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Conserved domains on  [gi|1477730887|ref|XP_392711|]
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MD-2-related lipid-recognition protein [Apis mellifera]

Protein Classification

NPC2 family protein( domain architecture ID 10097044)

NPC2 (Niemann-Pick proteins type C2) family protein similar to Homo sapiens NPC intracellular cholesterol transporter 2 (NPC2) that acts as intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Npc2_like cd00916
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a ...
 26-155 3.02e-41

Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Although Npc2 is known to bind cholesterol, the function of this protein is unknown. These proteins belong to the ML domain family.


:

Pssm-ID: 238458  Cd Length: 123  Bit Score: 134.36  E-value: 3.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887  26 WRQCPYPDPntqtncTIHEVYIDPCKEitegKPCKIKRGVIGNMTFHYTPAFSSDKVQGRIFWASQVMDIPFLGMNPDAC 105
Cdd:cd00916     1 FRDCGSSRP------TPSEVRISGCAT----LPCKLKRGSTAKVSIDFTPNFDSTSLKTEVHAILLGVPVPFPLPNPDAC 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1477730887 106 --LSTSCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWNDEEQ-ECCFMFQI 155
Cdd:cd00916    71 knLGTSCPLSAGEDVTYTLSLPVLAPYPGISVTVEWELTDDDGQvLTCFQIPA 123
 
Name Accession Description Interval E-value
Npc2_like cd00916
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a ...
 26-155 3.02e-41

Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Although Npc2 is known to bind cholesterol, the function of this protein is unknown. These proteins belong to the ML domain family.


Pssm-ID: 238458  Cd Length: 123  Bit Score: 134.36  E-value: 3.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887  26 WRQCPYPDPntqtncTIHEVYIDPCKEitegKPCKIKRGVIGNMTFHYTPAFSSDKVQGRIFWASQVMDIPFLGMNPDAC 105
Cdd:cd00916     1 FRDCGSSRP------TPSEVRISGCAT----LPCKLKRGSTAKVSIDFTPNFDSTSLKTEVHAILLGVPVPFPLPNPDAC 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1477730887 106 --LSTSCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWNDEEQ-ECCFMFQI 155
Cdd:cd00916    71 knLGTSCPLSAGEDVTYTLSLPVLAPYPGISVTVEWELTDDDGQvLTCFQIPA 123
E1_DerP2_DerF2 pfam02221
ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins ...
 24-157 1.64e-16

ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.


Pssm-ID: 460498  Cd Length: 133  Bit Score: 71.25  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887  24 VPWRQCPYPDPNTqtnCTIHEVYIDPckeitegkPCKIKRG--VIGNMTFhYTPAFSSD----KVQGRIFWasqvMDIPF 97
Cdd:pfam02221   2 VPFRDCGRNKDDA---PTPKSVDISP--------PCPLVRGqnLTISASG-TTSDEISQglkvDVEVRLGG----ITLPF 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1477730887  98 LGMNP-DAC------LSTSCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWNDEEQE-CCFMFQIKI 157
Cdd:pfam02221  66 PLPETrDLCdelevgSGLSCPIKAGEYVTYTLTLPLPSEYPPGKYTVEAELYDQDGKPlTCFKIDVSI 133
ML smart00737
Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) ...
 26-153 2.57e-13

Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.


Pssm-ID: 214796  Cd Length: 119  Bit Score: 62.38  E-value: 2.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887   26 WRQCPYPDPntqtnCTIHEVYIDPCKeitegkpckIKRGVIGNMTFHYTPAFSSDKVQGRIFWASQVMDIPFLGMNPDAC 105
Cdd:smart00737   1 FKDCGSNDP-----GQISSVSISPCP---------PVRGKTLTISISFTLNEDISKLKVVVHVKIGGIEVPIPGETYDLC 66

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1477730887  106 LST--SCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWN-DEEQECCFMF 153
Cdd:smart00737  67 KLTgsKCPIEKGETVNYTNSLTVPGIFPPGKYTVKWELTDeDGEELACINF 117
 
Name Accession Description Interval E-value
Npc2_like cd00916
Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a ...
 26-155 3.02e-41

Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Although Npc2 is known to bind cholesterol, the function of this protein is unknown. These proteins belong to the ML domain family.


Pssm-ID: 238458  Cd Length: 123  Bit Score: 134.36  E-value: 3.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887  26 WRQCPYPDPntqtncTIHEVYIDPCKEitegKPCKIKRGVIGNMTFHYTPAFSSDKVQGRIFWASQVMDIPFLGMNPDAC 105
Cdd:cd00916     1 FRDCGSSRP------TPSEVRISGCAT----LPCKLKRGSTAKVSIDFTPNFDSTSLKTEVHAILLGVPVPFPLPNPDAC 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1477730887 106 --LSTSCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWNDEEQ-ECCFMFQI 155
Cdd:cd00916    71 knLGTSCPLSAGEDVTYTLSLPVLAPYPGISVTVEWELTDDDGQvLTCFQIPA 123
E1_DerP2_DerF2 pfam02221
ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins ...
 24-157 1.64e-16

ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.


Pssm-ID: 460498  Cd Length: 133  Bit Score: 71.25  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887  24 VPWRQCPYPDPNTqtnCTIHEVYIDPckeitegkPCKIKRG--VIGNMTFhYTPAFSSD----KVQGRIFWasqvMDIPF 97
Cdd:pfam02221   2 VPFRDCGRNKDDA---PTPKSVDISP--------PCPLVRGqnLTISASG-TTSDEISQglkvDVEVRLGG----ITLPF 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1477730887  98 LGMNP-DAC------LSTSCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWNDEEQE-CCFMFQIKI 157
Cdd:pfam02221  66 PLPETrDLCdelevgSGLSCPIKAGEYVTYTLTLPLPSEYPPGKYTVEAELYDQDGKPlTCFKIDVSI 133
ML smart00737
Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) ...
 26-153 2.57e-13

Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.


Pssm-ID: 214796  Cd Length: 119  Bit Score: 62.38  E-value: 2.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477730887   26 WRQCPYPDPntqtnCTIHEVYIDPCKeitegkpckIKRGVIGNMTFHYTPAFSSDKVQGRIFWASQVMDIPFLGMNPDAC 105
Cdd:smart00737   1 FKDCGSNDP-----GQISSVSISPCP---------PVRGKTLTISISFTLNEDISKLKVVVHVKIGGIEVPIPGETYDLC 66

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1477730887  106 LST--SCPIEAGSRNTYHVEIPILKKYPVRTYDLKWKIWN-DEEQECCFMF 153
Cdd:smart00737  67 KLTgsKCPIEKGETVNYTNSLTVPGIFPPGKYTVKWELTDeDGEELACINF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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