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Conserved domains on  [gi|114326524|ref|NP_001041611|]
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5-azacytidine-induced protein 2 isoform b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBD super family cl15118
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 227-261 1.14e-12

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


The actual alignment was detected with superfamily member pfam12845:

Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 61.68  E-value: 1.14e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 114326524  227 HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLK 261
Cdd:pfam12845   2 DSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLK 36
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 46-197 6.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326524    46 EDIKKRLKDSEKENSFLKKRIRALEERL--VGARADEETSSVGREQVNKAYHAYREVCIDR--DNLKNQLEKINKdNSES 121
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELtlLNEEAANLRERLESLERRIAATERRLEDLEEqiEELSEDIESLAA-EIEE 863

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326524   122 LKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLscDLKIHGLEQELGLLRKECSDLRTELQKARQT 197
Cdd:TIGR02168  864 LEELIEELESELEALLNERASLEEALALLRSELEELSEELREL--ESKRSELRRELEELREKLAQLELRLEGLEVR 937
 
Name Accession Description Interval E-value
TBD pfam12845
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 227-261 1.14e-12

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 61.68  E-value: 1.14e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 114326524  227 HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLK 261
Cdd:pfam12845   2 DSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLK 36
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 46-197 6.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326524    46 EDIKKRLKDSEKENSFLKKRIRALEERL--VGARADEETSSVGREQVNKAYHAYREVCIDR--DNLKNQLEKINKdNSES 121
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELtlLNEEAANLRERLESLERRIAATERRLEDLEEqiEELSEDIESLAA-EIEE 863

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326524   122 LKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLscDLKIHGLEQELGLLRKECSDLRTELQKARQT 197
Cdd:TIGR02168  864 LEELIEELESELEALLNERASLEEALALLRSELEELSEELREL--ESKRSELRRELEELREKLAQLELRLEGLEVR 937
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
51-196 9.37e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.59  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326524   51 RLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKayhayrevciDRDNLKNQLEKINKDNSESLKMLNEQLQ 130
Cdd:COG4913   282 RLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALRE----------ELDELEAQIRGNGGDRLEQLEREIERLE 351

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114326524  131 SKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLK--IHGLEQELGLLRKECSDLRTELQKARQ 196
Cdd:COG4913   352 RELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAalLEALEEELEALEEALAEAEAALRDLRR 419
 
Name Accession Description Interval E-value
TBD pfam12845
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 227-261 1.14e-12

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 61.68  E-value: 1.14e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 114326524  227 HHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLK 261
Cdd:pfam12845   2 DSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLK 36
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 46-197 6.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326524    46 EDIKKRLKDSEKENSFLKKRIRALEERL--VGARADEETSSVGREQVNKAYHAYREVCIDR--DNLKNQLEKINKdNSES 121
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELtlLNEEAANLRERLESLERRIAATERRLEDLEEqiEELSEDIESLAA-EIEE 863

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326524   122 LKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLscDLKIHGLEQELGLLRKECSDLRTELQKARQT 197
Cdd:TIGR02168  864 LEELIEELESELEALLNERASLEEALALLRSELEELSEELREL--ESKRSELRRELEELREKLAQLELRLEGLEVR 937
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
51-196 9.37e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.59  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326524   51 RLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKayhayrevciDRDNLKNQLEKINKDNSESLKMLNEQLQ 130
Cdd:COG4913   282 RLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALRE----------ELDELEAQIRGNGGDRLEQLEREIERLE 351

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114326524  131 SKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLK--IHGLEQELGLLRKECSDLRTELQKARQ 196
Cdd:COG4913   352 RELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAalLEALEEELEALEEALAEAEAALRDLRR 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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