NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462519840|ref|XP_054222159|]
View 

outer dynein arm-docking complex subunit 2 isoform X8 [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein similar to Homo sapiens deoxyhypusine hydroxylase (DOHH), which catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
730-908 2.97e-08

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.48  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 730 VKASAAWALCpcIKNAKDAgemvrsfvggLELIVNLLKSDNKEVLASVCAAitniakdqenLAVITDHGVVPLLSKLANT 809
Cdd:COG1413     1 VRRAAARALG--RLGDPAA----------VPALIAALADEDPDVRAAAARA----------LGRLGDPRAVPALLEALKD 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 810 NNNKLRHHLAEAISRccmwgrnrvaFGEHKAVAPLVRYLKSNDTNMHRATAQALYQLSEDAdncitmhengAVKLLLDMV 889
Cdd:COG1413    59 PDPEVRAAAAEALGR----------IGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEAL 118

                         170
                  ....*....|....*....
gi 2462519840 890 GSPDQDLQEAAAGCISNIR 908
Cdd:COG1413   119 KDPDWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
503-658 9.38e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 503 AIRKAGGIPLLARLLKTSHENMLIPVVGTLqecaseenyrAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKet 582
Cdd:COG1413    11 RLGDPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE-- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462519840 583 rdlvrlhgGLKPLASLLNNTDNKERLAAVTGaiwkcsiskenVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGE 658
Cdd:COG1413    79 --------AVPALIAALKDEDPEVRRAAAEA-----------LGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 325-560 9.35e-04

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 9.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  325 SEYWQ---IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEvkCKIGSLKILKEISHNP 401
Cdd:PLN03200  1644 SEYYFevpVAVLVKLLRSTSESTVVVALNALLVLERDDSSSAEQMAESGAIEALLELLRSHQ--CEEAAARLLEALFNNV 1721

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  402 QIRQ-NIVDLGGLPIMVNILDsPH---KSLKCLAAETIANVAkfkrarrvvrQHGGITKlvalldcAHDSTKP--AQSSL 475
Cdd:PLN03200  1722 KVREmKATKYAIAPLSQYLLD-PQtrsQQARLLAALALGDLF----------QHEGLAR-------STDAVSAcrALVSL 1783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  476 YEARDVE----VARCGALALWSCSKshTNKEAIRKAGGIPLLARLLKTSHEN------MLIPVV---GTLQECASEENYR 542
Cdd:PLN03200  1784 LEDQPTEemkmVAICALQNLVMHSR--TNKRAVAEAGGVQVVQELLLSSNPDtsgqaaLLIKLLfsnHTIQEYASSELIR 1861

                          250       260
                   ....*....|....*....|....*.
gi 2462519840  543 AAIKA-ER-------IIENLVKNLNS 560
Cdd:PLN03200  1862 ALTAAlEKdlwstatVNEEVLRALNV 1887
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
730-908 2.97e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.48  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 730 VKASAAWALCpcIKNAKDAgemvrsfvggLELIVNLLKSDNKEVLASVCAAitniakdqenLAVITDHGVVPLLSKLANT 809
Cdd:COG1413     1 VRRAAARALG--RLGDPAA----------VPALIAALADEDPDVRAAAARA----------LGRLGDPRAVPALLEALKD 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 810 NNNKLRHHLAEAISRccmwgrnrvaFGEHKAVAPLVRYLKSNDTNMHRATAQALYQLSEDAdncitmhengAVKLLLDMV 889
Cdd:COG1413    59 PDPEVRAAAAEALGR----------IGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEAL 118

