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Conserved domains on  [gi|2462624489|ref|XP_054218844|]
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tenascin isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1980-2189 8.14e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 368.77  E-value: 8.14e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1980 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2058
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2059 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2130
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624489 2131 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2189
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 2.80e-23

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 107.40  E-value: 2.80e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 2462624489 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1616-1959 1.93e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1616 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDLTGLREATEYEIELYGISK 1695
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1696 GRQSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1774
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1775 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 1849
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1850 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 1921
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2462624489 1922 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1959
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.24e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.24e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624489 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
804-884 1.51e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2462624489  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
713-793 8.18e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 8.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 2462624489  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.19e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 2462624489 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
1533-1605 2.15e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.15e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489 1533 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
624-779 1.20e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 1.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 2462624489  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.12e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.12e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 8.60e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 46.91  E-value: 8.60e-07
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 3.93e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 45.37  E-value: 3.93e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 6.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 44.60  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 1.26e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 41.13  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 2.49e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 3.44e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.59  E-value: 3.44e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 5.10e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 5.68e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.20  E-value: 5.68e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 1.00e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.43  E-value: 1.00e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 1.46e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 2.43e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.28  E-value: 2.43e-03
                           10        20
                   ....*....|....*....|....*....
gi 2462624489  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 2.93e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.28  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 4.56e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.51  E-value: 4.56e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 9.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 35.74  E-value: 9.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1980-2189 8.14e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 368.77  E-value: 8.14e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1980 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2058
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2059 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2130
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624489 2131 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2189
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1979-2188 1.06e-107

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 342.30  E-value: 1.06e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1979 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 2058
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2059 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 2137
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462624489 2138 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2188
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1980-2188 6.17e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 340.02  E-value: 6.17e-107
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  1980 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 2059
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  2060 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 2137
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462624489  2138 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2188
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 2.80e-23

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 107.40  E-value: 2.80e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 2462624489 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1616-1959 1.93e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1616 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDLTGLREATEYEIELYGISK 1695
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1696 GRQSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1774
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1775 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 1849
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1850 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 1921
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2462624489 1922 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1959
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1888-1960 3.29e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 3.29e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489 1888 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1960
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.24e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.24e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624489 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
894-976 2.89e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 2462624489  970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1888-1960 2.80e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.25  E-value: 2.80e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489  1888 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1960
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 1.02e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 2462624489  971 DKESNPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
804-884 1.51e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2462624489  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1711-1797 1.88e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1711 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1786
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2462624489 1787 ESEPV-SGSFTT 1797
Cdd:cd00063     82 ESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
713-793 8.18e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 8.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 2462624489  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.19e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 2462624489 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 3.03e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.03e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 3.40e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 3.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  667 QFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401    264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401    341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401    418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*..
gi 2462624489  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401    498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
fn3 pfam00041
Fibronectin type III domain;
1533-1605 2.15e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.15e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489 1533 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 1.20e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 1.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 2462624489  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.12e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.12e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 3.45e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 3.45e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489   881 SS 882
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 2.24e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.24e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 4.32e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 4.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 2462624489  700 KSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1344 1.66e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 1.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1260 GNLTVTEVSWDALRLNWTTPDGTY---DQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTR 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                   ....*...
gi 2462624489 1337 PLAVEVVT 1344
Cdd:cd00063     85 PSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 3.42e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 2462624489  790 TRGPGLKRVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1990-2023 3.96e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.33  E-value: 3.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462624489 1990 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 2023
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 4.02e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 4.02e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 2462624489   791 RGPG 794
Cdd:smart00060   80 AGEG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 8.60e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.91  E-value: 8.60e-07
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 3.93e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.37  E-value: 3.93e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 6.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.60  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1326 1.03e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.03e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624489  1261 NLTVTEVSWDALRLNWTTPD---GTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTL 1326
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 1.11e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 1.11e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489   624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 1.26e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.13  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 2.49e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 3.44e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.44e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1351-1435 4.00e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 4.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1351 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1426
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 2462624489 1427 PVLSAEAST 1435
Cdd:cd00063     85 PSESVTVTT 93
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 5.10e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 5.68e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 5.68e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 1.00e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.43  E-value: 1.00e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 1.46e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 2.43e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.43e-03
                           10        20
                   ....*....|....*....|....*....
gi 2462624489  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 2.84e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.84e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462624489  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 2.93e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1352-1420 4.30e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 4.30e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624489  1352 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1420
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 4.56e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 4.56e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-496 4.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.92e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462624489  471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054      8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1617 5.75e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 5.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1533 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKlLDPQEF-TLSGTQRKLELRGLITGIGYEVMVSGFTQGHQT 1608
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGS-GDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 2462624489 1609 KPLRAEIVT 1617
Cdd:cd00063     84 PPSESVTVT 92
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
339-454 8.74e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 38.97  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  339 EDCGkpTCPHACHTQGRCEEGQCVCDEGfaGVDCSekrcpadchnrGRCVDGRCEcddgftGADCGElkCPNGCSGHGRC 418
Cdd:NF041328    40 SNCG--ACGVACGAGQTCVAGACGCGPG--TVACG-----------GACVDTASD------PAHCGA--CGAACAPGQVC 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462624489  419 VNGQC--VCDEGYT--GEDCSQLR--------CPNDCHSRGRCVEGKC 454
Cdd:NF041328    97 EGGACreACSEGLTrcGGACVDLAtdplhcgaCGVACDPGESCRGGAC 144
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 381-403 9.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  381 CHNRGRCVDG----RCECDDGFTGADC 403
Cdd:cd00054     11 CQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 9.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 9.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1980-2189 8.14e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 368.77  E-value: 8.14e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1980 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2058
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2059 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2130
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624489 2131 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2189
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1979-2188 1.06e-107

