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Conserved domains on  [gi|54124343|ref|NP_001005751|]
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WASH complex subunit 2A isoform 1 [Homo sapiens]

Protein Classification

CAP-ZIP_m domain-containing protein( domain architecture ID 10633686)

CAP-ZIP_m domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
943-1080 1.36e-75

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


:

Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 246.67  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343    943 APFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQAD 1022
Cdd:pfam15255    1 NPFKTKEPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQAD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   1023 TLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADG--AISPNGHR 1080
Cdd:pfam15255   81 TLHSANKSRAKVTGKRRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
595-816 4.88e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   595 LQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDdlf 674
Cdd:PTZ00108 1169 LRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKS--- 1245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   675 aIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVESakeslk 754
Cdd:PTZ00108 1246 -KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG------ 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54124343   755 fGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
943-1080 1.36e-75

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 246.67  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343    943 APFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQAD 1022
Cdd:pfam15255    1 NPFKTKEPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQAD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   1023 TLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADG--AISPNGHR 1080
Cdd:pfam15255   81 TLHSANKSRAKVTGKRRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
595-816 4.88e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   595 LQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDdlf 674
Cdd:PTZ00108 1169 LRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKS--- 1245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   675 aIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVESakeslk 754
Cdd:PTZ00108 1246 -KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG------ 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54124343   755 fGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
943-1080 1.36e-75

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 246.67  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343    943 APFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQAD 1022
Cdd:pfam15255    1 NPFKTKEPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQAD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   1023 TLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADG--AISPNGHR 1080
Cdd:pfam15255   81 TLHSANKSRAKVTGKRRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
595-816 4.88e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   595 LQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDdlf 674
Cdd:PTZ00108 1169 LRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKS--- 1245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54124343   675 aIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVESakeslk 754
Cdd:PTZ00108 1246 -KKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG------ 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 54124343   755 fGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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