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Conserved domains on  [gi|77735781|ref|NP_001029585|]
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ankyrin repeat and SOCS box protein 11 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 5.04e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 5.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILL 183
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 184 ANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQ 262
Cdd:COG0666 174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                       250       260
                ....*....|....*....|
gi 77735781 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666 254 TALLLAAAAGAALIVKLLLL 273
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 282-323 2.11e-18

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 77.14  E-value: 2.11e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 5.04e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 5.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILL 183
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 184 ANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQ 262
Cdd:COG0666 174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                       250       260
                ....*....|....*....|
gi 77735781 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666 254 TALLLAAAAGAALIVKLLLL 273
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-268 7.47e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.04  E-value: 7.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   45 RKEAARIAEEIFGEISDCWAD----RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
Cdd:PHA02876 154 QQDELLIAEMLLEGGADVNAKdiycITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDN 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  121 -----------------------------GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHE 169
Cdd:PHA02876 234 rsninkndlsllkairnedletslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  170 AVKRG-NRECMEILLANNVNIDQEVPHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHL 246
Cdd:PHA02876 314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINT 393

                        250       260
                 ....*....|....*....|..
gi 77735781  247 LIDYGANLKCKNAQGQSALDLA 268
Cdd:PHA02876 394 LLDYGADIEALSQKIGTALHFA 415
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 282-323 2.11e-18

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 77.14  E-value: 2.11e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
167-258 1.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   167 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 246
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 77735781   247 LIDYGANLKCKN 258
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 283-321 1.44e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.63  E-value: 1.44e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 77735781   283 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 321
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 285-323 1.52e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.24  E-value: 1.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 77735781    285 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 323
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 133-265 3.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 3.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 133 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 204
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77735781 205 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 265
Cdd:cd22192  98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 229-254 5.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 5.18e-04
                           10        20
                   ....*....|....*....|....*.
gi 77735781    229 DTPLHAAAKQNSVEIIHLLIDYGANL 254
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 5.04e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 5.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666  14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILL 183
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 184 ANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQ 262
Cdd:COG0666 174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                       250       260
                ....*....|....*....|
gi 77735781 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666 254 TALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-223 1.42e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.80  E-value: 1.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSA 144
Cdd:COG0666 120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 145 ACVNVLLEFGAKAQLEVHL-ASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN 223
Cdd:COG0666 200 EIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-268 7.47e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.04  E-value: 7.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   45 RKEAARIAEEIFGEISDCWAD----RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
Cdd:PHA02876 154 QQDELLIAEMLLEGGADVNAKdiycITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDN 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  121 -----------------------------GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHE 169
Cdd:PHA02876 234 rsninkndlsllkairnedletslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  170 AVKRG-NRECMEILLANNVNIDQEVPHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHL 246
Cdd:PHA02876 314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINT 393

                        250       260
                 ....*....|....*....|..
gi 77735781  247 LIDYGANLKCKNAQGQSALDLA 268
Cdd:PHA02876 394 LLDYGADIEALSQKIGTALHFA 415
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 282-323 2.11e-18

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 77.14  E-value: 2.11e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-284 7.72e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.48  E-value: 7.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   39 YIVKG-----NRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA- 112
Cdd:PHA03100   4 YIVLTksriiKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLt 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  113 ----CAKALLENGAHVNGVTVHGATPLFNA--CCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNR--ECMEILL 183
Cdd:PHA03100  84 dvkeIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  184 ANNVNIDQEvphlgtplyaactyqrlDCVKKLLELGANVN----HGqwlDTPLHAAAKQNSVEIIHLLIDYGANLKCKNA 259
Cdd:PHA03100 164 DKGVDINAK-----------------NRVNYLLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        250       260
                 ....*....|....*....|....*.
gi 77735781  260 QGQSALDLAAPKSSVE-QALLLREGP 284
Cdd:PHA03100 224 YGDTPLHIAILNNNKEiFKLLLNNGP 249
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-279 8.56e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 78.18  E-value: 8.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   59 ISDCwaDRSPLHEAAAQGRLLAL-KTLIAQGVNVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGVTVHGATPLF 136
Cdd:PHA02876 269 IDDC--KNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLH 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  137 NACC-SGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPL-YAACTYQRLDCVK 213
Cdd:PHA02876 347 QASTlDRNKDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVK 426

