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Conserved domains on  [gi|85060518|ref|NP_001034215|]
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ankyrin repeat and SOCS box protein 1 isoform a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-220 6.49e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 6.49e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  38 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 117
Cdd:COG0666  87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 118 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 195
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                       170       180
                ....*....|....*....|....*
gi 85060518 196 PLYISAAYHNLQCFRLLLQAGANPD 220
Cdd:COG0666 222 ALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 295-336 6.27e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.62  E-value: 6.27e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 85060518 295 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-220 6.49e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 6.49e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  38 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 117
Cdd:COG0666  87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 118 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 195
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                       170       180
                ....*....|....*....|....*
gi 85060518 196 PLYISAAYHNLQCFRLLLQAGANPD 220
Cdd:COG0666 222 ALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 295-336 6.27e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.62  E-value: 6.27e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 85060518 295 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-174 3.45e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518    83 LRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEaGADPNGSRHHRsTPVYHASRVGRDDILK 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 85060518   163 ALIRYGADVDVN 174
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 95-274 4.31e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 4.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   95 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 173
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  174 nhhltpdtrppfsrrLTSLVVCPLYISAAY-HNLQCFRLLLQAGANpdfncngpVNTQEFYRG-SPgcvMDAVLRhgcEA 251
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|...
gi 85060518  252 AFVSLLVEFGANLNLVKWESLGP 274
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTP 303
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 297-334 1.29e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 1.29e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 85060518   297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLL 334
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 298-336 1.67e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 1.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 85060518    298 RTLLSLCRVAVRRALGKyrlhlVPSLPLPDPIKKFLLYE 336
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 39-178 6.39e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.78  E-value: 6.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  39 DTRLHDAAYVGDLQTLRNLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGNCVDFLIRkgAEVDLVDV-------K 111
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 112 GQTALYVAVVNGHLESTEILLEAGADPNGSR--------------HHRSTPVYHASRVGRDDILKALIRYGADV------ 171
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdsl 168


                ....*....
gi 85060518 172 --DVNHHLT 178
Cdd:cd22192 169 gnTVLHILV 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 111-139 2.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 2.63e-04
                           10        20
                   ....*....|....*....|....*....
gi 85060518    111 KGQTALYVAVVNGHLESTEILLEAGADPN 139
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 100-285 2.97e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.76  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   100 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTEILLEagadpNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDv 173
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAF- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   174 nhhltPDTRPP----------FSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANPDFNCNGpvntQEFYRGSpgcvMDA 243
Cdd:TIGR00870 109 -----RKSGPLelandqytseFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACG----DFFVKSQ----GVD 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 85060518   244 VLRHG--------CEA--AFVSLLVEFGANLNLVkwESLGPEARGRRKMDPE 285
Cdd:TIGR00870 171 SFYHGesplnaaaCLGspSIVALLSEDPADILTA--DSLGNTLLHLLVMENE 220
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-220 6.49e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 6.49e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  38 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 117
Cdd:COG0666  87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 118 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 195
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                       170       180
                ....*....|....*....|....*
gi 85060518 196 PLYISAAYHNLQCFRLLLQAGANPD 220
Cdd:COG0666 222 ALDLAAENGNLEIVKLLLEAGADLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-202 3.49e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.03  E-value: 3.49e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  38 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 117
Cdd:COG0666 120 GETPLHLAAYNGNLEIVKLLLE---AGADVNAQDND--GN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 118 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHHLTPDTRPPFSRRLTSLVVCPL 197
Cdd:COG0666 192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271


                ....*
gi 85060518 198 YISAA 202
Cdd:COG0666 272 LLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-323 1.51e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 1.51e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 160
Cdd:COG0666  56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 161 LKALIRYGADVDV--NHHLTpdtrppfsrrltslvvcPLYISAAYHNLQCFRLLLQAGANpdfncngpVNTQEFYRGSPg 238
Cdd:COG0666 136 VKLLLEAGADVNAqdNDGNT-----------------PLHLAAANGNLEIVKLLLEAGAD--------VNARDNDGETP- 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 239 cVMDAVlRHGCEAAfVSLLVEFGANLNLVKWESLGPEARGRRKMDPEALQVFKEARSIPRTLLSLCRVAVRRALGKYRLH 318
Cdd:COG0666 190 -LHLAA-ENGHLEI-VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266


