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Conserved domains on  [gi|155372099|ref|NP_001094658|]
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ankyrin repeat and SOCS box protein 16 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 7.78e-32

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 7.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 108 KAKHTAPLTIVAARGYTNCARYLIRQGAELDARV-GGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVP 186
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 187 ESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpssSRRHQAA 266
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA--------ENGHLEI 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 155372099 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQA 327
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 6.06e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


:

Pssm-ID: 239686  Cd Length: 42  Bit Score: 59.82  E-value: 6.06e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 155372099 406 NQPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 7.78e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 7.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 108 KAKHTAPLTIVAARGYTNCARYLIRQGAELDARV-GGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVP 186
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 187 ESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpssSRRHQAA 266
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA--------ENGHLEI 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 155372099 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQA 327
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
Ank_2 pfam12796
Ankyrin repeats (3 copies);
147-239 1.57e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  147 LHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEagaTVNLAARDSEVTPLHVAAARGLEGHV 226
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 155372099  227 ALYLEHGADVNLR 239
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 147-332 9.01e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 9.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 147 LHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHV 226
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 227 ALYLEHGADVNLRTSQGETALNAACAgaegpsssrrHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG-GLAELLLR 305
Cdd:PHA02874 207 KLLIDHGNHIMNKCKNGFTPLHNAII----------HNRSAIELLINNASINDQDIDGSTPLHHAINPPCDiDIIDILLY 276

                        170       180
                 ....*....|....*....|....*..
gi 155372099 306 HGACAAVPNGAGQTPMDCALQAVQDAP 332
Cdd:PHA02874 277 HKADISIKDNKGENPIDTAFKYINKDP 303
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 6.06e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 59.82  E-value: 6.06e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 155372099 406 NQPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 407-445 2.88e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 2.88e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 155372099  407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLL 445
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 175-250 1.59e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 53.93  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  175 EGTTPLHLCTVPESLQCAKLLLEAGATVNLAA------RDSEVT-------PLHVAAARGLEGHVALYLEHGADVNLRTS 241
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLLERGASVPARAcgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADS 206


                  ....*....
gi 155372099  242 QGETALNAA 250
Cdd:TIGR00870 207 LGNTLLHLL 215
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 122-249 1.05e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 51.03  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 122 GYTNCARYLIRQGAELDARVGgRAALHEAC---ARAQFDCVQLLVTFGAKVNVLSE-----------EGTTPLHLCTVPE 187
Cdd:cd21882    6 GLLECLRWYLTDSAYQRGATG-KTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENR 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155372099 188 SLQCAKLLLEAGATVNLAA-----RDSEVT-------PLHVAAARGLEGHVALYLEHGAD---VNLRTSQGETALNA 249
Cdd:cd21882   85 NLNLVRLLVENGADVSARAtgrffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLHA 161
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 409-447 1.03e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.01  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 155372099   409 RRLQHLARLAMRAQLGSRCreaasCLPLPPLLKDYLLLR 447
Cdd:smart00969   1 RSLQHLCRLAIRRSLGGID-----KLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-327 7.78e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 7.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 108 KAKHTAPLTIVAARGYTNCARYLIRQGAELDARV-GGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVP 186
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 187 ESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpssSRRHQAA 266
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA--------ENGHLEI 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 155372099 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQA 327
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
105-326 8.18e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 8.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 105 LTPKAKHTAPLTIVAARGYTNCARYLIRQGAELDARVGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCT 184
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 185 VPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACAgaegpsssRRHQ 264
Cdd:COG0666   96 RNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA--------NGNL 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 155372099 265 AAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQ 326
Cdd:COG0666  167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-252 1.25e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  99 EQGFWVLTPKAKHTAPLTIVAARGYTNCARYLIRQGAELDAR-VGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGT 177
Cdd:COG0666  108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 155372099 178 TPLHLCTVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACA 252
Cdd:COG0666  188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK-TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
127-350 1.31e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 1.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 127 ARYLIRQGAELDARVGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNLAA 206
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 207 RDSEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACAgaegpsssRRHQAAARRLLEAGADARAAGRKRHT 286
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY--------NGNLEIVKLLLEAGADVNAQDNDGNT 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 155372099 287 PLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQavqdapNWEPEVLfAALLDYGAQP 350
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE------NGHLEIV-KLLLEAGADV 212
Ank_2 pfam12796
Ankyrin repeats (3 copies);
147-239 1.57e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  147 LHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEagaTVNLAARDSEVTPLHVAAARGLEGHV 226
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 155372099  227 ALYLEHGADVNLR 239
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 147-332 9.01e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 9.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 147 LHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHV 226
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 227 ALYLEHGADVNLRTSQGETALNAACAgaegpsssrrHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG-GLAELLLR 305
Cdd:PHA02874 207 KLLIDHGNHIMNKCKNGFTPLHNAII----------HNRSAIELLINNASINDQDIDGSTPLHHAINPPCDiDIIDILLY 276

