|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
278-480 |
1.70e-113 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 349.21 E-value: 1.70e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 278 LPSKVRDLYVQlKGIKKLYDWQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKI 357
Cdd:cd18026 1 LPDAVREAYAK-KGIKKLYDWQKECLSLPGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKKALFVLPYVSIVQEKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 358 SSLSSFGIELGFFVEEYAGSKGRFPPiKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILE 437
Cdd:cd18026 80 DALSPLFEELGFRVEGYAGNKGRSPP-KRRKSLSVAVCTIEKANSLVNSLIEEGRLDELGLVVVDELHMLGDGHRGALLE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 124487403 438 MTLAKVLYTSK-TTQIIGMSATLNNVEDLQAFLKAEYYTSQFRP 480
Cdd:cd18026 159 LLLTKLLYAAQkNIQIVGMSATLPNLEELASWLRAELYTTNFRP 202
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
278-845 |
8.71e-107 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 343.80 E-value: 8.71e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 278 LPSKVRDLYVQlKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEKI 357
Cdd:COG1204 7 PLEKVIEFLKE-RGIEELYPPQAEALE-AGLLEGKNLVVSAPTASGKTLIAELAILKALL-NGGKALYIVPLRALASEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 358 SSLSSFGIELGFFVEEYAGskGRFPPIKRREKKSLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILE 437
Cdd:COG1204 84 REFKRDFEELGIKVGVSTG--DYDSDDEWLGRYDILVATPEKLDSLLRN--GPSWLRDVDLVVVDEAHLIDDESRGPTLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 438 MTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDsqaadgmtfsrllsyKYSEA 517
Cdd:COG1204 160 VLLARLRRLNPEAQIVALSATIGNAEEIAEWLDAELVKSDWRPVPLNEGVLYDGVLRFDD---------------GSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 518 LkkmdpDRLVALVTEVIP-NYSCLVFCPSKKNCENVAEMLCKFLsKDYLNHREKEKC-EVIKSLRNIGNG-KVCPVLKRT 594
Cdd:COG1204 225 K-----DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEtHTNEKLADC 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 595 VPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPY-VANTFLKRNQYKQMVGRAGRAGID 673
Cdd:COG1204 299 LEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAGRPGYD 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 674 TAGESILLLQEKD--KQQVLELISGPLETCCSHLVEEftKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQkillKE 751
Cdd:COG1204 379 PYGEAILVAKSSDeaDELFERYILGEPEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQY----DK 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 752 KSLWEITVDALEHLTEKGLLQKDSCGdneglechFRITKLGQASFKGAIDLAYCDTLYRDLKKGLEGLVLESLLHLIYLT 831
Cdd:COG1204 453 GDLEEVVDDALEFLLENGFIEEDGDR--------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLGLLHLILIL 524
|
570
....*....|....
gi 124487403 832 TpydlaaqsepDWM 845
Cdd:COG1204 525 R----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
277-1024 |
9.68e-93 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 312.28 E-value: 9.68e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 277 SLPSKVRDLYVQlKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEK 356
Cdd:PRK02362 7 PLPEGVIEFYEA-EGIEELYPPQAEAVE-AGLLDGKNLLAAIPTASGKTLIAELAMLKAIA-RGGKALYIVPLRALASEK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 357 ---ISSLSSFGIELGFfveeyagSKGRFppiKRRE----KKSLYIATIEKAHSLV-NaliETSRLSTLGLVVVDELHMIG 428
Cdd:PRK02362 84 feeFERFEELGVRVGI-------STGDY---DSRDewlgDNDIIVATSEKVDSLLrN---GAPWLDDITCVVVDEVHLID 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 429 EGSRGAILEMTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQaadgmtfsr 508
Cdd:PRK02362 151 SANRGPTLEVTLAKLRRLNPDLQVVALSATIGNADELADWLDAELVDSEWRPIDLREGVFYGGAIHFDDSQ--------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 509 llsykysEALKKMDPDRLVALVTEVI-PNYSCLVFCPSKKNCENVAEMLCKFLSKdYLNHREKEK-CEVIKSLRNIGNGK 586
Cdd:PRK02362 222 -------REVEVPSKDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKK-TLTAAERAElAELAEEIREVSDTE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 587 VCPVLKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILR-----------APyvantfL 655
Cdd:PRK02362 294 TSKDLADCVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQP------I 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 656 KRNQYKQMVGRAGRAGIDTAGESILLlqEKDKQQVLEL----ISGPLETCCSHLVEEftkgiQAL---FLSLIGLKIAAS 728
Cdd:PRK02362 368 PVLEYHQMAGRAGRPGLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE-----PALrthVLSTIASGFART 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 729 LGDIYQFMSGTFFGVQQKillKEKSLWEITVDALEHLTEKGLLQKDscGDneglecHFRITKLGQAsfkgaidlayCDTL 808
Cdd:PRK02362 441 RDGLLEFLEATFYATQTD---DTGRLERVVDDVLDFLERNGMIEED--GE------TLEATELGHL----------VSRL 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 809 YRD------LKKGLEGLVLES---LLHLIYLTtpydlaaqsePD-WMVYFKqfgqlSPTEQNVAALLGVSES-FIGKKAA 877
Cdd:PRK02362 500 YIDplsaaeIIDGLEAAKKPTdlgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 878 gqavrkkVDKNVVNRLYLSFVLYSLL-----KETNVWSVSEKFNLPRGYIQNL------LMGAASfsscvlHFCEELEEF 946
Cdd:PRK02362 565 -------EFEDDEFEDFLSAVKTALLledwiDEVDEERITERYGVGPGDIRGKvetaewLLHAAE------RLASELDLD 631
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487403 947 WVYKAllVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTidhLSRRQARQIVSSAK 1024
Cdd:PRK02362 632 LARAA--RELEKRVEYGVREELLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
479-681 |
1.65e-42 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 152.32 E-value: 1.65e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 479 RPVELKEFLKVndtiyevdsqaadgmtFSRLLSYKYSEALKKMDPDRLVALVTEVIPNY-SCLVFCPSKKNCENVAEMLc 557
Cdd:cd18795 1 RPVPLEEYVLG----------------FNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGkPVLVFCSSRKECEKTAKDL- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 558 kflskdylnhrekekcevikslrnigngkvcpvlkrtvpFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVN 637
Cdd:cd18795 64 ---------------------------------------AGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVN 104
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 124487403 638 LPARRVILRAPYVAN----TFLKRNQYKQMVGRAGRAGIDTAGESILL 681
Cdd:cd18795 105 LPARTVIIKGTQRYDgkgyRELSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
676-772 |
1.68e-26 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 104.17 E-value: 1.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 676 GESILLLQEKDKQQVLELISGPLETCCSHLVEEfTKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSlw 755
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 124487403 756 eiTVDALEHLTEKGLLQ 772
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
304-465 |
