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Conserved domains on  [gi|226371768|ref|NP_001122060|]
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urea transporter 1 isoform 1 [Homo sapiens]

Protein Classification

urea transporter( domain architecture ID 10505473)

urea transporter is an integral membrane protein that facilitates the rapid and passive diffusion of urea down its concentration gradient

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
115-410 2.75e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


:

Pssm-ID: 460863  Cd Length: 292  Bit Score: 367.64  E-value: 2.75e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  115 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 194
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  195 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 274
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  275 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 354
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226371768  355 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 410
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
115-410 2.75e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 367.64  E-value: 2.75e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  115 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 194
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  195 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 274
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  275 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 354
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226371768  355 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 410
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
111-408 1.03e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 235.92  E-value: 1.03e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 111 VLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMA 190
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 191 VFSDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISW 270
Cdd:COG4413   83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 271 SDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLAC 350
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226371768 351 IAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 408
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
113-406 2.72e-47

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 164.41  E-value: 2.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  113 QFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVF 192
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  193 SDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNiSWSD 272
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPV-AFGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  273 LSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIA 352
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226371768  353 MGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFL 406
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFL 291
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
115-410 2.75e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 367.64  E-value: 2.75e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  115 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 194
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  195 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 274
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  275 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 354
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226371768  355 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 410
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
111-408 1.03e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 235.92  E-value: 1.03e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 111 VLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMA 190
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 191 VFSDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISW 270
Cdd:COG4413   83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 271 SDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLAC 350
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226371768 351 IAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 408
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
113-406 2.72e-47

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 164.41  E-value: 2.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  113 QFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVF 192
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  193 SDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNiSWSD 272
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPV-AFGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  273 LSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIA 352
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226371768  353 MGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFL 406
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFL 291
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
109-239 1.54e-22

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 97.25  E-value: 1.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 109 PVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGvl 188
Cdd:COG4413  162 LTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA-- 239
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 226371768 189 MAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMA 239
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLA 290
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
274-420 1.61e-20

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 91.47  E-value: 1.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768 274 SALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAM 353
Cdd:COG4413    2 PLLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLAL 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226371768 354 gGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPL 420
Cdd:COG4413   82 -GFFFGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPL 147
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
90-244 8.88e-13

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 68.50  E-value: 8.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768   90 ALGYVTGDMKELANQLK----DKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALL 165
Cdd:TIGR03441 135 AFKGLHTDAPVLPHDIEpvafGGPARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAIL 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  166 LSQDRSLIASGLYGYNATL----VGVLMAVFSDKGdyfwwLLLPVCAMSMTCpIFSSALNSMLSKWDLPVFTLPFNMALS 241
Cdd:TIGR03441 215 LGADLDSINQGLFGFNPVLtaiaLGVVFLRPSIRS-----AAYAVLGVVLTV-FVQGALDTLLTPLGLPTLTFPFVLVTW 288

                  ...
gi 226371768  242 MYL 244
Cdd:TIGR03441 289 LFL 291
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
277-408 9.32e-11

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 62.34  E-value: 9.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371768  277 ELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGgM 356
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALP-L 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 226371768  357 FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 408
Cdd:TIGR03441  81 FLAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTWIFLLA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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