                         170
                  ....*....|....*....
gi 2462519840 890 GSPDQDLQEAAAGCISNIR 908
Cdd:COG1413   119 KDPDWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
503-658 9.38e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 503 AIRKAGGIPLLARLLKTSHENMLIPVVGTLqecaseenyrAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKet 582
Cdd:COG1413    11 RLGDPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE-- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462519840 583 rdlvrlhgGLKPLASLLNNTDNKERLAAVTGaiwkcsiskenVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGE 658
Cdd:COG1413    79 --------AVPALIAALKDEDPEVRRAAAEA-----------LGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 718-823 3.17e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 40.40  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 718 LLWSLLKNPHPDVKASAAWALCPCikNAKDAgemvrsfvggLELIVNLLKSDNKEVLASVCAAitniakdqenLAVITDH 797
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRI--GDPEA----------VPALLELLKDEDPAVRRAAAEA----------LGKIGDP 61

                          90       100
                  ....*....|....*....|....*..
gi 2462519840 798 GVVPLLSKLANTNNNK-LRHHLAEAIS 823
Cdd:pfam13646  62 EALPALLELLRDDDDDvVRAAAAEALA 88
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 501-738 6.67e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  501 KEAIRKAGGIPLLARLLKT----SHENMLIpVVGTLqeCASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQC 576
Cdd:PLN03200   481 KWAITAAGGIPPLVQLLETgsqkAKEDSAT-VLWNL--CCHSEDIRACVESAGAVPALLWLLKNGGPKGQEIAAKTLTKL 557

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  577 AEDKETRDLVRLhgglkpLASLLNNT-DNKERLAAVTGAIWkCSISKENVtkFRE----YKAIETLVGLLTDQPEEVLVN 651
Cdd:PLN03200   558 VRTADAATISQL------TALLLGDLpESKVHVLDVLGHVL-SVASLEDL--VREgsaaNDALRTLIQLLSSSKEETQEK 628

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  652 VVGALGECCQERENrvivrKCGG------IQPLVNLLVGINQALLVNVTKAVGA---CAVEPESMMIIDRlDGVRLLWSL 722
Cdd:PLN03200   629 AASVLADIFSSRQD-----LCESlatdeiINPCIKLLTNNTEAVATQSARALAAlsrSIKENRKVSYAAE-DAIKPLIKL 702

                          250
                   ....*....|....*.
gi 2462519840  723 LKNPHPDVKASAAWAL 738
Cdd:PLN03200   703 AKSSSIEVAEQAVCAL 718
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 500-537 7.16e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 7.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462519840 500 NKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECAS 537
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 325-560 9.35e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 9.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  325 SEYWQ---IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEvkCKIGSLKILKEISHNP 401
Cdd:PLN03200  1644 SEYYFevpVAVLVKLLRSTSESTVVVALNALLVLERDDSSSAEQMAESGAIEALLELLRSHQ--CEEAAARLLEALFNNV 1721

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  402 QIRQ-NIVDLGGLPIMVNILDsPH---KSLKCLAAETIANVAkfkrarrvvrQHGGITKlvalldcAHDSTKP--AQSSL 475
Cdd:PLN03200  1722 KVREmKATKYAIAPLSQYLLD-PQtrsQQARLLAALALGDLF----------QHEGLAR-------STDAVSAcrALVSL 1783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  476 YEARDVE----VARCGALALWSCSKshTNKEAIRKAGGIPLLARLLKTSHEN------MLIPVV---GTLQECASEENYR 542
Cdd:PLN03200  1784 LEDQPTEemkmVAICALQNLVMHSR--TNKRAVAEAGGVQVVQELLLSSNPDtsgqaaLLIKLLfsnHTIQEYASSELIR 1861

