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Concise Results
Standard Results
Full Results
nardilysin isoform b precursor [Homo sapiens]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 713.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 102 E I V KSP S DP K QYR Y I K L Q NGL QA LL I SD lsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025 34 T I I KSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 182 hdddldtedneleeleeraeark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP DENGFDA F LK KHGG 261
Cdd:COG1025 62 ----------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP EPGEYQE F IS KHGG 117
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 262 S D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KEMLFGSLAR P G HP MG 341
Cdd:COG1025 118 S H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IYQVHKETLN P A HP FS 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 342 K F FW GN A ETL K hep R K NNIDTHAR L RE F WM RYYS SHY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG L PR P nfghltd P FD 421
Cdd:COG1025 198 R F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYS ANL M K LV LY S NQS LD E LEK LARQT F GA IPN RN L SV P ------- P IT 267
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 422 T P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SF L R K KCW A LA L FG G N G ET G fe 496
Cdd:COG1025 268 V P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL A ES L SA G G G IS G -- 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 497 qn STYSV FSIS IT LTD E G YE H FY E VAYT VF Q Y LKMLQKL G PEKRI F E E IRKIEDNE F HY QE Q T D P VE YV ENMCE NM QL YP 576
Cdd:COG1025 346 -- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P MD YV SWLSD NM LR YP 423
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 577 LQ D I L TG D Q L LFEYK P EV I GEA L N QL V P QK A NLV L L S GANEG kc D LKEK W FG T Q YS IED I ENSWAEL W N s NFEL NP D L H L 656
Cdd:COG1025 424 VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLAK W Q - QASQ NP A L S L 500
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 657 P AE N K YI AT DF T L KAF D c P E TEY P VKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V VL FDIFVNI L THN L 736
Cdd:COG1025 501 P EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q VL TRLLDYL L NDA L 579
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 737 A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y LA E F NS T PAV F TMITE QL KKTYF N ilikp ETL AK DV 816
Cdd:COG1025 580 N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q LA S F EP T EER F AQAKS QL LRQLD N ----- AEK AK PY 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 817 RL L ILEYA R WSMIDKYQ ----- A LMDGLS L ES L LS F VKEFKS QL FV E G LV Q GN VTSTESMDFLKYVVDK L nf K P LEQEMP 891
Cdd:COG1025 655 SQ L FSPLS R LLQPPYFE reell A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSLKKQ L -- A P NGTGEE 732
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 892 VQF QVV E L PSGHH L CKV KA LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT LGY H V --- Y PTCRN 968
Cdd:COG1025 733 PRR QVV D L DKSGS L NLE KA CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ LGY V V gag Y MPLGR 810
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 969 TS G I l GF S V tvgt Q ATKYNSEVVDKK I EE FL SS FEE KIEN L T EE A F NTQVTA LI K - L K E c E D TH L G EE VD R N W NEVVTQQ 1047
Cdd:COG1025 811 QP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S EE E F AQYKQG LI N q L L E - P D QN L S EE AQ R L W VDIGNGD 884