                        170       180
                 ....*....|....*....|....*..
gi 155372099 306 HGACAAVPNGAGQTPMDCALQAVQDAP 332
Cdd:PHA02874 277 HKADISIKDNKGENPIDTAFKYINKDP 303
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-250 5.78e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 70.68  E-value: 5.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 108 KAKHT--APLTIVAARGYTNCARYLIRQGAELDA-RVGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCT 184
Cdd:PHA02878 163 KDRHKgnTALHYATENKDQRLTELLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155372099 185 VP-ESLQCAKLLLEAGATVNLAARDSEVTPLHVAAARglEGHVALYLEHGADVNLRTSQGETALNAA 250
Cdd:PHA02878 243 GYcKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
115-204 1.41e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  115 LTIVAARGYTNCARYLIRQGAELDARVG-GRAALHEACARAQFDCVQLLVTFgAKVNVlSEEGTTPLHLCTVPESLQCAK 193
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEH-ADVNL-KDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 155372099  194 LLLEAGATVNL 204
Cdd:pfam12796  79 LLLEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 406-447 6.06e-12

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 59.82  E-value: 6.06e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 155372099 406 NQPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 407-447 6.22e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.79  E-value: 6.22e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 155372099 407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 130-349 1.08e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.01  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 130 LIRQGAELDAR-VGGRAALHeACARAQFDC--VQLLVTFGAKVNVLSEEGTTPLH-LCTVPESLQCAKLLLEAGATVNla 205
Cdd:PHA02876 293 LLERGADVNAKnIKGETPLY-LMAKNGYDTenIRTLIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGANVN-- 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 206 ARD-SEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACAGAEgPSSSrrhqaaARRLLEAGADARAAGRKR 284
Cdd:PHA02876 370 ARDyCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTN-PYMS------VKTLIDRGANVNSKNKDL 442

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 155372099 285 HTPLHNACANGCG-GLAELLLRHGACAAVPNGAGQTPMDCALqavqdapnwEPEVLFAALLDYGAQ 349
Cdd:PHA02876 443 STPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIAL---------EYHGIVNILLHYGAE 499
Ank_2 pfam12796
Ankyrin repeats (3 copies);
214-308 1.73e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  214 LHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpssSRRHQAAARRLLEagADARAAGRKRHTPLHNACA 293
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA--------KNGHLEIVKLLLE--HADVNLKDNGRTALHYAAR 70

                          90
                  ....*....|....*
gi 155372099  294 NGCGGLAELLLRHGA 308
Cdd:pfam12796  71 SGHLEIVKLLLEKGA 85
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-452 4.33e-11

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 57.84  E-value: 4.33e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 155372099 406 NQPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLRVEGRI 452
Cdd:cd03723    1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVL 47
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 407-445 2.88e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 2.88e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 155372099  407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLL 445
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 128-291 1.25e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 128 RYLIRQGAELDA--RVGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNla 205
Cdd:PHA02878 151 KLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD-- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 206 ARDS-EVTPLHVAAARGLEGHV-ALYLEHGADVNLRTS-QGETALNaacagaegpsSSRRHQAAARRLLEAGADARAAGR 282
Cdd:PHA02878 229 ARDKcGNTPLHISVGYCKDYDIlKLLLEHGVDVNAKSYiLGLTALH----------SSIKSERKLKLLLEYGADINSLNS 298


