPFYILHP-----KFIWQLWdiiqe 423
Cdd:cd23969  130 ATDKEkfverlrqlgDSIL--WIPAFVSKGGE------EHVQWTNEIILKH---KLNVKTAYPplrlnHAIRGYW----- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 424 nTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIP---SVRQTELcHYHelYYD--AACTLGAYH--PLLYEKLLVqrln 496
Cdd:cd23969  194 -LTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPfseDGNGRAV-KYH--YYDnrKYLTTARPHkmPEEFRALRS---- 265

                        250
                 ....*....|....*
gi 215272345 497 mgtqgdLHRKGKVVL 511
Cdd:cd23969  266 ------LHQRGALRL 274
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 296-457 3.10e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 83.83  E-value: 3.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 296 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPSHHFIDSSlykDVILVAWD 371
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKETN---ETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 372 PApysANLNLWYKKPDYNLFTpyiQHRQRNPNQPFYILHPKFIWQLWDIIQENT-KEKIQPNP-PSSGFIGILIMMSMCR 449
Cdd:cd23975   81 PF---RNMRKDGKGIVYNMLK---KAVESYPQAKIYVTTEKRMSYCDTVFKKETgKDRVQSGSyLSTGWFTLILAMDACY 154


                 ....*...
gi 215272345 450 EVHVYEYI 457
Cdd:cd23975  155 GIHVYGMI 162
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 293-474 7.72e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 83.46  E-value: 7.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 293 LRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTrGYEKDVGNKTTIRIINSQILTNPSH-------HFIDS-SLYKD 364
Cdd:cd23971   64 LKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANPSILREKFHnlkkrrrPFVERmKVYGN 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 365 VILvaWDPA-PYSANlnlwyKKPDYNLFtpYIQHRQRNPNQPFYiLHPKFIWQL---WdiiqentKEK-IQPNPPSSGFI 439
Cdd:cd23971  143 ALL--LLPAfSYTSN-----TEPSLRAL--YTLEDFGSPQKVLF-FNPEYLRNLsryW-------KSKgLKARRLSTGLM 205

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 215272345 440 GILIMMSMCREVHVYEYIP-SVR-QTELCHYHelYYD 474
Cdd:cd23971  206 LVSAALELCENVHLYGFWPfSTDlDGNPISHH--YYD 240
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 275-511 1.52e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 82.83  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 275 GWRRLVPAV-PLSQLHprgLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQIL---- 349
Cdd:cd23970   52 NLRSLLPEVsPFQNKH---YNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILekyy 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 350 ------TNPSHHFIDSSLYKDVILvaWDPA---PYSAnlnlwykkPDYNLFTPYIQHRQRNPNQ----PFYILhpKFIWQ 416
Cdd:cd23970  129 nnlltiQDRNNFFLSLKKLDGAIL--WIPAfffHTSA--------TVTRTLVDFFVEHRGQLKVqlawPGNIM--QHVNR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 417 LWdiiqenTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIP---SVRQTELcHYHelYYDAACTLGAY-----HPLLYE 488
Cdd:cd23970  197 YW------KTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPfgfDPTGTPL-PYH--YYDKKGTKFTTkwqesHQLPAE 267

                        250       260
                 ....*....|....*....|...
gi 215272345 489 KLLVQRlnmgtqgdLHRKGKVVL 511
Cdd:cd23970  268 FVLLYK--------MHGAGVLKL 282
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 294-489 7.59e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 80.30  E-value: 7.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN----SQILTNpSHHFIDSSlyKDVILVA 369
Cdd:cd23976   16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAhssiQRILRN-RNELLNVS--QGTVFIF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 370 WDPAPYsanlnlwYKKPDYNLFTPYIQ-HRQRNPNQPFYILHPKFIWQLWDIIQENTKE--KIQPNPPSSGFIGILIMMS 446
Cdd:cd23976   93 WGPSNY-------MRRDGKGLVYNNLQlMNQILPKLKVYTITRHKMLQFDELFKRETGKdrKISNTWLSTGWFTMIIALE 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272345 447 MCREVHVYEYIPSvrqtELC----------HYHELYYDAACTL---------GAYHPLLYEK 489
Cdd:cd23976  166 LCDRINVYGMVPP----DFCrdpnhpsvpyHYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 290-344 1.03e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 80.40  E-value: 1.03e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272345 290 PRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRII 344
Cdd:cd23966   74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM 128
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 294-495 4.75e-16

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 77.09  E-value: 4.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVIL----VA 369
Cdd:cd23983    3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFksvdFA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 370 W-------DPAPYSANLNLWYKKPDYNLFTPYiQHRQRNP----NQPFYILH---PKFIWQLWDiiqentkekiqPNPPS 435
Cdd:cd23983   83 WlkamvkkEPLSFWSRLFFWKEVADSIPLKPS-QFRILNPliikETALDILQypePQSRLWGWD-----------KNVPT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272345 436 SGFIGILIMMSMCREVHV--YEYIPSVRQTELcHYHELYYDAACTLGAYHPLLYEKLLVQRL 495
Cdd:cd23983  151 LGVTAVVLATHLCDEVSLagFGYDLSQPHAPL-HYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 294-495 1.36e-15

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 75.73  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYkdvILVAWDPA 373
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLF---VLAGFKWQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 374 PYSANLNLWYKKPDYNLFTPYIQHRQRNPNQP--FYILHPKFIWQ-LWDIIQENTKEKI--QPNPPSSGFIGILIMMSMC 448
Cdd:cd23981   80 DFKWLKYIVYKEKVSASDGFWKSVATRVPREPheIRILNPYFIQEaAFSFIGLPFNNGLmgRGNIPTLGSVAITMALHNC 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 215272345 449 REVHV--YEYIPSVRQTELcHYHELYYDAACTLGAYHPLLYEKLLVQRL 495
Cdd:cd23981  160 DEVAVagFGYDMNTPNAPL-HYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 284-456 2.58e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 76.46  E-value: 2.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 284 PLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpsHHFIDSSLYK 363
Cdd:cd23980   72 PLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-------------HHFVYPESFR 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 364 DV------ILVawdpaPYSANLNLWYKKPdynLFTPYIQH-------RQRNPNQPFYILHPKFIWQLWDIIQENtkekiQ 430
Cdd:cd23980  139 ELaqnvsmILV-----PFKTLDLEWVISA---TTTGTISHtyvpvprKIKVKKEKILIYHPAFIKYVFDRWLQG-----H 205

                        170       180
                 ....*....|....*....|....*.
gi 215272345 431 PNPPSSGFIGILIMMSMCREVHVYEY 456
Cdd:cd23980  206 GRYPSTGILSVIFSLHVCDEVDLYGF 231
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 296-511 9.77e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 75.17  E-value: 9.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 296 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNpshhfiDSSLYKDvilVAWDPAPY 375
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMN------SLRAYAG---VGFNGPPQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 376 SAN---LNLWYKKPDYNLFTPYIQH------RQRNPNQPFY-----------ILHPKFIWQ-----LWDIIQENTKEKIQ 430
Cdd:cd23974  158 SKEtryIFLPDHDRDYLLVKAALTHtpidrgRDKSKRPSKYfgkdvtaekfkIYHPDFIRYlrnrfLWSPILNTKQRDIY 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 431 pnPPSSGFIGILIMMSMCREVHVYEYIPSVRQTelchYHELYYDAactlgAYHPLLYEKLLVQRLNMGTQGDLHRKGKVV 510
Cdd:cd23974  238 --RPSTGAVMLLAALHTCDQVSAYGFMTPDYGK----YSDHYYDK-----TYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306


                 .
gi 215272345 511 L 511
Cdd:cd23974  307 L 307
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 296-474 3.90e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 69.78  E-value: 3.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 296 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQI-------LTNPSHHFI-DSSLYKDVI 366
Cdd:cd23991   67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIisikyakLNERRKPFLeTVSVYGDAF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 367 LVAwdPA-PYSANLNLWYKkpdynlfTPYIQHRQRNPNQPFYiLHPKF---IWQLWdiiqentKEK-IQPNPPSSGFIGI 441
Cdd:cd23991  147 LLL--PAfSYRSNTALSFK-------VYYTLEDFKAKQKVIF-FHPIYlkhLAQFW-------RSKgVQVYRLSTGLMIT 209

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 215272345 442 LIMMSMCREVHVYEYIPSVRQTE---LCHYhelYYD 474
Cdd:cd23991  210 SAALELCEEVKLYGFWPFSKNTEgkpISHH---YYD 242
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 279-474 1.14e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.01  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 279 LVPAVPLSQL----HPRGLR--SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNP 352
Cdd:cd23973   63 LIPKPKEQQLlalsPPGGDGciRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSS 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 353 -----SHHFIDSSLYKDV--ILVAWDPAPYS--ANLNLWYKKPDYNLFTPYIQHR---QRNPNQpFYILHPKFIWQLWD- 419
Cdd:cd23973  143 lmilqKRGFKNIPQDKDIkyILFPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYfsgDFTEDK-YLVLHPDFLRYVKNr 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272345 420 IIQENTKEKI--QPNPPSSGFIGILIMMSMCREVHVYEYIpsvrqTE-LCHYHELYYD 474
Cdd:cd23973  222 FLRSKTLKGKywAIYRPTTGAFLLLTALHLCDTVSAYGFI-----TEdYRKYPDHYYD 274
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 278-475 6.26e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.12  E-value: 6.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 278 RLVPAVplSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFI 357
Cdd:cd23987   51 ELLPRT--SPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 358 DSSlYKDVIL---------VAWDPAPYSAN-------LNLWYKKPDYNLFTPYIQHRqrnpnqpfyILHPkfIWQLWdii 421
Cdd:cd23987  129 NET-WKEKFLqrlqslngsILWIPAFMAKGgeervewVNDLILKHHINVRTAYPSLR---------LLHA--VRGYW--- 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272345 422 qenTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVR--QTELCHYHelYYDA 475
Cdd:cd23987  194 ---LTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRdqNQNPVKYH--YYDS 244
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 279-511 4.51e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 63.82  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 279 LVPAVplSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFID 358
Cdd:cd23988   52 LLPEV--SPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 359 SSLYKDVI--------LVAWDPA-------PYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHpkfiwqlwdiiqe 423
Cdd:cd23988  130 ESDREKFVhrlsmlndSVLWIPAfmvkggeKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTN------------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 424 ntkeKIQPNPPSSGFIGILIMMSMCREVHVYEYIP-----SVRQTELCHYHELYYDAACTLGAYH-PLLYEKLLVqrlnm 497
Cdd:cd23988  197 ----KVNIKRPSTGLLMYTLATRFCDEIHLYGFWPfpkdaNGNPVKYHYYDDLKYRYFSNAGPHRmPLEFKTLNV----- 267

                        250
                 ....*....|....
gi 215272345 498 gtqgdLHRKGKVVL 511
Cdd:cd23988  268 -----LHNRGALKL 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 284-357 1.65e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 61.81  E-value: 1.65e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272345 284 PLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpsHHFI 357
Cdd:cd23979   71 PYRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT-------------HHFM 131
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 294-504 4.35e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 60.62  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 294 RSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPSHH-------FIDS-SLYKD 364
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKlekwrrpFYEVlQVYEN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 365 VILVAwdPAPYSAnlnlwyKKPDYNLFTPYIQHRQRNPnQPFYILHPKFiwqLWDIIQENTKEKIQPNPPSSGFIGILIM 444
Cdd:cd23990  145 ASVVL--PAFYNT------RNTDVSIRVKYVLDDFESQ-QAVYYFHPQY---LLNVSRFWLRQGVRAKRISSGLMLVTAA 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 445 MSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEklLVQRLNMGTQGDLH 504
Cdd:cd23990  213 LELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPRPGFHAMPSE--IFNFLHMHSRGILR 270
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 290-496 3.94e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 57.91  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 290 PRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKT-----TIRIINSQILTNPSHHFIDSSLYKD 364
Cdd:cd23972   79 PGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTRTPQGQD 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 365 V--ILVAWDPAPY----SANLNL----WYKKPDYnlftpyiQHRQRNPN---QPFYILHPKFIWQLWDIIQENTKEKIQP 431
Cdd:cd23972  159 LqyIFIPSDIRDYvmlrSAILGVpvpeGLDKGDR-------PHKYFGPEasaKKFKLLHPDFISYLTDRFLKSKLLNTHY 231

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272345 432 NP---PSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHE------LYYdaactlgAYHPLLYEKLLVQRLN 496
Cdd:cd23972  232 GHlymPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYErkkkplVFY-------ANHDMLLEAALWRRLH 298
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 290-490 5.45e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 54.07  E-value: 5.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 290 PRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPSHH-------FIDS-S 360
Cdd:cd23989   60 QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSIIDKRFQNllwsrksFVESmK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272345 361 LYKDVILvaWDPApYSANLNLwykKPDynlFTPYIQHRQRNPNQPFYILHPKFIWQlwdiIQENTKEK-IQPNPPSSGFI 439
Cdd:cd23989  140 VYGRSYI--YMPA-FSMKTGT---DPS---LRVYYTLADVGANQTVLFANPNFLRN----VGKFWKSKgVHAKRLSTGLF 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272345 440 GILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKL 490
Cdd:cd23989  207 LVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAMPEEFL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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