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Conserved domains on  [gi|59938780|ref|NP_001012361|]
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WD repeat-containing protein 31 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 9.18e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 9.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  48 RIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRM 126
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 127 VMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 206
Cdd:COG2319 186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 207 SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVF 286
Cdd:COG2319 265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59938780 287 LPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMD 354
Cdd:COG2319 339 SPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 9.18e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 9.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  48 RIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRM 126
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 127 VMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 206
Cdd:COG2319 186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 207 SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVF 286
Cdd:COG2319 265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59938780 287 LPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMD 354
Cdd:COG2319 339 SPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-350 4.88e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 4.88e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  61 HMDTVSVVAAL-NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHgSSQPR 139
Cdd:cd00200   8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 140 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 219
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 220 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNgfggeGCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 297
Cdd:cd00200 167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 59938780 298 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 350
Cdd:cd00200 235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
PTZ00421 PTZ00421
coronin; Provisional
 101-266 5.44e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 5.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  101 GHEHEITKVACIP-KSSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLL 172
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  173 WDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SN 250
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKD 224

                        170       180
                 ....*....|....*....|..
gi 59938780  251 GFGGEGC------EATLWDLRQ 266
Cdd:PTZ00421 225 LIITLGCsksqqrQIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 8.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59938780    135 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
136-174 5.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 59938780   136 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 9.18e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 9.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  48 RIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRM 126
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 127 VMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 206
Cdd:COG2319 186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 207 SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVF 286
Cdd:COG2319 265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59938780 287 LPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMD 354
Cdd:COG2319 339 SPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-350 4.88e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 4.88e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  61 HMDTVSVVAAL-NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHgSSQPR 139
Cdd:cd00200   8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 140 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 219
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 220 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNgfggeGCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 297
Cdd:cd00200 167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 59938780 298 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 350
Cdd:cd00200 235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
66-333 1.22e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 1.22e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  66 SVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHgSSQPRQQLCGH 145
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLTGH 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 146 AMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHM 225
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 226 FPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCK 305
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGRLLAS-----GSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDG----KLLASGSDDGT 311

                       250       260
                ....*....|....*....|....*...
gi 59938780 306 VKIWNQDTGACLFTLSlDGSGPLTSLAV 333
Cdd:COG2319 312 VRLWDLATGKLLRTLT-GHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
77-313 3.79e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 3.79e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  77 VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSsQPRQQLCGHAMVVTGLAVSP 156
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 157 DSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYC 236
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59938780 237 EVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDT 313
Cdd:COG2319 337 AFSPDGKTLAS-----GSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDG----RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-310 1.23e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.39  E-value: 1.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  61 HMDTVSVVAAL-NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHgSSQPR 139
Cdd:cd00200  50 HTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 140 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 219
Cdd:cd00200 129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 220 LQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRqTRNRICEYKGHFQTVASCVFLPRALALmpliAT 299
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDGKRL----AS 278

                       250
                ....*....|.
gi 59938780 300 SSHDCKVKIWN 310
Cdd:cd00200 279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
59-354 2.47e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 2.47e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  59 PAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGsSQP 138
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 139 RQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR 218
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 219 GLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVFLP--RalalmpL 296
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGKLLAS-----GSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPdgR------L 260

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 59938780 297 IATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMD 354
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
68-350 1.79e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 1.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  68 VAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLhGSSQPRQQLCGHAM 147
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-AAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 148 VVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFP 227
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 228 AKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLRqTRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVK 307
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLAS-----GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG----KLLASGSADGTVR 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 59938780 308 IWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 350
Cdd:COG2319 230 LWDLATGKLLRTLT-GHSGSVRSVAFsPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-350 8.24e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 8.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 138 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDS 217
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780 218 RGLQVAHMFpaKQHIQ--TYCEVSVDGHkCISCSngfgGEGCEATLWDLRQTRNRICeYKGHFQTVASCVFLPRALalmp 295
Cdd:cd00200  81 ETGECVRTL--TGHTSyvSSVAFSPDGR-ILSSS----SRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGT---- 148

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 59938780 296 LIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 350
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFsPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
48-177 4.03e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 4.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  48 RIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRM 126
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 59938780 127 VMMWDLHGsSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVT 177
Cdd:COG2319 354 VRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 101-266 5.44e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 5.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  101 GHEHEITKVACIP-KSSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLL 172
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780  173 WDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SN 250
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKD 224

                        170       180
                 ....*....|....*....|..
gi 59938780  251 GFGGEGC------EATLWDLRQ 266
Cdd:PTZ00421 225 LIITLGCsksqqrQIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 8.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59938780    135 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 1.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.56e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59938780     92 TGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
136-174 5.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 59938780   136 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 115-196 1.09e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.99  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780   115 SSQFFSASRDRMVmmwdlhgssqprQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERAsvSRNVVTHL 194
Cdd:pfam20426 105 SFQVISLNDGRMV------------QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEF 170


                  ..
gi 59938780   195 CW 196
Cdd:pfam20426 171 PR 172
WD40 pfam00400
WD domain, G-beta repeat;
93-131 4.51e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 59938780    93 GNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 68-175 8.15e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 8.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780   68 VAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHeheiTKVACIP------KSSQFFSAsrDRMVMMWDLHGSSQPRQQ 141
Cdd:PLN00181 583 YSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTK----ANICCVQfpsesgRSLAFGSA--DHKVYYYDLRNPKLPLCT 656

                         90       100       110
                 ....*....|....*....|....*....|....
gi 59938780  142 LCGHAMVVTGLAVSpDSSQLCTGSRDNTLLLWDV 175
Cdd:PLN00181 657 MIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 267-310 3.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 59938780    267 TRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 310
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG----KYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 93-169 5.76e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 5.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59938780    93 GNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD-LHGSSQ---------------------PRQQLCGHAMVVT 150
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEvLRGRSSekrsrntqtefprkdhviaetPFHILCGHDDIIT 193

                          90
                  ....*....|....*....
gi 59938780   151 GLAVSPDSSQLCTGSRDNT 169
Cdd:pfam20426 194 CLYVSVELDIVISGSKDGT 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-216 8.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59938780    177 TGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD 216
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
268-310 8.73e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 8.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 59938780   268 RNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 310
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG----KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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