                 ....*....
gi 155372099 283 KRHTPLHNA 291
Cdd:PHA02878 299 YKLTPLSSA 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 149-253 1.53e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.57  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 149 EACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLC---TVPESLQCAKLLLEAGATVNLAARdSEVTPLHVAAARG-LEG 224
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYlhySSEKVKDIVRLLLEAGADVNAPER-CGFTPLHLYLYNAtTLD 98

                         90       100
                 ....*....|....*....|....*....
gi 155372099 225 HVALYLEHGADVNLRTSQGETALNAACAG 253
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTPLHVYLSG 127
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-171 2.46e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 2.46e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 155372099  114 PLTIVAARGYTNCARYLIRQgAELDARVGGRAALHEACARAQFDCVQLLVTFGAKVNV 171
Cdd:pfam12796  33 ALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 127-349 3.04e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 3.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 127 ARYLIRQGAELDAR-VGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHlCTVP------------------- 186
Cdd:PHA02876 161 AEMLLEGGADVNAKdIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLE-CAVDsknidtikaiidnrsnink 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 187 -----------ESLQCAKLLLEAGATVNlAARDSEVTPLHVAA-ARGLEGHVALYLEHGADVNLRTSQGETALNAACAGA 254
Cdd:PHA02876 240 ndlsllkairnEDLETSLLLYDAGFSVN-SIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 255 EGPSSsrrhqaaARRLLEAGADARAAGRKRHTPLHNACA-NGCGGLAELLLRHGACAAVPNGAGQTPMDCAlqAVQDAPn 333
Cdd:PHA02876 319 YDTEN-------IRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYA--AVRNNV- 388

                        250
                 ....*....|....*.
gi 155372099 334 wepeVLFAALLDYGAQ 349
Cdd:PHA02876 389 ----VIINTLLDYGAD 400
PHA03095 PHA03095
ankyrin-like protein; Provisional
 128-305 1.02e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 128 RYLIRQGAELDARVG-GRAALHeACAR---AQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTV-----PESLqcaKLLLEA 198
Cdd:PHA03095 101 KLLIKAGADVNAKDKvGRTPLH-VYLSgfnINPKVIRLLLRKGADVNALDLYGMTPLAVLLKsrnanVELL---RLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 199 GATV---------------------------------NLAARD-SEVTPLHVAAARGL--EGHVALYLEHGADVNLRTSQ 242
Cdd:PHA03095 177 GADVyavddrfrsllhhhlqsfkprarivreliragcDPAATDmLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRY 256

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 155372099 243 GETALNAAcagaegpsSSRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLR 305
Cdd:PHA03095 257 GQTPLHYA--------AVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 175-250 1.59e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 53.93  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099  175 EGTTPLHLCTVPESLQCAKLLLEAGATVNLAA------RDSEVT-------PLHVAAARGLEGHVALYLEHGADVNLRTS 241
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLLERGASVPARAcgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADS 206


                  ....*....
gi 155372099  242 QGETALNAA 250
Cdd:TIGR00870 207 LGNTLLHLL 215
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 122-249 1.05e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 51.03  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 122 GYTNCARYLIRQGAELDARVGgRAALHEAC---ARAQFDCVQLLVTFGAKVNVLSE-----------EGTTPLHLCTVPE 187
Cdd:cd21882    6 GLLECLRWYLTDSAYQRGATG-KTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENR 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155372099 188 SLQCAKLLLEAGATVNLAA-----RDSEVT-------PLHVAAARGLEGHVALYLEHGAD---VNLRTSQGETALNA 249
Cdd:cd21882   85 NLNLVRLLVENGADVSARAtgrffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLHA 161
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 110-237 1.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 110 KHTAPLTIVAAR--GYTNCARYLIRQGAELDA-RVGGRAALHEA--CARAQFDCVQLLVTFGAKVNV-------LS---- 173
Cdd:PHA03100 105 NGITPLLYAISKksNSYSIVEYLLDNGANVNIkNSDGENLLHLYleSNKIDLKILKLLIDKGVDINAknrvnylLSygvp 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 155372099 174 -----EEGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDsEVTPLHVAAARGLEGHVALYLEHGADVN 237
Cdd:PHA03100 185 inikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKY-GDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 159-308 4.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.89  E-value: 4.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 159 VQLLVTFGAKVNVLSEEGTTPLHLC--TVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAaargLEGH------VALYL 230
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGE-NLLHLY----LESNkidlkiLKLLI 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 231 EHGADVNLRTS----------------QGETALNAACagaegpssSRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN 294
Cdd:PHA03100 164 DKGVDINAKNRvnyllsygvpinikdvYGFTPLHYAV--------YNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235