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 156071452 1048 YL FD RLAHE I E A L K SFSKS DL VNW F KAH - RG P GSKM L SVHVV G 1089
Cdd:COG1025 885 FE FD TREKL I A A V K KLTRA DL IDF F QQA v IA P QGLR L LSQSQ G 927
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 713.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 102 E I V KSP S DP K QYR Y I K L Q NGL QA LL I SD lsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025 34 T I I KSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 182 hdddldtedneleeleeraeark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP DENGFDA F LK KHGG 261
Cdd:COG1025 62 ----------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP EPGEYQE F IS KHGG 117
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 262 S D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KEMLFGSLAR P G HP MG 341
Cdd:COG1025 118 S H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IYQVHKETLN P A HP FS 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 342 K F FW GN A ETL K hep R K NNIDTHAR L RE F WM RYYS SHY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG L PR P nfghltd P FD 421
Cdd:COG1025 198 R F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYS ANL M K LV LY S NQS LD E LEK LARQT F GA IPN RN L SV P ------- P IT 267
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 422 T P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SF L R K KCW A LA L FG G N G ET G fe 496
Cdd:COG1025 268 V P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL A ES L SA G G G IS G -- 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 497 qn STYSV FSIS IT LTD E G YE H FY E VAYT VF Q Y LKMLQKL G PEKRI F E E IRKIEDNE F HY QE Q T D P VE YV ENMCE NM QL YP 576
Cdd:COG1025 346 -- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P MD YV SWLSD NM LR YP 423
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 577 LQ D I L TG D Q L LFEYK P EV I GEA L N QL V P QK A NLV L L S GANEG kc D LKEK W FG T Q YS IED I ENSWAEL W N s NFEL NP D L H L 656
Cdd:COG1025 424 VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLAK W Q - QASQ NP A L S L 500
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 657 P AE N K YI AT DF T L KAF D c P E TEY P VKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V VL FDIFVNI L THN L 736
Cdd:COG1025 501 P EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q VL TRLLDYL L NDA L 579
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 737 A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y LA E F NS T PAV F TMITE QL KKTYF N ilikp ETL AK DV 816
Cdd:COG1025 580 N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q LA S F EP T EER F AQAKS QL LRQLD N ----- AEK AK PY 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 817 RL L ILEYA R WSMIDKYQ ----- A LMDGLS L ES L LS F VKEFKS QL FV E G LV Q GN VTSTESMDFLKYVVDK L nf K P LEQEMP 891
Cdd:COG1025 655 SQ L FSPLS R LLQPPYFE reell A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSLKKQ L -- A P NGTGEE 732
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 892 VQF QVV E L PSGHH L CKV KA LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT LGY H V --- Y PTCRN 968
Cdd:COG1025 733 PRR QVV D L DKSGS L NLE KA CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ LGY V V gag Y MPLGR 810
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 969 TS G I l GF S V tvgt Q ATKYNSEVVDKK I EE FL SS FEE KIEN L T EE A F NTQVTA LI K - L K E c E D TH L G EE VD R N W NEVVTQQ 1047
