|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-380 |
7.63e-148 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 428.80 E-value: 7.63e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 1 MAGFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYG-IFCLVLTPT 79
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRaPQALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 80 RELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSsNTFNMKKIQFLVMDEADRLLE 159
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEADRMLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 160 QGctdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVKDAYLVHLV 239
Cdd:COG0513 160 MG---FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 240 QTFQDQledcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQV 319
Cdd:COG0513 237 RDEDPE----RAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSH 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67972435 320 VINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAE 380
Cdd:COG0513 313 VINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPGFE 373
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
4-208 |
6.01e-132 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 380.03 E-value: 6.01e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSN--TFNMKKIQFLVMDEADRLLEqg 161
Cdd:cd17955 81 YQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDdtTKVLSRVKFLVLDEADRLLT-- 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 67972435 162 cTDFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWE 208
Cdd:cd17955 159 -GSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
1-372 |
1.14e-95 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 296.71 E-value: 1.14e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 1 MAGFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTR 80
Cdd:PRK11776 3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 81 ELAYQIAEQFRVLGKPL-GLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLE 159
Cdd:PRK11776 83 ELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLR-KGTLDLDALNTLVLDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 160 QGctdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPffweAQATVRTVEQL---DQRYLLVPEKVKDAYLV 236
Cdd:PRK11776 162 MG---FQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDP----VEVKVESTHDLpaiEQRFYEVSPDERLPALQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 237 HLVQTFQDQledcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKF--KSSiyRILIATDVASRGLDI 314
Cdd:PRK11776 235 RLLLHHQPE----SCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFanRSC--SVLVATDVAARGLDI 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 67972435 315 PTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLA 372
Cdd:PRK11776 309 KALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLN 366
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
4-204 |
2.23e-93 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 281.51 E-value: 2.23e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQgct 163
Cdd:cd17954 82 QQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLNM--- 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 67972435 164 DFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17954 159 DFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
4-459 |
5.39e-93 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 288.76 E-value: 5.39e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSE----DPYGIFCLVLTPT 79
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfprrKSGPPRILILTPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 80 RELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEADRLLE 159
Cdd:PRK11192 83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEEN-FDCRAVETLILDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 160 QGctdFTTDLETILAAVPARRQTLLFSATLT-DTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKV-KDAYLVH 237
Cdd:PRK11192 162 MG---FAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEPSRRERKKIHQWYYRADDLEhKTALLCH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 238 LVQtfQDQLEdcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTV 317
Cdd:PRK11192 239 LLK--QPEVT--RSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 318 QVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEaevlqiLTQVNVVRRECEI 397
Cdd:PRK11192 315 SHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIEEPLKARVIDE------LRPKTKAPSEKKT 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67972435 398 KLeashfDEKKEINKRKqmilegkdpdlEAKRKAELAKIKQQNRRFKEKVGQtlRRQKAGST 459
Cdd:PRK11192 389 GK-----PSKKVLAKRA-----------EKKEKEKEKPKVKKRHRDTKNIGK--RRKPSGTS 432
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
13-204 |
3.19e-81 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 250.05 E-value: 3.19e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY----GIFCLVLTPTRELAYQIAE 88
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 89 QFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQGctdFTTD 168
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIE-RGKLDLSNVKYLVLDEADRMLDMG---FEED 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 67972435 169 LETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd00268 157 VEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNP 192
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
4-441 |
2.05e-80 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 262.09 E-value: 2.05e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPL-GLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSnTFNMKKIQFLVMDEADRLLEQGc 162
Cdd:PRK11634 88 VQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRG-TLDLSKLSGLVLDEADEMLRMG- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 163 tdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVKDAYLVHLVQTf 242
Cdd:PRK11634 166 --FIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEA- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 243 qdqlEDC-SIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVI 321
Cdd:PRK11634 243 ----EDFdAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 322 NHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAEvlqILTQVNVVRRECEI--KL 399
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIPEVELPNAE---LLGKRRLEKFAAKVqqQL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 67972435 400 EASHFDEKKEINKRKQMILEGKDPDLEAkRKAELAKIKQQNR 441
Cdd:PRK11634 396 ESSDLDQYRALLAKIQPTAEGEELDLET-LAAALLKMAQGER 436
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
4-380 |
3.92e-79 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 253.58 E-value: 3.92e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYG------IFCLVLT 77
Cdd:PRK10590 3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHakgrrpVRALILT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 78 PTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADRL 157
Cdd:PRK10590 83 PTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 158 LEQGctdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVKDAYLVH 237
Cdd:PRK10590 162 LDMG---FIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLSQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 238 LVQTFQDQledcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTV 317
Cdd:PRK10590 239 MIGKGNWQ----QVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEEL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67972435 318 QVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAE 380
Cdd:PRK10590 315 PHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIPRIAIPGYE 377
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
4-353 |
2.48e-76 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 248.92 E-value: 2.48e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-----GIFCLVLTP 78
Cdd:PTZ00110 132 FEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLlrygdGPIVLVLAP 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 79 TRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTfNMKKIQFLVMDEADRLL 158
Cdd:PTZ00110 212 TRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVT-NLRRVTYLVLDEADRML 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 159 EQGctdFTTDLETILAAVPARRQTLLFSATLTdtlKELQGLATN----EPFFWEAQA-TVRTVEQLDQRYLLVPEKVKDA 233
Cdd:PTZ00110 291 DMG---FEPQIRKIVSQIRPDRQTLMWSATWP---KEVQSLARDlckeEPVHVNVGSlDLTACHNIKQEVFVVEEHEKRG 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 234 YLVHLVQtfQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLD 313
Cdd:PTZ00110 365 KLKMLLQ--RIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLD 442
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 67972435 314 IPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVT 353
Cdd:PTZ00110 443 VKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT 482
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
13-204 |
9.79e-69 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 217.89 E-value: 9.79e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIF---CLVLTPTRELAYQIAEQ 89
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAatrVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 90 FRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGctdFTTDL 169
Cdd:cd17947 81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEG---FADEL 157
|
170 180 190
....*....|....*....|....*....|....*
gi 67972435 170 ETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17947 158 KEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
3-204 |
3.28e-62 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 201.38 E-value: 3.28e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 3 GFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL--SEDPYGIFCLVLTPTR 80
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLkaHSPTVGARALILSPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 81 ELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEADRLLEQ 160
Cdd:cd17959 82 ELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMN-LKLSSVEYVVFDEADRLFEM 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 67972435 161 GctdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17959 161 G---FAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEP 201
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
26-196 |
1.75e-60 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 195.54 E-value: 1.75e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 26 TPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIV 105
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 106 GGMDMVAQALELsRKPHVVIATPGRLADHLRSSNTFnmKKIQFLVMDEADRLLEQGctdFTTDLETILAAVPARRQTLLF 185
Cdd:pfam00270 81 GGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLLDMG---FGPDLEEILRRLPKKRQILLL 154
|
170
....*....|.