                        170
                 ....*....|....
gi 155372099 295 GCGGLAELLLRHGA 308
Cdd:PHA03100 236 NNKEIFKLLLNNGP 249
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 144-350 6.84e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 6.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 144 RAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLE 223
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE-SELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 224 GHVALYLEHGADVN-LRTSQGETALNAAcagaegpsSSRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
Cdd:PHA02875  82 KAVEELLDLGKFADdVFYKDGMTPLHLA--------TILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIEL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 155372099 303 LLRHGACAAVPNGAGQTPMDCALQAVQDApnwepevLFAALLDYGAQP 350
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMAKGDIA-------ICKMLLDSGANI 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 112-196 9.17e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 9.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 112 TAPLTIVAARGYTNCARYLIRQGAELDAR-VGGRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQ 190
Cdd:PTZ00322  83 TVELCQLAASGDAVGARILLTGGADPNCRdYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFRE 162


                 ....*.
gi 155372099 191 CAKLLL 196
Cdd:PTZ00322 163 VVQLLS 168
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 409-447 1.03e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.01  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 155372099   409 RRLQHLARLAMRAQLGSRCreaasCLPLPPLLKDYLLLR 447
Cdd:smart00969   1 RSLQHLCRLAIRRSLGGID-----KLPLPPRLKDYLLYY 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 212-253 1.33e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 1.33e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 155372099 212 TPLHVAAARGLEGHVALYLEHGADVNLRTSQGETAL-NAACAG 253
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwNAISAK 602
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 110-251 1.51e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.91  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 110 KHTAPLTIVAARGYTNCARYLIRQGAELDARVGGR-AALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPES 188
Cdd:PHA02875 101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 155372099 189 LQCAKLLLEAGATVNLAARDSEVTPLHVAAARGLEGHVALYLEHGADVNLRTS-QGE--TALNAAC 251
Cdd:PHA02875 181 IAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMFMiEGEecTILDMIC 246
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 406-445 1.92e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 1.92e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 155372099 406 NQPRRLQHLARLAMRAQLGsrcREAASCLPLPPLLKDYLL 445
Cdd:cd03717    1 TSVRSLQHLCRFVIRQCTR---RDLIDQLPLPRRLKDYLK 37
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 187-250 2.52e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 2.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 155372099 187 ESLQCAKLLLEAGATVNlaARD-SEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAA 250
Cdd:PHA02876 156 DELLIAEMLLEGGADVN--AKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
Ank_4 pfam13637
Ankyrin repeats (many copies);
143-196 2.83e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.83e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 155372099  143 GRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLL 196
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 145-247 3.43e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 3.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 145 AALHEACARAQF--DCVQLLVtfgaKVNVLSE--EGTTPLHLCTVPESLQCAKLLLEAGATVnLAARdseVT-------- 212
Cdd:cd22192   58 AALYDNLEAAVVlmEAAPELV----NEPMTSDlyQGETALHIAVVNQNLNLVRELIARGADV-VSPR---ATgtffrpgp 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 155372099 213 ---------PLHVAAARGLEGHVALYLEHGADVNLRTSQGETAL 247
Cdd:cd22192  130 knliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 159-232 3.58e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 3.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 155372099 159 VQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARGLEGHVALYLEH 232
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK-TPLELAEENGFREVVQLLSRH 170
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 408-447 4.48e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 40.99  E-value: 4.48e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 155372099 408 PRRLQHLARLAMRAQLGS---RCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03730    3 PRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 113-252 5.40e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 113 APLTIVAARGYTNCARYLIRqgAELDARVG---GRAALHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHLCTVPESL 189
Cdd:PLN03192 527 SNLLTVASTGNAALLEELLK--AKLDPDIGdskGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHH 604