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 342.30  E-value: 1.06e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1979 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 2058
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2059 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 2137
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462624489 2138 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2188
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1980-2188 6.17e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 340.02  E-value: 6.17e-107
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  1980 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 2059
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  2060 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 2137
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462624489  2138 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2188
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 2.80e-23

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 107.40  E-value: 2.80e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 2462624489 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1616-1959 1.93e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1616 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDLTGLREATEYEIELYGISK 1695
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1696 GRQSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1774
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1775 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 1849
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1850 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 1921
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2462624489 1922 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 1959
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1888-1960 3.29e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 3.29e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489 1888 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1960
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.24e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.24e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462624489 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
894-976 2.89e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 2462624489  970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1075-1154 2.62e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.62e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1075 PELENLTVTEVGWDGLRLNWTAADQ---AYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGY 1151
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 2462624489 1152 RTP 1154
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1888-1960 2.80e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 67.25  E-value: 2.80e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489  1888 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1960
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
1711-1790 2.83e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1711 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1786
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2462624489 1787 ESEP 1790
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
986-1064 3.06e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 3.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYSLPTGQ--WVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2462624489 1061 KSKP 1064
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 1.02e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 2462624489  971 DKESNPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
804-884 1.51e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2462624489  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1711-1797 1.88e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1711 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1786
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2462624489 1787 ESEPV-SGSFTT 1797
Cdd:cd00063     82 ESPPSeSVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1888-1973 6.55e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 6.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1888 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTAKIQALNGPL 1962
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2462624489 1963 RSNMIQTI-FTT 1973
Cdd:cd00063     82 ESPPSESVtVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 986-1065 6.81e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 6.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYS-LPTGQWVGVQLPR-NTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 2462624489 1061 KSKPA 1065
Cdd:cd00063     82 ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
713-793 8.18e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 8.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 2462624489  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1169-1241 1.51e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.51e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489 1169 GEVVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQD 1241
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.19e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 2462624489 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 3.03e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.03e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 3.40e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 3.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  667 QFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401    264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401    341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401    418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*..
gi 2462624489  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401    498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 4.64e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 4.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2462624489  881 SSNPAK-ETFTT 891
Cdd:cd00063     82 ESPPSEsVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1621-1700 7.64e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 7.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1621 PEVDNLLVSDATPDGFRLSWTADE---GVFDNFVLKIRDTKKQSEPLEITLLAPERTRDLTGLREATEYEIELYGISKGR 1697
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 2462624489 1698 QSQ 1700
Cdd:pfam00041   81 EGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1691-1960 1.94e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.18  E-value: 1.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1691 YGISKGRQSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAP-TAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKL 1769
Cdd:COG3401     32 SGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGtTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGL 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1770 IPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNT 1849
Cdd:COG3401    112 TSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTT 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1850 VEYALTDLEPATEYTLRIFA---EKGPQKSSTITA-KFTTDLDSPRDLTATEVQSETALLTWRP-PRASVTGYLLVYESV 1924
Cdd:COG3401    192 LVDGGGDIEPGTTYYYRVAAtdtGGESAPSNEVSVtTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNS 271

