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Conserved domains on  [gi|2462621315|ref|XP_054217329|]
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phospholipid phosphatase 5 isoform X1 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Homo sapiens phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 1-174 4.41e-75

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 224.41  E-value: 4.41e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   1 MLAPVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM---- 76
Cdd:cd03390    16 WLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgid 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  77 --CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQ 154
Cdd:cd03390    96 icCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFS 173

                         170       180
                  ....*....|....*....|
gi 2462621315 155 DVLVGSMIGMTFAYVCYRQY 174
Cdd:cd03390   174 DVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 1-174 4.41e-75

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 224.41  E-value: 4.41e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   1 MLAPVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM---- 76
Cdd:cd03390    16 WLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgid 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  77 --CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQ 154
Cdd:cd03390    96 icCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFS 173

                         170       180
                  ....*....|....*....|
gi 2462621315 155 DVLVGSMIGMTFAYVCYRQY 174
Cdd:cd03390   174 DVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 4-186 5.07e-59

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 187.83  E-value: 5.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   4 PVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCT 78
Cdd:PLN02250   72 PLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCT 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  79 GDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLV 158
Cdd:PLN02250  151 GAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFA 228

                         170       180
                  ....*....|....*....|....*...
gi 2462621315 159 GSMIGMTFAYVCYRQYYPPLTDAECHKP 186
Cdd:PLN02250  229 GALIGLTVASFCYLQFFPPPYDIDGWGP 256
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 44-175 7.58e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 91.33  E-value: 7.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  44 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 123
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462621315 124 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYY 175
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
46-171 1.37e-23

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 90.48  E-value: 1.37e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   46 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 125
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462621315  126 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 171
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 2-174 6.56e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.59  E-value: 6.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   2 LAPVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdk 81
Cdd:COG0671    44 LLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG------- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  82 dvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSM 161
Cdd:COG0671   116 ------GYSFPSGHAAAAFALALVLALLL---------------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGAL 174

                         170
                  ....*....|...
gi 2462621315 162 IGMTFAYVCYRQY 174
Cdd:COG0671   175 LGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 1-174 4.41e-75

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 224.41  E-value: 4.41e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   1 MLAPVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM---- 76
Cdd:cd03390    16 WLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgid 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  77 --CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQ 154
Cdd:cd03390    96 icCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFS 173

                         170       180
                  ....*....|....*....|
gi 2462621315 155 DVLVGSMIGMTFAYVCYRQY 174
Cdd:cd03390   174 DVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 4-186 5.07e-59

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 187.83  E-value: 5.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   4 PVIAFLSPLSLIFLAKFLKKaDTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCT 78
Cdd:PLN02250   72 PLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCT 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  79 GDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLV 158
Cdd:PLN02250  151 GAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF--DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFA 228

                         170       180
                  ....*....|....*....|....*...
gi 2462621315 159 GSMIGMTFAYVCYRQYYPPLTDAECHKP 186
Cdd:PLN02250  229 GALIGLTVASFCYLQFFPPPYDIDGWGP 256
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 4-202 6.92e-52

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 169.82  E-value: 6.92e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   4 PVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAH----SDLMCTG 79
Cdd:PLN02731   91 PVYAMLLPL-VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALydslGDVICHG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  80 DKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtpQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVG 159
Cdd:PLN02731  170 DKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF--DGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAG 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2462621315 160 SMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDS 202
Cdd:PLN02731  248 GLLGLAISTICYLQFFPPPYHTEGWGPYAYFQVLEAARVQGAA 290
PLN02715 PLN02715
lipid phosphate phosphatase
 4-202 1.15e-45

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 153.67  E-value: 1.15e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   4 PVIAFLSPLsLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSD----LMCTG 79
Cdd:PLN02715   97 PVYAVLLPI-ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDalggVICHG 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  80 DKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKswRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVG 159
Cdd:PLN02715  176 KAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVA--KLCLVIFPLLAACLVGISRVDDYWHHWQDVFAG 253

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462621315 160 SMIGMTFAYVCYRQYYPPLTDAECHKPF------QDKLVLSTAQKPGDS 202
Cdd:PLN02715  254 ALIGILVAAFCYRQFYPNPYHEEGWGPYayfkaaQERGVPVASSQNGDA 302
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 45-169 2.48e-30