gi 67972435 186 SATLTDTLKEL 196
Cdd:pfam00270 155 SATLPRNLEDL 165
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
4-378 |
1.32e-59 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 205.57 E-value: 1.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL----------SEDPYGifc 73
Cdd:PRK04537 11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpaladrkPEDPRA--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 74 LVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDE 153
Cdd:PRK04537 88 LILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 154 ADRLLEQGctdFTTDLETILAAVPAR--RQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVK 231
Cdd:PRK04537 168 ADRMFDLG---FIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 232 DAYLVHLVQtfqdQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRG 311
Cdd:PRK04537 245 QTLLLGLLS----RSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARG 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67972435 312 LDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQL-AELVVEE 378
Cdd:PRK04537 321 LHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIpVEPVTAE 388
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
4-200 |
4.99e-59 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 193.47 E-value: 4.99e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGI----------FC 73
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSvgrgrrkaypSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 74 LVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMDE 153
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFI-ERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 67972435 154 ADRLLEQGctdFTTDLETILAA----VPARRQTLLFSATLTdtlKELQGLA 200
Cdd:cd17967 161 ADRMLDMG---FEPQIRKIVEHpdmpPKGERQTLMFSATFP---REIQRLA 205
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
3-371 |
7.06e-59 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 201.29 E-value: 7.06e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 3 GFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYG-------IFCLV 75
Cdd:PRK01297 88 RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPkerymgePRALI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 76 LTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALEL-SRKPHVVIATPGRLADhlrssntFNMKK------IQF 148
Cdd:PRK01297 168 IAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLeARFCDILVATPGRLLD-------FNQRGevhldmVEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 149 LVMDEADRLLEQGctdFTTDLETILAAVP--ARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLV 226
Cdd:PRK01297 241 MVLDEADRMLDMG---FIPQVRQIIRQTPrkEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAV 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 227 PEKVKDAYLVHLVQtfQDQLEdcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATD 306
Cdd:PRK01297 318 AGSDKYKLLYNLVT--QNPWE--RVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATD 393
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67972435 307 VASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQL 371
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKI 458
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
4-382 |
5.25e-57 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 194.27 E-value: 5.25e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLAD-----HLRssntfnMKKIQFLVMDEADRLL 158
Cdd:PTZ00424 110 QQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDmidkrHLR------VDDLKLFILDEADEML 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 159 EQGctdFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLV-PEKVKDAYLVH 237
Cdd:PTZ00424 184 SRG---FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVeKEEWKFDTLCD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 238 LVQTfqdqLEDCSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTV 317
Cdd:PTZ00424 261 LYET----LTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQV 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67972435 318 QVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAEVL 382
Cdd:PTZ00424 337 SLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
20-190 |
2.12e-53 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 179.36 E-value: 2.12e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 20 LGLKQPTPVQLGCIP-AILEGRDCLGCAKTGSGKTAAFVLPILQKL-----SEDPYGI----FCLVLTPTRELAYQIAEQ 89
Cdd:cd17946 8 LGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLlsqksSNGVGGKqkplRALILTPTRELAVQVKDH 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 90 FRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTF--NMKKIQFLVMDEADRLLEQGCTDftt 167
Cdd:cd17946 88 LKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHlaNLKSLRFLVLDEADRMLEKGHFA--- 164
|
170 180 190
....*....|....*....|....*....|
gi 67972435 168 DLETILAAVPA-------RRQTLLFSATLT 190
Cdd:cd17946 165 ELEKILELLNKdragkkrKRQTFVFSATLT 194
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
18-206 |
7.31e-53 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 176.71 E-value: 7.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL------SEDpyGIFCLVLTPTRELAYQIAEQFR 91
Cdd:cd17941 6 KEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyrerwtPED--GLGALIISPTRELAMQIFEVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 92 VLGKPLGLKDCIIVGGMDMVAQALELSRKpHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGctdFTTDLET 171
Cdd:cd17941 84 KVGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMG---FKETLDA 159
|
170 180 190
....*....|....*....|....*....|....*
gi 67972435 172 ILAAVPARRQTLLFSATLTDTLKELQGLATNEPFF 206
Cdd:cd17941 160 IVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEY 194
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
19-205 |
1.16e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 176.62 E-value: 1.16e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 19 QLGLKQPTPVQLGCIPAILE-GRDCLGCAKTGSGKTAAFVLPILQKLSEDP-----YGIFCLVLTPTRELAYQIAEQFR- 91
Cdd:cd17964 11 RMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKpagrrSGVSALIISPTRELALQIAAEAKk 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 92 VLGKPLGLKDCIIVGGMDMVAQALELSR-KPHVVIATPGRLADHLRSSNTFNM-KKIQFLVMDEADRLLEQGctdFTTDL 169
Cdd:cd17964 91 LLQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADRLLDMG---FRPDL 167
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 67972435 170 ETILAAVPAR----RQTLLFSATLTDTLKELQGLATNEPF 205
Cdd:cd17964 168 EQILRHLPEKnadpRQTLLFSATVPDEVQQIARLTLKKDY 207
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
219-352 |
4.21e-52 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 172.31 E-value: 4.21e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 219 LDQRYLLVPEKVKDAYLVHLvqtFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSI 298
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLL---LLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 67972435 299 YRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLV 352
Cdd:cd18787 78 VRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
4-371 |
6.67e-51 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 178.63 E-value: 6.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIF-------CLVL 76
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDrkvnqprALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 77 TPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADR 156
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAK-QNHINLGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 157 LLEQGctdFTTDLETILAAVPA--RRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLdQRYLLVP---EKVK 231
Cdd:PRK04837 169 MFDLG---FIKDIRWLFRRMPPanQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRI-KEELFYPsneEKMR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 232 daylvhLVQTF--QDQLEDCsiIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVAS 309
Cdd:PRK04837 245 ------LLQTLieEEWPDRA--IIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67972435 310 RGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLV-TQYDIHlLHAIEEQIKQQL 371
Cdd:PRK04837 317 RGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLAcEEYALN-LPAIETYIGHSI 378
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
13-196 |
3.63e-50 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 170.58 E-value: 3.63e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY--------GIFCLVLTPTRELAY 84
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPldeetkddGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 85 QIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMDEADRLLEQGctd 164
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCL-ERRLLVLNQCTYVVLDEADRMIDMG--- 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 67972435 165 FTTDLETILAAVP--------------------ARRQTLLFSATLTDTLKEL 196
Cdd:cd17945 157 FEPQVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKI 208
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
13-196 |
1.41e-49 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 168.15 E-value: 1.41e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSE--DPYGIFCLVLTPTRELAYQIAEQF 90
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKprKKKGLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 91 RVLGKPLGLKDCIIVGGM-DMVAQALELSRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQGctdFTTDL 169
Cdd:cd17957 81 LKLSKGTGLRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLK-QGPIDLSSVEYLVLDEADKLFEPG---FREQT 156
|
170 180
....*....|....*....|....*...
gi 67972435 170 ETILAAVPARR-QTLLFSATLTDTLKEL 196
Cdd:cd17957 157 DEILAACTNPNlQRSLFSATIPSEVEEL 184
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
18-205 |
7.86e-49 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 166.61 E-value: 7.86e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL------SEDPYGIFCLVLTPTRELAYQIAEQFR 91
Cdd:cd17961 10 AKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTRELAQQVSKVLE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 92 VL----GKPLGLKDciIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGCTDftt 167
Cdd:cd17961 90 QLtaycRKDVRVVN--LSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSYGYEE--- 164
|
170 180 190
....*....|....*....|....*....|....*...
gi 67972435 168 DLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPF 205
Cdd:cd17961 165 DLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
20-206 |
8.01e-49 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 166.61 E-value: 8.01e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 20 LGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY------GIFCLVLTPTRELAYQIAEQFRVL 93
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPrvdrsdGTLALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 94 GKP-LGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGctdFTTDLETI 172
Cdd:cd17949 89 LKPfHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMG---FEKDITKI 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 67972435 173 LAAV-------------PARRQTLLFSATLTDTLKELQGLATNEPFF 206
Cdd:cd17949 166 LELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVY 212
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
19-196 |
2.45e-48 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 165.06 E-value: 2.45e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 19 QLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL-----SEDPYGIFCLVLTPTRELAYQIaeqFRVL 93
Cdd:cd17960 7 ELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILlkrkaNLKKGQVGALIISPTRELATQI---YEVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 94 GK-----PLGLKDCIIVGGMDMVAQALELSR-KPHVVIATPGRLADHLRSSNT-FNMKKIQFLVMDEADRLLEQGctdFT 166
Cdd:cd17960 84 QSflehhLPKLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEELLSRKADkVKVKSLEVLVLDEADRLLDLG---FE 160
|
170 180 190
....*....|....*....|....*....|
gi 67972435 167 TDLETILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEEL 190
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
18-206 |
1.11e-47 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 163.43 E-value: 1.11e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEG-RDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIfCLVLTPTRELAYQIAEQFRVLGKP 96
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGGR-VLVLVPTRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 97 LGLKDCIIVGGMDMVAQALEL-SRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQGctdFTTDLETILAA 175
Cdd:smart00487 81 LGLKVVGLYGGDSKREQLRKLeSGKTDILVTTPGRLLDLLE-NDKLSLSNVDLVILDEAHRLLDGG---FGDQLEKLLKL 156
|
170 180 190
....*....|....*....|....*....|.