                ....*
gi 85060518 319 LVPSL 323
Cdd:COG0666 267 IVKLL 271
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 295-336 6.27e-19

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.62  E-value: 6.27e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 85060518 295 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03720   1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-174 3.45e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518    83 LRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEaGADPNGSRHHRsTPVYHASRVGRDDILK 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 85060518   163 ALIRYGADVDVN 174
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-139 9.43e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 9.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518    42 LHDAAYVGDLQTLRNLLQEESyrsriNEKSVWCCGWlpcTPLRIAATAGHGNCVDFLIRKgAEVDLVDvKGQTALYVAVV 121
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-----DANLQDKNGR---TALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAAR 70

                          90
                  ....*....|....*...
gi 85060518   122 NGHLESTEILLEAGADPN 139
Cdd:pfam12796  71 SGHLEIVKLLLEKGADIN 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-176 5.71e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.92  E-value: 5.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  42 LHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVV 121
Cdd:COG0666 157 LHLAAANGNLEIVKLLLE---AGADVNARDND--GE---TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 85060518 122 NGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHH 176
Cdd:COG0666 229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 297-336 4.46e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 68.29  E-value: 4.46e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03716   3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-267 6.79e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 6.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 160
Cdd:COG0666  23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 161 LKALIRYGADVDVnhhltpdtrpPFSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANpdfncngpVNTQEFYRGSPgcV 240
Cdd:COG0666 103 VKLLLEAGADVNA----------RDKDGET-----PLHLAAYNGNLEIVKLLLEAGAD--------VNAQDNDGNTP--L 157

                       170       180
                ....*....|....*....|....*..
gi 85060518 241 MDAVlRHGCEAAfVSLLVEFGANLNLV 267
Cdd:COG0666 158 HLAA-ANGNLEI-VKLLLEAGADVNAR 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 297-336 7.50e-14

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.80  E-value: 7.50e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 95-274 4.31e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 4.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   95 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 173
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  174 nhhltpdtrppfsrrLTSLVVCPLYISAAY-HNLQCFRLLLQAGANpdfncngpVNTQEFYRG-SPgcvMDAVLRhgcEA 251
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|...
gi 85060518  252 AFVSLLVEFGANLNLVKWESLGP 274
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTP 303
Ank_2 pfam12796
Ankyrin repeats (3 copies);
116-222 3.62e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 3.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   116 LYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHHLTpdtrppfsrrltslvvc 195
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT----------------- 63

                          90       100
                  ....*....|....*....|....*..
gi 85060518   196 PLYISAAYHNLQCFRLLLQAGANPDFN 222
Cdd:pfam12796  64 ALHYAARSGHLEIVKLLLEKGADINVK 90
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 297-334 1.29e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 1.29e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 85060518   297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLL 334
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 99-224 7.53e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 59.23  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   99 IRKGAEVDLVDVkgqtaLYVAVVNGHLESTEILLEAGADPN----GSRHHRSTPVYHASRVGRDDILKALIRYGADVDvn 174
Cdd:PHA02884  25 IKKKNKICIANI-----LYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDCDNDDAAKLLIRYGADVN-- 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 85060518  175 hhltpdtrppfsRRLTSLVVCPLYISAAYHNLQCFRLLLQAGANPDFNCN 224
Cdd:PHA02884  98 ------------RYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTN 135
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 81-176 1.21e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.50  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEIL--LEAGADPngsrHHRSTPVYHASRVGRD 158
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDP----HAAGDLLCTAAKRNDL 635