5.01e-21 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 91.15 E-value: 5.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 304 TLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKD--VLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRF 381
Cdd:pfam00270 7 AIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGpqALVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGDSRK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 382 PPIKRREKKSLYIATIEKAHSLvnaLIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVlytSKTTQIIGMSATLN- 460
Cdd:pfam00270 87 EQLEKLKGPDILVGTPGRLLDL---LQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL---PKKRQILLLSATLPr 160
|
....*
gi 124487403 461 NVEDL 465
Cdd:pfam00270 161 NLEDL 165
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
310-669 |
3.91e-18 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 89.95 E-value: 3.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 310 ERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIV-------QEKISSLSSFGIELGffVEEYAGSKGRFP 382
Cdd:COG1202 224 EGKDQLVVSATATGKTLIGELAGIKNALEGKGKMLFLVPLVALAnqkyedfKDRYGDGLDVSIRVG--ASRIRDDGTRFD 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 383 PikrreKKSLYIATIEKahslVNALIETSR-LSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIGMSATLNN 461
Cdd:COG1202 302 P-----NADIIVGTYEG----IDHALRTGRdLGDIGTVVIDEVHMLEDPERGHRLDGLIARLKYYCPGAQWIYLSATVGN 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 462 VEDLQAFLKAEYYTSQFRPVELKEFLkvndtiyevdsqaadgmTFSRllsykysEALKKmdpdRLVA-LVTEVIPNYS-- 538
Cdd:COG1202 373 PEELAKKLGAKLVEYEERPVPLERHL-----------------TFAD-------GREKI----RIINkLVKREFDTKSsk 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 539 -----CLVFCPSKKNCENVAEMLckflskdylnhrekekcevikslrnigngkvcpvlkrtvPFGIAYHHSGLTSEERKL 613
Cdd:COG1202 425 gyrgqTIIFTNSRRRCHEIARAL---------------------------------------GYKAAPYHAGLDYGERKK 465
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487403 614 LEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTFLKRNQYKQMVGRAGR 669
Cdd:COG1202 466 VERRFADQELAAVVTTAALAAGVDFPASQVIFDSLAMGIEWLSVQEFHQMLGRAGR 521
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
287-486 |
7.01e-17 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 80.23 E-value: 7.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 287 VQLKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKD-VLMILPYVAIVQEKISSLSSFGI 365
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIE-ALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGrVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 366 ELGFFVEEYAGSKGRFPPIKR--REKKSLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKV 443
Cdd:smart00487 80 SLGLKVVGLYGGDSKREQLRKleSGKTDILVTTPGRLLDLLEN--DKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 124487403 444 lytSKTTQIIGMSATLNN--VEDLQAFLKAEYYTSQ-FRPVELKEF 486
Cdd:smart00487 158 ---PKNVQLLLLSATPPEeiENLLELFLNDPVFIDVgFTPLEPIEQ 200
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
597-671 |
2.73e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.08 E-value: 2.73e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487403 597 FGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLP-ARRVIlrapyVANTFLKRNQYKQMVGRAGRAG 671
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVI-----IYDLPWSPASYIQRIGRAGRAG 82
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
412-489 |
5.07e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 41.02 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 412 RLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLY-TSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVEL------K 484
Cdd:PRK13767 169 KLRTVKWVIVDEIHSLAENKRGVHLSLSLERLEElAGGEFVRIGLSATIEPLEEVAKFLVGYEDDGEPRDCEIvdarfvK 248
|
....*.
gi 124487403 485 EF-LKV 489
Cdd:PRK13767 249 PFdIKV 254
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
971-1024 |
8.15e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 35.54 E-value: 8.15e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 124487403 971 LMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTIDhLSRRQARQIVSSAK 1024
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
278-480 |
1.70e-113 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 349.21 E-value: 1.70e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 278 LPSKVRDLYVQlKGIKKLYDWQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKI 357
Cdd:cd18026 1 LPDAVREAYAK-KGIKKLYDWQKECLSLPGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKKALFVLPYVSIVQEKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 358 SSLSSFGIELGFFVEEYAGSKGRFPPiKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILE 437
Cdd:cd18026 80 DALSPLFEELGFRVEGYAGNKGRSPP-KRRKSLSVAVCTIEKANSLVNSLIEEGRLDELGLVVVDELHMLGDGHRGALLE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 124487403 438 MTLAKVLYTSK-TTQIIGMSATLNNVEDLQAFLKAEYYTSQFRP 480
Cdd:cd18026 159 LLLTKLLYAAQkNIQIVGMSATLPNLEELASWLRAELYTTNFRP 202
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
278-845 |
8.71e-107 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 343.80 E-value: 8.71e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 278 LPSKVRDLYVQlKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEKI 357
Cdd:COG1204 7 PLEKVIEFLKE-RGIEELYPPQAEALE-AGLLEGKNLVVSAPTASGKTLIAELAILKALL-NGGKALYIVPLRALASEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 358 SSLSSFGIELGFFVEEYAGskGRFPPIKRREKKSLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILE 437
Cdd:COG1204 84 REFKRDFEELGIKVGVSTG--DYDSDDEWLGRYDILVATPEKLDSLLRN--GPSWLRDVDLVVVDEAHLIDDESRGPTLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 438 MTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDsqaadgmtfsrllsyKYSEA 517
Cdd:COG1204 160 VLLARLRRLNPEAQIVALSATIGNAEEIAEWLDAELVKSDWRPVPLNEGVLYDGVLRFDD---------------GSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 518 LkkmdpDRLVALVTEVIP-NYSCLVFCPSKKNCENVAEMLCKFLsKDYLNHREKEKC-EVIKSLRNIGNG-KVCPVLKRT 594
Cdd:COG1204 225 K-----DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEtHTNEKLADC 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 595 VPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPY-VANTFLKRNQYKQMVGRAGRAGID 673
Cdd:COG1204 299 LEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAGRPGYD 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 674 TAGESILLLQEKD--KQQVLELISGPLETCCSHLVEEftKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQkillKE 751
Cdd:COG1204 379 PYGEAILVAKSSDeaDELFERYILGEPEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQY----DK 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 752 KSLWEITVDALEHLTEKGLLQKDSCGdneglechFRITKLGQASFKGAIDLAYCDTLYRDLKKGLEGLVLESLLHLIYLT 831
Cdd:COG1204 453 GDLEEVVDDALEFLLENGFIEEDGDR--------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLGLLHLILIL 524
|
570
....*....|....