gi 67972435 176 VPARRQTLLFSATLTDTLKELQGLATNEPFF 206
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVF 187
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
13-200 |
2.18e-47 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 162.15 E-value: 2.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-----GIFCLVLTPTRELAYQIA 87
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPlergdGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 88 EQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTfNMKKIQFLVMDEADRLLEQGctdFTT 167
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKT-NLRRVTYLVLDEADRMLDMG---FEP 156
|
170 180 190
....*....|....*....|....*....|...
gi 67972435 168 DLETILAAVPARRQTLLFSATLTdtlKELQGLA 200
Cdd:cd17966 157 QIRKIVDQIRPDRQTLMWSATWP---KEVRRLA 186
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
4-200 |
3.26e-47 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 163.98 E-value: 3.26e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDpyGI-----------F 72
Cdd:cd18052 45 FEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKE--GLtassfsevqepQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 73 CLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMD 152
Cdd:cd18052 123 ALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFI-GRGKISLSKLKYLILD 201
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 67972435 153 EADRLLEQGctdFTTDLETILAA--VPA--RRQTLLFSATLTDtlkELQGLA 200
Cdd:cd18052 202 EADRMLDMG---FGPEIRKLVSEpgMPSkeDRQTLMFSATFPE---EIQRLA 247
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
4-205 |
4.11e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 161.70 E-value: 4.11e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADRLLEQgct 163
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILD-LAKKGVADLSHCKTLVLDEADKLLSQ--- 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 67972435 164 DFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEPF 205
Cdd:cd17940 157 DFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
4-368 |
5.06e-46 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 167.66 E-value: 5.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKL-------SEDPYGIFCLVL 76
Cdd:PLN00206 123 FSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCctirsghPSEQRNPLAMVL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 77 TPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADR 156
Cdd:PLN00206 203 TPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLID-LLSKHDIELDNVSVLVLDEVDC 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 157 LLEQGctdFTTDLETILAAVPaRRQTLLFSATLTDTLKELQGLATNEPFFWEAQATVRTVEQLDQRYLLVPEKVKDAYLV 236
Cdd:PLN00206 282 MLERG---FRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLF 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 237 HLVQTFQDQLEdcSIIIFTNTCKTCQILCMMLRKFN-FPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIP 315
Cdd:PLN00206 358 DILKSKQHFKP--PAVVFVSSRLGADLLANAITVVTgLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLL 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 67972435 316 TVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIK 368
Cdd:PLN00206 436 RVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALLK 488
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
4-196 |
1.03e-45 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 158.69 E-value: 1.03e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPIL-----QKLSEDPYGIFCLVLTP 78
Cdd:cd17953 14 WSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhikdQRPVKPGEGPIGLIMAP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 79 TRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSN--TFNMKKIQFLVMDEADR 156
Cdd:cd17953 94 TRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrVTNLRRVTYVVLDEADR 173
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 67972435 157 LLEQGctdFTTDLETILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd17953 174 MFDMG---FEPQIMKIVNNIRPDRQTVLFSATFPRKVEAL 210
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
18-206 |
2.92e-45 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 156.75 E-value: 2.92e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLP---ILQKLSEDPY-GIFCLVLTPTRELAYQIAEQFRVL 93
Cdd:cd17942 6 EEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPaieLLYKLKFKPRnGTGVIIISPTRELALQIYGVAKEL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 94 GKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGctdFTTDLETIL 173
Cdd:cd17942 86 LKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIG---FEEEMRQII 162
|
170 180 190
....*....|....*....|....*....|....
gi 67972435 174 AAVPARRQTLLFSATLTDTLKELQGLA-TNEPFF 206
Cdd:cd17942 163 KLLPKRRQTMLFSATQTRKVEDLARISlKKKPLY 196
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
13-196 |
1.22e-44 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 155.27 E-value: 1.22e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-----GIFCLVLTPTRELAYQIA 87
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRElekgeGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 88 EQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTfNMKKIQFLVMDEADRLLEQGctdFTT 167
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKAT-NLQRVTYLVLDEADRMFDMG---FEY 156
|
170 180
....*....|....*....|....*....
gi 67972435 168 DLETILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd17952 157 QVRSIVGHVRPDRQTLLFSATFKKKIEQL 185
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
21-195 |
5.45e-43 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 150.95 E-value: 5.45e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 21 GLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLP-ILQKLSED---PY----GIFCLVLTPTRELA---YQIAEQ 89
Cdd:cd17951 9 GIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALEQEkklPFikgeGPYGLIVCPSRELArqtHEVIEY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 90 FRVL----GKPlGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMDEADRLLEQGctdF 165
Cdd:cd17951 89 YCKAlqegGYP-QLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDML-NKKKINLDICRYLCLDEADRMIDMG---F 163
|
170 180 190
....*....|....*....|....*....|
gi 67972435 166 TTDLETILAAVPARRQTLLFSATLTDTLKE 195
Cdd:cd17951 164 EEDIRTIFSYFKGQRQTLLFSATMPKKIQN 193
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
25-200 |
6.02e-43 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 152.12 E-value: 6.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 25 PTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFC----------------LVLTPTRELAYQIAE 88
Cdd:cd18051 44 PTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGESLpsesgyygrrkqyplaLVLAPTRELASQIYD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 89 QFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEADRLLEQGctdFTTD 168
Cdd:cd18051 124 EARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK-IGLDYCKYLVLDEADRMLDMG---FEPQ 199
|
170 180 190
....*....|....*....|....*....|....*.
gi 67972435 169 LETILA--AVPAR--RQTLLFSATLTdtlKELQGLA 200
Cdd:cd18051 200 IRRIVEqdTMPPTgeRQTLMFSATFP---KEIQMLA 232
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
13-206 |
3.29e-41 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 147.01 E-value: 3.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEG---------RDCLGCAKTGSGKTAAFVLPILQKLSEDPYG-IFCLVLTPTREL 82
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPrLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 83 AYQIAEQFRVLGKPLGLKDCIIVGGMD--------MVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEA 154
Cdd:cd17956 81 VQQVYKVFESLCKGTGLKVVSLSGQKSfkkeqkllLVDTSGRYLSRVDILVATPGRLVDHLNSTPGFTLKHLRFLVIDEA 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67972435 155 DRLLEQ----------------GCTDFTTDLETILAAVPARR-QTLLFSATLTDTLKELQGLATNEPFF 206
Cdd:cd17956 161 DRLLNQsfqdwletvmkalgrpTAPDLGSFGDANLLERSVRPlQKLLFSATLTRDPEKLSSLKLHRPRL 229
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
3-194 |
1.35e-40 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 144.80 E-value: 1.35e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 3 GFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTREL 82
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTREL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 83 AYQIAEQFRVLGKPL-GLKDCIIVGGMDMVAQALELSRK-PHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQ 160
Cdd:cd17950 83 AFQISNEYERFSKYMpNVKTAVFFGGVPIKKDIEVLKNKcPHIVVGTPGRILALVR-EKKLKLSHVKHFVLDECDKMLEQ 161
|
170 180 190
....*....|....*....|....*....|....
