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Conserved domains on  [gi|187828910|ref|NP_001120695|]
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CD59 glycoprotein preproprotein [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 26-95 1.18e-29

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467084  Cd Length: 70  Bit Score: 102.02  E-value: 1.18e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910  26 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 95
Cdd:cd23554    1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 26-95 1.18e-29

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 102.02  E-value: 1.18e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910  26 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 95
Cdd:cd23554    1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 26-97 2.80e-13

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 60.63  E-value: 2.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910    26 LQCYNCP-NPTADCKTAVNCSSDFDACLITKA-------GLQVYNKCWKFEHCNFNDVT-TRLRENELTYYCCKKDLCNF 96
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEECRSPDDVCLTVVAevisdsrGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCNA 80


                   .
gi 187828910    97 N 97
Cdd:smart00134  81 A 81
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 28-95 5.23e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 33.67  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910   28 CYNC-PNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKF-------EHCN------FNDVTTRLREneltyYCCKKDL 93
Cdd:pfam00021   1 CYSClGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVvskgcarSSCPrllsdfINGGIISVSE-----SCCQSDL 75


                  ..
gi 187828910   94 CN 95
Cdd:pfam00021  76 CN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 26-95 1.18e-29

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 102.02  E-value: 1.18e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910  26 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 95
Cdd:cd23554    1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 26-97 2.80e-13

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 60.63  E-value: 2.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910    26 LQCYNCP-NPTADCKTAVNCSSDFDACLITKA-------GLQVYNKCWKFEHCNFNDVT-TRLRENELTYYCCKKDLCNF 96
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEECRSPDDVCLTVVAevisdsrGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCNA 80


                   .
gi 187828910    97 N 97
Cdd:smart00134  81 A 81
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 21-95 1.17e-03

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 35.47  E-value: 1.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187828910  21 HSGHSLQCYNCpNPTADCKTAVNCSSDFDACLITKA----GLQVYNKCwkFEHCNFNDVTTRLRENELTYYCCKKDLCN 95
Cdd:cd23542    1 GPANALQCHVC-NSSSNCTNPVNCEGSERYCKTTTVvqpsGNLVKKGC--AETCPPSTSRQQVGSGISSVTCCQGDLCN 76
TFP_LU_ECD_SLURP1_like cd23560
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ...
 26-61 5.18e-03

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467090  Cd Length: 78  Bit Score: 33.57  E-value: 5.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 187828910  26 LQCYNCPNPT--ADCKTAVNCSSDFDACLITKAGLQVY 61
Cdd:cd23560    1 LRCYTCPEPTdsSLCTTIVNCSPNETACKTTLYSVDSG 38
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 28-95 5.23e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 33.67  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910   28 CYNC-PNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKF-------EHCN------FNDVTTRLREneltyYCCKKDL 93
Cdd:pfam00021   1 CYSClGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVvskgcarSSCPrllsdfINGGIISVSE-----SCCQSDL 75


                  ..
gi 187828910   94 CN 95
Cdd:pfam00021  76 CN 77
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 25-97 8.96e-03

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 33.19  E-value: 8.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187828910  25 SLQCYNCPNPT--ADCKTAVNCSSDFDAC---LITKAG-LQVYNK-CWKFEHCNFNDVTTRLRenelTYYCCKKDLCNFN 97
Cdd:cd23573    2 SLQCYTCKAQLsnSNCQTETPCRENAKACktdVIRAVGlLKVISKeCSSSCTEDYQDYFVGKR----NITCCSTDLCNVN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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