                         90
                 ....*....|....*...
gi 85060518  159 DILKALIRYGADVDVNHH 176
Cdd:PLN03192 636 TAMKELLKQGLNVDSEDH 653
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 95-224 1.27e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.21  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   95 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVN 174
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 85060518  175 HHltpdtrppfsrrltsLVVCPLYISAAYHNLQCFRLLLQAGANPDFNCN 224
Cdd:PHA02874 187 DN---------------NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCK 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 81-267 3.17e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 3.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVK-GQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDD 159
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  160 ILKALIRYGADVDVNhhltpdtrppfsrrlTSLVVCPLYISAAYHNLQCFRLLLQAGANPDfncngpvntqefYRGSPGC 239
Cdd:PHA02875 150 GIELLIDHKACLDIE---------------DCCGCTPLIIAMAKGDIAICKMLLDSGANID------------YFGKNGC 202

                        170       180       190
                 ....*....|....*....|....*....|.
gi 85060518  240 VmdAVLRHGCE---AAFVSLLVEFGANLNLV 267
Cdd:PHA02875 203 V--AALCYAIEnnkIDIVRLFIKRGADCNIM 231
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 297-336 5.00e-09

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 51.15  E-value: 5.00e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 297-336 6.36e-09

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 51.29  E-value: 6.36e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03723   3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLE 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 93-173 6.41e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 6.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   93 NCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVD 172
Cdd:PHA03100 173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252


                 .
gi 85060518  173 V 173
Cdd:PHA03100 253 T 253
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 81-249 6.73e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 6.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHA-SRVGRDD 159
Cdd:PHA02878 170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYD 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  160 ILKALIRYGADVDVNHHLtpdtrppfsRRLTslvvcPLYISaaYHNLQCFRLLLQAGANPdfncngpvNTQEFYRGSPgc 239
Cdd:PHA02878 250 ILKLLLEHGVDVNAKSYI---------LGLT-----ALHSS--IKSERKLKLLLEYGADI--------NSLNSYKLTP-- 303

                        170
                 ....*....|
gi 85060518  240 VMDAVLRHGC 249
Cdd:PHA02878 304 LSSAVKQYLC 313
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 297-336 9.34e-09

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 50.72  E-value: 9.34e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 87-167 1.35e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   87 ATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIR 166
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169


                 .
gi 85060518  167 Y 167
Cdd:PTZ00322 170 H 170
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-196 1.72e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.42  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   66 RINEKSVwcCGwlpCTPL----RIAATAghgNCVDFLIRKGAEVDLVDVKGQTAL--YVAVVNGHLESTEILLEAGADPN 139
Cdd:PHA03095  75 DVNAPER--CG---FTPLhlylYNATTL---DVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVN 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85060518  140 GSRHHRSTP--VYHASRVGRDDILKALIRYGAD---VDV------NHHL-TPDTRPPFSRRLTSLVVCP 196
Cdd:PHA03095 147 ALDLYGMTPlaVLLKSRNANVELLRLLIDAGADvyaVDDrfrsllHHHLqSFKPRARIVRELIRAGCDP 215
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-318 2.00e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.42  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   98 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTEI---LLEAGADPNGSRHHRSTP----VYHASRVgrdDILKALIRYGAD 170
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPlhlyLYNATTL---DVIKLLIKAGAD 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  171 VDVNHHLtpdTRPPFSRRLTSLVVCPLYIsaayhnlqcfRLLLQAGANpdfncngpVNTQEFYRGSPgcvMDAVLR-HGC 249
Cdd:PHA03095 110 VNAKDKV---GRTPLHVYLSGFNINPKVI----------RLLLRKGAD--------VNALDLYGMTP---LAVLLKsRNA 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  250 EAAFVSLLVEFGANLNLVkweslgpEARGRRKMDpEALQVFKEARSIPRTLLSL-CRVAVRRALGKYRLH 318
Cdd:PHA03095 166 NVELLRLLIDAGADVYAV-------DDRFRSLLH-HHLQSFKPRARIVRELIRAgCDPAATDMLGNTPLH 227
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 297-336 3.04e-08