gi 67972435 161 gcTDFTTDLETILAAVPARRQTLLFSATLTDTLK 194
Cdd:cd17950 162 --LDMRRDVQEIFRATPHDKQVMMFSATLSKEIR 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
13-196 |
5.03e-40 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 142.79 E-value: 5.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRV 92
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 93 LGKPL-GLKDCIIVGGMDmVAQALELSRKPHVVIATPGRLAdHLRSSNTFNMKKIQFLVMDEADRLLEQgctDFTTDLET 171
Cdd:cd17943 81 IGKKLeGLKCEVFIGGTP-VKEDKKKLKGCHIAVGTPGRIK-QLIELGALNVSHVRLFVLDEADKLMEG---SFQKDVNW 155
|
170 180
....*....|....*....|....*
gi 67972435 172 ILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNL 180
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
4-189 |
1.74e-37 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 136.30 E-value: 1.74e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSedpygifCLVLTPTRELA 83
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-------ALILEPSRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPL---GLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADRLLEQ 160
Cdd:cd17938 74 EQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLED-LIKTGKLDLSSVRFFVLDEADRLLSQ 152
|
170 180 190
....*....|....*....|....*....|....*
gi 67972435 161 GCTDFttdLETILAAVPA------RRQTLLFSATL 189
Cdd:cd17938 153 GNLET---INRIYNRIPKitsdgkRLQVIVCSATL 184
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
13-204 |
5.04e-37 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 134.90 E-value: 5.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY------GIFCLVLTPTRELAYQI 86
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIpreqrnGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 87 -AEQFRVLGKplGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADRLLEQGctdF 165
Cdd:cd17958 81 eAECSKYSYK--GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDMG---F 154
|
170 180 190
....*....|....*....|....*....|....*....
gi 67972435 166 TTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17958 155 EPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDP 193
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
3-196 |
5.68e-37 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 137.06 E-value: 5.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 3 GFAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-----GIFCLVLT 77
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYlergdGPICLVLA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 78 PTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTfNMKKIQFLVMDEADRL 157
Cdd:cd18050 143 PTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRM 221
|
170 180 190
....*....|....*....|....*....|....*....
gi 67972435 158 LEQGctdFTTDLETILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd18050 222 LDMG---FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 257
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
6-204 |
1.25e-36 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 133.60 E-value: 1.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 6 EIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQ 85
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 86 IAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMDEADRLLEQGctdF 165
Cdd:cd17939 81 IQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDML-QRRSLRTDKIKMFVLDEADEMLSRG---F 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 67972435 166 TTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17939 157 KDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDP 195
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
21-204 |
2.25e-36 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 133.06 E-value: 2.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 21 GLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPL-GL 99
Cdd:cd17962 9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKGLpPM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 100 KDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSnTFNMKKIQFLVMDEADRLLEQGctdFTTDLETILAAVPAR 179
Cdd:cd17962 89 KTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQS-SVELDNIKIVVVDEADTMLKMG---FQQQVLDILENISHD 164
|
170 180
....*....|....*....|....*
gi 67972435 180 RQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd17962 165 HQTILVSATIPRGIEQLAGQLLQNP 189
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
4-196 |
5.50e-36 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 133.21 E-value: 5.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-----GIFCLVLTP 78
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFlergdGPICLVLAP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 79 TRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTfNMKKIQFLVMDEADRLL 158
Cdd:cd18049 106 TRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRML 184
|
170 180 190
....*....|....*....|....*....|....*...
gi 67972435 159 EQGctdFTTDLETILAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd18049 185 DMG---FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 219
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
231-343 |
3.95e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 113.07 E-value: 3.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 231 KDAYLVHLVQTFQDQledcSIIIFTNTCKTCQIlCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASR 310
Cdd:pfam00271 2 KLEALLELLKKERGG----KVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 67972435 311 GLDIPTVQVVINHNTPGLPKIYIHRVGRTARAG 343
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
13-202 |
6.05e-30 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 116.70 E-value: 6.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-------GIFCLVLTPTRELAYQ 85
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLlaegpfnAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 86 IAEQFRVLGKPLGLKDCIIVGG---MDMVAQALElsrKPHVVIATPGRLADhLRSSNTFNMKKIQFLVMDEADRLLEQgc 162
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGrtkRQIRNPHFE---EVDILVATPGALSK-LLTSRIYSLEQLRHLVLDEADTLLDD-- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 67972435 163 tDFTTDLETILAAVP-------------ARRQTLLFSATLTDTLKELQGLATN 202
Cdd:cd17948 155 -SFNEKLSHFLRRFPlasrrsentdgldPGTQLVLVSATMPSGVGEVLSKVID 206
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
20-196 |
2.45e-29 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 113.82 E-value: 2.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 20 LGLKQPTPVQLGCIPAILEG--RDCLGCAKTGSGKTAAFVLPILQKLseDPYGIF--CLVLTPTRELAYQIAEQFRVLGK 95
Cdd:cd17963 12 MGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV--DPTLKSpqALCLAPTRELARQIGEVVEKMGK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 96 PLGLKDCIIVGGMDMVAqalelsRKP---HVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQGctDFTTDLETI 172
Cdd:cd17963 90 FTGVKVALAVPGNDVPR------GKKitaQIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTQ--GHGDQSIRI 160
|
170 180
....*....|....*....|....
gi 67972435 173 LAAVPARRQTLLFSATLTDTLKEL 196
Cdd:cd17963 161 KRMLPRNCQILLFSATFPDSVRKF 184
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
4-189 |
1.84e-28 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 111.77 E-value: 1.84e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLrSSNTFNMKKIQFLVMDEADRLLEQGct 163
Cdd:cd18046 81 QQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMI-NRRYLRTDYIKMFVLDEADEMLSRG-- 157
|
170 180
....*....|....*....|....*.
gi 67972435 164 dFTTDLETILAAVPARRQTLLFSATL 189
Cdd:cd18046 158 -FKDQIYDIFQKLPPDTQVVLLSATM 182
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
262-343 |
1.40e-25 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 99.59 E-value: 1.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 262 QILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTAR 341
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 67972435 342 AG 343
Cdd:smart00490 81 AG 82
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
4-204 |
3.53e-23 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 96.77 E-value: 3.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELA 83
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEADRLLEQGct 163
Cdd:cd18045 81 VQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRS-LRTRHIKMLVLDEADEMLNKG-- 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 67972435 164 dFTTDLETILAAVPARRQTLLFSATLTDTLKELQGLATNEP 204
Cdd:cd18045 158 -FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDP 197
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
27-188 |
5.10e-23 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 96.46 E-value: 5.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 27 PVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIF------CLVLTPTRELAYQIAEQFRVLGKPLGLK 100
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKrgrapkVLVLAPTRELANQVTKDFKDITRKLSVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 101 dCiIVGGMDMVAQALELSRKPHVVIATPGRLADHLRsSNTFNMKKIQFLVMDEADRLLEQGctdFTTDLETILAAVPARR 180
Cdd:cd17944 95 -C-FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQ-NGRLDLTKLKHVVLDEVDQMLDMG---FAEQVEEILSVSYKKD 168
|
170
....*....|...