Cdd:COG1025 811 QP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S EE E F AQYKQG LI N q L L E - P D QN L S EE AQ R L W VDIGNGD 884
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 156071452 1048 YL FD RLAHE I E A L K SFSKS DL VNW F KAH - RG P GSKM L SVHVV G 1089
Cdd:COG1025 885 FE FD TREKL I A A V K KLTRA DL IDF F QQA v IA P QGLR L LSQSQ G 927
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
553-834
4.36e-122
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 376.91
E-value: 4.36e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 553 F HY QE QTD P VE YV ENMCE NMQ L YP LQ DIL T GD Q LL F EY K PE V I G E A L NQ L V P QK A NLV L L S GAN EG KC D L KE K W F GT Q YS 632
Cdd:pfam16187 1 F RF QE KSP P SD YV SSLAS NMQ P YP PE DIL S GD Y LL R EY D PE L I Q E L L DY L T P EN A RIT L V S KEF EG ET D Q KE P W Y GT E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 633 I E D I ENSWAEL W NSNF E L NP D LHLP AE N KY I A TDF T LK AFDCP E - TE YPV K I VN TP QGC LWYKKD NK F KI PKA Y I RFH L I 711
Cdd:pfam16187 81 V E P I PEELLKK W KNAP E P NP E LHLP EP N PF I P TDF D LK KKEVK E p AK YPV L I RD TP LSR LWYKKD DT F WV PKA N I YLS L R 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 712 SPL IQK S AA N V VL FDIF V NI L THN L A E P AY E A DV A Q L E Y K L V A G E H GL IIR V K G F N H KLP L L FQL I IDY L AE F NST P AV F 791
Cdd:pfam16187 161 SPL AYS S PR N A VL TRLY V EL L KDS L N E Y AY D A EL A G L S Y S L S A T E R GL TLS V S G Y N D KLP V L LEK I LEK L RD F EID P DR F 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 156071452 792 TM I T EQL KKT Y F N - I L IK P ETL A K D VR L LI LE YAR W SMID K YQ A 834
Cdd:pfam16187 241 EI I K EQL LRS Y K N f A L EQ P YQQ A F D YL L YL LE ERS W TPEE K LE A 284
PRK15101
PRK15101 protease3; Provisional
103-1073
8.62e-107
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 358.14
E-value: 8.62e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 103 I V KS PS DP K QY RY I K L Q NG LQA LL I SD lsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefddeh 182
Cdd:PRK15101 34 I R KS EK DP R QY QA I R L D NG MTV LL V SD ----------------------------------------------------- 60
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 183 dddldtedneleeleeraear KKTT ek Q S A AAL CVG VGS FA DPD DLP GLAH F LEHMV F MGS L KYP DENGFDA FLKKHGGS 262
Cdd:PRK15101 61 --------------------- PQAV -- K S L AAL ALP VGS LE DPD AQQ GLAH Y LEHMV L MGS K KYP QPDSLAE FLKKHGGS 117
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 263 D NAST DCE RT V F QFD V QRKYFKE A L DR W A QFFIH PL MIRDAI DRE VE AV DS E YQL AR PS D AN R KEMLFGSLAR P G HP MGK 342
Cdd:PRK15101 118 H NAST ASY RT A F YLE V ENDALPP A V DR L A DAIAE PL LDPKNA DRE RN AV NA E LTM AR SR D GM R MAQVSAETIN P A HP GSR 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 343 F FW GN A ETL KHE P rkn NIDTHAR L RE F WM RYYS SHY M TL V VQ S KET L DT L E K WVTEI F SQI PN NGLPR P N fgh L T D P FD T 422
Cdd:PRK15101 198 F SG GN L ETL SDK P --- GSKLQDA L VD F YQ RYYS ANL M KA V IY S NQP L PE L A K LAADT F GRV PN KNASV P E --- I T V P VV T 271
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 423 P A f N K -- LYRV VP IRKIHA L TITWALPPQQQHY R V K PLH YIS W L V G HEGK G SILSF L R K KCW A LALFG G n GETGFEQ NS t 500
Cdd:PRK15101 272 D A - Q K gi IIHY VP AQPRKV L RVEFRIDNNSAKF R S K TDE YIS Y L I G NRSP G TLSDW L Q K QGL A EGISA G - ADPMVDR NS - 348
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 501 y S VF S IS IT LTD E G YEHFYE V AYTV F Q YL KM L QKL G PE K RI F E E IRKIE D NE F H Y QEQ T DPVE Y V E NMCEN M QLY P LQDI 580