                          250       260
                   ....*....|....*....|....*.
gi 2462519840  543 AAIKA-ER-------IIENLVKNLNS 560
Cdd:PLN03200  1862 ALTAAlEKdlwstatVNEEVLRALNV 1887
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 400-439 2.12e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 2.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462519840 400 NPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVA 439
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 497-532 2.62e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 2.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462519840  497 SHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTL 532
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 757-786 8.64e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.10  E-value: 8.64e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462519840  757 GGLELIVNLLKSDNKEVLASVCAAITNIAK 786
Cdd:smart00185  12 GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
730-908 2.97e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.48  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 730 VKASAAWALCpcIKNAKDAgemvrsfvggLELIVNLLKSDNKEVLASVCAAitniakdqenLAVITDHGVVPLLSKLANT 809
Cdd:COG1413     1 VRRAAARALG--RLGDPAA----------VPALIAALADEDPDVRAAAARA----------LGRLGDPRAVPALLEALKD 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 810 NNNKLRHHLAEAISRccmwgrnrvaFGEHKAVAPLVRYLKSNDTNMHRATAQALYQLSEDAdncitmhengAVKLLLDMV 889
Cdd:COG1413    59 PDPEVRAAAAEALGR----------IGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEAL 118

                         170
                  ....*....|....*....
gi 2462519840 890 GSPDQDLQEAAAGCISNIR 908
Cdd:COG1413   119 KDPDWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
716-866 1.20e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.86  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 716 VRLLWSLLKNPHPDVKASAAWALcpciknakdaGEMVRSfvGGLELIVNLLKSDNKEVLASVCAAITNIAKDQenlavit 795
Cdd:COG1413    18 VPALIAALADEDPDVRAAAARAL----------GRLGDP--RAVPALLEALKDPDPEVRAAAAEALGRIGDPE------- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462519840 796 dhgVVPLLSKLANTNNNKLRHHLAEAISRccmwgrnrvaFGEHKAVAPLVRYLKSNDTNMHRATAQALYQL 866
Cdd:COG1413    79 ---AVPALIAALKDEDPEVRRAAAEALGR----------LGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
503-658 9.38e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 503 AIRKAGGIPLLARLLKTSHENMLIPVVGTLqecaseenyrAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKet 582
Cdd:COG1413    11 RLGDPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE-- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462519840 583 rdlvrlhgGLKPLASLLNNTDNKERLAAVTGaiwkcsiskenVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGE 658
Cdd:COG1413    79 --------AVPALIAALKDEDPEVRRAAAEA-----------LGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 718-823 3.17e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 40.40  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 718 LLWSLLKNPHPDVKASAAWALCPCikNAKDAgemvrsfvggLELIVNLLKSDNKEVLASVCAAitniakdqenLAVITDH 797
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRI--GDPEA----------VPALLELLKDEDPAVRRAAAEA----------LGKIGDP 61

                          90       100
                  ....*....|....*....|....*..
gi 2462519840 798 GVVPLLSKLANTNNNK-LRHHLAEAIS 823
Cdd:pfam13646  62 EALPALLELLRDDDDDvVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
632-824 6.20e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 632 KAIETLVGLLTDQPEEVLVNVVGALGECCQERenrvivrkcggiqplvnllvginqallvnvtkavgacAVEPesmmiid 711
Cdd:COG1413    16 AAVPALIAALADEDPDVRAAAARALGRLGDPR-------------------------------------AVPA------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 712 rldgvrlLWSLLKNPHPDVKASAAWALCpCIKNAKdagemvrsfvgGLELIVNLLKSDNKEVLASVCAAitniakdqenL 791
Cdd:COG1413    52 -------LLEALKDPDPEVRAAAAEALG-RIGDPE-----------AVPALIAALKDEDPEVRRAAAEA----------L 102

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462519840 792 AVITDHGVVPLLSKLANTNNNKLRHHLAEAISR 824
Cdd:COG1413   103 GRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 501-738 6.67e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  501 KEAIRKAGGIPLLARLLKT----SHENMLIpVVGTLqeCASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQC 576
Cdd:PLN03200   481 KWAITAAGGIPPLVQLLETgsqkAKEDSAT-VLWNL--CCHSEDIRACVESAGAVPALLWLLKNGGPKGQEIAAKTLTKL 557

