guanine nucleotide exchange factor C9orf72 homolog isoform 1 [Mus musculus]
Protein Classification
C9orf72-like domain-containing protein( domain architecture ID 10633239)
C9orf72-like domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| C9orf72-like | pfam15019 | C9orf72-like protein family; The precise function of this family is unknown but members have ... |
61-324 | 1.88e-82 | |||||
C9orf72-like protein family; The precise function of this family is unknown but members have been found to be localized in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci. This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important. : Pssm-ID: 464450 Cd Length: 230 Bit Score: 254.51 E-value: 1.88e-82
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| Name | Accession | Description | Interval | E-value | |||||
| C9orf72-like | pfam15019 | C9orf72-like protein family; The precise function of this family is unknown but members have ... |
61-324 | 1.88e-82 | |||||
C9orf72-like protein family; The precise function of this family is unknown but members have been found to be localized in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci. This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important. Pssm-ID: 464450 Cd Length: 230 Bit Score: 254.51 E-value: 1.88e-82
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| Name | Accession | Description | Interval | E-value | |||||
| C9orf72-like | pfam15019 | C9orf72-like protein family; The precise function of this family is unknown but members have ... |
61-324 | 1.88e-82 | |||||
C9orf72-like protein family; The precise function of this family is unknown but members have been found to be localized in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci. This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important. Pssm-ID: 464450 Cd Length: 230 Bit Score: 254.51 E-value: 1.88e-82
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