Cdd:PRK15101 349 - G VF A IS VS LTD K G LAQRDQ V VAAI F S YL NL L REK G ID K SY F D E LAHVL D LD F R Y PSI T RDMD Y I E WLADT M LRV P VEHT 427
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 581 L TGDQLLFE Y K P EV I GEA L NQLV PQ K A NLVLL S ga NEGKCDLKEKWFGTQ Y SIED I ENSWAEL W N s NFEL N PD L H LP AE N 660
Cdd:PRK15101 428 L DAPYIADR Y D P KA I KAR L AEMT PQ N A RIWYI S -- PQEPHNKTAYFVDAP Y QVDK I SEQTFAD W Q - QKAQ N IA L S LP EL N 504
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 661 K YI AT DF T L KAF D c PETEY P VK IV NT P QGCLW Y KKDNK F - KI PKA Y I RFH L IS P LIQK SA A N V VLF --- D IFVNI lth N L 736
Cdd:PRK15101 505 P YI PD DF S L IKA D - KAYKH P EL IV DE P GLRVV Y MPSQY F a DE PKA D I SLV L RN P KAMD SA R N Q VLF aln D YLAGL --- A L 580
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 737 AEPAYE A D V AQLEYKLV A GE h GL IIRVK G FNHK LP L L F Q LIIDYLAE F NS T PAVF tmit E Q L K KT Y FNI L IKP E T l A K DV 816
Cdd:PRK15101 581 DQLSNQ A S V GGISFSTN A NN - GL MVNAN G YTQR LP Q L L Q ALLEGYFS F TP T EEQL ---- A Q A K SW Y REQ L DSA E K - G K AY 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 817 RLL I LEYARW S MI ----- D KYQA L MDGLS L ESL L SFVKEFK S QLFV E G LV Q GN V T STESMDFLKY V VDK L NFK ------- 884
Cdd:PRK15101 655 EQA I MPAQML S QV pyfer D ERRK L LPSIT L KDV L AYRDALL S GATP E F LV V GN L T EEQVTTLARD V QKQ L GAD gtewwrg 734
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 885 --- PLEQEMP V Q F Q vvelpsghhlckv KA LNKG D - A NSE V T V --- Y -- YQS GTR S lreytlme L L VMHMEE P C F - DF LRT 954
Cdd:PRK15101 735 kdv VVDKKQS V N F E ------------- KA GSST D s A LAA V Y V ptg Y de YQS SAY S -------- S L LGQIIQ P W F y NQ LRT 793
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 955 KQT LGY H V YPT cr NT S ----- G I l GF SVTVGTQATK Y nsev VDKKIEE F LSSF E E K IENLTE E A F NTQVT ALI - K L KECE 1028
Cdd:PRK15101 794 EEQ LGY A V FAF -- PM S vgrqw G M - GF LLQSNDKQPA Y ---- LWQRYQA F FPQA E A K LRAMKP E E F AQYQQ ALI n Q L LQAP 866
970 980 990 1000
....*....|....*....|....*....|....*....|....*
gi 156071452 1029 D T h LGEE VD R NWNEVVTQQYL FD RLAHE I EAL K SFSKSD L VNW F K 1073
Cdd:PRK15101 867 Q T - LGEE AS R LSKDFDRGNMR FD SRDKI I AQI K LLTPQK L ADF F H 910
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
209-411
5.22e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 134.23
E-value: 5.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 209 K QS AA A L C V GV GS FAD P DDL PGLAHFLEH MV F M G SLKYPDENGFDAFLKKH GG SD NA S T DCER T V F Q F DVQRKYFKEA L D 288
Cdd:TIGR02110 20 K RA AA L L R V AA GS HDE P SAW PGLAHFLEH LL F L G GERFQGDDRLMPWVQRQ GG QV NA T T LERT T A F F F ELPAAALAAG L A 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 289 R WAQFFIH PL MIRDAID RE V E AVDS EY QLARPSDANRK E MLFGSLARP GHP MGK F FW G NAET L K hepr KN N IDTHAR LR E 368
Cdd:TIGR02110 100 R LCDMLAR PL LTAEDQQ RE R E VLEA EY IAWQNDADTLR E AALLDALQA GHP LRR F HA G SRDS L A ---- LP N TAFQQA LR D 175
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 156071452 369 F WM R Y Y SSHY M T L VV Q SKET LD T LE KWVTEIFSQIPNN G LPRP 411
Cdd:TIGR02110 176 F HR R H Y QAGN M Q L WL Q GPQS LD E LE QLAARFGASLAAG G ECAQ 218
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 713.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 102 E I V KSP S DP K QYR Y I K L Q NGL QA LL I SD lsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025 34 T I I KSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 182 hdddldtedneleeleeraeark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP DENGFDA F LK KHGG 261