gi 67972435 181 -----QTLLFSAT 188
Cdd:cd17944 169 sednpQTLLFSAT 181
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
38-447 |
4.95e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 96.25 E-value: 4.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 38 EGRDCLGCAKTGSGKT--AAFvlpILQKLSEDPygiFCLVLTPTRELAYQIAEQFRVLgkplgLKDCIIVGGmdmvaqal 115
Cdd:COG1061 99 GGGRGLVVAPTGTGKTvlALA---LAAELLRGK---RVLVLVPRRELLEQWAEELRRF-----LGDPLAGGG-------- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 116 ELSRKPHVVIATPGRLADHLRSSNTFNmkKIQFLVMDEADRLleqgctdFTTDLETILAAVPARRqTLLFSAT------L 189
Cdd:COG1061 160 KKDSDAPITVATYQSLARRAHLDELGD--RFGLVIIDEAHHA-------GAPSYRRILEAFPAAY-RLGLTATpfrsdgR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 190 TDTLKELQGLATNEPFfWEAQ-----ATVRTVEQLD------QRYLLVPEKVKDAYL------VHLVQTFQDQL-EDCSI 251
Cdd:COG1061 230 EILLFLFDGIVYEYSL-KEAIedgylAPPEYYGIRVdltderAEYDALSERLREALAadaerkDKILRELLREHpDDRKT 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 252 IIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVI---NHNTPGL 328
Cdd:COG1061 309 LVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAIllrPTGSPRE 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 329 pkiYIHRVGRTARAGRQGQAITLVTQYDIHlLHAIEEQIKQQLAELV--VEEAEVLQILTQVNVVRRECEIKLEASHFDE 406
Cdd:COG1061 389 ---FIQRLGRGLRPAPGKEDALVYDFVGND-VPVLEELAKDLRDLAGyrVEFLDEEESEELALLIAVKPALEVKGELEEE 464
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 67972435 407 KKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKV 447
Cdd:COG1061 465 LLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKA 505
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
39-188 |
9.28e-19 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 82.84 E-value: 9.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 39 GRDCLGCAKTGSGKTAAFVLPILQKLseDPYGIFCLVLTPTRELAYQIAEQFRVLGKPlGLKDCIIVGGMDMVAQALELS 118
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 119 RKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLEQGcTDFTTDLETILAAVPARRQTLLFSAT 188
Cdd:cd00046 78 GDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDS-RGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
4-193 |
1.65e-18 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 84.30 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEG--RDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRE 81
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 82 LAYQIAEQFRVLGK-PLGLKDCIIVGGmDMVAQALELSRKphVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLLE- 159
Cdd:cd18048 100 LALQTGKVVEEMGKfCVGIQVIYAIRG-NRPGKGTDIEAQ--IVIGTPGTVLDWCFKLRLIDVTNISVFVLDEADVMINv 176
|
170 180 190
....*....|....*....|....*....|....
gi 67972435 160 QGCTDFTTDLETilaAVPARRQTLLFSATLTDTL 193
Cdd:cd18048 177 QGHSDHSVRVKR---SMPKECQMLLFSATFEDSV 207
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
24-189 |
7.47e-17 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 80.11 E-value: 7.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 24 QPTPVQLGCIPAILEGRDC----------------LGCAKTGSGKTAAFVLPILQKLSEDPYGIF--------------- 72
Cdd:cd17965 30 KPSPIQTLAIKKLLKTLMRkvtkqtsneepklevfLLAAETGSGKTLAYLAPLLDYLKRQEQEPFeeaeeeyesakdtgr 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 73 --CLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMD-MVAQALELSRKP-HVVIATPGRLADhLRSSNTFNMKKIQF 148
Cdd:cd17965 110 prSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGpSYQRLQLAFKGRiDILVTTPGKLAS-LAKSRPKILSRVTH 188
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 67972435 149 LVMDEADRLLEQGCTDFTTDletILAAVPARRQTLLFSATL 189
Cdd:cd17965 189 LVVDEADTLFDRSFLQDTTS---IIKRAPKLKHLILCSATI 226
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
26-191 |
1.37e-15 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 74.61 E-value: 1.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 26 TPVQLGCI-PAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEdpYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCII 104
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALAT--SGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 105 VGGMDMvaqALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEAdRLLEQGctDFTTDLETILAAVPAR---RQ 181
Cdd:cd17921 81 TGDPSV---NKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEA-HLIGDG--ERGVVLELLLSRLLRInknAR 154
|
170
....*....|
gi 67972435 182 TLLFSATLTD 191
Cdd:cd17921 155 FVGLSATLPN 164
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
4-193 |
1.66e-15 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 75.14 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 4 FAEIGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEG--RDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRE 81
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 82 LAYQIAEQFRVLGKplGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADRLL-EQ 160
Cdd:cd18047 83 LALQTGKVIEQMGK--FYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIaTQ 160
|
170 180 190
....*....|....*....|....*....|...
gi 67972435 161 GCTDFTTDLETILaavPARRQTLLFSATLTDTL 193
Cdd:cd18047 161 GHQDQSIRIQRML---PRNCQMLLFSATFEDSV 190
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
251-353 |
1.94e-14 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 75.92 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 251 IIIFTNTCKTCQILCMMLRKFNFPTVAL--------HSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVIN 322
Cdd:COG1111 356 IIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskegDKGLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIF 435
|
90 100 110
....*....|....*....|....*....|..
gi 67972435 323 HNtPGLPKI-YIHRVGRTARaGRQGQAITLVT 353
Cdd:COG1111 436 YE-PVPSEIrSIQRKGRTGR-KREGRVVVLIA 465
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
12-189 |
1.26e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 73.01 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 12 WLVEQCRQLGLKQPTPVQLGCIPA-ILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFclvLTPTRELAYQIAEQF 90
Cdd:COG1204 10 KVIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALY---IVPLRALASEKYREF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 91 RVLGKPLGLKDCIIVGGMDMVAQALElsrKPHVVIATPGRLaDHLRSSNTFNMKKIQFLVMDEA------DRlleqGCTd 164
Cdd:COG1204 87 KRDFEELGIKVGVSTGDYDSDDEWLG---RYDILVATPEKL-DSLLRNGPSWLRDVDLVVVDEAhliddeSR----GPT- 157
|
170 180
....*....|....*....|....*...
gi 67972435 165 fttdLETILA---AVPARRQTLLFSATL 189
Cdd:COG1204 158 ----LEVLLArlrRLNPEAQIVALSATI 181
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
243-354 |
3.22e-12 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 68.75 E-value: 3.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 243 QDQLE---DCSIIIFTNTCKTCQILCMMLRKFNFPTVAL--------HSMMKQKERFAALAKFKSSIYRILIATDVASRG 311
Cdd:PRK13766 357 KEQLGknpDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFvgqaskdgDKGMSQKEQIEILDKFRAGEFNVLVSTSVAEEG 436
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 67972435 312 LDIPTVQVVInhntpglpkIY---------IHRVGRTARaGRQGQAITLVTQ 354
Cdd:PRK13766 437 LDIPSVDLVI---------FYepvpseirsIQRKGRTGR-QEEGRVVVLIAK 478
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
23-97 |
5.13e-11 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 65.12 E-value: 5.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 23 KQPTPVQLGCIPAILEGRDCLGCAKTGSGKT-AAFvLPILQKLSEDPY------GIFCLVLTPTRELAYQIAeqfRVLGK 95
Cdd:COG1201 23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELARRPRpgelpdGLRVLYISPLKALANDIE---RNLRA 98
|
..
gi 67972435 96 PL 97
Cdd:COG1201 99 PL 100
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
235-351 |
1.40e-10 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 59.29 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 235 LVHLVQTFQDQLE------DCSIIIFTNTCKTCQILCMMLRKFNfPTVALH-----------SMMKQKERFAALAKFKSS 297
Cdd:cd18801 11 LEKLEEIVKEHFKkkqegsDTRVIIFSEFRDSAEEIVNFLSKIR-PGIRATrfigqasgkssKGMSQKEQKEVIEQFRKG 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 67972435 298 IYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARaGRQGQAITL 351
Cdd:cd18801 90 GYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVL 142
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
13-356 |
3.90e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 62.16 E-value: 3.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 13 LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPyGIFCLVLTPTRELAY-QIAEqFR 91
Cdd:COG1205 45 LRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP-GATALYLYPTKALARdQLRR-LR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 92 VLGKPLGLKDCIIV--GGMDMVAQAlELSRKPHVVIATP-----GRLADHLRSSNTFnmKKIQFLVMDEA---------- 154
Cdd:COG1205 123 ELAEALGLGVRVATydGDTPPEERR-WIREHPDIVLTNPdmlhyGLLPHHTRWARFF--RNLRYVVIDEAhtyrgvfgsh 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 155 -----DRLLEqgctdfttdletILAAVPARRQTLLFSATLTDTLKELQGLaTNEPF----------------FWEAQATV 213
Cdd:COG1205 200 vanvlRRLRR------------ICRHYGSDPQFILASATIGNPAEHAERL-TGRPVtvvdedgsprgertfvLWNPPLVD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 214 RTVEQldQRYLLVpekvkdAYLV-HLVQtfqdqlEDCSIIIFTNTCKTCQILCMMLRK-FNFPTVAL-----HSMMKQKE 286
Cdd:COG1205 267 DGIRR--SALAEA------ARLLaDLVR------EGLRTLVFTRSRRGAELLARYARRaLREPDLADrvaayRAGYLPEE 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 287 RFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAItLVTQYD 356
Cdd:COG1205 333 RREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVV-LVAGDD 401
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
39-191 |
7.85e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 54.90 E-value: 7.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 39 GRDCLGCAKTGSGKTAAFVLPILQKLSEDPY-GIFCLVLTPTRELayqIAEQFRVLGKPLglkDCIIVG-------GmDm 110
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEkGVQVLYISPLKAL---INDQERRLEEPL---DEIDLEipvavrhG-D- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 111 VAQALE---LSRKPHVVIATPGRLADHL---RSSNTFnmKKIQFLVMDEADRLL--EQGCTDFTTdLETI--LAAVPARR 180
Cdd:cd17922 73 TSQSEKakqLKNPPGILITTPESLELLLvnkKLRELF--AGLRYVVVDEIHALLgsKRGVQLELL-LERLrkLTGRPLRR 149
|
170
....*....|.