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 155372099 190 QCAKLLLE-AGATVNLAARDSevtpLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACA 252
Cdd:PLN03192 605 KIFRILYHfASISDPHAAGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMA 664
PHA02798 PHA02798
ankyrin-like protein; Provisional
 156-247 8.58e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.83  E-value: 8.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 156 FDCVQLLVTFGAKVNVLSEEGTTPlhLCTV-------PESLQCAKLLLEAGATVNLAARDSEvTPLHVAAARG----LEg 224
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTP--LCTIlsnikdyKHMLDIVKILIENGADINKKNSDGE-TPLYCLLSNGyinnLE- 126

                         90       100
                 ....*....|....*....|...
gi 155372099 225 HVALYLEHGADVNLRTSQGETAL 247
Cdd:PHA02798 127 ILLFMIENGADTTLLDKDGFTML 149
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 407-447 1.04e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 39.62  E-value: 1.04e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 155372099 407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03719    2 EPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 109-236 1.08e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 109 AKHTAPLTIVAARGYTNCARYLIRQGAELDAR-VGGRAALHEACARAQFDCVQLLVTFGAkvnvLSEEGTTPLHLCTVPE 187
Cdd:PLN03192 556 SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRdANGNTALWNAISAKHHKIFRILYHFAS----ISDPHAAGDLLCTAAK 631

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 155372099 188 --SLQCAKLLLEAGATVNLAARDSeVTPLHVAAARGLEGHVALYLEHGADV 236
Cdd:PLN03192 632 rnDLTAMKELLKQGLNVDSEDHQG-ATALQVAMAEDHVDMVRLLIMNGADV 681
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 147-330 3.61e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.95  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 147 LHEACARAQFDCVQLLVTFGAKVNVLSEEGTTPLHL-CTVPESLQCAKLLLEAGA-----------------TVNLAA-- 206
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIiCKEPNKLGMKEMIRSINKcsvfytlvaikdafnnrNVEIFKii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 207 --------RDSEVTPL-HVAAARGLEGH-VALYLEHGADVNLRT-SQGETALNAAcagaegpsSSRRHQAAARRLLEAGA 275
Cdd:PHA02878 121 ltnrykniQTIDLVYIdKKSKDDIIEAEiTKLLLSYGADINMKDrHKGNTALHYA--------TENKDQRLTELLLSYGA 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 155372099 276 DARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCALQAVQD 330
Cdd:PHA02878 193 NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKD 247
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 218-309 3.77e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 218 AARGLEGHVALYLEHGADVNLRTSQGETALNAACAGAegpsssrrHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG 297
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANG--------HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161

                         90
                 ....*....|..
gi 155372099 298 GLAELLLRHGAC 309
Cdd:PTZ00322 162 EVVQLLSRHSQC 173
Ank_5 pfam13857
Ankyrin repeats (many copies);
195-247 3.79e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 3.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 155372099  195 LLEAGATVNLAARDSEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETAL 247
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 192-250 3.87e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 3.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 192 AKLLLEAGATVNlaARD-SEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAA 250
Cdd:PTZ00322  98 ARILLTGGADPN--CRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 159-325 4.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 159 VQLLVTFGAKVNVLSEEGTTPLHLCTVPESLQCAKLL-----------------------LEAGATVNLAARDSEvTPLH 215
Cdd:PHA02874  51 VELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLidngvdtsilpipciekdmiktiLDCGIDVNIKDAELK-TFLH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 216 VAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpsssrRHQA--AARRLLEAGADARAAGRKRHTPLHNACA 293
Cdd:PHA02874 130 YAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI----------KHNFfdIIKLLLEKGAYANVKDNNGESPLHNAAE 199

