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Conserved domains on  [gi|156523239|ref|NP_001096030|]
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phospholipid phosphatase 5 isoform 3 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 43-155 1.26e-35

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03390:

Pssm-ID: 469784 [Multi-domain]  Cd Length: 193  Bit Score: 122.71  E-value: 1.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 156523239 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSC 155
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSF 119
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-155 1.26e-35

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 122.71  E-value: 1.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 156523239 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSC 155
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSF 119
PLN02250 PLN02250
lipid phosphate phosphatase
 25-154 6.40e-26

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 100.77  E-value: 6.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  25 LVTELLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFT 104
Cdd:PLN02250  37 VVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVIT 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 156523239 105 NTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSS 154
Cdd:PLN02250 115 DAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTS 169
acidPPc smart00014
Acid phosphatase homologues;
103-162 3.50e-09

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.96  E-value: 3.50e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239   103 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSCMNIIWTL 162
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALF 61
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-154 1.22e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 42.79  E-value: 1.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 156523239  101 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSS 154
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSA 54
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-154 1.13e-03

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 38.10  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  18 LALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLAL 97
Cdd:COG0671    3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 156523239  98 ALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSS 154
Cdd:COG0671   83 LLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAA 125
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-155 1.26e-35

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 122.71  E-value: 1.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  43 WLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 122
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 156523239 123 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSC 155
Cdd:cd03390   81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSF 119
PLN02250 PLN02250
lipid phosphate phosphatase
 25-154 6.40e-26

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 100.77  E-value: 6.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  25 LVTELLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFT 104
Cdd:PLN02250  37 VVLNVIEPFHRFVGKDMLTDLSYP-LQDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVIT 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 156523239 105 NTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSS 154
Cdd:PLN02250 115 DAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTS 169
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 29-154 7.41e-21

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 87.39  E-value: 7.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  29 LLPPFQRLIQPEEMWLYRNPyVEAEYFPTKPMFVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIK 108
Cdd:PLN02731  60 IIHPFYRFVGKDMMTDLSYP-LKSNTVPIWSVPVYAMLLPL-VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIK 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 156523239 109 LIVGRPRPDFFYRCFPDGLA----HSDLMCTGDKDVVNEGRKSFPSGHSS 154
Cdd:PLN02731 138 NAVGRPRPDFFWRCFPDGKAlydsLGDVICHGDKSVIREGHKSFPSGHTS 187
PLN02715 PLN02715
lipid phosphate phosphatase
 29-154 1.26e-17

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 78.56  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  29 LLPPFQRLIQPEEMWLYRNPYVEaEYFPTKPMFVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIK 108
Cdd:PLN02715  66 LISPFYRYVGKDMMTDLKYPFKD-NTVPIWSVPVYAVLLPI-ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIK 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 156523239 109 LIVGRPRPDFFYRCFPDGLAHSD----LMCTGDKDVVNEGRKSFPSGHSS 154
Cdd:PLN02715 144 VATGRPRPNFYWRCFPDGKELYDalggVICHGKAAEVKEGHKSFPSGHTS 193
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 102-154 1.27e-12

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 61.88  E-value: 1.27e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156523239 102 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSS 154
Cdd:cd03384   18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHAS 80
acidPPc smart00014
Acid phosphatase homologues;
103-162 3.50e-09

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.96  E-value: 3.50e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239   103 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSCMNIIWTL 162
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALF 61
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-156 3.78e-08

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 49.38  E-value: 3.78e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 156523239 100 NGVFTNTIKLIVGRPRPDFFYRCFPDglahsdlmctGDKDVVNEGRKSFPSGHSSCM 156
Cdd:cd01610   15 GLLLTGVLKYLFGRPRPYFLLRCGPD----------GDPLLLTEGGYSFPSGHAAFA 61
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-154 1.22e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 42.79  E-value: 1.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 156523239  101 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSS 154
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSA 54
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 18-154 1.13e-03

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 38.10  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523239  18 LALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLAL 97
Cdd:COG0671    3 LALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 156523239  98 ALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSS 154
Cdd:COG0671   83 LLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAA 125
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 101-162 2.57e-03

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 36.82  E-value: 2.57e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156523239 101 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSCMNIIWTL 162
Cdd:cd03392   75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGF 117
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 101-153 5.24e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 36.14  E-value: 5.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 156523239 101 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHS 153
Cdd:cd03389   82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHS 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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