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 49.21  E-value: 3.04e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 95-268 3.83e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 3.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   95 VDFLIRKGAEVDLVDVKGQTALYVAVVN--GHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDD--ILKALIRYGAD 170
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  171 VD----VNHHLT-------PDTRPpFSrrltslvvcPLYISAAYHNLQCFRLLLQAGANP-DFNCNGpvNTqefyrgspg 238
Cdd:PHA03100 169 INaknrVNYLLSygvpiniKDVYG-FT---------PLHYAVYNNNPEFVKYLLDLGANPnLVNKYG--DT--------- 227

                        170       180       190
                 ....*....|....*....|....*....|
gi 85060518  239 CVMDAVLRhgCEAAFVSLLVEFGANLNLVK 268
Cdd:PHA03100 228 PLHIAILN--NNKEIFKLLLNNGPSIKTII 255
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 297-335 5.55e-08

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 48.34  E-value: 5.55e-08
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 335
Cdd:cd03724   3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 29-274 7.65e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 7.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   29 FCDHPLEHCDDTRLHDAAYVGDLQTLRNLLQEESyrSRINEKSVwccgwLPCTPLRIAATAGHGN-CVDFLIRKGAEVDL 107
Cdd:PHA02876 264 FSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERG--ADVNAKNI-----KGETPLYLMAKNGYDTeNIRTLIMLGADVNA 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  108 VDVKGQTALYVAVVNGHLESTEI-LLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVnhhltpdtrppFS 186
Cdd:PHA02876 337 ADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA-----------LS 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  187 RRLTSLVVCPLYISAAYHNLqcfRLLLQAGANpdfncngpVNTQEFYRGSPgcvMDAVLRHGCEAAFVSLLVEFGANLNL 266
Cdd:PHA02876 406 QKIGTALHFALCGTNPYMSV---KTLIDRGAN--------VNSKNKDLSTP---LHYACKKNCKLDVIEMLLDNGADVNA 471


                 ....*...
gi 85060518  267 VKWESLGP 274
Cdd:PHA02876 472 INIQNQYP 479
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 297-336 7.78e-08

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 47.94  E-value: 7.78e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03721   3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 297-336 1.45e-07

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 47.32  E-value: 1.45e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03719   3 PHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 298-336 1.67e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 1.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 85060518    298 RTLLSLCRVAVRRALGKyrlhlVPSLPLPDPIKKFLLYE 336
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-257 2.80e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   71 SVWCCGWLPCTPLRIAATAGHGNC---VDFLIRKGAEVDLVDVKGQTALYVAVVNGH-LESTEILLEAGADPNGSRHHRS 146
Cdd:PHA03095  39 DVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  147 TP--VYHASRVGRDDILKALIRYGADV-DVNHHLtpdtrppfsrrLTSLVVcplYISAAYHNLQCFRLLLQAGANP---D 220
Cdd:PHA03095 119 TPlhVYLSGFNINPKVIRLLLRKGADVnALDLYG-----------MTPLAV---LLKSRNANVELLRLLIDAGADVyavD 184

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 85060518  221 FNCNGPVNTQ-EFYRGSPgCVMDAVLRHGCEAAFVSLL 257
Cdd:PHA03095 185 DRFRSLLHHHlQSFKPRA-RIVRELIRAGCDPAATDML 221
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 39-178 6.39e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.78  E-value: 6.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  39 DTRLHDAAYVGDLQTLRNLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGNCVDFLIRkgAEVDLVDV-------K 111
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518 112 GQTALYVAVVNGHLESTEILLEAGADPNGSR--------------HHRSTPVYHASRVGRDDILKALIRYGADV------ 171
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdsl 168