Cdd:COG1025 62 ----------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP EPGEYQE F IS KHGG 117
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 262 S D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KEMLFGSLAR P G HP MG 341
Cdd:COG1025 118 S H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IYQVHKETLN P A HP FS 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 342 K F FW GN A ETL K hep R K NNIDTHAR L RE F WM RYYS SHY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG L PR P nfghltd P FD 421
Cdd:COG1025 198 R F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYS ANL M K LV LY S NQS LD E LEK LARQT F GA IPN RN L SV P ------- P IT 267
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 422 T P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SF L R K KCW A LA L FG G N G ET G fe 496
Cdd:COG1025 268 V P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL A ES L SA G G G IS G -- 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 497 qn STYSV FSIS IT LTD E G YE H FY E VAYT VF Q Y LKMLQKL G PEKRI F E E IRKIEDNE F HY QE Q T D P VE YV ENMCE NM QL YP 576
Cdd:COG1025 346 -- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P MD YV SWLSD NM LR YP 423
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 577 LQ D I L TG D Q L LFEYK P EV I GEA L N QL V P QK A NLV L L S GANEG kc D LKEK W FG T Q YS IED I ENSWAEL W N s NFEL NP D L H L 656
Cdd:COG1025 424 VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLAK W Q - QASQ NP A L S L 500
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 657 P AE N K YI AT DF T L KAF D c P E TEY P VKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V VL FDIFVNI L THN L 736
Cdd:COG1025 501 P EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q VL TRLLDYL L NDA L 579
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 737 A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y LA E F NS T PAV F TMITE QL KKTYF N ilikp ETL AK DV 816
Cdd:COG1025 580 N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q LA S F EP T EER F AQAKS QL LRQLD N ----- AEK AK PY 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 817 RL L ILEYA R WSMIDKYQ ----- A LMDGLS L ES L LS F VKEFKS QL FV E G LV Q GN VTSTESMDFLKYVVDK L nf K P LEQEMP 891
Cdd:COG1025 655 SQ L FSPLS R LLQPPYFE reell A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSLKKQ L -- A P NGTGEE 732
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 892 VQF QVV E L PSGHH L CKV KA LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT LGY H V --- Y PTCRN 968
Cdd:COG1025 733 PRR QVV D L DKSGS L NLE KA CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ LGY V V gag Y MPLGR 810
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 969 TS G I l GF S V tvgt Q ATKYNSEVVDKK I EE FL SS FEE KIEN L T EE A F NTQVTA LI K - L K E c E D TH L G EE VD R N W NEVVTQQ 1047
Cdd:COG1025 811 QP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S EE E F AQYKQG LI N q L L E - P D QN L S EE AQ R L W VDIGNGD 884
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 156071452 1048 YL FD RLAHE I E A L K SFSKS DL VNW F KAH - RG P GSKM L SVHVV G 1089
Cdd:COG1025 885 FE FD TREKL I A A V K KLTRA DL IDF F QQA v IA P QGLR L LSQSQ G 927
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
553-834
4.36e-122
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 376.91
