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Conserved domains on  [gi|62752025|ref|NP_001015524|]
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activating signal cointegrator 1 complex subunit 2 [Bos taurus]

Protein Classification

ASCC2 family CUE domain-containing protein( domain architecture ID 10198858)

ASCC2 family CUE domain-containing protein similar to human activating signal cointegrator 1 complex subunit 2 (ASCC2) that plays a role in DNA damage repair as component of the ASCC complex

CATH:  1.10.8.10
Gene Ontology:  GO:0043130
PubMed:  12628920
SCOP:  4003786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 462-501 9.95e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


:

Pssm-ID: 270547  Cd Length: 40  Bit Score: 79.71  E-value: 9.95e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62752025 462 DSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEG 501
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 462-501 9.95e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 79.71  E-value: 9.95e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62752025 462 DSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEG 501
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 460-502 5.62e-09

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 52.11  E-value: 5.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 62752025    460 ELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGR 502
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 462-502 3.97e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 49.78  E-value: 3.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 62752025   462 DSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGR 502
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 462-501 9.95e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 79.71  E-value: 9.95e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62752025 462 DSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEG 501
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 460-502 5.62e-09

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 52.11  E-value: 5.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 62752025    460 ELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGR 502
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 462-502 3.97e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 49.78  E-value: 3.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 62752025   462 DSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGR 502
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
CUE_AUP1 cd14420
CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a ...
 460-505 4.54e-03

CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a component of the HRD1-SEL1L endoplasmic reticulum (ER) quality control complex and is essential for US11-mediated dislocation of class I MHC heavy chains. It also binds to the membrane-proximal KVGFFKR motif of the cytoplasmic tail of the integrin alphaCTs that plays a crucial role in the inside-out signaling of alpha(IIb)beta(3). AUP1 is found in both the ER and in lipid droplets. It contains two conserved cytoplasmic domains, an acyltransferase domain, a CUE domain and an E2 ubiquitin conjugase G2 (Ube2g2)-binding domain (G2BR). The acyltransferase domain transfers fatty acids onto phospholipids and CUE domain participates in ubiquitin binding or in recruitment of ubiquitin-conjugating enzymes to the site of dislocation.


Pssm-ID: 270603  Cd Length: 45  Bit Score: 35.66  E-value: 4.54e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 62752025 460 ELDSLISQVKDLLPDLGEGFILACLEHySYEPEQVINNILEGRLAP 505
Cdd:cd14420   1 RLARMAQQVKEVLPHVPLHVIRRDLEK-TRNVDTTITNILEGRVKF 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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