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2462624489 1925 DGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 1960
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA 307
fn3 pfam00041
Fibronectin type III domain;
1533-1605 2.15e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.15e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489 1533 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1802-1872 2.61e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 2.61e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489 1802 PSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKG 1872
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 894-974 1.08e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.08e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   894 DAPRNLRRVSQTDNSITLEWR-----NGKAAIDSYRIKYAPiSGGDHAEVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAV 968
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYRE-EGSEWKEVNVTPS---STSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2462624489   969 KEDKES 974
Cdd:smart00060   78 NGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 1.20e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 1.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-RELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 2462624489  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.12e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.12e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 3.45e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 3.45e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489   881 SS 882
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1711-1788 6.83e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 6.83e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  1711 GSPKEVIFSDITENSATVSWRAPT-AQVESFRITYVPITGGTPS---MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1786
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489  1787 ES 1788
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 2.24e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.24e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624489  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 4.32e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 4.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 2462624489  700 KSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1800-1876 7.05e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 7.05e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  1800 DGPSGLVTANITDSEALARWQ-PAIATVDSYVISYTGEKVPEITR----TVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1874
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSEwkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489  1875 KS 1876
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1344 1.66e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 1.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1260 GNLTVTEVSWDALRLNWTTPDGTY---DQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTR 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                   ....*...
gi 2462624489 1337 PLAVEVVT 1344
Cdd:cd00063     85 PSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1800-1885 2.38e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1800 DGPSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 1874
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2462624489 1875 KS-STITAKFTT 1885
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 3.42e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 2462624489  790 TRGPGLKRVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1990-2023 3.96e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.33  E-value: 3.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462624489 1990 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 2023
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 4.02e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 4.02e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 2462624489   791 RGPG 794
Cdd:smart00060   80 AGEG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 8.60e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.91  E-value: 8.60e-07
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1623-1708 1.69e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 1.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1623 VDNLLVSDATPDGFRLSWTA---DEGVFDNFVLKIRDtKKQSEPLEITLLAPERTR-DLTGLREATEYEIELYGISKGRQ 1698
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 2462624489 1699 SQ-TVSAIATT 1708
Cdd:cd00063     83 SPpSESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 3.93e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.37  E-value: 3.93e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 6.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.60  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1078-1162 8.98e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 8.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1078 ENLTVTEVGWDGLRLNWTAADQAY---EHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYR-T 1153
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 2462624489 1154 PVLSAEAST 1162
Cdd:cd00063     85 PSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1326 1.03e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.03e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624489  1261 NLTVTEVSWDALRLNWTTPD---GTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTL 1326
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1621-1699 4.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 4.10e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  1621 PEVDNLLVSDATPDGFRLSWTA-DEGVFDNFVLKIRDTKKQSEPLEITLLAPERTR--DLTGLREATEYEIELYGISKGR 1697
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2462624489  1698 QS 1699
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1253 4.58e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 4.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1171 VVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPL 1247
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 2462624489 1248 SVEVLT 1253
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1078-1147 7.24e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 7.24e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489  1078 ENLTVTEVGWDGLRLNWTA-ADQAYEHFIIQVQEANKVEAAR--NLTVPGSLRAVDIPGLKAATPYTVSIYGV 1147
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEwkEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1240 7.24e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 7.24e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489  1171 VVVAEVGWDALKLNWTAPEGAYEYFFI---QVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQ 1240
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIvgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 1.11e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 1.11e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624489   624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 1.26e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.13  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 2.49e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 412-434 3.38e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 3.38e-04
                           10        20
                   ....*....|....*....|....*
gi 2462624489  412 CSGHGRCVN--GQCVCDEGYTGEDC 434
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 3.41e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.41e-04
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 3.44e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.44e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1351-1435 4.00e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 4.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1351 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1426
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 2462624489 1427 PVLSAEAST 1435
Cdd:cd00063     85 PSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
868-1239 4.86e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 45.32  E-value: 4.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  868 EYEVSL--ISRRGDMSSNPAKETFTTGLD-----APRNLRrVSQTDNSITLEWRNGK-AAIDSYRIKYAPisGGDHAEVD 939
Cdd:COG4733    598 DYEVRVraINALGVSSAWAASSETTVTGKtapppAPTGLT-ATGGLGGITLSWSFPVdADTLRTEIRYST--TGDWASAT 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  940 VPKSQQATTKTTLTGLRPGTEYGIGVSAVkeDKESN--PATINAATELDTPKDLQVSETAETsltllwKTPLAKfdryRL 1017
Cdd:COG4733    675 VAQALYPGNTYTLAGLKAGQTYYYRARAV--DRSGNvsAWWVSGQASADAAGILDAITGQIL------ETELGQ----EL 742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1018 NYSLPTGQWVGVQLPRNTTsyvlrglepgqeynvlLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAA 1097
Cdd:COG4733    743 DAIIQNATVAEVVAATVTD----------------VTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAAD 806

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1098 DQAYEH-FIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEV 1176
Cdd:COG4733    807 AAGDASgGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADV 886

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462624489 1177 GWDALKLNWTAPEGAYEY--FFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVT 1239
Cdd:COG4733    887 SAVADSTAASLTAIVIAAttIIDAIGDGTTREPAGDIGASGGAQGFAVTIVGSFDGAGAVATVDA 951
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 713-783 4.88e-04

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 41.03  E-value: 4.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624489  713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893    3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 5.10e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 5.57e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 5.57e-04
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 5.68e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 5.68e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 1.00e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.43  E-value: 1.00e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 504-527 1.43e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  504 DCSNRGLCVD--GQCVCEDGFTGPDC 527
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 1.46e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 2.43e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.43e-03
                           10        20
                   ....*....|....*....|....*....
gi 2462624489  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1802-2172 2.71e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.45  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1802 PSGLVTANITDSEALARWQPAIAT--VDSYVISYTGEKVpeitRTVSGNTvEYALTDLEPATEYTLRIFA-EKGPQKSST 1878
Cdd:COG3979      6 PTGLTASNVTSSSVSLSWDASTDNvgVTGYDVYRGGDQV----ATVTGLT-AWTVTGLTPGTEYTFTVGAcDAAGNVSAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1879 ITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLS-PSTHYTAKIQA 1957
Cdd:COG3979     81 SGTSTAMFGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSgGTTTIITTGVE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1958 LNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVflrrkngreNFY 2037
Cdd:COG3979    161 GGGGSKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGT---------TAT 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 2038 QNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYH 2117
Cdd:COG3979    232 GGTVGITSAYGAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGGYGATGTT 311