E-value: 4.36e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 553 F HY QE QTD P VE YV ENMCE NMQ L YP LQ DIL T GD Q LL F EY K PE V I G E A L NQ L V P QK A NLV L L S GAN EG KC D L KE K W F GT Q YS 632
Cdd:pfam16187 1 F RF QE KSP P SD YV SSLAS NMQ P YP PE DIL S GD Y LL R EY D PE L I Q E L L DY L T P EN A RIT L V S KEF EG ET D Q KE P W Y GT E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 633 I E D I ENSWAEL W NSNF E L NP D LHLP AE N KY I A TDF T LK AFDCP E - TE YPV K I VN TP QGC LWYKKD NK F KI PKA Y I RFH L I 711
Cdd:pfam16187 81 V E P I PEELLKK W KNAP E P NP E LHLP EP N PF I P TDF D LK KKEVK E p AK YPV L I RD TP LSR LWYKKD DT F WV PKA N I YLS L R 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 712 SPL IQK S AA N V VL FDIF V NI L THN L A E P AY E A DV A Q L E Y K L V A G E H GL IIR V K G F N H KLP L L FQL I IDY L AE F NST P AV F 791
Cdd:pfam16187 161 SPL AYS S PR N A VL TRLY V EL L KDS L N E Y AY D A EL A G L S Y S L S A T E R GL TLS V S G Y N D KLP V L LEK I LEK L RD F EID P DR F 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 156071452 792 TM I T EQL KKT Y F N - I L IK P ETL A K D VR L LI LE YAR W SMID K YQ A 834
Cdd:pfam16187 241 EI I K EQL LRS Y K N f A L EQ P YQQ A F D YL L YL LE ERS W TPEE K LE A 284
PRK15101
PRK15101 protease3; Provisional
103-1073
8.62e-107
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 358.14
E-value: 8.62e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 103 I V KS PS DP K QY RY I K L Q NG LQA LL I SD lsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefddeh 182
Cdd:PRK15101 34 I R KS EK DP R QY QA I R L D NG MTV LL V SD ----------------------------------------------------- 60
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 183 dddldtedneleeleeraear KKTT ek Q S A AAL CVG VGS FA DPD DLP GLAH F LEHMV F MGS L KYP DENGFDA FLKKHGGS 262
Cdd:PRK15101 61 --------------------- PQAV -- K S L AAL ALP VGS LE DPD AQQ GLAH Y LEHMV L MGS K KYP QPDSLAE FLKKHGGS 117
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 263 D NAST DCE RT V F QFD V QRKYFKE A L DR W A QFFIH PL MIRDAI DRE VE AV DS E YQL AR PS D AN R KEMLFGSLAR P G HP MGK 342
Cdd:PRK15101 118 H NAST ASY RT A F YLE V ENDALPP A V DR L A DAIAE PL LDPKNA DRE RN AV NA E LTM AR SR D GM R MAQVSAETIN P A HP GSR 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 343 F FW GN A ETL KHE P rkn NIDTHAR L RE F WM RYYS SHY M TL V VQ S KET L DT L E K WVTEI F SQI PN NGLPR P N fgh L T D P FD T 422
Cdd:PRK15101 198 F SG GN L ETL SDK P --- GSKLQDA L VD F YQ RYYS ANL M KA V IY S NQP L PE L A K LAADT F GRV PN KNASV P E --- I T V P VV T 271
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 423 P A f N K -- LYRV VP IRKIHA L TITWALPPQQQHY R V K PLH YIS W L V G HEGK G SILSF L R K KCW A LALFG G n GETGFEQ NS t 500
Cdd:PRK15101 272 D A - Q K gi IIHY VP AQPRKV L RVEFRIDNNSAKF R S K TDE YIS Y L I G NRSP G TLSDW L Q K QGL A EGISA G - ADPMVDR NS - 348
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 501 y S VF S IS IT LTD E G YEHFYE V AYTV F Q YL KM L QKL G PE K RI F E E IRKIE D NE F H Y QEQ T DPVE Y V E NMCEN M QLY P LQDI 580
Cdd:PRK15101 349 - G VF A IS VS LTD K G LAQRDQ V VAAI F S YL NL L REK G ID K SY F D E LAHVL D LD F R Y PSI T RDMD Y I E WLADT M LRV P VEHT 427
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 581 L TGDQLLFE Y K P EV I GEA L NQLV PQ K A NLVLL S ga NEGKCDLKEKWFGTQ Y SIED I ENSWAEL W N s NFEL N PD L H LP AE N 660
