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Conserved domains on  [gi|237858695|ref|NP_001028174|]
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RPA-interacting protein isoform b [Homo sapiens]

Protein Classification

RPA_interact_N and RPA_interact_C domain-containing protein( domain architecture ID 10632127)

protein containing domains RPA_interact_N, RPA_interact_M, and RPA_interact_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 3.06e-29

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


:

Pssm-ID: 464305  Cd Length: 80  Bit Score: 104.30  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695  136 ICPVCTKYNLRITSGVVVCQCGLSIPsHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEkSSLLMSCLACDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLN-TGDSITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGL-SSLYLSCESCDFL 78


                  ..
gi 237858695  216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 2.16e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


:

Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.16  E-value: 2.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858695    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 6.80e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


:

Pssm-ID: 434193  Cd Length: 82  Bit Score: 64.36  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858695  127 L 127
Cdd:pfam14767  82 V 82
 
Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 3.06e-29

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 104.30  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695  136 ICPVCTKYNLRITSGVVVCQCGLSIPsHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEkSSLLMSCLACDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLN-TGDSITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGL-SSLYLSCESCDFL 78


                  ..
gi 237858695  216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 2.16e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.16  E-value: 2.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858695    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 6.80e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 64.36  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858695  127 L 127
Cdd:pfam14767  82 V 82
 
Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 3.06e-29

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 104.30  E-value: 3.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695  136 ICPVCTKYNLRITSGVVVCQCGLSIPsHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEkSSLLMSCLACDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLN-TGDSITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGL-SSLYLSCESCDFL 78


                  ..
gi 237858695  216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 2.16e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.16  E-value: 2.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 237858695    8 PRRSLYKlVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQA 47
Cdd:pfam14766   1 PRRASYK-SRSPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 60-127 6.80e-14

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 64.36  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237858695   60 LVQEVMEEEWNALQSVENCPE-------DLAQLEELIDM------AVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIM 126
Cdd:pfam14767   2 AVQEVMSDELEKLKQSSTSLPslkiptaDNDDMGESEDIllemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAAA 81


                  .
gi 237858695  127 L 127
Cdd:pfam14767  82 V 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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