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  577 AEDKETRDLVRLhgglkpLASLLNNT-DNKERLAAVTGAIWkCSISKENVtkFRE----YKAIETLVGLLTDQPEEVLVN 651
Cdd:PLN03200   558 VRTADAATISQL------TALLLGDLpESKVHVLDVLGHVL-SVASLEDL--VREgsaaNDALRTLIQLLSSSKEETQEK 628

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  652 VVGALGECCQERENrvivrKCGG------IQPLVNLLVGINQALLVNVTKAVGA---CAVEPESMMIIDRlDGVRLLWSL 722
Cdd:PLN03200   629 AASVLADIFSSRQD-----LCESlatdeiINPCIKLLTNNTEAVATQSARALAAlsrSIKENRKVSYAAE-DAIKPLIKL 702

                          250
                   ....*....|....*.
gi 2462519840  723 LKNPHPDVKASAAWAL 738
Cdd:PLN03200   703 AKSSSIEVAEQAVCAL 718
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 500-537 7.16e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 7.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462519840 500 NKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECAS 537
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 325-560 9.35e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 9.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  325 SEYWQ---IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEvkCKIGSLKILKEISHNP 401
Cdd:PLN03200  1644 SEYYFevpVAVLVKLLRSTSESTVVVALNALLVLERDDSSSAEQMAESGAIEALLELLRSHQ--CEEAAARLLEALFNNV 1721

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  402 QIRQ-NIVDLGGLPIMVNILDsPH---KSLKCLAAETIANVAkfkrarrvvrQHGGITKlvalldcAHDSTKP--AQSSL 475
Cdd:PLN03200  1722 KVREmKATKYAIAPLSQYLLD-PQtrsQQARLLAALALGDLF----------QHEGLAR-------STDAVSAcrALVSL 1783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840  476 YEARDVE----VARCGALALWSCSKshTNKEAIRKAGGIPLLARLLKTSHEN------MLIPVV---GTLQECASEENYR 542
Cdd:PLN03200  1784 LEDQPTEemkmVAICALQNLVMHSR--TNKRAVAEAGGVQVVQELLLSSNPDtsgqaaLLIKLLfsnHTIQEYASSELIR 1861

                          250       260
                   ....*....|....*....|....*.
gi 2462519840  543 AAIKA-ER-------IIENLVKNLNS 560
Cdd:PLN03200  1862 ALTAAlEKdlwstatVNEEVLRALNV 1887
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 878-907 1.23e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.43  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462519840 878 ENGAVKLLLDMVGSPDQDLQEAAAGCISNI 907
Cdd:pfam00514  10 EAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 400-439 2.12e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 2.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462519840 400 NPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVA 439
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 497-532 2.62e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 2.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462519840  497 SHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTL 532
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 757-786 8.64e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.10  E-value: 8.64e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462519840  757 GGLELIVNLLKSDNKEVLASVCAAITNIAK 786
Cdd:smart00185  12 GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 799-901 8.89e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 799 VVPLLSKLANTNNNKLRHHLAEAISRccmwgrnrvaFGEHKAVAPLVRYLKSNDTNMHRATAQALYQLSEDAdncitmhe 878
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGR----------IGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPE-------- 62

                          90       100
                  ....*....|....*....|....
gi 2462519840 879 ngAVKLLLDMVGS-PDQDLQEAAA 901
Cdd:pfam13646  63 --ALPALLELLRDdDDDVVRAAAA 84
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 761-863 9.07e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 9.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519840 761 LIVNLLKSDNKEVLASVCAAITNIaKDQEnlavitdhgVVPLLSKLANTNNNKLRHHLAEAISRccmwgrnrvaFGEHKA 840
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRI-GDPE---------AVPALLELLKDEDPAVRRAAAEALGK----------IGDPEA 63

                          90       100
                  ....*....|....*....|....
gi 2462519840 841 VAPLVRYLKSNDTNMHRATA-QAL 863
Cdd:pfam13646  64 LPALLELLRDDDDDVVRAAAaEAL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH