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Conserved domains on  [gi|209862915|ref|NP_001129527|]
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CD82 antigen [Mus musculus]

Protein Classification

tetraspanin family protein( domain architecture ID 13626516)

tetraspanin family protein similar to CD37 antigen (also known as tetraspanin-26), a transmembrane (TM) protein with four TM segments which may act as a molecular facilitator in diverse processes such as in the immune system, fusion, adhesion, migration to apoptosis, and alterations of cell morphology

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 106-228 2.38e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


:

Pssm-ID: 239413  Cd Length: 117  Bit Score: 161.01  E-value: 2.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 106 FYFNADKLKKEMGNTVMDIIRNYTANAT-SSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTYPCSCEKIKEEDN 184
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPEnKTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 209862915 185 QLIVKKGFCEADNSTvsennpeDWPVNTEGCMEKAQAWLQENFG 228
Cdd:cd03160   81 SPRPSKGFCEAPASL-------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
24-253 1.04e-30

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 112.80  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915   24 GAVILGFGVWILADKNSFISVLQTSSSSLqvgAYVFIGVGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVG 103
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYI---PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915  104 VLFYFNADKLKKEMGNTVMDIIRNYTANATSSR---EEAWDYVQAQVKCCGwvshynwteneelmgftkttypcscekik 180
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYsclNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 209862915  181 eednqlivkkgfceadnstvsennpedwpvnteGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCR 253
Cdd:pfam00335 144 ---------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 106-228 2.38e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 161.01  E-value: 2.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 106 FYFNADKLKKEMGNTVMDIIRNYTANAT-SSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTYPCSCEKIKEEDN 184
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPEnKTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 209862915 185 QLIVKKGFCEADNSTvsennpeDWPVNTEGCMEKAQAWLQENFG 228
Cdd:cd03160   81 SPRPSKGFCEAPASL-------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
24-253 1.04e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 112.80  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915   24 GAVILGFGVWILADKNSFISVLQTSSSSLqvgAYVFIGVGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVG 103
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYI---PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915  104 VLFYFNADKLKKEMGNTVMDIIRNYTANATSSR---EEAWDYVQAQVKCCGwvshynwteneelmgftkttypcscekik 180
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYsclNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 209862915  181 eednqlivkkgfceadnstvsennpedwpvnteGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCR 253
Cdd:pfam00335 144 ---------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 106-228 2.38e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 161.01  E-value: 2.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 106 FYFNADKLKKEMGNTVMDIIRNYTANAT-SSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTYPCSCEKIKEEDN 184
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPEnKTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 209862915 185 QLIVKKGFCEADNSTvsennpeDWPVNTEGCMEKAQAWLQENFG 228
Cdd:cd03160   81 SPRPSKGFCEAPASL-------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
24-253 1.04e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 112.80  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915   24 GAVILGFGVWILADKNSFISVLQTSSSSLqvgAYVFIGVGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVG 103
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYI---PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915  104 VLFYFNADKLKKEMGNTVMDIIRNYTANATSSR---EEAWDYVQAQVKCCGwvshynwteneelmgftkttypcscekik 180
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYsclNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 209862915  181 eednqlivkkgfceadnstvsennpedwpvnteGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCR 253
Cdd:pfam00335 144 ---------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 107-226 1.62e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 61.75  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 107 YFNADKLKKEMGNTVMDIIRNYTANATSSreEAWDYVQAQVKCCGWVSHYNWTENEelmgftkTTYPCSCEKIKEEDNQL 186
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQ--EAMDALQSTFECCGVNGPTDYLDLR-------LLVPSSCCKGTDGNCGL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 209862915 187 ivkkgfceadnstvsennpedwPVNTEGCMEKAQAWLQEN 226
Cdd:cd03127   72 ----------------------NLYTEGCLEKLVDFLRSN 89
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 111-226 1.14e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 48.90  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 111 DKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTENeelmgFTKTTYPCSCekikeednqlivkk 190
Cdd:cd03165    5 EKVDLTAKDDLKEGLELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDWYEV-----LGENRVPDSC-------------- 65

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 209862915 191 gfCEADNSTVSENNPEDWpvNTEGCMEKAQAWLQEN 226
Cdd:cd03165   66 --CQEDSQDCGRNPTELW--WKTGCYEKVQQWLVDN 97
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 107-226 1.43e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 42.85  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 107 YFNADKLKKEMGNTVMDIIRNYTANATSSreEAWDYVQAQVKCCGWVSHYNWtenEELMGFTKTTYPCSCEKIkeednql 186
Cdd:cd03166    1 YVFRDKVMSEFNDSFNQMISNYNKTNDFR--KILDRMQKDLKCCGANNYTDW---ENIPSLDTDSVPDSCCIN------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 209862915 187 iVKKGFCEADNSTVsennpedwpVNTEGCMEKAQAWLQEN 226
Cdd:cd03166   69 -VTKGCGINFDEKV---------IHLEGCVTKIEGWLKKN 98
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 107-227 5.19e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 41.56  E-value: 5.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 107 YFNADKLKKEMGNTVMD-IIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTY--PCSCEKIkeed 183
Cdd:cd03155    1 YTYYQQLEDELKESLKRtMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRlvPDSCCKT---- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 209862915 184 nqlIVKKGFCEADNStvseNNPedWPVnTEGCMEKAQAWLQENF 227
Cdd:cd03155   77 ---VVDRCGCLRDHP----SNI--YKV-EGGCIPKLEDFLYDHL 110
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 107-225 1.74e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 40.10  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862915 107 YFNADKLKKEMgNTVMDIIRNYTaNATSSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTYPCSCekikeednql 186
Cdd:cd03163    2 YVYRAKVEDEL-NPSIDKVFNKY-NGTNAESRAVDYLQRQLQCCGIHNYTDWENTPWFKESKNNSVPLSC---------- 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 209862915 187 ivkkgfCEAD--NSTVSENNPEDwpVNTEGCMEKAQAWLQE 225
Cdd:cd03163   70 ------CKETftSCTGSLTQPKD--LYQEGCEAKLVKKLQE 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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