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Conserved domains on  [gi|156231075|ref|NP_001095900|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Mus musculus]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1763 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1015.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   15 ALEKILADKEVKKahHSQLRKACEVALEEIKVETEKQSPP--HGEAKAGSGTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMErerhrqqqhllqspvshhe 240
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  241 pesphlrylPPQTVD---HINQEHEGDLEPQTHDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDILydgD 317
Cdd:PLN03076  234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLL---D 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  318 YEEKplDIVQSIVEEMvniivgdmgeGMAISAsTEGNTGTVEDGSDSEniqangipgtpisvaytpslpDDRLSVSSNDT 397
Cdd:PLN03076  298 STDK--DMLDAKYWEI----------SMYKSA-LEGRKGELADGEVEK---------------------DDDLEVQIGNK 343

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  398 qesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFIN 476
Cdd:PLN03076  344 ------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLG 403

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  477 AIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICAD 555
Cdd:PLN03076  404 AIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVD 483

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  556 AQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQ 634
Cdd:PLN03076  484 SQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPA 563

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  635 TTlgqEKPSEQEIS-EVKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRG 713
Cdd:PLN03076  564 SL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKG 634

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  714 IQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQK 793
Cdd:PLN03076  635 IEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQK 714

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  794 IDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNE 873
Cdd:PLN03076  715 IDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYER 792

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  874 IAGKKISMKEtkELTIPTKstKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATH 938
Cdd:PLN03076  793 ISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATD 868

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  939 LEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQK 1018
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQK 945

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1019 NIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-- 1073
Cdd:PLN03076  946 NIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlq 1025

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1074 ---EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMD 1150
Cdd:PLN03076 1026 yaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSME 1100

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1151 ELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQ 1230
Cdd:PLN03076 1101 ELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQ 1180

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1231 KDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHF 1310
Cdd:PLN03076 1181 NEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYF 1256

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1311 PATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMSVAPEDRVWVRG-------- 1378
Cdd:PLN03076 1257 PYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeft 1336

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1379 --------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQ 1440
Cdd:PLN03076 1337 dkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEG 1416

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1441 QTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKF 1512
Cdd:PLN03076 1417 QGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLF 1495

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1513 TLEIWDKTCNCTLDIFKTTIPHAlltwrptsgeaeppsPSAVSEKPLDAISQKSVDI-HDSIQPRSSDNRQQAPLVSVST 1591
Cdd:PLN03076 1496 SDEKWLEVVLSLKEAANATLPDF---------------SYVVSGEYMPAENIQDSENaEAASSSTADNDAEAERSRRLYA 1560

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1592 VseeVSKVKSTAkfpeqklfaallikcVVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-F 1670
Cdd:PLN03076 1561 A---ISDAKCRA---------------AVQLLLIQAVMEIY---------------------------------NMYRpR 1589

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1671 LTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQ 1749
Cdd:PLN03076 1590 LSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVES 1669

                        1850
                  ....*....|....
gi 156231075 1750 RLLNVCREALSYFL 1763
Cdd:PLN03076 1670 RLVELCEEVLQFYI 1683
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1763 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1015.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   15 ALEKILADKEVKKahHSQLRKACEVALEEIKVETEKQSPP--HGEAKAGSGTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMErerhrqqqhllqspvshhe 240
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  241 pesphlrylPPQTVD---HINQEHEGDLEPQTHDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDILydgD 317
Cdd:PLN03076  234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLL---D 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  318 YEEKplDIVQSIVEEMvniivgdmgeGMAISAsTEGNTGTVEDGSDSEniqangipgtpisvaytpslpDDRLSVSSNDT 397
Cdd:PLN03076  298 STDK--DMLDAKYWEI----------SMYKSA-LEGRKGELADGEVEK---------------------DDDLEVQIGNK 343

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  398 qesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFIN 476
Cdd:PLN03076  344 ------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLG 403

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  477 AIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICAD 555
Cdd:PLN03076  404 AIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVD 483

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  556 AQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQ 634
Cdd:PLN03076  484 SQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPA 563

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  635 TTlgqEKPSEQEIS-EVKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRG 713
Cdd:PLN03076  564 SL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKG 634

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  714 IQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQK 793
Cdd:PLN03076  635 IEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQK 714

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  794 IDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNE 873
Cdd:PLN03076  715 IDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYER 792

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  874 IAGKKISMKEtkELTIPTKstKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATH 938
Cdd:PLN03076  793 ISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATD 868

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  939 LEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQK 1018
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQK 945

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1019 NIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-- 1073
Cdd:PLN03076  946 NIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlq 1025

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1074 ---EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMD 1150
Cdd:PLN03076 1026 yaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSME 1100

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1151 ELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQ 1230
Cdd:PLN03076 1101 ELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQ 1180

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1231 KDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHF 1310
Cdd:PLN03076 1181 NEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYF 1256

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1311 PATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMSVAPEDRVWVRG-------- 1378
Cdd:PLN03076 1257 PYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeft 1336

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1379 --------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQ 1440
Cdd:PLN03076 1337 dkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEG 1416

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1441 QTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKF 1512
Cdd:PLN03076 1417 QGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLF 1495

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1513 TLEIWDKTCNCTLDIFKTTIPHAlltwrptsgeaeppsPSAVSEKPLDAISQKSVDI-HDSIQPRSSDNRQQAPLVSVST 1591
Cdd:PLN03076 1496 SDEKWLEVVLSLKEAANATLPDF---------------SYVVSGEYMPAENIQDSENaEAASSSTADNDAEAERSRRLYA 1560