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 108.87  E-value: 2.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  45 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKL 114
Cdd:cd03384    18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462621315 115 hcftpqgrgkSWRFCAFLSPLL------FAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYV 169
Cdd:cd03384    98 ----------KLRGSRLLRPLLqflllaLALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 43-171 2.98e-26

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 97.53  E-value: 2.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  43 NGVFTNTIKLIVGRPRPDFFYRCFPDGlahsdlmctgDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLhcftpqgr 122
Cdd:cd01610    15 GLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-------- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462621315 123 gksWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 171
Cdd:cd01610    77 ---LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 44-175 7.58e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 91.33  E-value: 7.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  44 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 123
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462621315 124 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYY 175
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
46-171 1.37e-23

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 90.48  E-value: 1.37e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   46 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 125
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462621315  126 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 171
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 2-174 6.56e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.59  E-value: 6.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315   2 LAPVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPdFFYRCFPDGLAHSDlmctgdk 81
Cdd:COG0671    44 LLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAG------- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  82 dvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSM 161
Cdd:COG0671   116 ------GYSFPSGHAAAAFALALVLALLL---------------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGAL 174

                         170
                  ....*....|...
gi 2462621315 162 IGMTFAYVCYRQY 174
Cdd:COG0671   175 LGLAIALLLLALL 187
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 44-174 7.29e-12

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 61.57  E-value: 7.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  44 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHSSFAFAgLAFASFYLAGKlhcftpqgrg 123
Cdd:cd03389    82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHSATAGA-AAAALALLFPR---------- 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462621315 124 ksWRFCAflspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 174
Cdd:cd03389   142 --YRWAF----ILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 47-168 8.57e-12

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 59.27  E-value: 8.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  47 TNTIKLIVGRPRPDffyrcfpdglahsdlmctGDkdvvNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrGKSW 126
Cdd:cd03394    19 TEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFLQYRY------------GWRW 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462621315 127 rfcAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAY 168
Cdd:cd03394    65 ---YGIPAYALASLVGASRVVANRHWLSDVLAGAAIGILVGY 103
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 44-174 1.02e-10

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 58.39  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  44 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrG 123
Cdd:cd03392    75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGFLAYLLARRLP-------R 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462621315 124 KSWRFCAFLSPLLFAAVIALSRTcdYKH-HW-QDVLVGSMIGMTFAYVCYRQY 174
Cdd:cd03392   129 RRVRILLLILAAILILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALLILLY 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 43-172 2.22e-07

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 48.80  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  43 NGVFTNTIKLIVGRPRPdffyrCFPDGLAHsdlmctgDKDVVNEGRK-SFPSGHSSFAFAGLAFASFYlagklhcftpqg 121
Cdd:cd03395    69 DQLASGFLKPLVARLRP-----CNALDGVR-------LVVLGDQGGSySFASSHAANSFALALFIWLF------------ 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462621315 122 rgksWRFCAFLSPLLF-AAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYR 172
Cdd:cd03395   125 ----FRRGLFSPVLLLwALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 50-163 2.09e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 45.77  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  50 IKLIVGRPRPdffyrcfpdglAHsdlMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrgkswrfc 129
Cdd:cd03391    66 LKALVRRRRP-----------AY---NSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVP-------------- 117

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462621315 130 aFLSPL-LFAAVIALSRTCDYKHHWQDVLVGSMIG 163
Cdd:cd03391   118 -LRVLLvLWATVVGISRVLLGRHHVLDVLAGAFLG 151
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 43-171 2.18e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 43.03  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  43 NGVFTNTIKLIVGRPRPDFfyrcfpdglaHSDLMCTGdkdvvnegrKSFPSGHSSFAFaglaFASFYLAGKLHCFTPQGR 122
Cdd:cd03382    54 NEALNYVLKRIIKEPRPCS----------GAYFVRSG---------YGMPSSHSQFMG----FFAVYLLLFIYLRLGRLN 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462621315 123 GKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 171
Cdd:cd03382   111 SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILWF 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 45-172 5.80e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 36.51  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621315  45 VFTNTIKLIVGRPRPdFFYRCFPDGLAHSDLMCTGDKDvvNEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqgRGK 124
Cdd:cd03396    81 LVVAILKSHWGRPRP-WDLTEFGGDAPYTPLFSGPSNG--CGKGCSFPSGHASAGFALLALYFLFRR----------RRP 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462621315 125 SWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYR 172
Cdd:cd03396   148 RLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLIALLLYR 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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