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Conserved domains on  [gi|80861463|ref|NP_001030333|]
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pro-opiomelanocortin preproprotein [Homo sapiens]

Protein Classification

NPP and Op_neuropeptide domain-containing protein( domain architecture ID 10551814)

protein containing domains NPP, ACTH_domain, and Op_neuropeptide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.72e-17

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


:

Pssm-ID: 429962  Cd Length: 43  Bit Score: 73.22  E-value: 2.72e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 80861463    28 CLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 237-264 6.95e-11

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


:

Pssm-ID: 462343  Cd Length: 30  Bit Score: 55.91  E-value: 6.95e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 80861463   237 YGGFMTS--EKSQTPLVTLFKNAIIKNAYK 264
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
218-236 1.79e-07

Corticotropin ACTH domain;


:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.10  E-value: 1.79e-07
                          10
                  ....*....|....*....
gi 80861463   218 EGPYRMEHFRWGSPPKDKR 236
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain super family cl03048
Corticotropin ACTH domain;
136-154 2.60e-04

Corticotropin ACTH domain;


The actual alignment was detected with superfamily member pfam00976:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*....
gi 80861463   136 KRSYSMEHFRWGKPVGKKR 154
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain super family cl03048
Corticotropin ACTH domain;
74-91 2.60e-04

Corticotropin ACTH domain;


The actual alignment was detected with superfamily member pfam00976:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*...
gi 80861463    74 PRKYVMGHFRWDRFGRRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.72e-17

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 73.22  E-value: 2.72e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 80861463    28 CLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 237-264 6.95e-11

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 55.91  E-value: 6.95e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 80861463   237 YGGFMTS--EKSQTPLVTLFKNAIIKNAYK 264
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
218-236 1.79e-07

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.10  E-value: 1.79e-07
                          10
                  ....*....|....*....
gi 80861463   218 EGPYRMEHFRWGSPPKDKR 236
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
136-154 2.60e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*....
gi 80861463   136 KRSYSMEHFRWGKPVGKKR 154
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
74-91 2.60e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*...
gi 80861463    74 PRKYVMGHFRWDRFGRRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.72e-17

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 73.22  E-value: 2.72e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 80861463    28 CLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 237-264 6.95e-11

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 55.91  E-value: 6.95e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 80861463   237 YGGFMTS--EKSQTPLVTLFKNAIIKNAYK 264
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
218-236 1.79e-07

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.10  E-value: 1.79e-07
                          10
                  ....*....|....*....
gi 80861463   218 EGPYRMEHFRWGSPPKDKR 236
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
136-154 2.60e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*....
gi 80861463   136 KRSYSMEHFRWGKPVGKKR 154
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
74-91 2.60e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.24  E-value: 2.60e-04
                          10
                  ....*....|....*...
gi 80861463    74 PRKYVMGHFRWDRFGRRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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