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1592 VseeVSKVKSTAkfpeqklfaallikcVVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-F 1670
Cdd:PLN03076 1561 A---ISDAKCRA---------------AVQLLLIQAVMEIY---------------------------------NMYRpR 1589

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1671 LTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQ 1749
Cdd:PLN03076 1590 LSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVES 1669

                        1850
                  ....*....|....
gi 156231075 1750 RLLNVCREALSYFL 1763
Cdd:PLN03076 1670 RLVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 695-879 3.45e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.10  E-value: 3.45e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   695 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 774
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   775 VSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 854
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 156231075   855 GINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 695-879 7.20e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 292.59  E-value: 7.20e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  695 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 773
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  774 FVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 853
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 156231075  854 RGINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 692-879 1.14e-84

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 274.94  E-value: 1.14e-84
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075    692 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 770
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075    771 GKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 850
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 156231075    851 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1763 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1015.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   15 ALEKILADKEVKKahHSQLRKACEVALEEIKVETEKQSPP--HGEAKAGSGTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMErerhrqqqhllqspvshhe 240
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  241 pesphlrylPPQTVD---HINQEHEGDLEPQTHDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDILydgD 317
Cdd:PLN03076  234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLL---D 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  318 YEEKplDIVQSIVEEMvniivgdmgeGMAISAsTEGNTGTVEDGSDSEniqangipgtpisvaytpslpDDRLSVSSNDT 397
Cdd:PLN03076  298 STDK--DMLDAKYWEI----------SMYKSA-LEGRKGELADGEVEK---------------------DDDLEVQIGNK 343

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  398 qesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFIN 476
Cdd:PLN03076  344 ------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLG 403

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  477 AIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICAD 555
Cdd:PLN03076  404 AIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVD 483

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  556 AQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQ 634
Cdd:PLN03076  484 SQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPA 563

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  635 TTlgqEKPSEQEIS-EVKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRG 713
Cdd:PLN03076  564 SL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKG 634

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  714 IQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQK 793
Cdd:PLN03076  635 IEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQK 714

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  794 IDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNE 873
Cdd:PLN03076  715 IDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYER 792

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  874 IAGKKISMKEtkELTIPTKstKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATH 938
Cdd:PLN03076  793 ISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATD 868

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  939 LEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQK 1018
Cdd:PLN03076  869 VVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQK 945

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1019 NIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-- 1073
Cdd:PLN03076  946 NIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlq 1025

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1074 ---EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMD 1150
Cdd:PLN03076 1026 yaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSME 1100

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1151 ELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQ 1230
Cdd:PLN03076 1101 ELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQ 1180

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1231 KDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHF 1310
Cdd:PLN03076 1181 NEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYF 1256

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1311 PATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMSVAPEDRVWVRG-------- 1378
Cdd:PLN03076 1257 PYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeft 1336

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1379 --------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQ 1440
Cdd:PLN03076 1337 dkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEG 1416

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1441 QTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKF 1512
Cdd:PLN03076 1417 QGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLF 1495

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1513 TLEIWDKTCNCTLDIFKTTIPHAlltwrptsgeaeppsPSAVSEKPLDAISQKSVDI-HDSIQPRSSDNRQQAPLVSVST 1591
Cdd:PLN03076 1496 SDEKWLEVVLSLKEAANATLPDF---------------SYVVSGEYMPAENIQDSENaEAASSSTADNDAEAERSRRLYA 1560

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1592 VseeVSKVKSTAkfpeqklfaallikcVVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-F 1670
Cdd:PLN03076 1561 A---ISDAKCRA---------------AVQLLLIQAVMEIY---------------------------------NMYRpR 1589

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075 1671 LTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQ 1749
Cdd:PLN03076 1590 LSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVES 1669

                        1850
                  ....*....|....
gi 156231075 1750 RLLNVCREALSYFL 1763
Cdd:PLN03076 1670 RLVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 695-879 3.45e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.10  E-value: 3.45e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   695 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 774
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   775 VSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 854
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 156231075   855 GINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 695-879 7.20e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 292.59  E-value: 7.20e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  695 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 773
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  774 FVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 853
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 156231075  854 RGINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 692-879 1.14e-84

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 274.94  E-value: 1.14e-84
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075    692 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 770
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075    771 GKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 850
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 156231075    851 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 879
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1619-1825 2.17e-59

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 202.08  E-value: 2.17e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  1619 VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNE 1698
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  1699 QRTALWKAGFkGKSKPNLLKQETSSLACGLRILFRMYMDES-RVSAWEEVQQRLLNVCREALSYFLTL-TSESHRE--AW 1774
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEpRTSQREEVEERLIPLCEDILEYYLSLdEEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 156231075  1775 TNLLLLFLTKVLKISDSRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFL 1825
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 416-571 8.48e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 179.61  E-value: 8.48e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   416 LQKDAFLVFRSLCKLS-MKPLSDgpPDPKSHELRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSV 494
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156231075   495 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILEtSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLN 571
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 29-209 8.92e-50

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 174.37  E-value: 8.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075    29 HHSQLRKACEVALEEIKVETEKQSPP-HGEAKAGSGTLPPVKSK----TNFIEA-DKYFLPFELACQSKCPRIVSTSLDC 102
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKYPPvKEASEKGILRLRTVHSSsplmQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075   103 LQKLIAYGHLTGRApdsttpgkklIDRIIETICGCFQGPQTdegVQLQIIKALLTAVTSQHIeIHEGTVLQAVRTCYNIY 182
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 156231075   183 LaSKNLINQTTAKATLTQMLNVIFARM 209
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1217-1298 1.90e-39

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 141.47  E-value: 1.90e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231075  1217 KFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQ 1296
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 156231075  1297 TT 1298
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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