gi 67972435 181 QTLlfSATLTD 191
Cdd:cd17922 150 IGL--SATLGN 158
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
222-342 |
1.45e-08 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 53.36 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 222 RYLLVPEKVKDayLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMML----RKFNFPTVAL-----------HSMMKQKE 286
Cdd:cd18802 1 EEIVVIPKLQK--LIEILREYFPKTPDFRGIIFVERRATAVVLSRLLkehpSTLAFIRCGFligrgnssqrkRSLMTQRK 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 67972435 287 RFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRtARA 342
Cdd:cd18802 79 QKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
222-347 |
1.67e-07 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 50.28 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 222 RYLLVPEKVKDAYLVHLVQTFQDQLEDCsIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRI 301
Cdd:cd18794 5 FYSVRPKDKKDEKLDLLKRIKVEHLGGS-GIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQV 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 67972435 302 LIATDVASRGLDIPTVQVVINHntpGLPKI---YIHRVGrtaRAGRQGQ 347
Cdd:cd18794 84 IVATVAFGMGIDKPDVRFVIHY---SLPKSmesYYQESG---RAGRDGL 126
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
46-344 |
1.70e-07 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 53.20 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 46 AKTGSGKT---AAFVLPILQKLSEDPyGIFCLvltPTRELAYQIAEQFR-VLGKPLGLKDCIIVGGMDMVAQALEL---- 117
Cdd:cd09639 6 APTGYGKTeaaLLWALHSLKSQKADR-VIIAL---PTRATINAMYRRAKeAFGETGLYHSSILSSRIKEMGDSEEFehlf 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 118 ---SRKPHVVIATPGRLA--DHLRSSNTFNMKKIQF---------LVMDEADRLLeqgctDFTtdLETILAAVPARRQT- 182
Cdd:cd09639 82 plyIHSNDTLFLDPITVCtiDQVLKSVFGEFGHYEFtlasianslLIFDEVHFYD-----EYT--LALILAVLEVLKDNd 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 183 ---LLFSATLTDTLKELqGLATNEPFFWEAqatvrtveqldqrylLVPEKVKDAYLVHLV-------QTFQDQLEDC--- 249
Cdd:cd09639 155 vpiLLMSATLPKFLKEY-AEKIGYVEENEP---------------LDLKPNERAPFIKIEsdkvgeiSSLERLLEFIkkg 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 250 -SIIIFTNTCKTCQILCMMLRKFN--FPTVALHSMMKQKERFAA----LAKFKSSIYRILIATDVASRGLDIpTVQVVIN 322
Cdd:cd09639 219 gSVAIIVNTVDRAQEFYQQLKEKGpeEEIMLIHSRFTEKDRAKKeaelLLEFKKSEKFVIVATQVIEASLDI-SVDVMIT 297
|
330 340
....*....|....*....|..
gi 67972435 323 HNTPglPKIYIHRVGRTARAGR 344
Cdd:cd09639 298 ELAP--IDSLIQRLGRLHRYGE 317
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
12-153 |
2.10e-07 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 53.74 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 12 WLVEQcrqlgLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKT-AAF--VLPILQKLSED---PYGIFCLVLTPTRELAYQ 85
Cdd:PRK13767 25 WFKEK-----FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFlaIIDELFRLGREgelEDKVYCLYVSPLRALNND 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 86 IaeqFRVLGKPL-GLKDCIIVGGMDM----VA-----------QALeLSRKPHVVIATPGRLADHLRSSNtFN--MKKIQ 147
Cdd:PRK13767 100 I---HRNLEEPLtEIREIAKERGEELpeirVAirtgdtssyekQKM-LKKPPHILITTPESLAILLNSPK-FRekLRTVK 174
|
....*.
gi 67972435 148 FLVMDE 153
Cdd:PRK13767 175 WVIVDE 180
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
27-189 |
7.51e-07 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 49.25 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 27 PVQLGCIPA-ILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFclvLTPTRELAYQIAEQFRVLgKPLGLKDCIIV 105
Cdd:cd18028 4 PPQAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALY---LVPLRALASEKYEEFKKL-EEIGLKVGIST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 106 GGMDMVAQALElsrKPHVVIATPGRLADHLRSSNTFnMKKIQFLVMDE----ADRllEQGCTdfttdLETILA---AVPA 178
Cdd:cd18028 80 GDYDEDDEWLG---DYDIIVATYEKFDSLLRHSPSW-LRDVGVVVVDEihliSDE--ERGPT-----LESIVArlrRLNP 148
|
170
....*....|.
gi 67972435 179 RRQTLLFSATL 189
Cdd:cd18028 149 NTQIIGLSATI 159
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
18-207 |
8.46e-07 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 49.46 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILqkLSEdpyGIfCLVLTPTRELayqIAEQFRVLgKPL 97
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPAL--LLD---GV-TLVVSPLISL---MQDQVDRL-QQL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 98 GLKDCIIVGGMDM--VAQALELSRKP--HVVIATPGRLA-----DHLRSSNtfNMKKIQFLVMDEADRLLEQGcTDFTTD 168
Cdd:cd17920 76 GIRAAALNSTLSPeeKREVLLRIKNGqyKLLYVTPERLLspdflELLQRLP--ERKRLALIVVDEAHCVSQWG-HDFRPD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 67972435 169 ---LETILAAVPaRRQTLLFSATLTDTLKE--LQGLATNEPFFW 207
Cdd:cd17920 153 ylrLGRLRRALP-GVPILALTATATPEVREdiLKRLGLRNPVIF 195
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
6-430 |
9.81e-07 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 51.36 E-value: 9.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 6 EIGLSSWLVEQCRQLGLKQPTPVQLGCIPA-ILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDpyGIFCLVLTPTRELAY 84
Cdd:PRK00254 5 ELRVDERIKRVLKERGIEELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVNKLLRE--GGKAVYLVPLKALAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 85 QIAEQFRVLGKpLGLKDCIIVGGMDMVAQALElsrKPHVVIATPGRLADHLRSSNTFnMKKIQFLVMDEADRLleqGCTD 164
Cdd:PRK00254 83 EKYREFKDWEK-LGLRVAMTTGDYDSTDEWLG---KYDIIIATAEKFDSLLRHGSSW-IKDVKLVVADEIHLI---GSYD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 165 FTTDLETILAAVPARRQTLLFSATLTDTlKEL-------------------QGLATNEPFFWEAQATVRTVEQLDQRYLL 225
Cdd:PRK00254 155 RGATLEMILTHMLGRAQILGLSATVGNA-EELaewlnaelvvsdwrpvklrKGVFYQGFLFWEDGKIERFPNSWESLVYD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 226 VPEKVKDAY---------------LVHLVQTF-----QDQLEDCSIIIFTNtcKTCQILCMMLRKfnfpTVAL-HSMMKQ 284
Cdd:PRK00254 234 AVKKGKGALvfvntrrsaekealeLAKKIKRFltkpeLRALKELADSLEEN--PTNEKLKKALRG----GVAFhHAGLGR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 285 KERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVI-------NHNTPGLPKIYIHRVgrTARAGR-----QGQAITLV 352
Cdd:PRK00254 308 TERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIrdtkrysNFGWEDIPVLEIQQM--MGRAGRpkydeVGEAIIVA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 353 TQYDIHLL--HAIE---EQIKQQLAELVVEEAEVLQILTQVNVvrreceikleaSHFDEKKEINKRKQMILEGKDPD-LE 426
Cdd:PRK00254 386 TTEEPSKLmeRYIFgkpEKLFSMLSNESAFRSQVLALITNFGV-----------SNFKELVNFLERTFYAHQRKDLYsLE 454
|
....