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462624489 2118 NGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHW 2172
Cdd:COG3979    312 VAGAAGVGGTKSGTGALGLSGAGGAGAAVSGTATGDDDAGADDSTAGVSGAGSTT 366
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 2.84e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.84e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462624489  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 2.93e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1352-1420 4.30e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 4.30e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624489  1352 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1420
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 4.56e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 4.56e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462624489  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-496 4.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.92e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462624489  471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054      8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1617 5.75e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 5.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1533 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKlLDPQEF-TLSGTQRKLELRGLITGIGYEVMVSGFTQGHQT 1608
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGS-GDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 2462624489 1609 KPLRAEIVT 1617
Cdd:cd00063     84 PPSESVTVT 92
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
277-424 5.90e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 41.55  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  277 DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCeegftgedcgkptCPHACHTQGRC 356
Cdd:COG4624      3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCC-------------CCCCRCCVAIS 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624489  357 EEGQCVCDEGFaGVDCSEKRCPADCHNRGRCVDgrcECDDGFTGADCGELKcpngcSGHGRCVN-GQCV 424
Cdd:COG4624     70 CIQVRGIIIID-KRGPSIIRDKEKCKNCYPCVR---ACPVKAIKVDDGKAE-----IDEEKCIScGQCV 129
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 532-558 8.22e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 8.22e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  532 CPNDCHGQGRCVNGQCVCHEGFMGKDC 558
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
895-1242 8.50e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 40.91  E-value: 8.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  895 APRNLRRVSQTDNSITLEWRngkAAIDSYRIKYAPI-SGGDhaEVDVPKSQqatTKTTLTGLRPGTEYGIGVSAVkeDKE 973
Cdd:COG3979      5 APTGLTASNVTSSSVSLSWD---ASTDNVGVTGYDVyRGGD--QVATVTGL---TAWTVTGLTPGTEYTFTVGAC--DAA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  974 SN----PATINAATELDTPKDLQVSETAETSLTllWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEY 1049
Cdd:COG3979     75 GNvsaaSGTSTAMFGGSSTTLGSAEGVADTSGN--LAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTT 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1050 NVLLTAEKGRHKSKPARVKASTEQAPelenlTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAV 1129
Cdd:COG3979    153 TIITTGVEGGGGSKTAQSLNAITAAG-----TAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSG 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489 1130 DIPGLKAATPYTVSIYGVIQGYRTPV--LSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEA 1207
Cdd:COG3979    228 TTATGGTVGITSAYGAGVSGNAAVNVnaGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGGYGA 307

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2462624489 1208 AQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDF 1242
Cdd:COG3979    308 TGTTVAGAAGVGGTKSGTGALGLSGAGGAGAAVSG 342
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 224-247 8.63e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 8.63e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  224 DCNDQGKCVN--GVCICFEGYAGADC 247
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
339-454 8.74e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 38.97  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624489  339 EDCGkpTCPHACHTQGRCEEGQCVCDEGfaGVDCSekrcpadchnrGRCVDGRCEcddgftGADCGElkCPNGCSGHGRC 418
Cdd:NF041328    40 SNCG--ACGVACGAGQTCVAGACGCGPG--TVACG-----------GACVDTASD------PAHCGA--CGAACAPGQVC 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462624489  419 VNGQC--VCDEGYT--GEDCSQLR--------CPNDCHSRGRCVEGKC 454
Cdd:NF041328    97 EGGACreACSEGLTrcGGACVDLAtdplhcgaCGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 194-216 8.89e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 8.89e-03
                           10        20
                   ....*....|....*....|....*
gi 2462624489  194 CHLRGRCID--GQCICDDGFTGEDC 216
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 381-403 9.16e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  381 CHNRGRCVDG----RCECDDGFTGADC 403
Cdd:cd00054     11 CQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 9.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 9.16e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462624489  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 566-589 9.42e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.40  E-value: 9.42e-03
                           10        20
                   ....*....|....*....|....*.
gi 2462624489  566 DCHGQGRCVD--GQCICHEGFTGLDC 589
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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