gi 124487403 832 TpydlaaqsepDWM 845
Cdd:COG1204 525 R----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
277-1024 |
9.68e-93 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 312.28 E-value: 9.68e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 277 SLPSKVRDLYVQlKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEK 356
Cdd:PRK02362 7 PLPEGVIEFYEA-EGIEELYPPQAEAVE-AGLLDGKNLLAAIPTASGKTLIAELAMLKAIA-RGGKALYIVPLRALASEK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 357 ---ISSLSSFGIELGFfveeyagSKGRFppiKRRE----KKSLYIATIEKAHSLV-NaliETSRLSTLGLVVVDELHMIG 428
Cdd:PRK02362 84 feeFERFEELGVRVGI-------STGDY---DSRDewlgDNDIIVATSEKVDSLLrN---GAPWLDDITCVVVDEVHLID 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 429 EGSRGAILEMTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQaadgmtfsr 508
Cdd:PRK02362 151 SANRGPTLEVTLAKLRRLNPDLQVVALSATIGNADELADWLDAELVDSEWRPIDLREGVFYGGAIHFDDSQ--------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 509 llsykysEALKKMDPDRLVALVTEVI-PNYSCLVFCPSKKNCENVAEMLCKFLSKdYLNHREKEK-CEVIKSLRNIGNGK 586
Cdd:PRK02362 222 -------REVEVPSKDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKK-TLTAAERAElAELAEEIREVSDTE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 587 VCPVLKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILR-----------APyvantfL 655
Cdd:PRK02362 294 TSKDLADCVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQP------I 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 656 KRNQYKQMVGRAGRAGIDTAGESILLlqEKDKQQVLEL----ISGPLETCCSHLVEEftkgiQAL---FLSLIGLKIAAS 728
Cdd:PRK02362 368 PVLEYHQMAGRAGRPGLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE-----PALrthVLSTIASGFART 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 729 LGDIYQFMSGTFFGVQQKillKEKSLWEITVDALEHLTEKGLLQKDscGDneglecHFRITKLGQAsfkgaidlayCDTL 808
Cdd:PRK02362 441 RDGLLEFLEATFYATQTD---DTGRLERVVDDVLDFLERNGMIEED--GE------TLEATELGHL----------VSRL 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 809 YRD------LKKGLEGLVLES---LLHLIYLTtpydlaaqsePD-WMVYFKqfgqlSPTEQNVAALLGVSES-FIGKKAA 877
Cdd:PRK02362 500 YIDplsaaeIIDGLEAAKKPTdlgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 878 gqavrkkVDKNVVNRLYLSFVLYSLL-----KETNVWSVSEKFNLPRGYIQNL------LMGAASfsscvlHFCEELEEF 946
Cdd:PRK02362 565 -------EFEDDEFEDFLSAVKTALLledwiDEVDEERITERYGVGPGDIRGKvetaewLLHAAE------RLASELDLD 631
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487403 947 WVYKAllVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTidhLSRRQARQIVSSAK 1024
Cdd:PRK02362 632 LARAA--RELEKRVEYGVREELLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
290-1006 |
2.79e-60 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 220.46 E-value: 2.79e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 290 KGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGiELGF 369
Cdd:PRK00254 19 RGIEELYPPQAEALK-SGVLEGKNLVLAIPTASGKTLVAEIVMVNKLLREGGKAVYLVPLKALAEEKYREFKDWE-KLGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 370 FVEEYAG---SK----GRFPPIkrrekkslyIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAK 442
Cdd:PRK00254 97 RVAMTTGdydSTdewlGKYDII---------IATAEKFDSLLRH--GSSWIKDVKLVVADEIHLIGSYDRGATLEMILTH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 443 VLytsKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLLSYkysEALKKmd 522
Cdd:PRK00254 166 ML---GRAQILGLSATVGNAEELAEWLNAELVVSDWRPVKLRKGVFYQGFLFWEDGKIERFPNSWESLVY---DAVKK-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 523 pdrlvalvtevipNYSCLVFCPSKKNCENVAEMLCKFLsKDYLNHREKEKC-EVIKSLR-NIGNGKvcpvLKRTVPFGIA 600
Cdd:PRK00254 238 -------------GKGALVFVNTRRSAEKEALELAKKI-KRFLTKPELRALkELADSLEeNPTNEK----LKKALRGGVA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 601 YHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTF----LKRNQYKQMVGRAGRAGIDTAG 676
Cdd:PRK00254 300 FHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFgwedIPVLEIQQMMGRAGRPKYDEVG 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 677 ESILLLQEKDKQQVLE-LISGPLETCCSHLVEEftKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILlkeKSLW 755
Cdd:PRK00254 380 EAIIVATTEEPSKLMErYIFGKPEKLFSMLSNE--SAFRSQVLALITNFGVSNFKELVNFLERTFYAHQRKDL---YSLE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 756 EITVDALEHLTEKGLLQKDscgdnegLECHFRITKLGQASFKGAIDlAYCDTLYRDLKKGLE------GlvlesLLHLIY 829
Cdd:PRK00254 455 EKAKEIVYFLLENEFIDID-------LEDRFIPLPLGIRTSQLYID-PLTAKKFKDAFPKIEknpnplG-----IFQLIA 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 830 LT---TPYDLAAQSEPDWMVYFKQFgqlsptEQNVAALLGVSESFIGKKAAGQAVRKKvdknvvnrlylsfVLYSLLKET 906
Cdd:PRK00254 522 STpdmTPLNYSRKEMEDLLDEAYEM------EDRLYFNIPYWEDYKFQKFLRAFKTAK-------------VLLDWINEV 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 907 NVWSVSEKFNLPRGYIQNLLmgaasfsscvlhfceELEEFWVYKalLVELTK-----------------KLTYCVKAELI 969
Cdd:PRK00254 583 PEGEIVETYNIDPGDLYRIL---------------ELADWLMYS--LIELYKlfepkqevldyletlhlRVKHGVREELL 645
|
730 740 750
....*....|....*....|....*....|....*..
gi 124487403 970 PLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVK 1006
Cdd:PRK00254 646 ELMRLPMIGRKRARALYNAGFRSIEDIVNAKPSELLK 682
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
294-1030 |
1.93e-57 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 211.28 E-value: 1.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 294 KLYDwqHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEKISSLSSFGiELGFFVEE 373
Cdd:PRK01172 22 ELYD--HQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFL-AGLKSIYIVPLRSLAMEKYEELSRLR-SLGMRVKI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 374 YAGSKGRFPP-IKRREkksLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQI 452
Cdd:PRK01172 98 SIGDYDDPPDfIKRYD---VVILTSEKADSLIHH--DPYIINDVGLIVADEIHIIGDEDRGPTLETVLSSARYVNPDARI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 453 IGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYeVDSQAADGMTfsrllsykysealkkmdpdrLVALVTE 532
Cdd:PRK01172 173 LALSATVSNANELAQWLNASLIKSNFRPVPLKLGILYRKRLI-LDGYERSQVD--------------------INSLIKE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 533 VI-PNYSCLVFCPSKKNCENVAEMLCKFLSKDYLNHREKEKCEVIKSLrnigngkvcpvLKRTVPFGIAYHHSGLTSEER 611
Cdd:PRK01172 232 TVnDGGQVLVFVSSRKNAEDYAEMLIQHFPEFNDFKVSSENNNVYDDS-----------LNEMLPHGVAFHHAGLSNEQR 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 612 KLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVIL----RAPYVANTFLKRNQYKQMVGRAGRAGIDTAGESILLLQEKDK 687
Cdd:PRK01172 301 RFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVrditRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYGIGYIYAASPAS 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 688 QQVL-ELISGPLETCCSHLVEEftKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSLWEitvdALEHLT 766
Cdd:PRK01172 381 YDAAkKYLSGEPEPVISYMGSQ--RKVRFNTLAAISMGLASSMEDLILFYNETLMAIQNGVDEIDYYIES----SLKFLK 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 767 EKGLLQKDScgdneglecHFRITKLGQASfkgaidlaycDTLYRDlkkgleglvLESLLHLI-YLTTPYDlaaqsEPDWM 845
Cdd:PRK01172 455 ENGFIKGDV---------TLRATRLGKLT----------SDLYID---------PESALILKsAFDHDYD-----EDLAL 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 846 VYFKQFGQLSP--TEQNVAAL-----LGVSESFIgkKAAGQAVrkkvdknvvnrlylsfVLYSLLKETNVWSVSEKFNLP 918
Cdd:PRK01172 502 YYISLCREIIPanTRDDYYAMefledIGVIDGDI--SAAKTAM----------------VLRGWISEASMQKITDTYGIA 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 919 RGYIQNLLMGAASFSSCVLHFCEeleefwVYK----ALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIM 994
Cdd:PRK01172 564 PGDVQARASSADWISYSLARLSS------IYKpemrRKLEILNIRIKEGIREDLIDLVLIPKVGRVRARRLYDAGFKTVD 637
|
730 740 750
....*....|....*....|....*....|....*.
