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Conserved domains on  [gi|4507305|ref|NP_001047|]
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sulfotransferase 1C2 isoform a [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 3.50e-118

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 3.50e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305     39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTHLS 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    112 TQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    192 LFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 4507305    272 AQNERFDEIYRRKMEGT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 3.50e-118

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 3.50e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305     39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTHLS 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    112 TQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    192 LFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 4507305    272 AQNERFDEIYRRKMEGT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-290 6.43e-36

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 131.58  E-value: 6.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    35 FEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPS-GVEKAKAMPsprILKTH 109
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPSvDVLKDKGNT---LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305   110 LSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MKDR 186
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305   187 HQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTVSKSildqsiS 254
Cdd:PLN02164 232 DRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAVYAN------S 305

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 4507305   255 SFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 290
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 3.50e-118

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 3.50e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305     39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW----ARPPQPSGVEKAKAMPSPRILKTHLS 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    112 TQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    192 LFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 4507305    272 AQNERFDEIYRRKMEGT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-290 6.43e-36

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 131.58  E-value: 6.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    35 FEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPS-GVEKAKAMPsprILKTH 109
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPSvDVLKDKGNT---LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305   110 LSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MKDR 186
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305   187 HQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTVSKSildqsiS 254
Cdd:PLN02164 232 DRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAVYAN------S 305

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 4507305   255 SFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 290
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
48-213 3.04e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 43.43  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305     48 PKAGTTWIQEIVD-------MIEQNGDVEKCqRAIIQHRHPFIEWARP---PQPSGVEKakaMPS-----PRILKthlst 112
Cdd:pfam13469   7 PRSGTTLLHRLLAahpdvrpPEETWFVIPRI-LALLQAWGKSLEALARvpsYARWLCDK---SPShlfhlDLLLK----- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507305    113 qLLPpsfwenNCKFLYVARNAKDCMVSyyhfQRMNHMLPDPGTWEEYFETFINGKVVWgsWFDHVKGWWEMKDRH---QI 189
Cdd:pfam13469  78 -AFP------DAKFIHLHRDPVDTVIS----SYCSLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARVppgRF 144

                         170       180
                  ....*....|....*....|....
gi 4507305    190 LFLFYEDIKRDPKHEIRKVMQFMG 213
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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