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77735781  214 KLLELGANVN-HGQWLDTPLHAAAKQN-SVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALL 279
Cdd:PHA02876 427 TLIDRGANVNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILL 494
Ank_2 pfam12796
Ankyrin repeats (3 copies);
167-258 1.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   167 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 246
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 77735781   247 LIDYGANLKCKN 258
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 81-268 2.12e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 2.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   81 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 159
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  160 EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRldCVKKLLELGANVNHgQWLD--TPLHAAAK 237
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190
                 ....*....|....*....|....*....|..
gi 77735781  238 QN-SVEIIHLLIDYGANLKCKNAQGQSALDLA 268
Cdd:PHA02874 264 PPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 282-323 1.17e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 66.75  E-value: 1.17e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-191 4.03e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 4.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVHLASPIHEAVKRGNRECMEI 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 77735781   182 LLANNVNIDQ 191
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-156 7.74e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 7.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781    69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgVTVHGATPLFNACCSGSAACVN 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 77735781   149 VLLEFGAK 156
Cdd:pfam12796  79 LLLEKGAD 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 115-273 7.62e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 7.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  115 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILLANNVNIDQE 192
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  193 VPHLGTPLYAACTY-QRLDCVKKLLELGANVNHGQWLD--TPLHAAAKqnSVEIIHLLIDYGANLKCKNAQGQSALDLAA 269
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 77735781  270 PKSS 273
Cdd:PHA02878 309 KQYL 312
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 76-269 1.36e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   76 GRLLALKTLIAQGVN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFG 154
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  155 AKAQLevhlaSPIHEAvkrgNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN----HGQWldt 230
Cdd:PHA02874  92 VDTSI-----LPIPCI----EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNieddNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 77735781  231 PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 269
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 67-253 4.48e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 4.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH-GATPLFNACCSGSAA 145
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  146 CVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH 224
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 77735781  225 -GQWLD-TPLHAAAKQNSVEIIHLLIDYGAN 253
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 284-323 9.56e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.02  E-value: 9.56e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 101-275 1.63e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 1.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGNRECM 179
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  180 EILLANNVNIDQEVPHLG-TPLYAACTYQRLDCVKKLLELGANVNHGQwLD--TPLHAAAKQNSVEIIHLLIDYGANLKC 256
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 77735781  257 KNAQGQSALDLAAPKSSVE 275
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 69-262 1.68e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 148
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  149 VLLEFGAKAQLEVHLA-SPIHEAVKRgNRECMEiLLANNVNIDQEVPHLGTPLYAACTYQ-RLDCVKKLLELGANV---- 222
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAIIH-NRSAIE-LLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADIsikd 285

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 77735781  223 NHGQwldTPLHAAAKQ-NSVEIIHLLIdygANLKCKNAQGQ 262
Cdd:PHA02874 286 NKGE---NPIDTAFKYiNKDPVIKDII---ANAVLIKEADK 320
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-258 7.67e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 7.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVhgatPLFNAccsgsaAC 146
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI----PCIEK------DM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  147 VNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGA--NVN 223
Cdd:PHA02874 107 IKTILDCGIDVNIkDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVK 186

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 77735781  224 HgQWLDTPLHAAAKQNSVEIIHLLIDYGANL--KCKN 258
Cdd:PHA02874 187 D-NNGESPLHNAAEYGDYACIKLLIDHGNHImnKCKN 222
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 283-321 1.44e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.63  E-value: 1.44e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 77735781   283 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 321
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 133-282 3.63e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 3.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  133 TPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNID-QEVPHLGTplyaactyqrlD 210
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSiLPIPCIEK-----------D 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 77735781  211 CVKKLLELGANVN-HGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 282
Cdd:PHA02874 106 MIKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-269 4.20e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   95 TINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKR 173
Cdd:PHA02876 142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiIALDDLSVLECAVDS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  174 GNRECMEILLANNVNIDQEvphlGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSV-EIIHLLIDYG 251
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSLsRLVPKLLERG 297

                        170
                 ....*....|....*...
gi 77735781  252 ANLKCKNAQGQSALDLAA 269
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMA 315
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-266 6.72e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.57  E-value: 6.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   71 EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGVTVHGATPLFnaCCSGSAACV 147
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLH--LYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  148 NVllefgakaqlevhlaspiheavkrgnrecMEILLANNVNIDQEVPHLGTPLYAACTYQRLD--CVKKLLELGANVN-- 223
Cdd:PHA03095  98 DV-----------------------------IKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNal 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 77735781  224 --HGQwldTPLHAAAKQN--SVEIIHLLIDYGANLKCKNAQGQSALD 266
Cdd:PHA03095 149 dlYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 135-280 8.68e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 8.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  135 LFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVK 213
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 77735781  214 KLLELGANVNHGQWLD--TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 280
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 57-224 4.82e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 4.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   57 GEISDCWADrSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLF 136
Cdd:PLN03192 518 GEHDDPNMA-SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  137 NACCSGSAACVNVLLEFGAKAqlEVHLASPIH-EAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKL 215
Cdd:PLN03192 597 NAISAKHHKIFRILYHFASIS--DPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674