gi 124487403 995 HLANANPEvLVKTIDHLSRRQARQIVSSAKMLLHEK 1030
Cdd:PRK01172 638 DIARSSPE-RIKKIYGFSDTLANAIVNRAMKISSMY 672
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
479-681 |
1.65e-42 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 152.32 E-value: 1.65e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 479 RPVELKEFLKVndtiyevdsqaadgmtFSRLLSYKYSEALKKMDPDRLVALVTEVIPNY-SCLVFCPSKKNCENVAEMLc 557
Cdd:cd18795 1 RPVPLEEYVLG----------------FNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGkPVLVFCSSRKECEKTAKDL- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 558 kflskdylnhrekekcevikslrnigngkvcpvlkrtvpFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVN 637
Cdd:cd18795 64 ---------------------------------------AGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVN 104
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 124487403 638 LPARRVILRAPYVAN----TFLKRNQYKQMVGRAGRAGIDTAGESILL 681
Cdd:cd18795 105 LPARTVIIKGTQRYDgkgyRELSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
295-473 |
4.63e-36 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 134.70 E-value: 4.63e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 295 LYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFFVEEY 374
Cdd:cd17921 2 LNPIQREALR-ALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 375 AGSkgRFPPIKRREKKSLYIATIEKAHSLVNALIETSRLStLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIG 454
Cdd:cd17921 81 TGD--PSVNKLLLAEADILVATPEKLDLLLRNGGERLIQD-VRLVVVDEAHLIGDGERGVVLELLLSRLLRINKNARFVG 157
|
170
....*....|....*....
gi 124487403 455 MSATLNNVEDLQAFLKAEY 473
Cdd:cd17921 158 LSATLPNAEDLAEWLGVED 176
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
295-699 |
2.53e-35 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 144.70 E-value: 2.53e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 295 LYDWQHTclTLRSVQERKNLIYSLPTSGGKTLVAEiLMLQELLCRQKDVLMILPYVAIVQEKISSLSS-FGielgffvEE 373
Cdd:COG4581 26 LDPFQEE--AILALEAGRSVLVAAPTGSGKTLVAE-FAIFLALARGRRSFYTAPIKALSNQKFFDLVErFG-------AE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 374 YAG------SKGRFPPIkrrekkslYIATIEkahSLVNALIETSR-LSTLGLVVVDELHMIGEGSRGAILEMTLakvLYT 446
Cdd:COG4581 96 NVGlltgdaSVNPDAPI--------VVMTTE---ILRNMLYREGAdLEDVGVVVMDEFHYLADPDRGWVWEEPI---IHL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 447 SKTTQIIGMSATLNNVEDLQAFLKA-----EYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLlsykySEALKKM 521
Cdd:COG4581 162 PARVQLVLLSATVGNAEEFAEWLTRvrgetAVVVSEERPVPLEFHYLVTPRLFPLFRVNPELLRPPSR-----HEVIEEL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 522 DPDRLValvteviPNYsclVFCPSKKNCENVAEMLckfLSKDYLNHREKEK-CEVIKSLR---NIGNGKVcpvLKRTVPF 597
Cdd:COG4581 237 DRGGLL-------PAI---VFIFSRRGCDEAAQQL---LSARLTTKEERAEiREAIDEFAedfSVLFGKT---LSRLLRR 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 598 GIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILrapyvanTFL-KRN----------QYKQMVGR 666
Cdd:COG4581 301 GIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVF-------TKLsKFDgerhrpltarEFHQIAGR 373
|
410 420 430
....*....|....*....|....*....|....
gi 124487403 667 AGRAGIDTAGESILLLQE-KDKQQVLELISGPLE 699
Cdd:COG4581 374 AGRRGIDTEGHVVVLAPEhDDPKKFARLASARPE 407
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
312-476 |
1.29e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 113.20 E-value: 1.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 312 KNLIYSLPTSGGKTLVAEILMLQELLcRQKDVLMILPYVAIVQEKISSLSSFGiELGFFVeeyAGSKGRFP-PIKRREKK 390
Cdd:cd18028 18 ENLLISIPTASGKTLIAEMAMVNTLL-EGGKALYLVPLRALASEKYEEFKKLE-EIGLKV---GISTGDYDeDDEWLGDY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 391 SLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLK 470
Cdd:cd18028 93 DIIVATYEKFDSLLRH--SPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRRLNPNTQIIGLSATIGNPDELAEWLN 170
|
....*.
gi 124487403 471 AEYYTS 476
Cdd:cd18028 171 AELVES 176
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
676-772 |
1.68e-26 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 104.17 E-value: 1.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 676 GESILLLQEKDKQQVLELISGPLETCCSHLVEEfTKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSlw 755
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 124487403 756 eiTVDALEHLTEKGLLQ 772
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
304-465 |
5.01e-21 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 91.15 E-value: 5.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 304 TLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKD--VLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRF 381
Cdd:pfam00270 7 AIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGpqALVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGDSRK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 382 PPIKRREKKSLYIATIEKAHSLvnaLIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVlytSKTTQIIGMSATLN- 460
Cdd:pfam00270 87 EQLEKLKGPDILVGTPGRLLDL---LQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL---PKKRQILLLSATLPr 160
|
....*
gi 124487403 461 NVEDL 465
Cdd:pfam00270 161 NLEDL 165
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
310-669 |
3.91e-18 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 89.95 E-value: 3.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 310 ERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIV-------QEKISSLSSFGIELGffVEEYAGSKGRFP 382
Cdd:COG1202 224 EGKDQLVVSATATGKTLIGELAGIKNALEGKGKMLFLVPLVALAnqkyedfKDRYGDGLDVSIRVG--ASRIRDDGTRFD 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 383 PikrreKKSLYIATIEKahslVNALIETSR-LSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIGMSATLNN 461
Cdd:COG1202 302 P-----NADIIVGTYEG----IDHALRTGRdLGDIGTVVIDEVHMLEDPERGHRLDGLIARLKYYCPGAQWIYLSATVGN 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 462 VEDLQAFLKAEYYTSQFRPVELKEFLkvndtiyevdsqaadgmTFSRllsykysEALKKmdpdRLVA-LVTEVIPNYS-- 538
Cdd:COG1202 373 PEELAKKLGAKLVEYEERPVPLERHL-----------------TFAD-------GREKI----RIINkLVKREFDTKSsk 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 539 -----CLVFCPSKKNCENVAEMLckflskdylnhrekekcevikslrnigngkvcpvlkrtvPFGIAYHHSGLTSEERKL 613
Cdd:COG1202 425 gyrgqTIIFTNSRRRCHEIARAL---------------------------------------GYKAAPYHAGLDYGERKK 465
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487403 614 LEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTFLKRNQYKQMVGRAGR 669
Cdd:COG1202 466 VERRFADQELAAVVTTAALAAGVDFPASQVIFDSLAMGIEWLSVQEFHQMLGRAGR 521
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
312-458 |
6.19e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 78.60 E-value: 6.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 312 KNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSF---GIELGFFVEEYAgSKGRFPPIKRRE 388