Cdd:PRK15101 428 L DAPYIADR Y D P KA I KAR L AEMT PQ N A RIWYI S -- PQEPHNKTAYFVDAP Y QVDK I SEQTFAD W Q - QKAQ N IA L S LP EL N 504
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 661 K YI AT DF T L KAF D c PETEY P VK IV NT P QGCLW Y KKDNK F - KI PKA Y I RFH L IS P LIQK SA A N V VLF --- D IFVNI lth N L 736
Cdd:PRK15101 505 P YI PD DF S L IKA D - KAYKH P EL IV DE P GLRVV Y MPSQY F a DE PKA D I SLV L RN P KAMD SA R N Q VLF aln D YLAGL --- A L 580
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 737 AEPAYE A D V AQLEYKLV A GE h GL IIRVK G FNHK LP L L F Q LIIDYLAE F NS T PAVF tmit E Q L K KT Y FNI L IKP E T l A K DV 816
Cdd:PRK15101 581 DQLSNQ A S V GGISFSTN A NN - GL MVNAN G YTQR LP Q L L Q ALLEGYFS F TP T EEQL ---- A Q A K SW Y REQ L DSA E K - G K AY 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 817 RLL I LEYARW S MI ----- D KYQA L MDGLS L ESL L SFVKEFK S QLFV E G LV Q GN V T STESMDFLKY V VDK L NFK ------- 884
Cdd:PRK15101 655 EQA I MPAQML S QV pyfer D ERRK L LPSIT L KDV L AYRDALL S GATP E F LV V GN L T EEQVTTLARD V QKQ L GAD gtewwrg 734
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 885 --- PLEQEMP V Q F Q vvelpsghhlckv KA LNKG D - A NSE V T V --- Y -- YQS GTR S lreytlme L L VMHMEE P C F - DF LRT 954
Cdd:PRK15101 735 kdv VVDKKQS V N F E ------------- KA GSST D s A LAA V Y V ptg Y de YQS SAY S -------- S L LGQIIQ P W F y NQ LRT 793
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 955 KQT LGY H V YPT cr NT S ----- G I l GF SVTVGTQATK Y nsev VDKKIEE F LSSF E E K IENLTE E A F NTQVT ALI - K L KECE 1028
Cdd:PRK15101 794 EEQ LGY A V FAF -- PM S vgrqw G M - GF LLQSNDKQPA Y ---- LWQRYQA F FPQA E A K LRAMKP E E F AQYQQ ALI n Q L LQAP 866
970 980 990 1000
....*....|....*....|....*....|....*....|....*
gi 156071452 1029 D T h LGEE VD R NWNEVVTQQYL FD RLAHE I EAL K SFSKSD L VNW F K 1073
Cdd:PRK15101 867 Q T - LGEE AS R LSKDFDRGNMR FD SRDKI I AQI K LLTPQK L ADF F H 910
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
205-337
1.50e-45
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 160.93
E-value: 1.50e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 205 KTTEKQ S AAA L CVGV GS FAD PD DLP GLAHFLEHM V F M G SL KYP D e N GFDAF L K K H GGS D NA S T DC E R TV FQFD V QRKYFK 284
Cdd:pfam00675 7 DPPADT S TVG L WIDA GS RYE PD NNN GLAHFLEHM A F K G TK KYP S - N ELEEE L E K L GGS L NA F T SR E N TV YYAE V LNDDLP 85
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156071452 285 E A L DR W A Q FF IH PL MIRDA I D R ------- EVEAVDSE Y QL ---- ARPSD A N R KEM L FG SL AR PG 337
Cdd:pfam00675 86 K A V DR L A D FF RN PL FTESE I E R erlvvly EVEAVDSE P QL vvle NLHAA A Y R NTP L GR SL LG PG 149
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
209-411
5.22e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 134.23
E-value: 5.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 209 K QS AA A L C V GV GS FAD P DDL PGLAHFLEH MV F M G SLKYPDENGFDAFLKKH GG SD NA S T DCER T V F Q F DVQRKYFKEA L D 288
Cdd:TIGR02110 20 K RA AA L L R V AA GS HDE P SAW PGLAHFLEH LL F L G GERFQGDDRLMPWVQRQ GG QV NA T T LERT T A F F F ELPAAALAAG L A 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 289 R WAQFFIH PL MIRDAID RE V E AVDS EY QLARPSDANRK E MLFGSLARP GHP MGK F FW G NAET L K hepr KN N IDTHAR LR E 368
Cdd:TIGR02110 100 R LCDMLAR PL LTAEDQQ RE R E VLEA EY IAWQNDADTLR E AALLDALQA GHP LRR F HA G SRDS L A ---- LP N TAFQQA LR D 175
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 156071452 369 F WM R Y Y SSHY M T L VV Q SKET LD T LE KWVTEIFSQIPNN G LPRP 411