                ....*....
gi 85060518 172 --DVNHHLT 178
Cdd:cd22192 169 gnTVLHILV 177
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-267 1.84e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   77 WLPCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGH-----LESTEILLEAGADPNGSRHHRSTPVYH 151
Cdd:PHA03100  33 KKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518  152 AS--RVGRDDILKALIRYGADVDVnhhLTPDTRPPFsrrltslvvcPLYISAAYHNLQCFRLLLQAGANPD--------F 221
Cdd:PHA03100 113 AIskKSNSYSIVEYLLDNGANVNI---KNSDGENLL----------HLYLESNKIDLKILKLLIDKGVDINaknrvnylL 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 85060518  222 NCNGPVNTQEFYRGSPgcVMDAVLRHGCEaaFVSLLVEFGANLNLV 267
Cdd:PHA03100 180 SYGVPINIKDVYGFTP--LHYAVYNNNPE--FVKYLLDLGANPNLV 221
Ank_4 pfam13637
Ankyrin repeats (many copies);
81-132 2.17e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 2.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 85060518    81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL 132
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 295-335 4.15e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 43.23  E-value: 4.15e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 85060518 295 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 335
Cdd:cd03729   1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-109 4.92e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 4.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518    23 EWLREQFCD-HPLEHCDDTRLHDAAYVGDLQTLRNLLQEESYRSRINEKsvwccgwlpcTPLRIAATAGHGNCVDFLIRK 101
Cdd:pfam12796  14 KLLLENGADaNLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR----------TALHYAARSGHLEIVKLLLEK 83


                  ....*...
gi 85060518   102 GAEVDLVD 109
Cdd:pfam12796  84 GADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 42-172 9.81e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.91  E-value: 9.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   42 LHDAAYVGDLQTLRNLLQEESYRSRINEKSvwccgwlPCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVV 121
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKD-------GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVM 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 85060518  122 NGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVD 172
Cdd:PHA02875 145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 297-335 2.45e-05

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 40.93  E-value: 2.45e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 335
Cdd:cd03728   3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 291-335 6.01e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.97  E-value: 6.01e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 85060518    291 KEARSIPRTLLSLCRVAVRRALgkyRLHLVPSLPLPDPIKKFLLY 335
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCT---RTDQIKTLPLPPKLKDYLSY 42
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 297-336 9.95e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 39.45  E-value: 9.95e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 336
Cdd:cd03726   3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 297-335 1.92e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 38.35  E-value: 1.92e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 85060518 297 PRTLLSLCRVAVRRAlgkYRLHLVPSLPLPDPIKKFLLY 335
Cdd:cd03717   3 VRSLQHLCRFVIRQC---TRRDLIDQLPLPRRLKDYLKE 38
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 297-336 2.47e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.67  E-value: 2.47e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLH---LVPSLPLPDPIKKFLLYE 336
Cdd:cd03730   3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
PHA03095 PHA03095
ankyrin-like protein; Provisional
 81-166 2.52e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 2.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   81 TPLRIAATagHGNC----VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVG 156
Cdd:PHA03095 224 TPLHSMAT--GSSCkrslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNN 301

                         90
                 ....*....|
gi 85060518  157 RDDILKALIR 166
Cdd:PHA03095 302 NGRAVRAALA 311
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 111-139 2.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 2.63e-04
                           10        20
                   ....*....|....*....|....*....
gi 85060518    111 KGQTALYVAVVNGHLESTEILLEAGADPN 139
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 100-285 2.97e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.76  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   100 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTEILLEagadpNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDv 173
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAF- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   174 nhhltPDTRPP----------FSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANPDFNCNGpvntQEFYRGSpgcvMDA 243
Cdd:TIGR00870 109 -----RKSGPLelandqytseFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACG----DFFVKSQ----GVD 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 85060518   244 VLRHG--------CEA--AFVSLLVEFGANLNLVkwESLGPEARGRRKMDPE 285
Cdd:TIGR00870 171 SFYHGesplnaaaCLGspSIVALLSEDPADILTA--DSLGNTLLHLLVMENE 220
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 130-185 2.98e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 2.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 85060518  130 ILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVnhhLTPDTRPPF 185
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL---LDKDGKTPL 152
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-165 2.99e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 2.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 85060518   114 TALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALI 165
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 40-139 4.14e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   40 TRLHDAAYVGDLQTLRNLLQeesYRSRINEKSvwCCGwlpCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQ-TALYV 118
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLID---HKACLDIED--CCG---CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCY 208