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELfgpGIRVAVLVGGSS-AEEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 389 KksLYIATIEKAHSLVNALiETSRLSTLGLVVVDELHMIGEGSRGAiLEMTLAKVLYTSKTTQIIGMSAT 458
Cdd:cd00046 81 D--IIIATPDMLLNLLLRE-DRLFLKDLKLIIVDEAHALLIDSRGA-LILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
287-486 |
7.01e-17 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 80.23 E-value: 7.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 287 VQLKGIKKLYDWQHTCLTlRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKD-VLMILPYVAIVQEKISSLSSFGI 365
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIE-ALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGrVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 366 ELGFFVEEYAGSKGRFPPIKR--REKKSLYIATIEKAHSLVNAliETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKV 443
Cdd:smart00487 80 SLGLKVVGLYGGDSKREQLRKleSGKTDILVTTPGRLLDLLEN--DKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 124487403 444 lytSKTTQIIGMSATLNN--VEDLQAFLKAEYYTSQ-FRPVELKEF 486
Cdd:smart00487 158 ---PKNVQLLLLSATPPEeiENLLELFLNDPVFIDVgFTPLEPIEQ 200
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
294-667 |
2.04e-14 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 77.37 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 294 KLYDWQHTCLT---LRSVQERKNLIYSLPTSGGKTLVAEILMLQelLCRQKDVLMILPYVAIV---QEKISSLssFGIEL 367
Cdd:COG1061 80 ELRPYQQEALEallAALERGGGRGLVVAPTGTGKTVLALALAAE--LLRGKRVLVLVPRRELLeqwAEELRRF--LGDPL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 368 GffveeYAGSKGRFPPIkrrekkslYIATIekaHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVlyts 447
Cdd:COG1061 156 A-----GGGKKDSDAPI--------TVATY---QSLARRAHLDELGDRFGLVIIDEAHHAGAPSYRRILEAFPAAY---- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 448 kttqIIGMSATLnnvedlqaflkaeYYTSQfRPVELKEFLKVndtIYEVDSQAA---------------DGMTFSRLLSY 512
Cdd:COG1061 216 ----RLGLTATP-------------FRSDG-REILLFLFDGI---VYEYSLKEAiedgylappeyygirVDLTDERAEYD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 513 KYSEALKK---MDPDRLVALVTEVIPNYS----CLVFCPSKKNCENVAEMLckflskdylnHREKEKCEVIkslrnigng 585
Cdd:COG1061 275 ALSERLREalaADAERKDKILRELLREHPddrkTLVFCSSVDHAEALAELL----------NEAGIRAAVV--------- 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 586 kvcpvlkrtvpfgiayhHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLP-ARRVILRAPYVAntflkRNQYKQMV 664
Cdd:COG1061 336 -----------------TGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPrLDVAILLRPTGS-----PREFIQRL 393
|
...
gi 124487403 665 GRA 667
Cdd:COG1061 394 GRG 396
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
292-472 |
4.22e-14 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 72.40 E-value: 4.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 292 IKKLYDWQHTCL----TLRSVQER---------KNLIYSLPTSGGKTLVAEILMLQEL-LCRQKD---------VLMILP 348
Cdd:cd18019 1 IEELPDWAQPAFegfkSLNRIQSKlfpaafetdENLLLCAPTGAGKTNVALLTILREIgKHRNPDgtinldafkIVYIAP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 349 YVAIVQEKISSLSSFGIELGFFVEEYAG----SKGRFppikrrEKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDEL 424
Cdd:cd18019 81 MKALVQEMVGNFSKRLAPYGITVAELTGdqqlTKEQI------SETQIIVTTPEKWDIITRKSGDRTYTQLVRLIIIDEI 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 124487403 425 HMIGEgSRGAILEMTLAKVLYTSKTTQ----IIGMSATLNNVEDLQAFLKAE 472
Cdd:cd18019 155 HLLHD-DRGPVLESIVARTIRQIEQTQeyvrLVGLSATLPNYEDVATFLRVD 205
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
597-671 |
2.73e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.08 E-value: 2.73e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487403 597 FGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLP-ARRVIlrapyVANTFLKRNQYKQMVGRAGRAG 671
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVI-----IYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
308-480 |
3.00e-13 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 69.69 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 308 VQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKD------VLMILPYVAIVQEKISSL-SSFGiELGFFVEEYAGSKGr 380
Cdd:cd18023 14 LYSDKNFVVSAPTGSGKTVLFELAILRLLKERNPLpwgnrkVVYIAPIKALCSEKYDDWkEKFG-PLGLSCAELTGDTE- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 381 FPPIKRREKKSLYIATIEKAHSLVNALIETSRL-STLGLVVVDELHMIGEgSRGAILEMTLA--KVLYTSKTT------- 450
Cdd:cd18023 92 MDDTFEIQDADIILTTPEKWDSMTRRWRDNGNLvQLVALVLIDEVHIIKE-NRGATLEVVVSrmKTLSSSSELrgstvrp 170
|
170 180 190
....*....|....*....|....*....|....*.
gi 124487403 451 -QIIGMSATLNNVEDLQAFLKAEY-----YTSQFRP 480
Cdd:cd18023 171 mRFVAVSATIPNIEDLAEWLGDNPagcfsFGESFRP 206
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
278-671 |
8.26e-13 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 72.56 E-value: 8.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 278 LPSKVRDlYVQLKGIKKLYdwQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLC-RQKDVLMILPYVAIVQEK 356
Cdd:COG1205 41 LPPELRA-ALKKRGIERLY--SHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEdPGATALYLYPTKALARDQ 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 357 ISSLSSF--GIELGFFVEEYAGSKgrfPPIKRRE--KKSLYIAT--------IEKAHSLVNALietsrLSTLGLVVVDEL 424
Cdd:COG1205 118 LRRLRELaeALGLGVRVATYDGDT---PPEERRWirEHPDIVLTnpdmlhygLLPHHTRWARF-----FRNLRYVVIDEA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 425 HMIgegsRGaILEMTLAKVL---------YTSKTtQIIGMSATLNNVEDLqaflkAEYYTSqfRPVEL----------KE 485
Cdd:COG1205 190 HTY----RG-VFGSHVANVLrrlrricrhYGSDP-QFILASATIGNPAEH-----AERLTG--RPVTVvdedgsprgeRT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 486 FLKVNDTIYEvdsqaaDGMTFSRllsykYSEAlkkmdpDRLVA-LVTEvipNYSCLVFCPSKKNCENVAEMLCKFLSKDY 564
Cdd:COG1205 257 FVLWNPPLVD------DGIRRSA-----LAEA------ARLLAdLVRE---GLRTLVFTRSRRGAELLARYARRALREPD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 565 LNHRekekcevikslrnigngkvcpvlkrtvpfgIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLP---Ar 641
Cdd:COG1205 317 LADR------------------------------VAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGgldA- 365
|
410 420 430
....*....|....*....|....*....|.
gi 124487403 642 rVILRA-PYvantflKRNQYKQMVGRAGRAG 671
Cdd:COG1205 366 -VVLAGyPG------TRASFWQQAGRAGRRG 389
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
312-469 |
3.09e-12 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 66.63 E-value: 3.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 312 KNLIYSLPTSGGKTLVAEILMLQELLCR-QKDVLMILPYVAIVQEKISSLSS-FGIELGFFVEEYAGSKGrfPPIKRREK 389
Cdd:cd18022 18 NNVLLGAPTGSGKTIAAELAMFRAFNKYpGSKVVYIAPLKALVRERVDDWKKrFEEKLGKKVVELTGDVT--PDMKALAD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 390 KSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEgSRGAILEMTLAKVLY----TSKTTQIIGMSATLNNVEDL 465
Cdd:cd18022 96 ADIIITTPEKWDGISRSWQTREYVQQVSLIIIDEIHLLGS-DRGPVLEVIVSRMNYissqTEKPVRLVGLSTALANAGDL 174
|
....