gi 67972435 427 AKRK 430
Cdd:PRK00254 455 EKAK 458
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
251-322 |
1.03e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 47.86 E-value: 1.03e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67972435 251 IIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFK--SSIYRILIATDVASRGLDIPTVQVVIN 322
Cdd:cd18793 30 VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNedPDIRVFLLSTKAGGVGLNLTAANRVIL 103
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
35-154 |
1.31e-06 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 48.74 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 35 AILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPyGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKdcIIV----GGMDM 110
Cdd:cd17923 11 AARAGRSVVVTTGTASGKSLCYQLPILEALLRDP-GSRALYLYPTKALAQDQLRSLRELLEQLGLG--IRVatydGDTPR 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 67972435 111 VAQALELSRKPHVVIATP-----GRLADHLRSSNTFNMKKiqFLVMDEA 154
Cdd:cd17923 88 EERRAIIRNPPRILLTNPdmlhyALLPHHDRWARFLRNLR--YVVLDEA 134
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
296-352 |
1.38e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 45.77 E-value: 1.38e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 67972435 296 SSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAG-RQGQAITLV 352
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILFV 77
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
28-128 |
2.25e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 48.51 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 28 VQLGCIPAILEG-RDCLGCAKTGSGKTAAFVLPILQKLSE----DPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC 102
Cdd:cd18023 5 IQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLLKErnplPWGNRKVVYIAPIKALCSEKYDDWKEKFGPLGLSCA 84
|
90 100
....*....|....*....|....*.
gi 67972435 103 IIVGgmDMVAQALELSRKPHVVIATP 128
Cdd:cd18023 85 ELTG--DTEMDDTFEIQDADIILTTP 108
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
215-352 |
3.72e-06 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 46.95 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 215 TVEQLDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIiiftntcKTCQILCMMLRKFNFP--TVAL-HSMMKQKERFAAL 291
Cdd:cd18811 8 FHTRLDKVYEFVREEIAKGRQAYVIYPLIEESEKLDL-------KAAVAMYEYLKERFRPelNVGLlHGRLKSDEKDAVM 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67972435 292 AKFKSSIYRILIATDVASRGLDIP--TVQVVINHNTPGLPKIYIHRvGRTARAGRQGQAITLV 352
Cdd:cd18811 81 AEFREGEVDILVSTTVIEVGVDVPnaTVMVIEDAERFGLSQLHQLR-GRVGRGDHQSYCLLVY 142
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
48-154 |
4.24e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 47.26 E-value: 4.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 48 TGSGKTAAFVLPILQKLS----EDPYGIFCLVLTPTRELAYQiaeQFRVLGKPLGLKDCIIVGGMDMVAQA----LELSR 119
Cdd:cd18034 25 TGSGKTLIAVMLIKEMGElnrkEKNPKKRAVFLVPTVPLVAQ---QAEAIRSHTDLKVGEYSGEMGVDKWTkerwKEELE 101
|
90 100 110
....*....|....*....|....*....|....*
gi 67972435 120 KPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEA 154
Cdd:cd18034 102 KYDVLVMTAQILLDALRHGF-LSLSDINLLIFDEC 135
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
226-385 |
8.18e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 48.21 E-value: 8.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 226 VPEKVKDAYLVHLVQTFQDQledcSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIAT 305
Cdd:COG0514 212 KPPDDKLAQLLDFLKEHPGG----SGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 306 dVA-SRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLLHAIEEQIKQQLAELVVEEAEVLQI 384
Cdd:COG0514 288 -IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERAKLDAM 366
|
.
gi 67972435 385 L 385
Cdd:COG0514 367 L 367
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
33-156 |
3.22e-05 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 44.43 E-value: 3.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 33 IPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEdpYGIFCLVLTPTRELAYQIAEQFR-VLGKPLglkDCIIVGGMDMV 111
Cdd:cd18035 10 IAAVALNGNTLIVLPTGLGKTIIAILVAADRLTK--KGGKVLILAPSRPLVEQHAENLKrVLNIPD---KITSLTGEVKP 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 67972435 112 AQALELSRKPHVVIATPGRLADHLRSSNtFNMKKIQFLVMDEADR 156
Cdd:cd18035 85 EERAERWDASKIIVATPQVIENDLLAGR-ITLDDVSLLIFDEAHH 128
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
278-352 |
1.51e-04 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 42.25 E-value: 1.51e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67972435 278 LHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVI--NHNTPGLPKIYIHRvGRTARAGRQGQAITLV 352
Cdd:cd18792 66 LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIieDADRFGLSQLHQLR-GRVGRGKHQSYCYLLY 141
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
18-168 |
2.74e-04 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 42.12 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 18 RQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILqkLSEdpyGIfCLVLTPTRELayqIAEQFRVLgKPL 97
Cdd:cd18016 11 KKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPAC--VSP---GV-TVVISPLRSL---IVDQVQKL-TSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 98 GLKDCIIVGGMDMVAQA---LELSRKPHVV---------IATPGRLADHLrsSNTFNMKKIQFLVMDEAdRLLEQGCTDF 165
Cdd:cd18016 81 DIPATYLTGDKTDAEATkiyLQLSKKDPIIkllyvtpekISASNRLISTL--ENLYERKLLARFVIDEA-HCVSQWGHDF 157
|
...
gi 67972435 166 TTD 168
Cdd:cd18016 158 RPD 160
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
27-128 |
3.67e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 41.48 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 27 PVQLGCIPAILEGRD-CLGCAKTGSGKTAAFVLPILQKLSEDPYGIfCLVLTPTRELAYQIAEQFRV-LGKPLGLKDCII 104
Cdd:cd18021 6 PIQTQVFNSLYNTDDnVFVGAPTGSGKTVCAELALLRHWRQNPKGR-AVYIAPMQELVDARYKDWRAkFGPLLGKKVVKL 84
|
90 100
....*....|....*....|....
gi 67972435 105 VGGMdmvAQALELSRKPHVVIATP 128
Cdd:cd18021 85 TGET---STDLKLLAKSDVILATP 105
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
23-156 |
4.13e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 41.65 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 23 KQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDP--YGIFCLVLTPTRELAYQIAEQFRVLGKPLGLK 100
Cdd:cd17927 1 FKPRNYQLELAQPALKGKNTIICLPTGSGKTFVAVLICEHHLKKFPagRKGKVVFLANKVPLVEQQKEVFRKHFERPGYK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 67972435 101 DCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEADR 156
Cdd:cd17927 81 VTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
21-360 |
5.99e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 42.39 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 21 GLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQK------------LSED------PYGIF--CLVLTPTR 80
Cdd:PRK11057 22 GYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLdgltlvvsplisLMKDqvdqllANGVAaaCLNSTQTR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 81 ElayqiaEQFRVLgkplglkdciivggMDMVAQALELsrkphVVIAtPGRLA-----DHLRSSNtfnmkkIQFLVMDEAd 155
Cdd:PRK11057 102 E------QQLEVM--------------AGCRTGQIKL-----LYIA-PERLMmdnflEHLAHWN------PALLAVDEA- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 156 RLLEQGCTDFTTDLETiLAAVPARRQTLLF---SATLTDTLKE--LQGLATNEPffweaQATVRTVEQLDQRYLLVpEKV 230
Cdd:PRK11057 149 HCISQWGHDFRPEYAA-LGQLRQRFPTLPFmalTATADDTTRQdiVRLLGLNDP-----LIQISSFDRPNIRYTLV-EKF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 231 KDayLVHLVQTFQDQLEDCSIIiFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASR 310
Cdd:PRK11057 222 KP--LDQLMRYVQEQRGKSGII-YCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGM 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 67972435 311 GLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLL 360
Cdd:PRK11057 299 GINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAWL 348
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
43-208 |
6.75e-04 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 40.88 E-value: 6.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 43 LGCAKTGSGKTAAFVLPILQKLSE--DPYGI-----FCLV-LTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQA 114
Cdd:cd18020 21 LICAPTGAGKTNIAMLTILHEIRQhvNQGGVikkddFKIVyIAPMKALAAEMVEKFSKRLAPLGIKVKELTGDMQLTKKE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 115 LElsrKPHVVIATPGRLADHLRSSNTFN--MKKIQFLVMDEADRLLEqgctdfttDLETILAAVPARRQTLLFSatlTDT 192
Cdd:cd18020 101 IA---ETQIIVTTPEKWDVVTRKSSGDValSQLVRLLIIDEVHLLHD--------DRGPVIESLVARTLRQVES---TQS 166
|
170
....*....|....*.
