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Conserved domains on  [gi|85701652|ref|NP_001028321|]
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tetratricopeptide repeat protein 9A [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
121-210 2.61e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 2.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 121 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDT 195
Cdd:COG0457  67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                        90
                ....*....|....*
gi 85701652 196 NVIRYIQLTEMKLSR 210
Cdd:COG0457 145 DALYNLGIALEKLGR 159
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-210 2.61e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 2.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 121 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDT 195
Cdd:COG0457  67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                        90
                ....*....|....*
gi 85701652 196 NVIRYIQLTEMKLSR 210
Cdd:COG0457 145 DALYNLGIALEKLGR 159
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 114-210 1.03e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652   114 EEQSKTVEAIEIDCYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEART 189
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSPLAHYLKALVDfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK 323

                          90       100
                  ....*....|....*....|.
gi 85701652   190 RQPTDTNVIRYIQLTEMKLSR 210
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGR 344
TPR_1 pfam00515
Tetratricopeptide repeat;
162-194 6.01e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 6.01e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 85701652   162 KALYRSGVAFYHLGDYDKALYYLKEARTRQPTD 194
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 161-194 1.88e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 85701652    161 FKALYRSGVAFYHLGDYDKALYYLKEARTRQPTD 194
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
lysogeny_AimR NF038310
AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR ...
 126-218 8.22e-03

AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR (arbitrium receptor), is a DNA-binding phage regulatory protein that acts as a receptor for a 6-amino acid signaling peptide cleaved from the C-terminus of AimP. AimR controls expression of AimX, the third member of the quorum sensing-like arbitrium system and an inhibitor of phage lysogeny.


Pssm-ID: 468467  Cd Length: 363  Bit Score: 36.74  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652  126 DCYNS-----LAACLLQAElvNYERVKEYCLKVLKKEGE--NFKAlyrsgVAFYHLG------DYDKALYYLKEArtrqp 192
Cdd:NF038310 183 DSYEYrikelLAYAYLRRN--ELEEAREYCNEIINSANNfpLLKA-----TAYYCLGesyifeDYEKALKYLEKS----- 250

                         90       100
                 ....*....|....*....|....*.
gi 85701652  193 tdtnvirYIQLTEMKLSRCSQREKEA 218
Cdd:NF038310 251 -------LELLKKIKNKKIERKYKAF 269
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-210 2.61e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 2.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 121 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDT 195
Cdd:COG0457  67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                        90
                ....*....|....*
gi 85701652 196 NVIRYIQLTEMKLSR 210
Cdd:COG0457 145 DALYNLGIALEKLGR 159
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 114-210 1.03e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652   114 EEQSKTVEAIEIDCYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEART 189
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSPLAHYLKALVDfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK 323

                          90       100
                  ....*....|....*....|.
gi 85701652   190 RQPTDTNVIRYIQLTEMKLSR 210
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGR 344
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-210 1.15e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 121 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDT 195
Cdd:COG0457  33 KALELDpddaeALYNLGLAYLRLG--RYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                        90
                ....*....|....*
gi 85701652 196 NVIRYIQLTEMKLSR 210
Cdd:COG0457 111 EALYNLGLALLELGR 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 128-196 1.42e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 1.42e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85701652 128 YNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDTN 196
Cdd:COG4235  54 LLDLAEALLAAG--DTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 131-197 5.03e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 5.03e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 85701652 131 LAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDTNV 197
Cdd:COG4783  10 LAQALLLAG--DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA 74
TPR_1 pfam00515
Tetratricopeptide repeat;
162-194 6.01e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 6.01e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 85701652   162 KALYRSGVAFYHLGDYDKALYYLKEARTRQPTD 194
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 142-210 6.24e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 6.24e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85701652 142 NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDTNVIRYIQLTEMKLSR 210
Cdd:COG5010  69 DFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
126-194 6.83e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 6.83e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85701652 126 DCYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTD 194
Cdd:COG0457   9 EAYNNLGLAYRRLG--RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-207 1.20e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 121 EAIEIDcYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDTN 196
Cdd:COG2956 169 KALKLD-PDCARALLLLAELYleqgDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247

                        90
                ....*....|.
gi 85701652 197 VIRYIQLTEMK 207
Cdd:COG2956 248 LLALADLLERK 258
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 161-194 1.88e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 85701652    161 FKALYRSGVAFYHLGDYDKALYYLKEARTRQPTD 194
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
46-208 2.17e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.97  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652  46 AAEPAELIRRAHEFKSQGAQCYKDKKFREAIGKYHRALLELKGLLPSQEERDARPASSAGVPKSSRL-------SEEQSK 118
Cdd:COG4785   9 LLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLyyergvaYDSLGD 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652 119 TVEAIE------------IDCYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKE 186
Cdd:COG4785  89 YDLAIAdfdqaleldpdlAEAYNNRGLAYLLLG--DYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                       170       180
                ....*....|....*....|..
gi 85701652 187 ARTRQPTDTNVIRYIQLTEMKL 208
Cdd:COG4785 167 ALELDPNDPERALWLYLAERKL 188
lysogeny_AimR NF038310
AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR ...
 126-218 8.22e-03

AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR (arbitrium receptor), is a DNA-binding phage regulatory protein that acts as a receptor for a 6-amino acid signaling peptide cleaved from the C-terminus of AimP. AimR controls expression of AimX, the third member of the quorum sensing-like arbitrium system and an inhibitor of phage lysogeny.


Pssm-ID: 468467  Cd Length: 363  Bit Score: 36.74  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701652  126 DCYNS-----LAACLLQAElvNYERVKEYCLKVLKKEGE--NFKAlyrsgVAFYHLG------DYDKALYYLKEArtrqp 192
Cdd:NF038310 183 DSYEYrikelLAYAYLRRN--ELEEAREYCNEIINSANNfpLLKA-----TAYYCLGesyifeDYEKALKYLEKS----- 250

                         90       100
                 ....*....|....*....|....*.
gi 85701652  193 tdtnvirYIQLTEMKLSRCSQREKEA 218
Cdd:NF038310 251 -------LELLKKIKNKKIERKYKAF 269
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 142-192 9.40e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 34.97  E-value: 9.40e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 85701652 142 NYERVKEYCLKVLKKEGENFK---ALYRSGVAFYHLGDYDKALYYLKEARTRQP 192
Cdd:COG1729  45 DYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYDKARATLEELIKKYP 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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