gi 124487403 466 QAFL 469
Cdd:cd18022 175 ANWL 178
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
312-478 |
1.80e-11 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 64.37 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 312 KNLIYSLPTSGGKTLVAEILMLQELLCR-------QKD---VLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKgrf 381
Cdd:cd18020 18 ENMLICAPTGAGKTNIAMLTILHEIRQHvnqggviKKDdfkIVYIAPMKALAAEMVEKFSKRLAPLGIKVKELTGDM--- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 382 pPIKRREKKSLYI--ATIEK------AHSLVNALIETSRLstlglVVVDELHMIGEgSRGAILEMTLAKVLYTSKTTQ-- 451
Cdd:cd18020 95 -QLTKKEIAETQIivTTPEKwdvvtrKSSGDVALSQLVRL-----LIIDEVHLLHD-DRGPVIESLVARTLRQVESTQsm 167
|
170 180
....*....|....*....|....*....
gi 124487403 452 --IIGMSATLNNVEDLQAFLKAEYYTSQF 478
Cdd:cd18020 168 irIVGLSATLPNYLDVADFLRVNPYKGLF 196
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
591-671 |
1.61e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 59.15 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 591 LKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVilrapyVANTFLKRN--QYKQMVGRAG 668
Cdd:pfam00271 33 LLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDL------VINYDLPWNpaSYIQRIGRAG 106
|
...
gi 124487403 669 RAG 671
Cdd:pfam00271 107 RAG 109
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
298-465 |
2.25e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 60.68 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 298 WQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLcRQKDV--LMILPYVAIVQEKISSLSSF--GIELGFFVEE 373
Cdd:cd17923 2 YSHQAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALL-RDPGSraLYLYPTKALAQDQLRSLRELleQLGLGIRVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 374 YAGSKgrfpPIKRREKK-----SLYIATIEKAHSLV--NALIETSRLSTLGLVVVDELHMIgEGSRGAILEMTLAKVL-- 444
Cdd:cd17923 81 YDGDT----PREERRAIirnppRILLTNPDMLHYALlpHHDRWARFLRNLRYVVLDEAHTY-RGVFGSHVALLLRRLRrl 155
|
170 180
....*....|....*....|...
gi 124487403 445 --YTSKTTQIIGMSATLNNVEDL 465
Cdd:cd17923 156 crRYGADPQFILTSATIGNPAEH 178
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
373-668 |
3.64e-10 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 64.56 E-value: 3.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 373 EYAGSKGRFPPIKRREKKSLYIATIEKAHslvnaliETSR-LSTlglVVVDELHMIGEGSRGAILEMTLAKV---LYTSk 448
Cdd:PRK09751 91 ERSKLTRNPPDILITTPESLYLMLTSRAR-------ETLRgVET---VIIDEVHAVAGSKRGAHLALSLERLdalLHTS- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 449 tTQIIGMSATLNNVEDLQAFLKAEyytsqfRPV-----------ELKEFLKVND--TIYEVDSQAADGMTFSRLLS-YKY 514
Cdd:PRK09751 160 -AQRIGLSATVRSASDVAAFLGGD------RPVtvvnppamrhpQIRIVVPVANmdDVSSVASGTGEDSHAGREGSiWPY 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 515 SEAlkkmdpdrlvALVTEVIPNYSCLVFcpskKNCENVAEMLCKFLSKDYLNH--REKEKCEVIKSLRNIgNGKVCPVLK 592
Cdd:PRK09751 233 IET----------GILDEVLRHRSTIVF----TNSRGLAEKLTARLNELYAARlqRSPSIAVDAAHFEST-SGATSNRVQ 297
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487403 593 RTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRA---PYVANTFlkrnqykQMVGRAG 668
Cdd:PRK09751 298 SSDVFIARSHHGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVatpLSVASGL-------QRIGRAG 369
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
313-465 |
6.03e-10 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 59.96 E-value: 6.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 313 NLIYSLPTSGGKTLVAEILMLQeLLCRQKDVLMIlpYVAIVQEKISSL-----SSFGIELGFFVEEYAGSKGRfpPIKRR 387
Cdd:cd18021 21 NVFVGAPTGSGKTVCAELALLR-HWRQNPKGRAV--YIAPMQELVDARykdwrAKFGPLLGKKVVKLTGETST--DLKLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 388 EKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGeGSRGAILEMTLAKVLY----TSKTTQIIGMSATLNNVE 463
Cdd:cd18021 96 AKSDVILATPEQWDVLSRRWKQRKNVQSVELFIADELHLIG-GENGPVYEVVVSRMRYissqLEKPIRIVGLSSSLANAR 174
|
..
gi 124487403 464 DL 465
Cdd:cd18021 175 DV 176
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
312-469 |
8.52e-10 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 58.75 E-value: 8.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 312 KNLIYSLPTSGGKTLVAEILMLQELLCRQKD---VLMILPYVAI---VQEKISSLSSfGIELGFFVEEYAGSKGrfPPIK 385
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLADEPEKgvqVLYISPLKALindQERRLEEPLD-EIDLEIPVAVRHGDTS--QSEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 386 RREKKS---LYIATIEkahSLvnALIETSR-----LSTLGLVVVDELHMIGEGSRGAILEMTLAKV-LYTSKTTQIIGMS 456
Cdd:cd17922 79 AKQLKNppgILITTPE---SL--ELLLVNKklrelFAGLRYVVVDEIHALLGSKRGVQLELLLERLrKLTGRPLRRIGLS 153
|
170
....*....|...
gi 124487403 457 ATLNNVEDLQAFL 469
Cdd:cd17922 154 ATLGNLEEAAAFL 166
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
292-458 |
1.51e-09 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 58.07 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 292 IKKLYDWQHTCLT----LRSVQERKNLIySLPTSGGKTLVAEILM--LQELLCRQKdVLMILPYVAIVQEKISSLSSFGI 365
Cdd:pfam04851 1 KLELRPYQIEAIEnlleSIKNGQKRGLI-VMATGSGKTLTAAKLIarLFKKGPIKK-VLFLVPRKDLLEQALEEFKKFLP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 366 ELGFFVEEYAGSKGRFPpikrREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMtlakvly 445
Cdd:pfam04851 79 NYVEIGEIISGDKKDES----VDDNKIVVTTIQSLYKALELASLELLPDFFDVIIIDEAHRSGASSYRNILEY------- 147
|
170
....*....|...
gi 124487403 446 tSKTTQIIGMSAT 458
Cdd:pfam04851 148 -FKPAFLLGLTAT 159
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
412-668 |
4.40e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 57.42 E-value: 4.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 412 RLSTLGLVVVDELHMIGEGSRGAILEMTLAK-VLYTSKTTQIIGMSATLNNVEDLQAFLKAeyyTSQFRPVELkeflkvn 490
Cdd:COG1201 158 LLRGVRTVIVDEIHALAGSKRGVHLALSLERlRALAPRPLQRIGLSATVGPLEEVARFLVG---YEDPRPVTI------- 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 491 dtiyeVDSQAADGMTFSRLLSYKYSEALKKMDP-------DRLVALVTEvipNYSCLVFCPSKKNCENVAEMLCKFLSKD 563
Cdd:COG1201 228 -----VDAGAGKKPDLEVLVPVEDLIERFPWAGhlwphlyPRVLDLIEA---HRTTLVFTNTRSQAERLFQRLNELNPED 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 564 YLNhrekekcevikslrnigngkvcpvlkrtvpfgIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPA-RR 642
Cdd:COG1201 300 ALP--------------------------------IAAHHGSLSREQRLEVEEALKAGELRAVVATSSLELGIDIGDvDL 347
|
250 260
....*....|....*....|....*..
gi 124487403 643 VI-LRAPYVANTFLKRnqykqmVGRAG 668
Cdd:COG1201 348 VIqVGSPKSVARLLQR------IGRAG 368
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
303-461 |
4.14e-07 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 51.66 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 303 LTLRSVQER--------KNLIYSLPTSGGKTLVAEILM---LQELLCRQKD-VLMILPYVAIVQEKISSLSSFGIELGFF 370
Cdd:cd17927 1 FKPRNYQLElaqpalkgKNTIICLPTGSGKTFVAVLICehhLKKFPAGRKGkVVFLANKVPLVEQQKEVFRKHFERPGYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 371 VEEYAG---SKGRFPPIKRREKksLYIATiekAHSLVNALI--ETSRLSTLGLVVVDELHM-IGEGSRGAIL-EMTLAKV 443
Cdd:cd17927 81 VTGLSGdtsENVSVEQIVESSD--VIIVT---PQILVNDLKsgTIVSLSDFSLLVFDECHNtTKNHPYNEIMfRYLDQKL 155
|
170
....*....|....*...
gi 124487403 444 LYTSKTTQIIGMSATLNN 461
Cdd:cd17927 156 GSSGPLPQILGLTASPGV 173
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
538-669 |
1.07e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 49.18 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 538 SCLVFCPSKKNCENVAEMLckflskdylnhreKEKCEvikslrnigngkvcpvlKRTVPFGIAYHHSGLTSEERKLLEEA 617
Cdd:cd18796 40 STLVFTNTRSQAERLAQRL-------------RELCP-----------------DRVPPDFIALHHGSLSRELREEVEAA 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 124487403 618 YSTGVLCLLTCTSTLAAGVNLPA-RRVI-LRAPYVANTFLKRnqykqmVGRAGR 669
Cdd:cd18796 90 LKRGDLKVVVATSSLELGIDIGDvDLVIqIGSPKSVARLLQR------LGRSGH 137
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
524-682 |
4.85e-06 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 47.12 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 524 DRLVALVTEVIPNYSCLVFCPSKKNCENVAEMLCKFlskdylnhreKEKCEVIkslrnigngkvcpvlkrtvpfgiayhH 603
Cdd:cd18787 15 LLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEEL----------GIKVAAL--------------------------H 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 604 SGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPA-RRVI-LRAPYVANTFLKRnqykqmVGRAGRAGidTAGESILL 681
Cdd:cd18787 59 GDLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGvDHVInYDLPRDAEDYVHR------IGRTGRAG--RKGTAITF 130
|
.
gi 124487403 682 L 682
Cdd:cd18787 131 V 131
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
304-457 |
4.97e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 48.42 E-value: 4.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 304 TLRSVQE-------RKNLIYSLPTSGGKTLVAEILMLQEL-LCRQKD-----VLMILPYVAIVQEKISSLSSfgiELGFF 370
Cdd:cd18034 2 TPRSYQLelfeaalKRNTIVVLPTGSGKTLIAVMLIKEMGeLNRKEKnpkkrAVFLVPTVPLVAQQAEAIRS---HTDLK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 371 VEEYAGSKGrfPPIKRREKKSLYIATIE----KAHSLVNALIETS-RLSTLGLVVVDELHMIGEGSRGAilemTLAKVLY 445
Cdd:cd18034 79 VGEYSGEMG--VDKWTKERWKEELEKYDvlvmTAQILLDALRHGFlSLSDINLLIFDECHHATGDHPYA----RIMKEFY 152
|
170
....*....|....*.
gi 124487403 446 TSKTTQ----IIGMSA 457
Cdd:cd18034 153 HLEGRTsrprILGLTA 168
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
303-459 |
7.35e-06 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 47.86 E-value: 7.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 303 LTLRSVQER--------KNLIYSLPTSGGKTLVAEILMLQELLCRQKD-----VLMILPYVAIVQEKISSLSSFgIELGF 369
Cdd:cd18036 1 LELRNYQLElvlpalrgKNTIICAPTGSGKTRVAVYICRHHLEKRRSAgekgrVVVLVNKVPLVEQQLEKFFKY-FRKGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 370 FVEEYAGS---KGRFPPIKRREKKSLYIATIekahsLVNALI-----ETSRLSTLGLVVVDELHMI-GEGSRGAILEMTL 440
Cdd:cd18036 80 KVTGLSGDsshKVSFGQIVKASDVIICTPQI-----LINNLLsgreeERVYLSDFSLLIFDECHHTqKEHPYNKIMRMYL 154
|
170 180
....*....|....*....|
gi 124487403 441 AKVLYTS-KTTQIIGMSATL 459
Cdd:cd18036 155 DKKLSSQgPLPQILGLTASP 174
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
295-459 |
2.33e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 45.37 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 295 LYDWQHTCL--TLRSVQERKNLIySLPTSGGKTLVAEILMlqeLLCRQKDVLMILPYVAIV---QEKISSLSSfGIELGF 369
Cdd:cd17926 1 LRPYQEEALeaWLAHKNNRRGIL-VLPTGSGKTLTALALI---AYLKELRTLIVVPTDALLdqwKERFEDFLG-DSSIGL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 370 FveeyagskgRFPPIKRREKKSLYIATIEkahSLVNALIETSRLSTL-GLVVVDELHMIGEGSRGAILEMTLAKVLytsk 448
Cdd:cd17926 76 I---------GGGKKKDFDDANVVVATYQ---SLSNLAEEEKDLFDQfGLLIVDEAHHLPAKTFSEILKELNAKYR---- 139
|
170
....*....|.
gi 124487403 449 ttqiIGMSATL 459
Cdd:cd17926 140 ----LGLTATP 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
311-458 |
8.49e-05 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 46.65 E-value: 8.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 311 RKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFgieLGFFVEEYAGSKGRFPPIKRR--- 387
Cdd:COG1111 17 RKNTLVVLPTGLGKTAVALLVIAERLHKKGGKVLFLAPTKPLVEQHAEFFKEA---LNIPEDEIVVFTGEVSPEKRKelw 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487403 388 EKKSLYIAT---IEkahslvNALIeTSRLST--LGLVVVDELH-MIGEGSRGAILEmtlaKVLYTSKTTQIIGMSAT 458
Cdd:COG1111 94 EKARIIVATpqvIE------NDLI-AGRIDLddVSLLIFDEAHrAVGNYAYVYIAE----RYHEDAKDPLILGMTAS 159
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
305-460 |
9.55e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 44.45 E-value: 9.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 305 LRSVQERKNLIYSLPTSGGKTLVAEIlmlqELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFF-----VEEYAGSKG 379
Cdd:cd17920 21 INAVLAGRDVLVVMPTGGGKSLCYQL----PALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAAALnstlsPEEKREVLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 380 RfppIKRREKKSLYIaTIEKAHS--LVNALIETSRLSTLGLVVVDELHMI---GEGSRGAILEmtLAKVLYTSKTTQIIG 454
Cdd:cd17920 97 R---IKNGQYKLLYV-TPERLLSpdFLELLQRLPERKRLALIVVDEAHCVsqwGHDFRPDYLR--LGRLRRALPGVPILA 170
|
....*.