                        170       180       190
                 ....*....|....*....|....*....|..
gi 155372099 294 NGCGGLAELLLRHGACAAVPNGAGQTPMDCAL 325
Cdd:PHA02874 200 YGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI 231
Ank_4 pfam13637
Ankyrin repeats (many copies);
210-253 4.71e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 4.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 155372099  210 EVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACAG 253
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 157-255 6.28e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 42.09  E-value: 6.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 157 DCVQLLVTFGAKVNVLSE-----------EGTTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEV-------------T 212
Cdd:cd22193   46 DTIRILLDIAEKTDNLKRfinaeytdeyyEGQTALHIAIERRQGDIVALLVENGADVHAHAKGRFFqpkyqgegfyfgeL 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 155372099 213 PLHVAAARGLEGHVALYLEHG---ADVNLRTSQGETALNAACAGAE 255
Cdd:cd22193  126 PLSLAACTNQPDIVQYLLENEhqpADIEAQDSRGNTVLHALVTVAD 171
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 408-447 6.80e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 37.50  E-value: 6.80e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 155372099 408 PRRLQHLARLAMRAQLG-SRCREAASC--LPLPPLLKDYLLLR 447
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGlQKLQQPSSMkkLPLPPALKRYILYK 45
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 193-350 7.00e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 193 KLLLEAGATVNLAARDSEVTPLHVAAARGLEGHVALYLEHGADVNLRTSQGETALNAACagaegpssSRRHQAAARRLLE 272
Cdd:PHA02878 151 KLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAV--------KHYNKPIVHILLE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 273 AGADARAAGRKRHTPLHNA---CANgcGGLAELLLRHGACAAVPNGA-GQTPMDCALQavqdapnwEPEVLfAALLDYGA 348
Cdd:PHA02878 223 NGASTDARDKCGNTPLHISvgyCKD--YDILKLLLEHGVDVNAKSYIlGLTALHSSIK--------SERKL-KLLLEYGA 291


                 ..
gi 155372099 349 QP 350
Cdd:PHA02878 292 DI 293
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 407-447 8.47e-04

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 37.13  E-value: 8.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 155372099 407 QPRRLQHLARLAMRAQLGSR-CREAASCLPLPPLLKDYLLLR 447
Cdd:cd03727    2 APGTLKALARYAVRRSLGVQyLPEAVKQLPLPRSVKEYLLLL 43
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 407-445 1.17e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.51  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 155372099   407 QPRRLQHLARLAMRAQLGsrcREAASCLPLPPLLKDYLL 445
Cdd:smart00253   6 NVPSLQHLCRFTIRRCTR---TDQIKTLPLPPKLKDYLS 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
259-326 2.06e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 155372099  259 SSRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNgaGQTPMDCALQ 326
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAAR 70
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 408-447 4.64e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 34.76  E-value: 4.64e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 155372099 408 PRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 407-447 5.50e-03

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 34.59  E-value: 5.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 155372099 407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYLLLR 447
Cdd:cd03718    2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 212-240 6.23e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 6.23e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 155372099  212 TPLHVAAAR-GLEGHVALYLEHGADVNLRT 240
Cdd:pfam00023   4 TPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 156-250 7.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.43  E-value: 7.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155372099 156 FDCVQLLVTFGAKVNV---LSEEG-TTPLHLCTVPESLQCAKLLLEAGATVNLAARDSEVTPLHVAAARGLEGHVALYLE 231
Cdd:PHA02884  46 TDIIDAILKLGADPEApfpLSENSkTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLS 125

                         90
                 ....*....|....*....
gi 155372099 232 HGADVNLRTSQGETALNAA 250
Cdd:PHA02884 126 YGADINIQTNDMVTPIELA 144
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 407-444 7.34e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 34.44  E-value: 7.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 155372099 407 QPRRLQHLARLAMRAQLGSRCREAASCLPLPPLLKDYL 444
Cdd:cd03726    2 QPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYL 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 267-324 9.07e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.34  E-value: 9.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 155372099 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRHGACAAVPNGAGQTPMDCA 324
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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