                 ....*....
gi 77735781  216 LELGANVNH 224
Cdd:PLN03192 675 IMNGADVDK 683
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-248 1.86e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLfnaccsgsa 144
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL--------- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  145 acvnvllefgakaqlevhlaspiHEAVKR-GNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQRLdcVKKLLELGANV 222
Cdd:PHA02878 239 -----------------------HISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKSERK--LKLLLEYGADI 293

                        170       180
                 ....*....|....*....|....*...
gi 77735781  223 NHGQWL-DTPLHAAAKQNS-VEIIHLLI 248
Cdd:PHA02878 294 NSLNSYkLTPLSSAVKQYLcINIGRILI 321
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 282-323 2.50e-07

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 46.78  E-value: 2.50e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03721   1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 67-196 2.51e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   67 SPLHEAAAQGR--LLALKTLIAQGVNVNLvtINRVsslheaclgghvacaKALLENGAHVNGVTVHGATPLFNACCSGSA 144
Cdd:PHA03100 143 NLLHLYLESNKidLKILKLLIDKGVDINA--KNRV---------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNP 205

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 77735781  145 ACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHL 196
Cdd:PHA03100 206 EFVKYLLDLGANPNLvNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 114-183 3.98e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 3.98e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77735781  114 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILL 183
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-118 4.67e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 4.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77735781    66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 118
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 284-323 6.26e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 45.37  E-value: 6.26e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 29-221 6.71e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   29 KVFLallthFYIVKGNRKEAARI-----AEEIFGEISDCWadrsPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLH 103
Cdd:PHA02874 125 KTFL-----HYAIKKGDLESIKMlfeygADVNIEDDNGCY----PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  104 EACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAAcVNVLLEFGAKAQLEVHLASPIHEAVKRG-NRECMEIL 182
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-IELLINNASINDQDIDGSTPLHHAINPPcDIDIIDIL 274

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 77735781  183 LANNVNIDQEVPHLGTPLYAACTYQRLDCVKKllELGAN 221
Cdd:PHA02874 275 LYHKADISIKDNKGENPIDTAFKYINKDPVIK--DIIAN 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 81-224 2.25e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   81 LKTLIAQGVNVNLVTINRVSSLHeACLGG---HVACAKALLENGAHVNGVTVHGATPLfnACCSGSAAC----VNVLLEF 153
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  154 GAKAQ---------LEVHLASP------IHEAVKRG-----------------------NRECMEILLANNVNIDQEVPH 195
Cdd:PHA03095 177 GADVYavddrfrslLHHHLQSFkprariVRELIRAGcdpaatdmlgntplhsmatgsscKRSLVLPLLIAGISINARNRY 256

                        170       180       190
                 ....*....|....*....|....*....|
gi 77735781  196 LGTPL-YAACTYQRLDCVKkLLELGANVNH 224
Cdd:PHA03095 257 GQTPLhYAAVFNNPRACRR-LIALGADINA 285
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 284-323 2.45e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 43.71  E-value: 2.45e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03724   3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-125 4.26e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 4.26e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781    66 RSPLHEAAAQGRLLALKTLIAQgVNVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 125
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-248 4.66e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 4.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77735781   198 TPLYAACTYQRLDCVKKLLELGANVNH--GQWlDTPLHAAAKQNSVEIIHLLI 248
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLLL 54
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 284-323 5.25e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 42.79  E-value: 5.25e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03720   3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
215-268 7.23e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 7.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 77735781   215 LLELG-ANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLA 268
Cdd:pfam13857   1 LLEHGpIDLNRlDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 284-321 1.18e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.04  E-value: 1.18e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 321
Cdd:cd03723   3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 102-283 1.43e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS--------------------- 143
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  144 --------------------------AACVNVLLEFGAKAQL--EVHLASPIHEAVKRGNRECMEILLANNVNIDqeVPH 195
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVN--IPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  196 LG--TPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLH-AAAKQNSVEIIHLLIDYGAnlkCKNAQ----GQSALDL 267
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGV---DVNAKsyilGLTALHS 275

                        250
                 ....*....|....*.
gi 77735781  268 AApKSSVEQALLLREG 283
Cdd:PHA02878 276 SI-KSERKLKLLLEYG 290
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 285-323 1.52e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.24  E-value: 1.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 77735781    285 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 323
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
230-280 2.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 77735781   230 TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 280
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 284-323 3.21e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 40.73  E-value: 3.21e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 284-322 4.79e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 40.15  E-value: 4.79e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLY 322
Cdd:cd03729   3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-151 6.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77735781    98 RVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 151
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 69-157 8.43e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 148
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 77735781  149 VLL-------EFGAKA 157
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 63-156 1.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781   63 WADRSPLHEAAAQGRL----------------------------------LALKTLIAQGVNVNLVTINRVSSLHEACLG 108
Cdd:PHA02876 373 YCDKTPIHYAAVRNNVviintlldygadiealsqkigtalhfalcgtnpyMSVKTLIDRGANVNSKNKDLSTPLHYACKK 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 77735781  109 G-HVACAKALLENGAHVNGVTVHGATPLFNACcsGSAACVNVLLEFGAK 156
Cdd:PHA02876 453 NcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE 499
PHA03095 PHA03095
ankyrin-like protein; Provisional
 201-283 1.75e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  201 YAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHA---AAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQ 276
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFrGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLD 98