gi 67972435 193 LKELQGLATNEPFFWE 208
Cdd:cd18020 167 MIRIVGLSATLPNYLD 182
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
251-348 |
7.49e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 39.93 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 251 IIIFTntcKTCQILCMMLRKFNFPtvALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQV-VINHNTPGLP 329
Cdd:cd18789 52 IIVFT---DNVEALYRYAKRLLKP--FITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPEANVaIQISGHGGSR 126
|
90
....*....|....*....
gi 67972435 330 KIYIHRVGRTARAGRQGQA 348
Cdd:cd18789 127 RQEAQRLGRILRPKKGGGK 145
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
25-91 |
8.31e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 40.48 E-value: 8.31e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67972435 25 PTPVQLGCIPAIL------EGRDCLGCAKTGSGKTAAFVLPILQKLSEdpyGIFCLVLTPTRELAYQIAEQFR 91
Cdd:cd17918 16 LTKDQAQAIKDIEkdlhspEPMDRLLSGDVGSGKTLVALGAALLAYKN---GKQVAILVPTEILAHQHYEEAR 85
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
250-349 |
9.52e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 39.55 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 250 SIIIFTNTCKTCQILCMMLRKF------NFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINH 323
Cdd:cd18796 40 STLVFTNTRSQAERLAQRLRELcpdrvpPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQI 119
|
90 100
....*....|....*....|....*.
gi 67972435 324 NTPGLPKIYIHRVGrtaRAGRQGQAI 349
Cdd:cd18796 120 GSPKSVARLLQRLG---RSGHRPGAA 142
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
183-314 |
9.82e-04 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 41.61 E-value: 9.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 183 LLFSATLT----DTLKELQGLATNEPffweAQATVRTVEQLDQRYLLVPEKVKDAylvHLVQTFQDQLEDC-SIIIFTNT 257
Cdd:COG1203 303 ILMTATLPpllrEELLEAYELIPDEP----EELPEYFRAFVRKRVELKEGPLSDE---ELAELILEALHKGkSVLVIVNT 375
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67972435 258 CKTCQILCMMLRK--FNFPTVALHSMMKQKERFAALAK----FKSSIYRILIATDVASRGLDI 314
Cdd:COG1203 376 VKDAQELYEALKEklPDEEVYLLHSRFCPADRSEIEKEikerLERGKPCILVSTQVVEAGVDI 438
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
252-341 |
2.67e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.54 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 252 IIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKER---FAALAKFKSSIYRILIATDVASRGLDIPTV-QVVINHNTpG 327
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgdeALILLFFGELKPPILVTVDLLTTGVDIPEVdNVVFLRPT-E 88
|
90
....*....|....
gi 67972435 328 LPKIYIHRVGRTAR 341
Cdd:cd18799 89 SRTLFLQMLGRGLR 102
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
5-188 |
2.73e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 40.33 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 5 AEIGLSSWLVEQCRQLGLKQPTPVQLGCIPA-ILEGRDCLGCAKTGSGKTAAFVLPILQKLSEdpyGIFCLVLTPTRELA 83
Cdd:PRK02362 4 AELPLPEGVIEFYEAEGIEELYPPQAEAVEAgLLDGKNLLAAIPTASGKTLIAELAMLKAIAR---GGKALYIVPLRALA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 84 YQIAEQFRVLGKpLGLKDCIIVGGMDMVAQAleLSRKpHVVIATPGRlADHLRSSNTFNMKKIQFLVMDE------ADRl 157
Cdd:PRK02362 81 SEKFEEFERFEE-LGVRVGISTGDYDSRDEW--LGDN-DIIVATSEK-VDSLLRNGAPWLDDITCVVVDEvhlidsANR- 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 67972435 158 leqGCTdfttdLETILAAVpaRR-----QTLLFSAT 188
Cdd:PRK02362 155 ---GPT-----LEVTLAKL--RRlnpdlQVVALSAT 180
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
278-365 |
3.26e-03 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 38.09 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 278 LHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVI--NHNTPGLPKIYIHRvGRTARAGRQGQAITLV--- 352
Cdd:cd18810 57 AHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIieRADKFGLAQLYQLR-GRVGRSKERAYAYFLYpdq 135
|
90
....*....|....*.
gi 67972435 353 ---TQYDIHLLHAIEE 365
Cdd:cd18810 136 kklTEDALKRLEAIQE 151
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
251-377 |
3.36e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 39.82 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 251 IIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKS--SIYRILIATDVASRGLDIPTVQVVINHNTPGL 328
Cdd:COG0553 552 VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEgpEAPVFLISLKAGGEGLNLTAADHVIHYDLWWN 631
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 67972435 329 PKIYIHRVGRTARAG--RQGQAITLVTQydihllHAIEEQI------KQQLAELVVE 377
Cdd:COG0553 632 PAVEEQAIDRAHRIGqtRDVQVYKLVAE------GTIEEKIlelleeKRALAESVLG 682
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
20-154 |
7.33e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 37.62 E-value: 7.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 20 LGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPyGIfCLVLTPTRELayqIAEQFRVLgkPLGL 99
Cdd:cd18018 8 FGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRRRGP-GL-TLVVSPLIAL---MKDQVDAL--PRAI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 67972435 100 KDCIIVGGMDM--VAQALEL--SRKPHVVIATPGRLADHLRSSNTFNMKKIQFLVMDEA 154
Cdd:cd18018 81 KAAALNSSLTReeRRRILEKlrAGEVKILYVSPERLVNESFRELLRQTPPISLLVVDEA 139
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
48-157 |
8.21e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 36.90 E-value: 8.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 48 TGSGKTAafvlpILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRvlgKPLGLKDCIIVGGmdmVAQALELSRKphVVIAT 127
Cdd:cd17926 27 TGSGKTL-----TALALIAYLKELRTLIVVPTDALLDQWKERFE---DFLGDSSIGLIGG---GKKKDFDDAN--VVVAT 93
|
90 100 110
....*....|....*....|....*....|
gi 67972435 128 PGRLADHLRSSNTFNMKKIQFLVmDEADRL 157
Cdd:cd17926 94 YQSLSNLAEEEKDLFDQFGLLIV-DEAHHL 122
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
364-447 |
9.74e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 38.51 E-value: 9.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67972435 364 EEQIKQQLAELVVEEAEVLQILTQVNVVRRECEIKLEASHfDEKKEINKRKQMI--LEGKDPDLEAKRKAELAKIKQQNR 441
Cdd:PRK03918 188 TENIEELIKEKEKELEEVLREINEISSELPELREELEKLE-KEVKELEELKEEIeeLEKELESLEGSKRKLEEKIRELEE 266
|
....*.
gi 67972435 442 RFKEKV 447
Cdd:PRK03918 267 RIEELK 272
|
|
| |