gi 124487403 455 MSATLN 460
Cdd:cd17920 171 LTATAT 176
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
539-671 |
3.15e-04 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 42.24 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 539 CLVFCPSKKNCENVAEMLckflskdylnhrekeKCEVIKSLRNIGNgkvcpvlkrtvpfgIAYHHSGLTSEERKLLEEAY 618
Cdd:cd18797 38 TIVFCRSRKLAELLLRYL---------------KARLVEEGPLASK--------------VASYRAGYLAEDRREIEAEL 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487403 619 STGVLCLLTCTSTLAAGVNLPARRVILRAPY---VANtflkrnqYKQMVGRAGRAG 671
Cdd:cd18797 89 FNGELLGVVATNALELGIDIGGLDAVVLAGYpgsLAS-------LWQQAGRAGRRG 137
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
611-681 |
4.11e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.99 E-value: 4.11e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487403 611 RKLLEEAYStgVLCLLTCTSTLAAGVNLP-ARRVILRAPYVAntflkRNQYKQMVGRAGRAGiDTAGESILL 681
Cdd:cd18785 13 IEHAEEIAS--SLEILVATNVLGEGIDVPsLDTVIFFDPPSS-----AASYIQRVGRAGRGG-KDEGEVILF 76
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
304-479 |
1.26e-03 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 41.30 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 304 TLRSVQERKNLIYSLPTSGGKTLVAEilmLQELLCRQKDVLmILPYVAIVQEKISSLSSFGIELgffveEYAGSKGRFPP 383
Cdd:cd18014 22 TMAVVKGNKDVFVCMPTGAGKSLCYQ---LPALLAKGITIV-ISPLIALIQDQVDHLKTLKIRV-----DSLNSKLSAQE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 384 IKR---------REKKSLYIaTIEKAHS-----LVNALIETSRLSTLglvVVDELHMI---GEGSRGAILEMTLAKVLYt 446
Cdd:cd18014 93 RKRiiadlesekPQTKFLYI-TPEMAATssfqpLLSSLVSRNLLSYL---VVDEAHCVsqwGHDFRPDYLRLGALRSRY- 167
|
170 180 190
....*....|....*....|....*....|....*
gi 124487403 447 sKTTQIIGMSATLNN--VEDLQAFLKAEYYTSQFR 479
Cdd:cd18014 168 -GHVPWVALTATATPqvQEDIFAQLRLKKPVAIFK 201
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
339-669 |
3.28e-03 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 41.50 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 339 RQKDVLMILPYVAIV-QEKISSLSSfgieLGFfvEEYAGSkgrfpPIKRREK--KSLYIATIEKAHSLVNAL--IETSRL 413
Cdd:PHA02653 221 IERPIVLSLPRVALVrLHSITLLKS----LGF--DEIDGS-----PISLKYGsiPDELINTNPKPYGLVFSThkLTLNKL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 414 STLGLVVVDELHmigEGSR-GAILEMTLAKvlYTSKTTQIIGMSATLNNVED-LQAFLKAeyytsqfrpvelKEFLKV-N 490
Cdd:PHA02653 290 FDYGTVIIDEVH---EHDQiGDIIIAVARK--HIDKIRSLFLMTATLEDDRDrIKEFFPN------------PAFVHIpG 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 491 DTIYEVdSQAADGMTFSRLLSYKYSEALKKmdpDRLVALVTEVIPNYSC-LVFCPSKKNCENVAEMLCKFLS--KDYLNH 567
Cdd:PHA02653 353 GTLFPI-SEVYVKNKYNPKNKRAYIEEEKK---NIVTALKKYTPPKGSSgIVFVASVSQCEEYKKYLEKRLPiyDFYIIH 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 568 -REKEKCEVIKSLRNigNGKVC-----PVLKRTVPFGIAYHhsgltseerklleeAYSTGvlclltctstlaagvnlpar 641
Cdd:PHA02653 429 gKVPNIDEILEKVYS--SKNPSiiistPYLESSVTIRNATH--------------VYDTG-------------------- 472
|
330 340
....*....|....*....|....*....
gi 124487403 642 RVILRAPYVAN-TFLKRNQYKQMVGRAGR 669
Cdd:PHA02653 473 RVYVPEPFGGKeMFISKSMRTQRKGRVGR 501
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
412-489 |
5.07e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 41.02 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 412 RLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLY-TSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVEL------K 484
Cdd:PRK13767 169 KLRTVKWVIVDEIHSLAENKRGVHLSLSLERLEElAGGEFVRIGLSATIEPLEEVAKFLVGYEDDGEPRDCEIvdarfvK 248
|
....*.
gi 124487403 485 EF-LKV 489
Cdd:PRK13767 249 PFdIKV 254
|
|
| DEXHc_RLR-2 |
cd18074 |
DEXH-box helicase domain of RLR-2; RIG-I-like receptor 2 (RLR-2, also known as melanoma ... |
303-425 |
6.96e-03 |
|
DEXH-box helicase domain of RLR-2; RIG-I-like receptor 2 (RLR-2, also known as melanoma differentiation-associated protein 5 or Mda5 and IFIH1) is a viral double-stranded RNA (dsRNA) receptor that shares sequence similarity and signaling pathways with RIG-I, yet plays essential functions in antiviral immunity through distinct specificity for viral RNA. RLR-2 recognizes the internal duplex structure, whereas RIG-I recognizes the terminus of dsRNA. RLR-2 uses direct protein-protein contacts to stack along dsRNA in a head-to-tail arrangement. The signaling domain (tandem CARD), which decorates the outside of the core RLR-2 filament, also has an intrinsic propensity to oligomerize into an elongated structure that activates the signaling adaptor, MAVS. RLR-2 uses long dsRNA as a signaling platform to cooperatively assemble the core filament, which in turn promotes stochastic assembly of the tandem CARD oligomers for signaling. LGP2 appears to positively and negatively regulate RLR-2 and RIG-I signaling, respectively. RLR-2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350832 [Multi-domain] Cd Length: 216 Bit Score: 39.07 E-value: 6.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487403 303 LTLRSVQ--------ERKNLIYSLPTSGGKTLVAeILMLQELLCRQKD------VLMILPYVAIVQEKISSLSSFGIELG 368
Cdd:cd18074 1 LTLRDYQmevakpalEGKNIIICLPTGSGKTRVA-VYITKDHLDKKRKasepgkVIVLVNKVPLVEQHYRKEFNPFLKHW 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487403 369 FFVEEYAGS---KGRFPPIKRRekkslYIATIEKAHSLVNALI-------ETSRLSTLGLVVVDELH 425
Cdd:cd18074 80 YQVIGLSGDsqlKISFPEVVKR-----YDVIICTAQILENSLLnateeedEGVQLSDFSLIIIDECH 141
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
971-1024 |
8.15e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 35.54 E-value: 8.15e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 124487403 971 LMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTIDhLSRRQARQIVSSAK 1024
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
|
|
| |