                         90       100
                 ....*....|....*....|.
gi 85060518  119 AVVNGHLESTEILLEAGADPN 139
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGADCN 229
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 298-334 5.44e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 37.01  E-value: 5.44e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 85060518 298 RTLLSLCRVAVRRalgKYRLHLVPSLPLPDPIKKFLL 334
Cdd:cd03740   4 RSLQYLCRFVIRQ---YTRIDLIQKLPLPNKMKGYLL 37
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 81-179 5.64e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 160
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90       100
                 ....*....|....*....|.
gi 85060518  161 LKALIRYGADVDV--NHHLTP 179
Cdd:PHA02874 206 IKLLIDHGNHIMNkcKNGFTP 226
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 294-335 6.45e-04

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 37.02  E-value: 6.45e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 85060518 294 RSIPrTLLSLCRVAVRRALGKYRlhlVPSLPLPDPIKKFLLY 335
Cdd:cd03733   1 RVVS-SLQHLCRMALRRVMTTQQ---VLALPIPKKMKEFLTY 38
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 125-173 8.02e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 8.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 85060518  125 LESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 173
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
PHA02946 PHA02946
ankyin-like protein; Provisional
 95-172 8.64e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.81  E-value: 8.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   95 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASrvGRDD----ILKALIRYGAD 170
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLS--GTDDevieRINLLVQYGAK 132


                 ..
gi 85060518  171 VD 172
Cdd:PHA02946 133 IN 134
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-137 8.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 8.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85060518   62 SYRSRINEKSVwcCGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGAD 137
Cdd:PHA03100 180 SYGVPINIKDV--YGF---TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 81-132 1.06e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 85060518   81 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL 132
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
40-99 1.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518    40 TRLHDAAYVGDLQTLRNLLQeesYRSRINEksVWCCGWlpcTPLRIAATAGHGNCVDFLI 99
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLE---KGADINA--VDGNGE---TALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 111-139 1.86e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 85060518   111 KGQTALYVAVV-NGHLESTEILLEAGADPN 139
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVN 30
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 297-336 1.94e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.96  E-value: 1.94e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 85060518 297 PRTLLSLCRVAVRRALGKYRLHLVPS---LPLPDPIKKFLLYE 336
Cdd:cd03731   3 PRPLKHLCRLKIRKLMGLQKLQQPSSmkkLPLPPALKRYILYK 45
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 295-334 2.47e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.20  E-value: 2.47e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 85060518 295 SIPRTLLSLCRVAVRRALG-KYRLHLVPSLPLPDPIKKFLL 334
Cdd:cd03727   1 SAPGTLKALARYAVRRSLGvQYLPEAVKQLPLPRSVKEYLL 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 144-173 2.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 85060518    144 HRSTPVYHASRVGRDDILKALIRYGADVDV 173
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 295-336 3.64e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 34.73  E-value: 3.64e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 85060518 295 SIPRTLLSLCRVAVRRALGKYRLHL-VPSLPLPDPIKKFLLYE 336
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVkVKALPLPDRLKWYLLPE 43
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 111-171 5.16e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 38.71  E-value: 5.16e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85060518 111 KGQTALYVAVVNGHLESTEILLEAGAD----PNGSRHHRST---------PVYHASRVGRDDILKALIRYGADV 171
Cdd:cd21882  72 QGQTALHIAIENRNLNLVRLLVENGADvsarATGRFFRKSPgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-152 5.72e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 5.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 85060518    98 LIRKG-AEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHA 152
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
 93-176 6.06e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 38.28  E-value: 6.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85060518   93 NCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL---EAGADP--NGSRHHRSTPVYHASRVGRD-DILKALIR 166
Cdd:PHA02798  90 DIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTtlLDKDGFTMLQVYLQSNHHIDiEIIKLLLE 169

                         90
                 ....*....|
gi 85060518  167 YGadVDVNHH 176
Cdd:PHA02798 170 KG--VDINTH 177
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-109 6.55e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 6.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 85060518    80 CTPLRIAAT-AGHGNCVDFLIRKGAEVDLVD 109
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 111-139 6.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.77  E-value: 6.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 85060518   111 KGQTALYVAVVNGHLESTEILLEAGADPN 139
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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