                 ....*....
gi 77735781  277 --ALLLREG 283
Cdd:PHA03095  99 viKLLIKAG 107
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 133-265 3.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 3.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781 133 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 204
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77735781 205 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 265
Cdd:cd22192  98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 181-273 4.61e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  181 ILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNhgqWLD----TPLHAAAKQNSVEIIHLLI-------D 249
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT---LLDkdgkTPLELAEENGFREVVQLLSrhsqchfE 176

                         90       100
                 ....*....|....*....|....
gi 77735781  250 YGANLKCKNAQGQSALDLAAPKSS 273
Cdd:PTZ00322 177 LGANAKPDSFTGKPPSLEDSPISS 200
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 229-254 5.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 5.18e-04
                           10        20
                   ....*....|....*....|....*.
gi 77735781    229 DTPLHAAAKQNSVEIIHLLIDYGANL 254
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 56-130 7.09e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.39  E-value: 7.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 77735781   56 FGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH 130
Cdd:PLN03192 613 FASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 284-323 8.30e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 36.47  E-value: 8.30e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 77735781 284 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 282-323 1.02e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 36.54  E-value: 1.02e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 77735781 282 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03719   1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 282-323 1.37e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.36  E-value: 1.37e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 77735781 282 EGPPALSQLCRLCVRKCLGR---NCHKTIHKLYLPDPLEKFLLYQ 323
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 229-258 1.65e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 77735781   229 DTPLHAAAKQ-NSVEIIHLLIDYGANLKCKN 258
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_2 pfam12796
Ankyrin repeats (3 copies);
232-269 1.69e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 77735781   232 LHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 269
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
165-216 2.55e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 2.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77735781   165 SPIHEAVKRGNRECMEILLANNVNIDqEVPHLG-TPLYAACTYQRLDCVKKLL 216
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGeTALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
84-135 2.76e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 2.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77735781    84 LIAQG-VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL 135
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02798 PHA02798
ankyrin-like protein; Provisional
 115-265 3.43e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.05  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  115 KALLENGAHVNGVTVHGATPLfnaCCSGSAACVNVL------LEFGAKAQLevhlaspiheaVKRGNRECMEILLANNVN 188
Cdd:PHA02798  93 KILIENGADINKKNSDGETPL---YCLLSNGYINNLeillfmIENGADTTL-----------LDKDGFTMLQVYLQSNHH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  189 IDqevphlgtplyaactyqrLDCVKKLLELGANVN-HGQWLD-TPLHAAAKQN----SVEIIHLLIDYGANLKCKNAQGQ 262
Cdd:PHA02798 159 ID------------------IEIIKLLLEKGVDINtHNNKEKyDTLHCYFKYNidriDADILKLFVDNGFIINKENKSHK 220


                 ...
gi 77735781  263 SAL 265
Cdd:PHA02798 221 KKF 223
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 210-263 4.50e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 38.57  E-value: 4.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  210 DCVKKLLELGANVNHGQWLDTPLHAAAKQNSV------EIIHLLIDYGANLKCKNAQGQS 263
Cdd:PHA02989  51 KIVKLLIDNGADVNYKGYIETPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVS 110
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 215-275 5.18e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 5.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77735781  215 LLELGANVNHGQ-WLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVE 275
Cdd:PHA02876 164 LLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID 225
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 165-265 6.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 37.49  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735781  165 SPIHEAV--KRGNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQR---LDCVKKLLELGANVNHgqwLD----TPLHA 234
Cdd:PHA02859  53 TPIFSCLekDKVNVEILKFLIENGADVNFKTRDNNlSALHHYLSFNKnvePEILKILIDSGSSITE---EDedgkNLLHM 129

                         90       100       110
                 ....*....|....*....|....*....|...
gi 77735781  235 AAKQNSV--EIIHLLIDYGANLKCKNAQGQSAL 265
Cdd:PHA02859 130 YMCNFNVriNVIKLLIDSGVSFLNKDFDNNNIL 162
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 198-223 6.23e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 6.23e-03
                           10        20
                   ....*....|....*....|....*.
gi 77735781    198 TPLYAACTYQRLDCVKKLLELGANVN 223
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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