Cdd:TIGR02110 176 F HR R H Y QAGN M Q L WL Q GPQS LD E LE QLAARFGASLAAG G ECAQ 218
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
212-553
7.63e-29
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 120.80
E-value: 7.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 212 AAA L C V G VGS FAD P DDLP GLAHFLEHM V F M G SL K YP d ENGFDAF L KKH GGS D NA S T DCER TV FQFD V QRKYFKE AL DRW A 291
Cdd:COG0612 38 SVR L W V R VGS RDE P PGKT GLAHFLEHM L F K G TK K RS - AGEIAEE L EAL GGS L NA F T SFDY TV YYLS V LSEDLEL AL ELL A 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 292 QFFIH P LMIRDAID RE VEA V DS E YQ -- LAR P SDANRKEM L fg SLARPG HP M G KFFW G NA E TLK heprkn N I d T HAR LR E F 369
Cdd:COG0612 117 DRLLN P TFDEEELE RE RGV V LE E IR ry EDD P DGLAFEAL L -- AALYGD HP Y G RPII G TE E SIE ------ A I - T RED LR A F 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 370 WM RYY SSHYMT LVV QSKETLDTLEKW V TEI F SQI P NNGL P RP nfghl T DP FDT P AFNKLYR VV PIRKIHALT I TWAL P - P 448
Cdd:COG0612 188 YK RYY RPNNAV LVV VGDVDPEEVLAL V EKY F GDL P AGPA P PR ----- P DP AEP P QTGPRRV VV DDPDAEQAH I LLGY P g P 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 449 QQQHYRVKP L HYISWLV G H e G KG S I L s F -- LR - KK CW A LALFG gnget G F EQNSTYSV F S I SITLTDEGY E HF yevaytv 525
Cdd:COG0612 263 ARDDPDYYA L DVLNEIL G G - G FS S R L - F qe LR e KK GL A YSVGS ----- S F SPYRDAGL F T I YAGTAPDKL E EA ------- 328
330 340
....*....|....*....|....*...
gi 156071452 526 fqylkmlqklgp EKR I F EE IRKIEDNEF 553
Cdd:COG0612 329 ------------ LAA I L EE LERLAKEGV 344
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
362-548
3.82e-28
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 112.10
E-value: 3.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 362 T HAR LR E F WMRY YS SHY M T LV VQSKETLDT L EKWVTEI F SQI P NN glprp NF G HLTD P FDT PA FN K LYR VV PIR K --- IH 438
Cdd:pfam05193 3 T RED LR D F YKKH YS PDN M V LV IVGDVDHEE L LDLAEKY F GDL P AS ----- PK G KPRP P PLE PA KL K GRE VV VPK K dep QA 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 439 A L TITWAL PP QQQHYRVKP L HYISW L V G HEGKGSILSF LR - K KCW A LALFGG N getgf EQN S TYSV F S I SI T LTD egy E H 517
Cdd:pfam05193 78 H L ALAFPG PP LNNDEDSLA L DVLNE L L G GGMSSRLFQE LR e K EGL A YSVSSF N ----- DSY S DSGL F G I YA T VDP --- E N 149
170 180 190
....*....|....*....|....*....|.
gi 156071452 518 FY EV AYTVFQY L KM L QKL G PEKRIF E EIRKI 548
Cdd:pfam05193 150 VD EV IELILEE L EK L AQE G VTEEEL E RAKNQ 180
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
839-1021
9.38e-14
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 70.88
E-value: 9.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 839 L SL E S L LS F V K EFK S QLFVEGLVQ G N V TST E SM D FLKYVVDK L NFK P leqem PVQFQVVE L PSGHHLCKVKALN K G D AN - 917
Cdd:pfam05193 2 L TR E D L RD F Y K KHY S PDNMVLVIV G D V DHE E LL D LAEKYFGD L PAS P ----- KGKPRPPP L EPAKLKGREVVVP K K D EP q 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452 918 SEVTVYYQS - GTRSLREYTLMEL L VMHMEE ---- PC F DF LR T K QT L G Y H V YPTCRNT S -- G IL G FSV TV gtqatky NS E V 990
Cdd:pfam05193 77 AHLALAFPG p PLNNDEDSLALDV L NELLGG gmss RL F QE LR E K EG L A Y S V SSFNDSY S ds G LF G IYA TV ------- DP E N 149
170 180 190
....*....|....*....|....*....|..
gi 156071452 991 VD KK IE EF L SSF E EKIEN - L TEE AFNTQVTA L 1021
Cdd:pfam05193 150 VD EV IE LI L EEL E KLAQE g V TEE ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
